Click here to switch to the map view.

The map label for this gene is cysK [H]

Identifier: 238916015

GI number: 238916015

Start: 53554

End: 54492

Strand: Direct

Name: cysK [H]

Synonym: EUBELI_00048

Alternate gene names: 238916015

Gene position: 53554-54492 (Clockwise)

Preceding gene: 238916014

Following gene: 238916022

Centisome position: 2.5

GC content: 43.45

Gene sequence:

>939_bases
ATGAGTAAAGTAATTAATAGTGCATTGGAACTTATTGGAAACACACCTCTTCTTAACGCAAGCCGTTACGCTAAGAATGC
AGGAATTGAAGGAGTTACACTTCTTACAAAGCTTGAGTATCTTAACCCGGCTGGTTCAGTTAAGGACAGAGTTGCCCTTG
CTATGATTGAGGACGCTGAGAAGAAGGGTGAGCTTAAGCCAGGAGCAATGATTATAGAACCAACATCAGGTAATACAGGT
ATTGGTCTTGCTGCAGTTGCAGTTGCTAAGGGATACAGAGCAGTTCTTACTCTTCCTGATACAATGTCAGTTGAGAGAAG
AAATCTTCTTAAGGCTTATGGTGCAGAGATTGTTCTTACAGAAGGCGCTAAGGGTATGAAGGGTGCTATCGCTAAGGCTG
AGGAATTAAAGGAGCAGAATCCTGGTTCAGTAATCTTAGGCCAGTTCGTAAATCCAGCTAACCCAGCAGTTCATAAGGCT
ACAACAGGTCCTGAAATCTGGGAGCAGACAGAAGGAAAGGTTGATATATTTGTTGCAGGTGTGGGTACAGGCGGAACTGT
TACAGGTGTTGGTGAATACCTTAAGTCACAGAACCCGGATGTAAAGATTGTTGCTGTAGAGCCAGCTACAAGCCCGGTTC
TTTCAAAGGGAGAGGCAGGACCACATAAGATTCAGGGTATTGGTGCAGGATTTGTTCCAGATACACTTAATACTAAGATA
TATGATGAAGTTATCGCAATCGAGAATGAAGATGCATTCGTAGAGGGTAGAAGCTTTGCAAAGAGCGAGGGTATACTTGT
TGGTATCTCTTCAGGTGCAGCACTTAAGGCAGCACAGATACTTGCAGCCCGCCCAGAGAATGCAGGAAAGACAATTGTTG
CACTTCTTCCAGATTCAGGTGACAGATATCTTTCAACAGCACTTTTTAATGAACAGTAA

Upstream 100 bases:

>100_bases
ATTTTATATTCAACAACACATTTACACATCAAGTTAGTAGGTTAATGGGAACGCAAAAGCATATTTGCAAATGCATTCAT
AATAAGGAGGAAAATAAAAC

Downstream 100 bases:

>100_bases
TATATTAGAAAAAAGGCAGGGACTTGAAAATTTCAAGTCCCTGCCTTTTTTCGTTAGATATTAAGTAAATCACTATATAC
CTTTAAAGCACCATCTGTAT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSKVINSALELIGNTPLLNASRYAKNAGIEGVTLLTKLEYLNPAGSVKDRVALAMIEDAEKKGELKPGAMIIEPTSGNTG
IGLAAVAVAKGYRAVLTLPDTMSVERRNLLKAYGAEIVLTEGAKGMKGAIAKAEELKEQNPGSVILGQFVNPANPAVHKA
TTGPEIWEQTEGKVDIFVAGVGTGGTVTGVGEYLKSQNPDVKIVAVEPATSPVLSKGEAGPHKIQGIGAGFVPDTLNTKI
YDEVIAIENEDAFVEGRSFAKSEGILVGISSGAALKAAQILAARPENAGKTIVALLPDSGDRYLSTALFNEQ

Sequences:

>Translated_312_residues
MSKVINSALELIGNTPLLNASRYAKNAGIEGVTLLTKLEYLNPAGSVKDRVALAMIEDAEKKGELKPGAMIIEPTSGNTG
IGLAAVAVAKGYRAVLTLPDTMSVERRNLLKAYGAEIVLTEGAKGMKGAIAKAEELKEQNPGSVILGQFVNPANPAVHKA
TTGPEIWEQTEGKVDIFVAGVGTGGTVTGVGEYLKSQNPDVKIVAVEPATSPVLSKGEAGPHKIQGIGAGFVPDTLNTKI
YDEVIAIENEDAFVEGRSFAKSEGILVGISSGAALKAAQILAARPENAGKTIVALLPDSGDRYLSTALFNEQ
>Mature_311_residues
SKVINSALELIGNTPLLNASRYAKNAGIEGVTLLTKLEYLNPAGSVKDRVALAMIEDAEKKGELKPGAMIIEPTSGNTGI
GLAAVAVAKGYRAVLTLPDTMSVERRNLLKAYGAEIVLTEGAKGMKGAIAKAEELKEQNPGSVILGQFVNPANPAVHKAT
TGPEIWEQTEGKVDIFVAGVGTGGTVTGVGEYLKSQNPDVKIVAVEPATSPVLSKGEAGPHKIQGIGAGFVPDTLNTKIY
DEVIAIENEDAFVEGRSFAKSEGILVGISSGAALKAAQILAARPENAGKTIVALLPDSGDRYLSTALFNEQ

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=40.7643312101911, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=40.7643312101911, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=40.7643312101911, Blast_Score=235, Evalue=4e-62,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=55.3459119496855, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI2367138, Length=303, Percent_Identity=45.5445544554455, Blast_Score=245, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=59.1503267973856, Blast_Score=324, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI17535051, Length=303, Percent_Identity=52.8052805280528, Blast_Score=320, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI17562970, Length=303, Percent_Identity=50.8250825082508, Blast_Score=299, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI32566674, Length=296, Percent_Identity=51.6891891891892, Blast_Score=294, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17561720, Length=308, Percent_Identity=47.0779220779221, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=53.7383177570093, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17534315, Length=323, Percent_Identity=39.0092879256966, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI25147552, Length=324, Percent_Identity=35.8024691358025, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=44.5378151260504, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321594, Length=323, Percent_Identity=40.5572755417957, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=37.6146788990826, Blast_Score=149, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=39.1025641025641, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=39.1025641025641, Blast_Score=201, Evalue=6e-52,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32417; Mature: 32286

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVINSALELIGNTPLLNASRYAKNAGIEGVTLLTKLEYLNPAGSVKDRVALAMIEDAE
CHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEHHHHCCCCCCHHHHEEEEEHHHHH
KKGELKPGAMIIEPTSGNTGIGLAAVAVAKGYRAVLTLPDTMSVERRNLLKAYGAEIVLT
HCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEEE
EGAKGMKGAIAKAEELKEQNPGSVILGQFVNPANPAVHKATTGPEIWEQTEGKVDIFVAG
CCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEE
VGTGGTVTGVGEYLKSQNPDVKIVAVEPATSPVLSKGEAGPHKIQGIGAGFVPDTLNTKI
CCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHCCCCCCCCEEEECCCCCCCCCCCCCE
YDEVIAIENEDAFVEGRSFAKSEGILVGISSGAALKAAQILAARPENAGKTIVALLPDSG
EEEEEEECCCCCEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCCC
DRYLSTALFNEQ
CCEEEEECCCCC
>Mature Secondary Structure 
SKVINSALELIGNTPLLNASRYAKNAGIEGVTLLTKLEYLNPAGSVKDRVALAMIEDAE
HHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEHHHHCCCCCCHHHHEEEEEHHHHH
KKGELKPGAMIIEPTSGNTGIGLAAVAVAKGYRAVLTLPDTMSVERRNLLKAYGAEIVLT
HCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEEE
EGAKGMKGAIAKAEELKEQNPGSVILGQFVNPANPAVHKATTGPEIWEQTEGKVDIFVAG
CCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEE
VGTGGTVTGVGEYLKSQNPDVKIVAVEPATSPVLSKGEAGPHKIQGIGAGFVPDTLNTKI
CCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHCCCCCCCCEEEECCCCCCCCCCCCCE
YDEVIAIENEDAFVEGRSFAKSEGILVGISSGAALKAAQILAARPENAGKTIVALLPDSG
EEEEEEECCCCCEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCCC
DRYLSTALFNEQ
CCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA