| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is gyrB [H]
Identifier: 238897209
GI number: 238897209
Start: 5207913
End: 5210330
Strand: Reverse
Name: gyrB [H]
Synonym: KP1_5480
Alternate gene names: 238897209
Gene position: 5210330-5207913 (Counterclockwise)
Preceding gene: 238897210
Following gene: 238897208
Centisome position: 99.27
GC content: 57.15
Gene sequence:
>2418_bases TTGATGTCGAATTCTTATGACTCCTCCAGTATCAAAGTCCTGAAAGGGCTGGATGCGGTGCGTAAGCGCCCGGGTATGTA TATCGGCGACACGGATGACGGCACCGGTCTGCACCACATGGTATTCGAGGTTGTGGATAACGCTATCGACGAAGCGCTCG CGGGTTACTGCAAAGATATCGTTGTCACCATCCACAGCGATAACTCCGTCTCCGTCCAGGATGACGGCCGCGGCATCCCG ACCGGCATTCACCCGGAAGAGGGCGTCTCCGCAGCGGAAGTTATCATGACCGTCCTGCACGCTGGCGGTAAATTCGATGA TAACTCCTATAAAGTTTCCGGCGGTCTGCACGGCGTAGGCGTCTCGGTGGTTAACGCCCTGTCGCAGAAGCTGGAGCTGG TTATCCAGCGCGATAACAAAGTTCACAAGCAGATGTACGAACACGGTGTGCCGCAGGCACCGCTGGCCGTGACTGGCGAA ACCGACAAAACCGGCACCATGGTGCGTTTCTGGCCAAGCCTGGAAACCTTCACCAATGTCACCGAATTTGAATATGACAT CCTGGCGAAACGCCTGCGCGAGCTGTCGTTCCTGAACTCCGGCGTCTCTATCCGCCTGCGCGATAAGCGCGACGGCAAAG AAGACCATTTCCACTACGAAGGCGGCATCAAGGCGTTCGTTGAGTATCTCAACAAGAACAAAACGCCGATCCACCCGAAT ATTTTCTATTTCTCCACCGAAAAAGACGGTATCGGCGTGGAAGTGGCCCTGCAGTGGAACGACGGCTTCCAGGAAAACAT CTACTGCTTTACCAACAACATTCCGCAGCGTGACGGCGGTACTCACCTCGCCGGCTTCCGCGCGGCGATGACCCGTACCC TTAACGCCTATATGGACAAAGAGGGCTACAGCAAAAAAGCGAAAGTCAGCGCCACCGGCGACGATGCGCGTGAAGGCCTG ATTGCCGTGGTATCCGTGAAGGTGCCGGATCCGAAATTCTCCTCGCAGACCAAAGACAAGCTGGTCTCCTCCGAGGTGAA ATCAGCGGTGGAGCAGCAGATGAACGAACTGCTGAGCGAATACCTGCTGGAAAACCCATCCGATGCGAAAATCGTAGTCG GCAAAATTATTGACGCCGCGCGCGCCCGTGAGGCCGCACGTCGCGCTCGTGAGATGACTCGTCGTAAAGGCGCGCTGGAT CTGGCAGGCCTGCCGGGCAAACTGGCGGATTGCCAGGAGCGCGACCCGGCGCTGTCCGAACTGTACCTGGTGGAAGGGGA CTCCGCGGGCGGCTCTGCTAAACAGGGTCGTAACCGCAAGAACCAGGCGATCCTACCGCTGAAGGGTAAAATCCTTAACG TTGAGAAAGCCCGCTTCGATAAAATGCTCTCTTCCCAGGAAGTGGCGACGCTGATCACCGCGCTGGGCTGCGGTATCGGT CGCGATGAGTACAATCCGGATAAACTGCGCTACCACAGCATCATCATCATGACCGATGCGGACGTCGACGGCTCGCACAT TCGTACCCTGCTGTTGACCTTCTTCTATCGTCAGATGCCGGAGATCGTTGAGCGCGGCCACGTCTACATTGCCCAGCCGC CGCTGTACAAAGTGAAGAAAGGCAAGCAGGAACAGTACATTAAAGACGACGAAGCGATGGATCAGTATCAGATCTCCATC GCGCTCGACGGTGCGACCCTGCACACCAACGCCAATGCGCCGGCGCTGGCGGGCGAACCGCTGGAAAAACTGGTTGCCGA GTTCAATGCCACCCAGAAAATGATTGGCCGCATGGAGCGCCGCTTCCCGAAAGCGCTGCTGAAAGAGCTTATCTATCAGC CGACCCTGACCGAGGCCGACCTGGCGGACGAGCAGAAGGTGACCCGCTGGGTGAACACCCTGGTCTCCGAGCTGAACGAG AAAGAACAGCACGGCAGCCAGTGGAAATTCGATCTCCACGAGAACAAAGAACTGCAGCATTTTGAGCCGGTTATTCGCGT ACGTACCCACGGCGTGGATACCGACTATCCGCTGGATAACGAGTTCATTATGGGGCCGGAATATCGTCGTATTTGTGCCC TGGGCGAGAAACTGCGCGGCCTGATGGAAGAAGATGCTTACATCGAGCGCGGCGAACGTCGTCAGCCGGTAGCCAGCTTC GAGCAGGCCCTGGACTGGCTGGTGAAAGAGTCCCGTCGCGGTCTCTCCATCCAGCGCTATAAAGGTCTGGGCGAGATGAA CCCGGATCAGCTGTGGGAAACCACCATGGATCCGGACAGCCGTCGCATGCTGCGCGTGACCGTCAAGGATGCCATCGCTG CCGATCAGCTGTTCACCACCCTGATGGGTGATGCCGTTGAGCCGCGTCGCGCGTTTATCGAAGAGAATGCCCTGAAAGCG GCGAATATCGATATTTAA
Upstream 100 bases:
>100_bases GCTGAACACGTTATGGACATGTCGGACAAAAATTCGAAGATGTTCCGCGTGGAAAAAGGTAAAATAACGGATTAACCCAA GATTAAATGAGCGAGAAACG
Downstream 100 bases:
>100_bases GCCGCATGTTTCCCGGTAACGAGTTTTACCGGGGCAACAGGATGTATAAGCCCGGTCGCATCGCGCGATCGGGCTTTTCT TTTGCCGCTAAAAGAGGAAT
Product: DNA gyrase subunit B
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 805; Mature: 805
Protein sequence:
>805_residues MMSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGYCKDIVVTIHSDNSVSVQDDGRGIP TGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQRDNKVHKQMYEHGVPQAPLAVTGE TDKTGTMVRFWPSLETFTNVTEFEYDILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPN IFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGL IAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLSEYLLENPSDAKIVVGKIIDAARAREAARRAREMTRRKGALD LAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG RDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISI ALDGATLHTNANAPALAGEPLEKLVAEFNATQKMIGRMERRFPKALLKELIYQPTLTEADLADEQKVTRWVNTLVSELNE KEQHGSQWKFDLHENKELQHFEPVIRVRTHGVDTDYPLDNEFIMGPEYRRICALGEKLRGLMEEDAYIERGERRQPVASF EQALDWLVKESRRGLSIQRYKGLGEMNPDQLWETTMDPDSRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKA ANIDI
Sequences:
>Translated_805_residues MMSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGYCKDIVVTIHSDNSVSVQDDGRGIP TGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQRDNKVHKQMYEHGVPQAPLAVTGE TDKTGTMVRFWPSLETFTNVTEFEYDILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPN IFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGL IAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLSEYLLENPSDAKIVVGKIIDAARAREAARRAREMTRRKGALD LAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG RDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISI ALDGATLHTNANAPALAGEPLEKLVAEFNATQKMIGRMERRFPKALLKELIYQPTLTEADLADEQKVTRWVNTLVSELNE KEQHGSQWKFDLHENKELQHFEPVIRVRTHGVDTDYPLDNEFIMGPEYRRICALGEKLRGLMEEDAYIERGERRQPVASF EQALDWLVKESRRGLSIQRYKGLGEMNPDQLWETTMDPDSRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKA ANIDI >Mature_805_residues MMSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGYCKDIVVTIHSDNSVSVQDDGRGIP TGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQRDNKVHKQMYEHGVPQAPLAVTGE TDKTGTMVRFWPSLETFTNVTEFEYDILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPN IFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGL IAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLSEYLLENPSDAKIVVGKIIDAARAREAARRAREMTRRKGALD LAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG RDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISI ALDGATLHTNANAPALAGEPLEKLVAEFNATQKMIGRMERRFPKALLKELIYQPTLTEADLADEQKVTRWVNTLVSELNE KEQHGSQWKFDLHENKELQHFEPVIRVRTHGVDTDYPLDNEFIMGPEYRRICALGEKLRGLMEEDAYIERGERRQPVASF EQALDWLVKESRRGLSIQRYKGLGEMNPDQLWETTMDPDSRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKA ANIDI
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0187
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the type II topoisomerase family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=566, Percent_Identity=25.2650176678445, Blast_Score=132, Evalue=1e-30, Organism=Homo sapiens, GI19913406, Length=545, Percent_Identity=26.4220183486239, Blast_Score=130, Evalue=4e-30, Organism=Escherichia coli, GI48994957, Length=804, Percent_Identity=95.0248756218905, Blast_Score=1571, Evalue=0.0, Organism=Escherichia coli, GI1789408, Length=555, Percent_Identity=40.9009009009009, Blast_Score=388, Evalue=1e-109, Organism=Caenorhabditis elegans, GI17535065, Length=542, Percent_Identity=27.4907749077491, Blast_Score=141, Evalue=2e-33, Organism=Caenorhabditis elegans, GI212645845, Length=517, Percent_Identity=25.1450676982592, Blast_Score=132, Evalue=6e-31, Organism=Caenorhabditis elegans, GI212645657, Length=153, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=595, Percent_Identity=25.2100840336134, Blast_Score=120, Evalue=6e-28, Organism=Drosophila melanogaster, GI17136538, Length=527, Percent_Identity=26.3757115749526, Blast_Score=134, Evalue=3e-31,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003594 - InterPro: IPR011557 - InterPro: IPR020568 - InterPro: IPR014721 - InterPro: IPR001241 - InterPro: IPR013759 - InterPro: IPR002288 - InterPro: IPR013506 - InterPro: IPR013760 - InterPro: IPR018522 [H]
Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 90219; Mature: 90219
Theoretical pI: Translated: 5.95; Mature: 5.95
Prosite motif: PS00177 TOPOISOMERASE_II
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MMSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGYCKDI CCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEE VVTIHSDNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVG EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHH VSVVNALSQKLELVIQRDNKVHKQMYEHGVPQAPLAVTGETDKTGTMVRFWPSLETFTNV HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCCCEEEECCCHHHHHCH TEFEYDILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPN HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCC IFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDK EEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC EGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLSE CCCCCCCEEECCCCHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH YLLENPSDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSE HHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCE LYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG EEEEECCCCCCCCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCC RDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKK CCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHC GKQEQYIKDDEAMDQYQISIALDGATLHTNANAPALAGEPLEKLVAEFNATQKMIGRMER CCHHHHCCCCCCCCEEEEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH RFPKALLKELIYQPTLTEADLADEQKVTRWVNTLVSELNEKEQHGSQWKFDLHENKELQH HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH FEPVIRVRTHGVDTDYPLDNEFIMGPEYRRICALGEKLRGLMEEDAYIERGERRQPVASF HHHHHHHEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH EQALDWLVKESRRGLSIQRYKGLGEMNPDQLWETTMDPDSRRMLRVTVKDAIAADQLFTT HHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHH LMGDAVEPRRAFIEENALKAANIDI HHCCCCCHHHHHHHHCCCCCCCCCC >Mature Secondary Structure MMSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGYCKDI CCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEE VVTIHSDNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVG EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHH VSVVNALSQKLELVIQRDNKVHKQMYEHGVPQAPLAVTGETDKTGTMVRFWPSLETFTNV HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCCCEEEECCCHHHHHCH TEFEYDILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPN HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCC IFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDK EEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC EGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLSE CCCCCCCEEECCCCHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH YLLENPSDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSE HHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCE LYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG EEEEECCCCCCCCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCC RDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKK CCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHC GKQEQYIKDDEAMDQYQISIALDGATLHTNANAPALAGEPLEKLVAEFNATQKMIGRMER CCHHHHCCCCCCCCEEEEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH RFPKALLKELIYQPTLTEADLADEQKVTRWVNTLVSELNEKEQHGSQWKFDLHENKELQH HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH FEPVIRVRTHGVDTDYPLDNEFIMGPEYRRICALGEKLRGLMEEDAYIERGERRQPVASF HHHHHHHEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH EQALDWLVKESRRGLSIQRYKGLGEMNPDQLWETTMDPDSRRMLRVTVKDAIAADQLFTT HHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHH LMGDAVEPRRAFIEENALKAANIDI HHCCCCCHHHHHHHHCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]