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The map label for this gene is purC

Identifier: 238916397

GI number: 238916397

Start: 461711

End: 462601

Strand: Direct

Name: purC

Synonym: EUBELI_00451

Alternate gene names: 238916397

Gene position: 461711-462601 (Clockwise)

Preceding gene: 238916395

Following gene: 238916398

Centisome position: 21.53

GC content: 39.17

Gene sequence:

>891_bases
ATGGATGAACTCATGGGAAAATGTGAATTACTCTATGAAGGAAAAGTAAGAGAAGTATATGATTGCGATGACAAGCTTGT
TATGGTTGCTACAGACCGTATCTCAGCATTTGATCACATTTTAAAGAATAAGGTTACAGAAAAGGGAGCAATTCTTACAC
AGATGTCAAAGTTCTGGTTTGATTATACTAAGGACGTTGTTGCTAATCATATGGTTTCGGTTGATGTTAATGACATGCCA
GAGTTCTTCCACAAAGATGAATATATTGGAAGAAGCATGCTTTGCAAGAAGCTTACAATGCTTCCTGTTGAGTGTATCGT
AAGAGGATACATTACAGGTAGTGGCTGGGCAAGCTACAAGGAAAACGGAACAGTCTGTGGAATTAAGCTTCCAGAGGGAC
TTAAGGAATCAGAGAAGCTTCCTGAACCAATCTACACACCAAGTACTAAGGCTGAGATTGGCGACCATGATGAGAATATT
TCATTTGAGAAGAGTATAGAAGTTCTTGAGAAGCAGTTCCCAGGTAAAGGTCTTGAGTATGCTACTAAGATTAAGGATGC
AACTATCACTCTTTACAAGAAGTGTGCAGAGTACGCTTTAAGCAAGGGTATTATTATTGCAGATACTAAGTTTGAATTTG
GTCTTGATGAGAATGGTGAGGTAGTTATCGGTGATGAGATGCTTACACCAGACAGCTCAAGATTCTGGCCATTAGAAGGA
TATGAGGCAGGAAAGAGCCAGCCATCATATGACAAGCAGTTTGTAAGAGACTGGTTAAAGGCTAATCCAGACAGTGATTA
TTTACTTCCAGATGATGTAATCGAGAAGACAGTTGAAAAGTACAAGGAAGCATATAAGCTTCTTACAGGCAAGGATTTTT
CCCGCAAATAA

Upstream 100 bases:

>100_bases
TGAATGGACGCTGGTATATAATATTTTTGTTTGTTTTTAAACCGCATAAACACTACGGTTTGATAACTTTTTAACTAATA
ATTATATTAAGAAGAAAAGG

Downstream 100 bases:

>100_bases
TCACAGTCGATAAGGAATGGAGAATTATGAATCAGATTGATATTAATGACAGCCACTATGCTGAAGATGAACTTCATGAG
GAATGCGGAGTCTTTGGTGT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MDELMGKCELLYEGKVREVYDCDDKLVMVATDRISAFDHILKNKVTEKGAILTQMSKFWFDYTKDVVANHMVSVDVNDMP
EFFHKDEYIGRSMLCKKLTMLPVECIVRGYITGSGWASYKENGTVCGIKLPEGLKESEKLPEPIYTPSTKAEIGDHDENI
SFEKSIEVLEKQFPGKGLEYATKIKDATITLYKKCAEYALSKGIIIADTKFEFGLDENGEVVIGDEMLTPDSSRFWPLEG
YEAGKSQPSYDKQFVRDWLKANPDSDYLLPDDVIEKTVEKYKEAYKLLTGKDFSRK

Sequences:

>Translated_296_residues
MDELMGKCELLYEGKVREVYDCDDKLVMVATDRISAFDHILKNKVTEKGAILTQMSKFWFDYTKDVVANHMVSVDVNDMP
EFFHKDEYIGRSMLCKKLTMLPVECIVRGYITGSGWASYKENGTVCGIKLPEGLKESEKLPEPIYTPSTKAEIGDHDENI
SFEKSIEVLEKQFPGKGLEYATKIKDATITLYKKCAEYALSKGIIIADTKFEFGLDENGEVVIGDEMLTPDSSRFWPLEG
YEAGKSQPSYDKQFVRDWLKANPDSDYLLPDDVIEKTVEKYKEAYKLLTGKDFSRK
>Mature_296_residues
MDELMGKCELLYEGKVREVYDCDDKLVMVATDRISAFDHILKNKVTEKGAILTQMSKFWFDYTKDVVANHMVSVDVNDMP
EFFHKDEYIGRSMLCKKLTMLPVECIVRGYITGSGWASYKENGTVCGIKLPEGLKESEKLPEPIYTPSTKAEIGDHDENI
SFEKSIEVLEKQFPGKGLEYATKIKDATITLYKKCAEYALSKGIIIADTKFEFGLDENGEVVIGDEMLTPDSSRFWPLEG
YEAGKSQPSYDKQFVRDWLKANPDSDYLLPDDVIEKTVEKYKEAYKLLTGKDFSRK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=307, Percent_Identity=47.557003257329, Blast_Score=278, Evalue=6e-76,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_EUBE2 (C4Z3J8)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002929914.1
- GeneID:   7957566
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_00451
- OMA:   LTLMDEV
- ProtClustDB:   PRK13961
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 33745; Mature: 33745

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELMGKCELLYEGKVREVYDCDDKLVMVATDRISAFDHILKNKVTEKGAILTQMSKFWF
CCCHHHHHHEEECCCCCCEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYTKDVVANHMVSVDVNDMPEFFHKDEYIGRSMLCKKLTMLPVECIVRGYITGSGWASYK
HHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCC
ENGTVCGIKLPEGLKESEKLPEPIYTPSTKAEIGDHDENISFEKSIEVLEKQFPGKGLEY
CCCCEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHH
ATKIKDATITLYKKCAEYALSKGIIIADTKFEFGLDENGEVVIGDEMLTPDSSRFWPLEG
HHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEECCCEECCCCCCCCCCCC
YEAGKSQPSYDKQFVRDWLKANPDSDYLLPDDVIEKTVEKYKEAYKLLTGKDFSRK
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDELMGKCELLYEGKVREVYDCDDKLVMVATDRISAFDHILKNKVTEKGAILTQMSKFWF
CCCHHHHHHEEECCCCCCEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYTKDVVANHMVSVDVNDMPEFFHKDEYIGRSMLCKKLTMLPVECIVRGYITGSGWASYK
HHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCC
ENGTVCGIKLPEGLKESEKLPEPIYTPSTKAEIGDHDENISFEKSIEVLEKQFPGKGLEY
CCCCEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHH
ATKIKDATITLYKKCAEYALSKGIIIADTKFEFGLDENGEVVIGDEMLTPDSSRFWPLEG
HHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEECCCEECCCCCCCCCCCC
YEAGKSQPSYDKQFVRDWLKANPDSDYLLPDDVIEKTVEKYKEAYKLLTGKDFSRK
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA