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The map label for this gene is lldD [H]

Identifier: 238897049

GI number: 238897049

Start: 5045608

End: 5046792

Strand: Direct

Name: lldD [H]

Synonym: KP1_5298

Alternate gene names: 238897049

Gene position: 5045608-5046792 (Clockwise)

Preceding gene: 238897048

Following gene: 238897050

Centisome position: 96.13

GC content: 63.63

Gene sequence:

>1185_bases
ATGATTATTTCCGCCGCCAGCGACTATCGCGCCGCCGCACAGCGTATCCTGCCGCCGTTTCTGTTCCACTATATTGACGG
CGGCGCCTACGCCGAGCATACCCTGCGCCGCAACGTCGAGGACCTGTCCGATGTGGCCTTGCGCCAGCGTATTTTGCGCA
ATATGTCGGACCTGAGTCTGGAAACGACATTATTCAACGAGAAGCTGGCGATGCCGACGGCGTTGGCGCCGGTCGGGCTG
TGCGGGATGTACGCCCGCCGCGGCGAAGTGCAGGCCGCCGGCGCGGCGGACGACAAAGGCATTCCATTCACCCTCTCTAC
CGTTTCCGTCTGCCCGATCGAAGAGGTCGCCCCGACCATCAAGCGCCCGATGTGGTTCCAGCTGTATGTCCTGCGCGACC
GCGGCTTTATGCGCAATGCGCTGGAGCGCGCCAAAGCCGCCGGCTGCTCGACGCTGGTCTTTACCGTCGATATGCCGACT
CCCGGCGCCCGCTACCGCGACGCCCATTCAGGCATGAGCGGCCCGAACGCCGCCCTGCGCCGCTACTGGCAGGCCGTCAC
CCATCCGCAGTGGGCGTGGGACGTCGGCCTTAACGGTCGCCCGCACGATCTGGGCAATATCTCCGCCTATCTCGGCAAAC
CGACCGGGCTTGAGGATTACATCGGCTGGCTGGCGAATAACTTCGATCCGTCGATTTCATGGAAAGACCTGGAGTGGATC
CGCGATTTCTGGGACGGTCCGATGGTGATCAAAGGGATCCTCGATCCGGAGGACGCCCGCGATGCGGTGCGCTTCGGCGC
TGACGGCATTGTCGTCTCCAACCACGGCGGCCGCCAGCTCGATGGCGTGCTCTCCTCGGCCCGCGCCCTGCCGGCAATTG
CCGACGCGGTGAAAGGCGACATCACTATTCTCGCCGACAGCGGCATCCGTAACGGGCTCGACGTGGTGCGGATGATCGCC
CTGGGCGCCGACAGCGTGCTACTGGGCCGCGCTTACCTGTACGCCCTGGCGACCCACGGTAAGCAGGGCGTGGCGAATCT
GCTGAACCTCATCGAGAAAGAGATGAAAGTGGCGATGACCCTCACCGGGGCGAAAAGCATCCGTGAAATCAGCCGTGATT
CGCTGGTGCAGAACGCCGAAGCGCTGCAGACCTTCGATGCGCTGAAGCAGAATAACGCCGCGTAA

Upstream 100 bases:

>100_bases
TCCACGCCACCATCAAACGTTTTGATGAAGACCAGGCCCGCCAGGCGCGAATTACCCGCCTGCCCGGTGACCACAATGAA
AATTCCAGGGAGAACTCGTG

Downstream 100 bases:

>100_bases
TTCTCCACGTTTTCCCTTACGCCGCCCCTCTCCCTCAGGGTGAGGGTTCAACAAATATCTGCTATTCTGCCCCCCGCAAT
TAAGGGGGCAGTATGCTGAA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MIISAASDYRAAAQRILPPFLFHYIDGGAYAEHTLRRNVEDLSDVALRQRILRNMSDLSLETTLFNEKLAMPTALAPVGL
CGMYARRGEVQAAGAADDKGIPFTLSTVSVCPIEEVAPTIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAALRRYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDITILADSGIRNGLDVVRMIA
LGADSVLLGRAYLYALATHGKQGVANLLNLIEKEMKVAMTLTGAKSIREISRDSLVQNAEALQTFDALKQNNAA

Sequences:

>Translated_394_residues
MIISAASDYRAAAQRILPPFLFHYIDGGAYAEHTLRRNVEDLSDVALRQRILRNMSDLSLETTLFNEKLAMPTALAPVGL
CGMYARRGEVQAAGAADDKGIPFTLSTVSVCPIEEVAPTIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAALRRYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDITILADSGIRNGLDVVRMIA
LGADSVLLGRAYLYALATHGKQGVANLLNLIEKEMKVAMTLTGAKSIREISRDSLVQNAEALQTFDALKQNNAA
>Mature_394_residues
MIISAASDYRAAAQRILPPFLFHYIDGGAYAEHTLRRNVEDLSDVALRQRILRNMSDLSLETTLFNEKLAMPTALAPVGL
CGMYARRGEVQAAGAADDKGIPFTLSTVSVCPIEEVAPTIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAALRRYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDITILADSGIRNGLDVVRMIA
LGADSVLLGRAYLYALATHGKQGVANLLNLIEKEMKVAMTLTGAKSIREISRDSLVQNAEALQTFDALKQNNAA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=377, Percent_Identity=33.1564986737401, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI54234014, Length=380, Percent_Identity=35, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI7705393, Length=380, Percent_Identity=35, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1790033, Length=377, Percent_Identity=93.8992042440318, Blast_Score=730, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=371, Percent_Identity=33.9622641509434, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32566217, Length=285, Percent_Identity=31.9298245614035, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323587, Length=379, Percent_Identity=28.4960422163588, Blast_Score=159, Evalue=8e-40,
Organism=Drosophila melanogaster, GI78707188, Length=384, Percent_Identity=33.8541666666667, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI281363140, Length=384, Percent_Identity=33.8541666666667, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI78707190, Length=384, Percent_Identity=33.8541666666667, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 43009; Mature: 43009

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISAASDYRAAAQRILPPFLFHYIDGGAYAEHTLRRNVEDLSDVALRQRILRNMSDLSL
CEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCH
ETTLFNEKLAMPTALAPVGLCGMYARRGEVQAAGAADDKGIPFTLSTVSVCPIEEVAPTI
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAALR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
ITILADSGIRNGLDVVRMIALGADSVLLGRAYLYALATHGKQGVANLLNLIEKEMKVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LTGAKSIREISRDSLVQNAEALQTFDALKQNNAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIISAASDYRAAAQRILPPFLFHYIDGGAYAEHTLRRNVEDLSDVALRQRILRNMSDLSL
CEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCH
ETTLFNEKLAMPTALAPVGLCGMYARRGEVQAAGAADDKGIPFTLSTVSVCPIEEVAPTI
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAALR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
ITILADSGIRNGLDVVRMIALGADSVLLGRAYLYALATHGKQGVANLLNLIEKEMKVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LTGAKSIREISRDSLVQNAEALQTFDALKQNNAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA