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The map label for this gene is gyrA [H]

Identifier: 238915982

GI number: 238915982

Start: 6285

End: 8804

Strand: Direct

Name: gyrA [H]

Synonym: EUBELI_00006

Alternate gene names: 238915982

Gene position: 6285-8804 (Clockwise)

Preceding gene: 238915981

Following gene: 238915983

Centisome position: 0.29

GC content: 37.14

Gene sequence:

>2520_bases
ATGGATGAACATATCTTTGATAAAGTTCAAGAAGTCGATATGCAGAAAACTATGGAAAACTATTATATAGATTATGCCAT
GAGTGTTATCGCTTCCAGAGCACTTCCGGATGTAAGAGATGGTCTTAAGCCGGTACAGAGAAGAATTCTATATTCAATGA
TAGAACTTAACAACGGTCCTGATAAGCCACATAGAAAATGTGCCCGTATCGTTGGTGATACAATGGGTAAATATCACCCA
CATGGTGATTCATCAATTTATGAGGCATTAGTAAAGCTGGCTCAGGATTTTAATACAAGATATCCACTTGTTGACGGACA
TGGTAACTTTGGTTCAGTCGATGGTGATGGTGCCGCAGCCATGCGATATACAGAGGCGAGACTCAGCAAGATATCTATGG
AGATGACAAGAGATCTTAACAAAGATACTGTAGATTTCATACCTAACTTTGATGAAACAGAAAAAGAACCTACAGTACTT
CCATCAAGATATCCTAACTTGTTATGTAATGGTACATCAGGTATTGCTGTAGGTATGGCAACTAATATTCCACCTCATAA
CTTAAGAGAAGTTATAGGTGCTGTTGTAAAGATGATTGACAATAAGGTGGAAGAAGACAGAGACACAACAATTGAGGAAA
TCCTTGATATAGTTAAAGGTCCTGATTTCCCTACAGGTGGAACAATCATCGGCAAGTTGGGAATTGAAGAGGCTTACCGT
ACAGGAAGAGCCAAGATAAAGGTAAGAGCTGTAACTAATATTGAGCCAATGAATAATGGCAAGAACAGAATTGTAGTTAC
AGAACTTCCATACATGGTTAATAAAGCAAAGCTTATCGAGAAAATAGCAGAGCTTGTAAGAGATAAGAAGATTGATGGAA
TCACAGATTTAAGAGATGAATCTGACAGAGAGGGTATGAGAATTGCCATTGAGTTAAGAAGAGATGTCAATCCTAACATA
GTACTTAACCAGTTATACAAACACACGCAGTTACAGGATACATTTGGTGTAATCATGCTTGCATTAGTAGATAATCAGCC
AAAGGTGCTTAACCTGTATGACATGTTAAAGTATTACCTTCTTCATCAGGAAGAAGTCGTTACAAGAAGAACAAAGTTTG
ATCTTAATAAGGCAGAAGAAAGAGCCCACATTTTAGAGGGCTTAATGATTGCTTTAGATAATATAGACAGAGTTATATCA
ATAATCAGAGGTTCTGCAAATGTACAGATTGCCAAGGAAAGCTTAATAGCTGAATTTGCACTTTCAGAAGCACAGGCTCA
GGCTATCGTAGATATGCGTCTGAGAGCTCTGACCGGTCTGGAAAGAAGCAAGCTTGAAGCTGAATTGAAGGAACTTCATG
AAAAGATTAAAGAATACAAGGCAATTCTTGCAGATAAAAAGTTACTTCTTGGAGTTATCAAGAATGAAATTTCAGAGATA
GCAGACAAGTATGGTGATGACAGAAGAACTTCTATCGGATATGATGAATACGATATTTCAATGGAAGACCTTATTCCAGA
TGAACCATGTGTTATTGCAAGAACTAACTTGGGTTATGTAAAGAGAATGACACCTGATAACTTTAAGAGCCAGCATCGTG
GGGGTAAGGGAATAAAGGGAATGCAGACAATTGATGATGATTATATCAAAGATTTATTCATGACAACATCACATCATGTA
CTTACATTCTTTACTAACACAGGACGAGCTTATAAGTTAAAGGCTTATGAAATTCCTGAAGCATCAAGAACTTCAAGAGG
AACTGCAATAATTAATCTTTTACAGTTAGCACCGGGAGAGACAATCACAGCAGTAGTTCCTGTTAAGATTGATACACTGC
AGGATACAGATTACCTGTTTATGGCAACTAAGAAGGGTATCGTTAAAAAGACACCTGTTAAAGAATTTGCCAATATAAGA
AAGACAGGAATCCAGGCAATTAATTTAAGAGAAGATGATGAACTTATAGAAGTTAAACTTACAGATGACCAGGCAGAGAT
TCTTATGGTAACAATGCTTGGACAGTGTATAAGATTTAAAGAAACAGATGTAAGACCTACGGGACGTTCAGCAATGGGTG
TTATAGGTATGAGTCTTATGGATGAGGATGAAGTTGTTGGTGTTCAGGTAAGTACCCAGGGAGATACTATGCTTATAGTT
TCTGAAAATGGTATGGGTAAGAGAACAGACATTGACGAGTATACAGTTCAGCATCGTGGTGGTAAAGGTGTCAAATGTTA
CAAGATAACAGAAAAGACAGGTAATGTCGTAGGAGCTAAGGCTGTAGATGATTCAAGAGAAGTAATGCTTATTACAACAG
AAGGAATTATAATCAGACTTCAGTGTTCAGATATATCTAATCTTGGAAGAATAACATCAGGTGTTAAACTTATTAACCTT
GATGAAGGAATTAAAGTAGCAACAATTGCCAAAGTAAGGAAGCAGCCTGCTGATGAAGATGGTAAGGATGCAGAAGGCTT
TGAAGAAGACACAGATAAAACAGTAGAATCTGAAGATTAA

Upstream 100 bases:

>100_bases
ATGTAGATTTTACGAATGCGCGTGATTAGGATTTACGCATAGCGTATTCCAGATTTACACATTGCGTTAATTAATAACTT
CACGGAAAGGAATTATAATA

Downstream 100 bases:

>100_bases
TCTTAAGGAAACTGCCACATTTATATATGTGACGGTTTCCTTTTTAGCAGGAGATAATATGGCTTTAATTAATATTAATT
ATGAATCAAAAAAACTTGGG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 839; Mature: 839

Protein sequence:

>839_residues
MDEHIFDKVQEVDMQKTMENYYIDYAMSVIASRALPDVRDGLKPVQRRILYSMIELNNGPDKPHRKCARIVGDTMGKYHP
HGDSSIYEALVKLAQDFNTRYPLVDGHGNFGSVDGDGAAAMRYTEARLSKISMEMTRDLNKDTVDFIPNFDETEKEPTVL
PSRYPNLLCNGTSGIAVGMATNIPPHNLREVIGAVVKMIDNKVEEDRDTTIEEILDIVKGPDFPTGGTIIGKLGIEEAYR
TGRAKIKVRAVTNIEPMNNGKNRIVVTELPYMVNKAKLIEKIAELVRDKKIDGITDLRDESDREGMRIAIELRRDVNPNI
VLNQLYKHTQLQDTFGVIMLALVDNQPKVLNLYDMLKYYLLHQEEVVTRRTKFDLNKAEERAHILEGLMIALDNIDRVIS
IIRGSANVQIAKESLIAEFALSEAQAQAIVDMRLRALTGLERSKLEAELKELHEKIKEYKAILADKKLLLGVIKNEISEI
ADKYGDDRRTSIGYDEYDISMEDLIPDEPCVIARTNLGYVKRMTPDNFKSQHRGGKGIKGMQTIDDDYIKDLFMTTSHHV
LTFFTNTGRAYKLKAYEIPEASRTSRGTAIINLLQLAPGETITAVVPVKIDTLQDTDYLFMATKKGIVKKTPVKEFANIR
KTGIQAINLREDDELIEVKLTDDQAEILMVTMLGQCIRFKETDVRPTGRSAMGVIGMSLMDEDEVVGVQVSTQGDTMLIV
SENGMGKRTDIDEYTVQHRGGKGVKCYKITEKTGNVVGAKAVDDSREVMLITTEGIIIRLQCSDISNLGRITSGVKLINL
DEGIKVATIAKVRKQPADEDGKDAEGFEEDTDKTVESED

Sequences:

>Translated_839_residues
MDEHIFDKVQEVDMQKTMENYYIDYAMSVIASRALPDVRDGLKPVQRRILYSMIELNNGPDKPHRKCARIVGDTMGKYHP
HGDSSIYEALVKLAQDFNTRYPLVDGHGNFGSVDGDGAAAMRYTEARLSKISMEMTRDLNKDTVDFIPNFDETEKEPTVL
PSRYPNLLCNGTSGIAVGMATNIPPHNLREVIGAVVKMIDNKVEEDRDTTIEEILDIVKGPDFPTGGTIIGKLGIEEAYR
TGRAKIKVRAVTNIEPMNNGKNRIVVTELPYMVNKAKLIEKIAELVRDKKIDGITDLRDESDREGMRIAIELRRDVNPNI
VLNQLYKHTQLQDTFGVIMLALVDNQPKVLNLYDMLKYYLLHQEEVVTRRTKFDLNKAEERAHILEGLMIALDNIDRVIS
IIRGSANVQIAKESLIAEFALSEAQAQAIVDMRLRALTGLERSKLEAELKELHEKIKEYKAILADKKLLLGVIKNEISEI
ADKYGDDRRTSIGYDEYDISMEDLIPDEPCVIARTNLGYVKRMTPDNFKSQHRGGKGIKGMQTIDDDYIKDLFMTTSHHV
LTFFTNTGRAYKLKAYEIPEASRTSRGTAIINLLQLAPGETITAVVPVKIDTLQDTDYLFMATKKGIVKKTPVKEFANIR
KTGIQAINLREDDELIEVKLTDDQAEILMVTMLGQCIRFKETDVRPTGRSAMGVIGMSLMDEDEVVGVQVSTQGDTMLIV
SENGMGKRTDIDEYTVQHRGGKGVKCYKITEKTGNVVGAKAVDDSREVMLITTEGIIIRLQCSDISNLGRITSGVKLINL
DEGIKVATIAKVRKQPADEDGKDAEGFEEDTDKTVESED
>Mature_839_residues
MDEHIFDKVQEVDMQKTMENYYIDYAMSVIASRALPDVRDGLKPVQRRILYSMIELNNGPDKPHRKCARIVGDTMGKYHP
HGDSSIYEALVKLAQDFNTRYPLVDGHGNFGSVDGDGAAAMRYTEARLSKISMEMTRDLNKDTVDFIPNFDETEKEPTVL
PSRYPNLLCNGTSGIAVGMATNIPPHNLREVIGAVVKMIDNKVEEDRDTTIEEILDIVKGPDFPTGGTIIGKLGIEEAYR
TGRAKIKVRAVTNIEPMNNGKNRIVVTELPYMVNKAKLIEKIAELVRDKKIDGITDLRDESDREGMRIAIELRRDVNPNI
VLNQLYKHTQLQDTFGVIMLALVDNQPKVLNLYDMLKYYLLHQEEVVTRRTKFDLNKAEERAHILEGLMIALDNIDRVIS
IIRGSANVQIAKESLIAEFALSEAQAQAIVDMRLRALTGLERSKLEAELKELHEKIKEYKAILADKKLLLGVIKNEISEI
ADKYGDDRRTSIGYDEYDISMEDLIPDEPCVIARTNLGYVKRMTPDNFKSQHRGGKGIKGMQTIDDDYIKDLFMTTSHHV
LTFFTNTGRAYKLKAYEIPEASRTSRGTAIINLLQLAPGETITAVVPVKIDTLQDTDYLFMATKKGIVKKTPVKEFANIR
KTGIQAINLREDDELIEVKLTDDQAEILMVTMLGQCIRFKETDVRPTGRSAMGVIGMSLMDEDEVVGVQVSTQGDTMLIV
SENGMGKRTDIDEYTVQHRGGKGVKCYKITEKTGNVVGAKAVDDSREVMLITTEGIIIRLQCSDISNLGRITSGVKLINL
DEGIKVATIAKVRKQPADEDGKDAEGFEEDTDKTVESED

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=351, Percent_Identity=24.5014245014245, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI19913408, Length=175, Percent_Identity=30.8571428571429, Blast_Score=82, Evalue=3e-15,
Organism=Escherichia coli, GI1788562, Length=863, Percent_Identity=46.9293163383546, Blast_Score=757, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=690, Percent_Identity=37.9710144927536, Blast_Score=446, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI212645845, Length=291, Percent_Identity=26.8041237113402, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=178, Percent_Identity=30.3370786516854, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=209, Percent_Identity=28.2296650717703, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115534553, Length=201, Percent_Identity=26.865671641791, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=247, Percent_Identity=30.3643724696356, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136538, Length=177, Percent_Identity=31.638418079096, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 94033; Mature: 94033

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00572 GLYCOSYL_HYDROL_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEHIFDKVQEVDMQKTMENYYIDYAMSVIASRALPDVRDGLKPVQRRILYSMIELNNGP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
DKPHRKCARIVGDTMGKYHPHGDSSIYEALVKLAQDFNTRYPLVDGHGNFGSVDGDGAAA
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHH
MRYTEARLSKISMEMTRDLNKDTVDFIPNFDETEKEPTVLPSRYPNLLCNGTSGIAVGMA
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEE
TNIPPHNLREVIGAVVKMIDNKVEEDRDTTIEEILDIVKGPDFPTGGTIIGKLGIEEAYR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHH
TGRAKIKVRAVTNIEPMNNGKNRIVVTELPYMVNKAKLIEKIAELVRDKKIDGITDLRDE
CCCEEEEEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SDREGMRIAIELRRDVNPNIVLNQLYKHTQLQDTFGVIMLALVDNQPKVLNLYDMLKYYL
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHH
LHQEEVVTRRTKFDLNKAEERAHILEGLMIALDNIDRVISIIRGSANVQIAKESLIAEFA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
LSEAQAQAIVDMRLRALTGLERSKLEAELKELHEKIKEYKAILADKKLLLGVIKNEISEI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADKYGDDRRTSIGYDEYDISMEDLIPDEPCVIARTNLGYVKRMTPDNFKSQHRGGKGIKG
HHHCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEECCCCEEECCCCCCHHHHCCCCCCCCC
MQTIDDDYIKDLFMTTSHHVLTFFTNTGRAYKLKAYEIPEASRTSRGTAIINLLQLAPGE
CHHCCHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCC
TITAVVPVKIDTLQDTDYLFMATKKGIVKKTPVKEFANIRKTGIQAINLREDDELIEVKL
EEEEEEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCCEEEECCCCCCEEEEEE
TDDQAEILMVTMLGQCIRFKETDVRPTGRSAMGVIGMSLMDEDEVVGVQVSTQGDTMLIV
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCEEEEE
SENGMGKRTDIDEYTVQHRGGKGVKCYKITEKTGNVVGAKAVDDSREVMLITTEGIIIRL
ECCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEEE
QCSDISNLGRITSGVKLINLDEGIKVATIAKVRKQPADEDGKDAEGFEEDTDKTVESED
EECCCHHHHHHHCCEEEEECCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDEHIFDKVQEVDMQKTMENYYIDYAMSVIASRALPDVRDGLKPVQRRILYSMIELNNGP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
DKPHRKCARIVGDTMGKYHPHGDSSIYEALVKLAQDFNTRYPLVDGHGNFGSVDGDGAAA
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHH
MRYTEARLSKISMEMTRDLNKDTVDFIPNFDETEKEPTVLPSRYPNLLCNGTSGIAVGMA
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEE
TNIPPHNLREVIGAVVKMIDNKVEEDRDTTIEEILDIVKGPDFPTGGTIIGKLGIEEAYR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHH
TGRAKIKVRAVTNIEPMNNGKNRIVVTELPYMVNKAKLIEKIAELVRDKKIDGITDLRDE
CCCEEEEEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SDREGMRIAIELRRDVNPNIVLNQLYKHTQLQDTFGVIMLALVDNQPKVLNLYDMLKYYL
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHH
LHQEEVVTRRTKFDLNKAEERAHILEGLMIALDNIDRVISIIRGSANVQIAKESLIAEFA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
LSEAQAQAIVDMRLRALTGLERSKLEAELKELHEKIKEYKAILADKKLLLGVIKNEISEI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADKYGDDRRTSIGYDEYDISMEDLIPDEPCVIARTNLGYVKRMTPDNFKSQHRGGKGIKG
HHHCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEECCCCEEECCCCCCHHHHCCCCCCCCC
MQTIDDDYIKDLFMTTSHHVLTFFTNTGRAYKLKAYEIPEASRTSRGTAIINLLQLAPGE
CHHCCHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCC
TITAVVPVKIDTLQDTDYLFMATKKGIVKKTPVKEFANIRKTGIQAINLREDDELIEVKL
EEEEEEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCCEEEECCCCCCEEEEEE
TDDQAEILMVTMLGQCIRFKETDVRPTGRSAMGVIGMSLMDEDEVVGVQVSTQGDTMLIV
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCEEEEE
SENGMGKRTDIDEYTVQHRGGKGVKCYKITEKTGNVVGAKAVDDSREVMLITTEGIIIRL
ECCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEEE
QCSDISNLGRITSGVKLINLDEGIKVATIAKVRKQPADEDGKDAEGFEEDTDKTVESED
EECCCHHHHHHHCCEEEEECCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]