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The map label for this gene is mtlA [H]

Identifier: 238897042

GI number: 238897042

Start: 5038297

End: 5040204

Strand: Direct

Name: mtlA [H]

Synonym: KP1_5289

Alternate gene names: 238897042

Gene position: 5038297-5040204 (Clockwise)

Preceding gene: 238897037

Following gene: 238897043

Centisome position: 95.99

GC content: 57.23

Gene sequence:

>1908_bases
ATGTCATCCGATATCAAGATCAAAGTGCAAAGCTTTGGTCGTTTCCTCAGCAATATGGTGATGCCGAATATCGGCGCGTT
TATCGCGTGGGGTATCATCACCGCGCTTTTCATTCCGACAGGGTGGTTGCCAAACGAAACGCTGGCGAAGCTGGTCGGTC
CGATGATCACCTACCTGCTGCCGCTGCTGATCGGTTACACCGGCGGTAAATTAGTCGGCGGCGAACGTGGCGGCGTGGTC
GGGGCGATCACCACCATGGGCGTTATCGTCGGCGCGGATATGCCGATGTTCCTCGGCTCCATGATTGCCGGCCCGCTGGG
CGGCTACTGCATCAAGAAATTCGATAACTGGGTAGACGGTAAGATCAAATCCGGTTTTGAAATGCTGGTGAATAACTTCT
CCGCCGGCATCATCGGGATGATCCTCGCCATTCTGGCCTTCCTCGGCATCGGCCCGGCGGTCGAAGTTCTGTCGAAAATT
CTGGCGGCTGGCGTTAACTTTATGGTGGCGCACGACATGCTGCCGCTGGCGTCTATCTTCGTCGAACCGGCAAAAATCCT
GTTCCTTAACAACGCCATCAACCACGGTATCTTCTCGCCGCTGGGTATTCAGCAGTCCCACGAGCTGGGTAAATCCATCT
TCTTCCTGATTGAAGCTAACCCGGGTCCAGGGATGGGCGTTCTGCTGGCGTACATGTTCTTTGGCCGCGGCAGCGCAAAA
CAGTCTGCAGGCGGGGCTGCTATCATCCACTTCCTGGGTGGTATCCATGAAATCTACTTCCCGTACGTACTGATGAACCC
GCGCCTGATCCTGGCCGTTATCCTCGGCGGGATGACCGGTGTCTTCACCCTGACTATCCTCAATGGCGGTCTGGTTTCCC
CGGCTTCCCCAGGCTCTATCCTGGCGGTACTGGCGATGACGCCGAAAGGCGCCTACTTCGCTAACATCGCCGCGATTATC
GCAGCGATGGCGGTCTCCTTCGTGGTCTCTGCGGTTCTGCTCAAGACCAGCAAAGTTAAAGAAGAAGACGATATCGAAGC
CGCAACGCGTCGTATGCATGACATGAAAGCGGAATCCAAAGGCGCCAGCCCGCTGGCGGCCGGTAATGTCACCAACGACC
TGAGCCATGTGCGTAAAATCATCGTCGCCTGCGACGCCGGGATGGGTTCCAGCGCCATGGGCGCCGGGGTACTGCGCAAG
AAAGTGCAGGATGCCGGGCTGAGCAACATCTCGGTCACCAACAGCGCAATCAATAACCTGCCGCCGGATGTTGACCTGGT
CATCACCCACCGCGACCTGACCGAGCGGGCCATGCGCCAGGTGCCGCAGGCGCAGCATATTTCGCTGACTAACTTCCTCG
ACAGCGGTCTGTACACCAGCCTGACCGAGCGCCTGGTCGCGGCCCAGCGCCACATCGACAACGAAGTCAAAGTCACCGAT
AGCCTGAAAGACAGCTTTGACGATACTAACAACAACCTGTTCCAGCTGGGCGCGGATAACATCTTCCTCGGTCGCAAAGC
AGCCACCAAAGAAGAAGCCATTCGCTTCGCCGGTGAGCAGCTGGTGAAAGGCGGCTACGTCGAGCCGGAATATGTGCAGG
CGATGCTGGACCGCGAAAAACTGACCTCGACCTATCTCGGCGAGTCCATTGCGGTACCGCACGGCACCATCGAAGCGAAG
GACCGCGTGCTGAAAACCGGCGTCGTCTTCTGCCAGTACCCGGAAGGCGTGCGCTTCGGTGAAGAAGAAGATGAAGTCGC
GCGTCTGGTCATCGGCATCGCCGCTCGTAATAACGAGCACATTCAGGTTATCACCAGTCTGACTAACGCGCTGGATGACG
AAACCGTGATTGAGCGCCTGGCGAAAACCACCAGCGTCGACGAAGTTCTGGCACTGTTAAATAAATAA

Upstream 100 bases:

>100_bases
CGCACTATCAATCAGGGCCCGGCTACCTCTGCCGCCACATTAACAACAAACCTCGGGCTTTAAGCCTGCGCGCTACGCAA
AACAGAAGAAGGGGTGTTTT

Downstream 100 bases:

>100_bases
TCAACGCTATCCAACCCTCTCCTTTGGGAGAGGGTTGGGGTGAGGGGAAAGGCCTCACCCCAGCCCTCTCAGGTGAAAAC
ATTAATTGAAGGTTAATACT

Product: mannitol-specific PTS family enzyme II component

Products: NA

Alternate protein names: EIICBA-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific EIIA component [H]

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MSSDIKIKVQSFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGYTGGKLVGGERGGVV
GAITTMGVIVGADMPMFLGSMIAGPLGGYCIKKFDNWVDGKIKSGFEMLVNNFSAGIIGMILAILAFLGIGPAVEVLSKI
LAAGVNFMVAHDMLPLASIFVEPAKILFLNNAINHGIFSPLGIQQSHELGKSIFFLIEANPGPGMGVLLAYMFFGRGSAK
QSAGGAAIIHFLGGIHEIYFPYVLMNPRLILAVILGGMTGVFTLTILNGGLVSPASPGSILAVLAMTPKGAYFANIAAII
AAMAVSFVVSAVLLKTSKVKEEDDIEAATRRMHDMKAESKGASPLAAGNVTNDLSHVRKIIVACDAGMGSSAMGAGVLRK
KVQDAGLSNISVTNSAINNLPPDVDLVITHRDLTERAMRQVPQAQHISLTNFLDSGLYTSLTERLVAAQRHIDNEVKVTD
SLKDSFDDTNNNLFQLGADNIFLGRKAATKEEAIRFAGEQLVKGGYVEPEYVQAMLDREKLTSTYLGESIAVPHGTIEAK
DRVLKTGVVFCQYPEGVRFGEEEDEVARLVIGIAARNNEHIQVITSLTNALDDETVIERLAKTTSVDEVLALLNK

Sequences:

>Translated_635_residues
MSSDIKIKVQSFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGYTGGKLVGGERGGVV
GAITTMGVIVGADMPMFLGSMIAGPLGGYCIKKFDNWVDGKIKSGFEMLVNNFSAGIIGMILAILAFLGIGPAVEVLSKI
LAAGVNFMVAHDMLPLASIFVEPAKILFLNNAINHGIFSPLGIQQSHELGKSIFFLIEANPGPGMGVLLAYMFFGRGSAK
QSAGGAAIIHFLGGIHEIYFPYVLMNPRLILAVILGGMTGVFTLTILNGGLVSPASPGSILAVLAMTPKGAYFANIAAII
AAMAVSFVVSAVLLKTSKVKEEDDIEAATRRMHDMKAESKGASPLAAGNVTNDLSHVRKIIVACDAGMGSSAMGAGVLRK
KVQDAGLSNISVTNSAINNLPPDVDLVITHRDLTERAMRQVPQAQHISLTNFLDSGLYTSLTERLVAAQRHIDNEVKVTD
SLKDSFDDTNNNLFQLGADNIFLGRKAATKEEAIRFAGEQLVKGGYVEPEYVQAMLDREKLTSTYLGESIAVPHGTIEAK
DRVLKTGVVFCQYPEGVRFGEEEDEVARLVIGIAARNNEHIQVITSLTNALDDETVIERLAKTTSVDEVLALLNK
>Mature_634_residues
SSDIKIKVQSFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGYTGGKLVGGERGGVVG
AITTMGVIVGADMPMFLGSMIAGPLGGYCIKKFDNWVDGKIKSGFEMLVNNFSAGIIGMILAILAFLGIGPAVEVLSKIL
AAGVNFMVAHDMLPLASIFVEPAKILFLNNAINHGIFSPLGIQQSHELGKSIFFLIEANPGPGMGVLLAYMFFGRGSAKQ
SAGGAAIIHFLGGIHEIYFPYVLMNPRLILAVILGGMTGVFTLTILNGGLVSPASPGSILAVLAMTPKGAYFANIAAIIA
AMAVSFVVSAVLLKTSKVKEEDDIEAATRRMHDMKAESKGASPLAAGNVTNDLSHVRKIIVACDAGMGSSAMGAGVLRKK
VQDAGLSNISVTNSAINNLPPDVDLVITHRDLTERAMRQVPQAQHISLTNFLDSGLYTSLTERLVAAQRHIDNEVKVTDS
LKDSFDDTNNNLFQLGADNIFLGRKAATKEEAIRFAGEQLVKGGYVEPEYVQAMLDREKLTSTYLGESIAVPHGTIEAKD
RVLKTGVVFCQYPEGVRFGEEEDEVARLVIGIAARNNEHIQVITSLTNALDDETVIERLAKTTSVDEVLALLNK

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=633, Percent_Identity=94.7867298578199, Blast_Score=1197, Evalue=0.0,
Organism=Escherichia coli, GI1789301, Length=469, Percent_Identity=52.4520255863539, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1788494, Length=141, Percent_Identity=48.2269503546099, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 67734; Mature: 67603

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDIKIKVQSFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLL
CCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
PLLIGYTGGKLVGGERGGVVGAITTMGVIVGADMPMFLGSMIAGPLGGYCIKKFDNWVDG
HHHHCCCCCEEECCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCCC
KIKSGFEMLVNNFSAGIIGMILAILAFLGIGPAVEVLSKILAAGVNFMVAHDMLPLASIF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VEPAKILFLNNAINHGIFSPLGIQQSHELGKSIFFLIEANPGPGMGVLLAYMFFGRGSAK
HCCHHEEEECCHHHCCCCCCCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCC
QSAGGAAIIHFLGGIHEIYFPYVLMNPRLILAVILGGMTGVFTLTILNGGLVSPASPGSI
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHEECCCCCCCCCCCCE
LAVLAMTPKGAYFANIAAIIAAMAVSFVVSAVLLKTSKVKEEDDIEAATRRMHDMKAESK
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
GASPLAAGNVTNDLSHVRKIIVACDAGMGSSAMGAGVLRKKVQDAGLSNISVTNSAINNL
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHCC
PPDVDLVITHRDLTERAMRQVPQAQHISLTNFLDSGLYTSLTERLVAAQRHIDNEVKVTD
CCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEHH
SLKDSFDDTNNNLFQLGADNIFLGRKAATKEEAIRFAGEQLVKGGYVEPEYVQAMLDREK
HHHHHCCCCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LTSTYLGESIAVPHGTIEAKDRVLKTGVVFCQYPEGVRFGEEEDEVARLVIGIAARNNEH
HHHHHCCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHEECCCCH
IQVITSLTNALDDETVIERLAKTTSVDEVLALLNK
HHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure 
SSDIKIKVQSFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLL
CCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
PLLIGYTGGKLVGGERGGVVGAITTMGVIVGADMPMFLGSMIAGPLGGYCIKKFDNWVDG
HHHHCCCCCEEECCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCCC
KIKSGFEMLVNNFSAGIIGMILAILAFLGIGPAVEVLSKILAAGVNFMVAHDMLPLASIF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VEPAKILFLNNAINHGIFSPLGIQQSHELGKSIFFLIEANPGPGMGVLLAYMFFGRGSAK
HCCHHEEEECCHHHCCCCCCCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCC
QSAGGAAIIHFLGGIHEIYFPYVLMNPRLILAVILGGMTGVFTLTILNGGLVSPASPGSI
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHEECCCCCCCCCCCCE
LAVLAMTPKGAYFANIAAIIAAMAVSFVVSAVLLKTSKVKEEDDIEAATRRMHDMKAESK
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
GASPLAAGNVTNDLSHVRKIIVACDAGMGSSAMGAGVLRKKVQDAGLSNISVTNSAINNL
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHCC
PPDVDLVITHRDLTERAMRQVPQAQHISLTNFLDSGLYTSLTERLVAAQRHIDNEVKVTD
CCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEHH
SLKDSFDDTNNNLFQLGADNIFLGRKAATKEEAIRFAGEQLVKGGYVEPEYVQAMLDREK
HHHHHCCCCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LTSTYLGESIAVPHGTIEAKDRVLKTGVVFCQYPEGVRFGEEEDEVARLVIGIAARNNEH
HHHHHCCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHEECCCCH
IQVITSLTNALDDETVIERLAKTTSVDEVLALLNK
HHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6309813; 8041620; 9278503; 3135464; 3142516; 1946374; 9551558 [H]