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The map label for this gene is ispD [H]

Identifier: 238916227

GI number: 238916227

Start: 291669

End: 292343

Strand: Direct

Name: ispD [H]

Synonym: EUBELI_00261

Alternate gene names: 238916227

Gene position: 291669-292343 (Clockwise)

Preceding gene: 238916226

Following gene: 238916228

Centisome position: 13.6

GC content: 38.37

Gene sequence:

>675_bases
ATGAATATAGCATTAGTGCTTGCCGGTGGAACGGGTACAAGACTTGGAGCAGATATTCCAAAGCAGTATATTGAAGTGCG
TGGAAAGATGATAATTGATTATTGTCTTGAGACAATGGAACATTCGAATGATATTGCTGAAGTGTGGATAGTTGCAGATG
AAATGTGGCGTGAACACATTAAGAAAGTTGATAAGTTTAAAGGATATGCGTGTCCTGGCAGAAACAGACAGTTATCTATA
TATAATGGATTGAAAGCAATTGAGGAGTCATTAGCTGATAAAGAGAAAGAAGTTAATGTTCTTATTCATGATGCAGCAAG
ACCATTTCTTACGGAAAAACTTATAAGAGAGTGCGTTAAGGCGGTTGAGGGTCATGATGGAGTGCTTCCGGTTCTTCCTA
TGAAAGATACAGTTTATTATAGTGAAGACGGAAAAGTTATTTCATCACTTATTAATCGTGATAAGTTATATGCAGGACAG
GCTCCGGAGTTATTCAGGCTGCAGCCTTATATTCAGGCAAATGAAGCTTTGCTGCCAGATAAGATTCTTTTGGTTAATGG
TTCTACAGAGCCGGCAATTATGGCAGGGATGGATATTGTTATGATTCCGGGAGACGAGAATAATTATAAGATAACTACGA
AGACAGATATGAAGCGGTTCACAGAAATGATGTAG

Upstream 100 bases:

>100_bases
TTCAGAGGAATTGGATTATTATTCAAAGAATGGAATAAAGGCATCTGAATATGTGTATAAAGACATTGTGGATGGTGTTT
TCAGGCTGTAAAGGAGTAAT

Downstream 100 bases:

>100_bases
ATTTATTTTTTCAGGAGAAAAATGATGAAAGCACAAGTGTTATATGGCATGGGTGATTTAAGATATAAGGATATAGAGAA
ACCACAGCTTAAAGAGGGCT

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNIALVLAGGTGTRLGADIPKQYIEVRGKMIIDYCLETMEHSNDIAEVWIVADEMWREHIKKVDKFKGYACPGRNRQLSI
YNGLKAIEESLADKEKEVNVLIHDAARPFLTEKLIRECVKAVEGHDGVLPVLPMKDTVYYSEDGKVISSLINRDKLYAGQ
APELFRLQPYIQANEALLPDKILLVNGSTEPAIMAGMDIVMIPGDENNYKITTKTDMKRFTEMM

Sequences:

>Translated_224_residues
MNIALVLAGGTGTRLGADIPKQYIEVRGKMIIDYCLETMEHSNDIAEVWIVADEMWREHIKKVDKFKGYACPGRNRQLSI
YNGLKAIEESLADKEKEVNVLIHDAARPFLTEKLIRECVKAVEGHDGVLPVLPMKDTVYYSEDGKVISSLINRDKLYAGQ
APELFRLQPYIQANEALLPDKILLVNGSTEPAIMAGMDIVMIPGDENNYKITTKTDMKRFTEMM
>Mature_224_residues
MNIALVLAGGTGTRLGADIPKQYIEVRGKMIIDYCLETMEHSNDIAEVWIVADEMWREHIKKVDKFKGYACPGRNRQLSI
YNGLKAIEESLADKEKEVNVLIHDAARPFLTEKLIRECVKAVEGHDGVLPVLPMKDTVYYSEDGKVISSLINRDKLYAGQ
APELFRLQPYIQANEALLPDKILLVNGSTEPAIMAGMDIVMIPGDENNYKITTKTDMKRFTEMM

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=170, Percent_Identity=31.7647058823529, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 25249; Mature: 25249

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIALVLAGGTGTRLGADIPKQYIEVRGKMIIDYCLETMEHSNDIAEVWIVADEMWREHI
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEHHHHHHHHH
KKVDKFKGYACPGRNRQLSIYNGLKAIEESLADKEKEVNVLIHDAARPFLTEKLIRECVK
HHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCCHHEEEEEECCCCHHHHHHHHHHHHH
AVEGHDGVLPVLPMKDTVYYSEDGKVISSLINRDKLYAGQAPELFRLQPYIQANEALLPD
HHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCC
KILLVNGSTEPAIMAGMDIVMIPGDENNYKITTKTDMKRFTEMM
EEEEEECCCCCCEEECCEEEEEECCCCCEEEEEHHHHHHHHHCC
>Mature Secondary Structure
MNIALVLAGGTGTRLGADIPKQYIEVRGKMIIDYCLETMEHSNDIAEVWIVADEMWREHI
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEHHHHHHHHH
KKVDKFKGYACPGRNRQLSIYNGLKAIEESLADKEKEVNVLIHDAARPFLTEKLIRECVK
HHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCCHHEEEEEECCCCHHHHHHHHHHHHH
AVEGHDGVLPVLPMKDTVYYSEDGKVISSLINRDKLYAGQAPELFRLQPYIQANEALLPD
HHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCC
KILLVNGSTEPAIMAGMDIVMIPGDENNYKITTKTDMKRFTEMM
EEEEEECCCCCCEEECCEEEEEECCCCCEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA