Click here to switch to the map view.

The map label for this gene is murP [H]

Identifier: 238897148

GI number: 238897148

Start: 5148611

End: 5150044

Strand: Direct

Name: murP [H]

Synonym: KP1_5411

Alternate gene names: 238897148

Gene position: 5148611-5150044 (Clockwise)

Preceding gene: 238897147

Following gene: 238897149

Centisome position: 98.1

GC content: 63.81

Gene sequence:

>1434_bases
ATGGCAAAAATAACGAAAGAGATGATAGCGCGGATCCTCGCCCACGTGGGCGGCGCCGCAAACGTCGCGCAGGCGGGCAA
CTGCATGACGCGCCTGCGCTTGACCCTGCGCGATGAAAGTCTGGCCGACAGCGCCGCCATCCGCCAGATTGACGGCGTGA
TGGGGGTGATCGTCAGCGACGAGCAGTTCCAGGTGGTGCTCGGCCCCGGCAAGGCGCAAACCGCCGCCGAAATGATGAAC
GGCCTGCTGGAGGCGGCGCCCGCCGCCGCGCCGACGCTGGCCGACGTCGCGGCGGAGAAAAAGCAGGCGCTGAAGGGCAA
GCAGACCAGCGCGGTGCAGAAGTTTCTCGCCAAATTCGCCACCATCTTTACGCCGCTGATCCCCGGCTTTATCGCCGTCG
GGCTGCTGCTGGGCTTCGCCACCCTGGCGGAACAGGTTTTCGTACTGGAGAACGCCCATCCGAACGCCAGCCTGGTGGCG
CTGATTGGCTATATGAAGGTCTTCAGCAAAGGGATGTTCACCTTTCTGAGTATCCTGATTGGCTATAACGCGCAGAAGGC
GTTCGGCGGCTCCGGCGTGAACGGCGCGATTATCGCCTCGCTGTTCGTGCTGGGCTACAACCCGGAGGCAACCAGCGGCT
TCTACGCCGGCATTTCCACCTTCTTCGGCCATGGCATCGATCCGCGCGGCAATATCATCGGCGTACTGATCGCCGCTATC
CTTGGCGCGTGGGTTGAACGCCAGGTGCGGCGGGTGATGCCGGCCAACCTCGATATGATCCTCACTTCGGCGGTGACGCT
GCTGATCATGGGCGCGGTGACCTTTACGGTGATCATGCCGATTGGCGGCTGGTTGTTTACCGGCATGTCGTGGCTGTTCC
TGCATCTTAACGGCAACCCGTTTGGCTCGGCGGTGCTGGCCGGCCTGTTCCTGCTGGCGGTGATGTTCGGCGTCCATCAG
GGGTTTGTCCCGGTCTATTTTGCGCTGGTGGACGCCCAGGGCTTTAACTCGCTGTTCCCGATCCTGGCGATGGCCGGGGC
CGGGCAGGTGGGGGCGGCGCTGGCGCTGTTCTGGCGGGCGAAGCGCGATTCGCTGCTGCGAACCCAGATTAAAGGGGCGA
TTATTCCGGGCTTCCTCGGGATTGGCGAGCCGCTGATCTACGGCGTCACCCTGCCGCGGATGAAGCCGTTTGTCACCGCC
TGCCTCGGCGGCGCCTGCGGCGGGTTCTTCGTCGGACTGATCGCCTGGCTGGGGCTGCCGGTCGGCCTGAACACGGTGTT
CGGTCCGTCCGGTCTGGTGGCGCTGCCGCTGATGACCTCCGGCAGCGGAATTTACGCCGGGATGGCGGTCTACGCCGGCG
GGCTGGCGGTCTCCTACCTGTGCGGTTTTGTCCTCACCTGGCTGTTCGGCAGTAAAAATGTCGATTTAAGCTAG

Upstream 100 bases:

>100_bases
CTTAAGCGCCGCAGAGGCGCAGTCGCTGCTGGCGAAAAACAACGGCTATATCCGCAAGGCGCTCAGCAACACCTGAGCGC
CGACAGACAGGTAACGGGCA

Downstream 100 bases:

>100_bases
AACGCGACTATCGGTTAATGCCCGGCGGCGGCTTCGCCTTACCGGGCCTGCAAAATAGTTACGCCGCCGCGCCCGACTAC
CATTTCCTGCCCCGCCGCCC

Product: PTS system N-acetylmuramic acid transporter subunits EIIBC

Products: NA

Alternate protein names: EIIBC-MurNAc; N-acetylmuramic acid-specific phosphotransferase enzyme IIB component; PTS system N-acetylmuramic acid-specific EIIB component; N-acetylmuramic acid permease IIC component; PTS system N-acetylmuramic acid-specific EIIC component [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MAKITKEMIARILAHVGGAANVAQAGNCMTRLRLTLRDESLADSAAIRQIDGVMGVIVSDEQFQVVLGPGKAQTAAEMMN
GLLEAAPAAAPTLADVAAEKKQALKGKQTSAVQKFLAKFATIFTPLIPGFIAVGLLLGFATLAEQVFVLENAHPNASLVA
LIGYMKVFSKGMFTFLSILIGYNAQKAFGGSGVNGAIIASLFVLGYNPEATSGFYAGISTFFGHGIDPRGNIIGVLIAAI
LGAWVERQVRRVMPANLDMILTSAVTLLIMGAVTFTVIMPIGGWLFTGMSWLFLHLNGNPFGSAVLAGLFLLAVMFGVHQ
GFVPVYFALVDAQGFNSLFPILAMAGAGQVGAALALFWRAKRDSLLRTQIKGAIIPGFLGIGEPLIYGVTLPRMKPFVTA
CLGGACGGFFVGLIAWLGLPVGLNTVFGPSGLVALPLMTSGSGIYAGMAVYAGGLAVSYLCGFVLTWLFGSKNVDLS

Sequences:

>Translated_477_residues
MAKITKEMIARILAHVGGAANVAQAGNCMTRLRLTLRDESLADSAAIRQIDGVMGVIVSDEQFQVVLGPGKAQTAAEMMN
GLLEAAPAAAPTLADVAAEKKQALKGKQTSAVQKFLAKFATIFTPLIPGFIAVGLLLGFATLAEQVFVLENAHPNASLVA
LIGYMKVFSKGMFTFLSILIGYNAQKAFGGSGVNGAIIASLFVLGYNPEATSGFYAGISTFFGHGIDPRGNIIGVLIAAI
LGAWVERQVRRVMPANLDMILTSAVTLLIMGAVTFTVIMPIGGWLFTGMSWLFLHLNGNPFGSAVLAGLFLLAVMFGVHQ
GFVPVYFALVDAQGFNSLFPILAMAGAGQVGAALALFWRAKRDSLLRTQIKGAIIPGFLGIGEPLIYGVTLPRMKPFVTA
CLGGACGGFFVGLIAWLGLPVGLNTVFGPSGLVALPLMTSGSGIYAGMAVYAGGLAVSYLCGFVLTWLFGSKNVDLS
>Mature_476_residues
AKITKEMIARILAHVGGAANVAQAGNCMTRLRLTLRDESLADSAAIRQIDGVMGVIVSDEQFQVVLGPGKAQTAAEMMNG
LLEAAPAAAPTLADVAAEKKQALKGKQTSAVQKFLAKFATIFTPLIPGFIAVGLLLGFATLAEQVFVLENAHPNASLVAL
IGYMKVFSKGMFTFLSILIGYNAQKAFGGSGVNGAIIASLFVLGYNPEATSGFYAGISTFFGHGIDPRGNIIGVLIAAIL
GAWVERQVRRVMPANLDMILTSAVTLLIMGAVTFTVIMPIGGWLFTGMSWLFLHLNGNPFGSAVLAGLFLLAVMFGVHQG
FVPVYFALVDAQGFNSLFPILAMAGAGQVGAALALFWRAKRDSLLRTQIKGAIIPGFLGIGEPLIYGVTLPRMKPFVTAC
LGGACGGFFVGLIAWLGLPVGLNTVFGPSGLVALPLMTSGSGIYAGMAVYAGGLAVSYLCGFVLTWLFGSKNVDLS

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788769, Length=478, Percent_Identity=66.5271966527197, Blast_Score=606, Evalue=1e-175,
Organism=Escherichia coli, GI1790159, Length=434, Percent_Identity=31.1059907834101, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI2367362, Length=429, Percent_Identity=24.009324009324, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI48994906, Length=427, Percent_Identity=25.7611241217799, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018113
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013 [H]

Pfam domain/function: PF00367 PTS_EIIB; PF02378 PTS_EIIC [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 49796; Mature: 49664

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS01035 PTS_EIIB_TYPE_1_CYS ; PS51098 PTS_EIIB_TYPE_1 ; PS51103 PTS_EIIC_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKITKEMIARILAHVGGAANVAQAGNCMTRLRLTLRDESLADSAAIRQIDGVMGVIVSD
CCCHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECC
EQFQVVLGPGKAQTAAEMMNGLLEAAPAAAPTLADVAAEKKQALKGKQTSAVQKFLAKFA
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TIFTPLIPGFIAVGLLLGFATLAEQVFVLENAHPNASLVALIGYMKVFSKGMFTFLSILI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GYNAQKAFGGSGVNGAIIASLFVLGYNPEATSGFYAGISTFFGHGIDPRGNIIGVLIAAI
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LGAWVERQVRRVMPANLDMILTSAVTLLIMGAVTFTVIMPIGGWLFTGMSWLFLHLNGNP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
FGSAVLAGLFLLAVMFGVHQGFVPVYFALVDAQGFNSLFPILAMAGAGQVGAALALFWRA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
KRDSLLRTQIKGAIIPGFLGIGEPLIYGVTLPRMKPFVTACLGGACGGFFVGLIAWLGLP
HHHHHHHHHHCCCCCCHHHCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VGLNTVFGPSGLVALPLMTSGSGIYAGMAVYAGGLAVSYLCGFVLTWLFGSKNVDLS
CCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AKITKEMIARILAHVGGAANVAQAGNCMTRLRLTLRDESLADSAAIRQIDGVMGVIVSD
CCHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECC
EQFQVVLGPGKAQTAAEMMNGLLEAAPAAAPTLADVAAEKKQALKGKQTSAVQKFLAKFA
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TIFTPLIPGFIAVGLLLGFATLAEQVFVLENAHPNASLVALIGYMKVFSKGMFTFLSILI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GYNAQKAFGGSGVNGAIIASLFVLGYNPEATSGFYAGISTFFGHGIDPRGNIIGVLIAAI
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LGAWVERQVRRVMPANLDMILTSAVTLLIMGAVTFTVIMPIGGWLFTGMSWLFLHLNGNP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
FGSAVLAGLFLLAVMFGVHQGFVPVYFALVDAQGFNSLFPILAMAGAGQVGAALALFWRA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
KRDSLLRTQIKGAIIPGFLGIGEPLIYGVTLPRMKPFVTACLGGACGGFFVGLIAWLGLP
HHHHHHHHHHCCCCCCHHHCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VGLNTVFGPSGLVALPLMTSGSGIYAGMAVYAGGLAVSYLCGFVLTWLFGSKNVDLS
CCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]