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The map label for this gene is mtlD [H]

Identifier: 238897043

GI number: 238897043

Start: 5040290

End: 5041453

Strand: Direct

Name: mtlD [H]

Synonym: KP1_5290

Alternate gene names: 238897043

Gene position: 5040290-5041453 (Clockwise)

Preceding gene: 238897042

Following gene: 238897044

Centisome position: 96.03

GC content: 57.82

Gene sequence:

>1164_bases
TTGAAGGTTAATACTATGAAAGCATTACATTTTGGCGCAGGTAATATCGGACGTGGCTTTATCGGTAAATTGCTGGCCGA
CGCGGGCATCGAACTGACGTTTGCCGATGTCAATCAGACCGTACTTGATGCCCTGAATGCCCGTCATAGCTATCAGGTTC
ACGTCGTCGGTGAGAATGAGCAGGTGGACACCGTCTCCGGCGTCAATGCCGTCAGCAGCATCGGCGATGAGGTTGTGGAC
CTGATCGCTGAGGTGGATCTGGTCACCACCGCCGTCGGTCCCGTCGTGCTCGAGCGCATCGCGCCAGCGATCGCCAAAGG
GCTGGCGCAGCGCAAAGCGCAGGGCACCGAACGCCCGCTGAACATCATCGCCTGCGAAAATATGGTGCGCGGCACCACGC
AGTTAAAAGGCCACGTGTTTAACGCGCTGGCGGAAGAAGATAAAGCGTGGGTGGAAGCGCATATCGGCTTTGTCGACTCT
GCCGTAGACCGTATTGTGCCGCCATCGGCTTCCGCCACTCATGACCCGCTGGAAGTCACCGTGGAAACCTTTAGCGAATG
GATTGTCGATAAGACTCAGTTCAAGGGCGCGCTGCCGACTATCCCGGGAATGGAATTAACTGATAACCTGATGGCATTTG
TCGAACGCAAGCTCTTCACCTTGAACACCGGGCATGCTATAACCGCCTACCTCGGAAAACTGGCGGGCCATCAGACGATT
CGCGACGCGATCCTCGACGAGAAAATTCGTGCCGTCGTGCAGGGCGCGATGGAAGAGAGCGGCGCGGTGCTGATCAAACG
TTACGCCTTTGACCCGCAGAAGCACGCGGCTTATATCCAGAAAATACTTGGCCGTTTCGAGAACCCGTACCTGAAAGACG
ATGTTGAGCGCGTTGGCCGTCAGCCGCTGCGCAAACTGAGCGCTGGCGACCGTTTAATTAAGCCGCTGCTGGGTACACTG
GAATACGGGCTGCCGCACCGCAACCTGGTGAAAGGGATTGCGGCGGCGATGCATTTCCGTAGCGAAGACGATCCGCAGGC
GCAGGAGCTGGCGGCACTGATCGCCGACAAGGGGCCGCAGGCCGCGCTGGCGCAGATTTCCGGCCTGGATGCCGCAAGTG
ATGTCGTCGCGGAGGCCGTTAACGACTACAACGCGGAAAAATGA

Upstream 100 bases:

>100_bases
CTGTTAAATAAATAATCAACGCTATCCAACCCTCTCCTTTGGGAGAGGGTTGGGGTGAGGGGAAAGGCCTCACCCCAGCC
CTCTCAGGTGAAAACATTAA

Downstream 100 bases:

>100_bases
TGCACAACCTGGCGCGGCCGACGTCGCGCCCATTACGACTCCTGTCAGATATGCAGGCAATGATGGAAGAAACACAAGCA
TTTGAAAACCGTGTGCTTGA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKVNTMKALHFGAGNIGRGFIGKLLADAGIELTFADVNQTVLDALNARHSYQVHVVGENEQVDTVSGVNAVSSIGDEVVD
LIAEVDLVTTAVGPVVLERIAPAIAKGLAQRKAQGTERPLNIIACENMVRGTTQLKGHVFNALAEEDKAWVEAHIGFVDS
AVDRIVPPSASATHDPLEVTVETFSEWIVDKTQFKGALPTIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTI
RDAILDEKIRAVVQGAMEESGAVLIKRYAFDPQKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTL
EYGLPHRNLVKGIAAAMHFRSEDDPQAQELAALIADKGPQAALAQISGLDAASDVVAEAVNDYNAEK

Sequences:

>Translated_387_residues
MKVNTMKALHFGAGNIGRGFIGKLLADAGIELTFADVNQTVLDALNARHSYQVHVVGENEQVDTVSGVNAVSSIGDEVVD
LIAEVDLVTTAVGPVVLERIAPAIAKGLAQRKAQGTERPLNIIACENMVRGTTQLKGHVFNALAEEDKAWVEAHIGFVDS
AVDRIVPPSASATHDPLEVTVETFSEWIVDKTQFKGALPTIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTI
RDAILDEKIRAVVQGAMEESGAVLIKRYAFDPQKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTL
EYGLPHRNLVKGIAAAMHFRSEDDPQAQELAALIADKGPQAALAQISGLDAASDVVAEAVNDYNAEK
>Mature_387_residues
MKVNTMKALHFGAGNIGRGFIGKLLADAGIELTFADVNQTVLDALNARHSYQVHVVGENEQVDTVSGVNAVSSIGDEVVD
LIAEVDLVTTAVGPVVLERIAPAIAKGLAQRKAQGTERPLNIIACENMVRGTTQLKGHVFNALAEEDKAWVEAHIGFVDS
AVDRIVPPSASATHDPLEVTVETFSEWIVDKTQFKGALPTIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTI
RDAILDEKIRAVVQGAMEESGAVLIKRYAFDPQKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTL
EYGLPHRNLVKGIAAAMHFRSEDDPQAQELAALIADKGPQAALAQISGLDAASDVVAEAVNDYNAEK

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790028, Length=380, Percent_Identity=91.5789473684211, Blast_Score=711, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=267, Percent_Identity=28.0898876404494, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788497, Length=233, Percent_Identity=27.8969957081545, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1790779, Length=259, Percent_Identity=27.027027027027, Blast_Score=86, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324401, Length=219, Percent_Identity=28.310502283105, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320765, Length=219, Percent_Identity=28.310502283105, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.17 [H]

Molecular weight: Translated: 41747; Mature: 41747

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVNTMKALHFGAGNIGRGFIGKLLADAGIELTFADVNQTVLDALNARHSYQVHVVGENE
CCCCHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCEEEEEECCCC
QVDTVSGVNAVSSIGDEVVDLIAEVDLVTTAVGPVVLERIAPAIAKGLAQRKAQGTERPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
NIIACENMVRGTTQLKGHVFNALAEEDKAWVEAHIGFVDSAVDRIVPPSASATHDPLEVT
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
VETFSEWIVDKTQFKGALPTIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTI
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
RDAILDEKIRAVVQGAMEESGAVLIKRYAFDPQKHAAYIQKILGRFENPYLKDDVERVGR
HHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QPLRKLSAGDRLIKPLLGTLEYGLPHRNLVKGIAAAMHFRSEDDPQAQELAALIADKGPQ
HHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCH
AALAQISGLDAASDVVAEAVNDYNAEK
HHHHHHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKVNTMKALHFGAGNIGRGFIGKLLADAGIELTFADVNQTVLDALNARHSYQVHVVGENE
CCCCHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCEEEEEECCCC
QVDTVSGVNAVSSIGDEVVDLIAEVDLVTTAVGPVVLERIAPAIAKGLAQRKAQGTERPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
NIIACENMVRGTTQLKGHVFNALAEEDKAWVEAHIGFVDSAVDRIVPPSASATHDPLEVT
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
VETFSEWIVDKTQFKGALPTIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTI
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
RDAILDEKIRAVVQGAMEESGAVLIKRYAFDPQKHAAYIQKILGRFENPYLKDDVERVGR
HHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QPLRKLSAGDRLIKPLLGTLEYGLPHRNLVKGIAAAMHFRSEDDPQAQELAALIADKGPQ
HHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCH
AALAQISGLDAASDVVAEAVNDYNAEK
HHHHHHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA