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The map label for this gene is aroE [H]

Identifier: 238896778

GI number: 238896778

Start: 4761472

End: 4762290

Strand: Reverse

Name: aroE [H]

Synonym: KP1_5000

Alternate gene names: 238896778

Gene position: 4762290-4761472 (Counterclockwise)

Preceding gene: 238896779

Following gene: 238896777

Centisome position: 90.74

GC content: 54.82

Gene sequence:

>819_bases
ATGGAAACCTATGCCGTTTTTGGTAATCCGATCGCGCACAGCAAGTCGCCTGCTATTCATCAGCTGTTTGCCCGCCAGTT
AGGAATTACTCATCCTTATGGACGTGTACTGGCGCCGCTGGACGATTTTGTCTCTTCTCTGAATCAGTTCTTTGCAGAAG
GAGGAAAGGGGGCCAACGTCACCGTTCCTTTTAAAGAGGAAGCCTTTGCGCGTGCCGACGAACTGACAGAACGCGCAGCG
CTGGCGGGAGCAGTAAACACCCTGAAACGCCTGGAAGATGGCCGTTTACTGGGGGACAACACCGACGGTATTGGTCTTCT
GAGCGATCTGGAACGCCTGGGATTCATTAAGCCACGCCAACGGATCCTGCTTGTTGGTGCTGGTGGGGCATCTCGCGGGG
TTCTTTTGCCGCTTCTGTCGCTGGGATGCGCCGTCACGATCGTGAATCGCACCTATTCTCGTGCCCGTGAGTTAGCCACT
CTCTTCGCCCATACCGGGAGCGTTAGCGCAAGGGAGATGGATACCTTATCCGGGGAAACATTCGATCTGATCGTCAATGC
GACGTCCAGTGGAATAGACGGTGATGTACCAGCTATCCCGGCATCTATTGTCAACGCTGACGTATATTGCTATGACATGT
TTTACCAGAAAGGGCCGACACCGTTTCTTCACTGGTGCCAGCAATATGGCGCAGTCCACTGTGCCGATGGGCTGGGAATG
CTGGTGGCGCAAGCCGCCCATGCTGTTCTGCTATGGCACGGCGTTCTGCCGGCTATCGCTCCGGTCATTGAAACGCTGCA
GCAGGAACTGAATGCATGA

Upstream 100 bases:

>100_bases
CGACAGCTTCCCGGTGGTGGATGGCGCCACGGGCGGCCGGCAAAACCCATCTGAAATCCGTGATGCCCTGACGGGTGAAC
TGTTCCGCCAGGGGTGAACC

Downstream 100 bases:

>100_bases
ATCAGGCGATTCAGTTTCCTGACCGGGAATCATGGGATGCCGAACGGCAGGGCGTGGTTTTTCCCGCGCTGGTGAATGGG
ATGCAATTAACCTGCGCAAT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
METYAVFGNPIAHSKSPAIHQLFARQLGITHPYGRVLAPLDDFVSSLNQFFAEGGKGANVTVPFKEEAFARADELTERAA
LAGAVNTLKRLEDGRLLGDNTDGIGLLSDLERLGFIKPRQRILLVGAGGASRGVLLPLLSLGCAVTIVNRTYSRARELAT
LFAHTGSVSAREMDTLSGETFDLIVNATSSGIDGDVPAIPASIVNADVYCYDMFYQKGPTPFLHWCQQYGAVHCADGLGM
LVAQAAHAVLLWHGVLPAIAPVIETLQQELNA

Sequences:

>Translated_272_residues
METYAVFGNPIAHSKSPAIHQLFARQLGITHPYGRVLAPLDDFVSSLNQFFAEGGKGANVTVPFKEEAFARADELTERAA
LAGAVNTLKRLEDGRLLGDNTDGIGLLSDLERLGFIKPRQRILLVGAGGASRGVLLPLLSLGCAVTIVNRTYSRARELAT
LFAHTGSVSAREMDTLSGETFDLIVNATSSGIDGDVPAIPASIVNADVYCYDMFYQKGPTPFLHWCQQYGAVHCADGLGM
LVAQAAHAVLLWHGVLPAIAPVIETLQQELNA
>Mature_272_residues
METYAVFGNPIAHSKSPAIHQLFARQLGITHPYGRVLAPLDDFVSSLNQFFAEGGKGANVTVPFKEEAFARADELTERAA
LAGAVNTLKRLEDGRLLGDNTDGIGLLSDLERLGFIKPRQRILLVGAGGASRGVLLPLLSLGCAVTIVNRTYSRARELAT
LFAHTGSVSAREMDTLSGETFDLIVNATSSGIDGDVPAIPASIVNADVYCYDMFYQKGPTPFLHWCQQYGAVHCADGLGM
LVAQAAHAVLLWHGVLPAIAPVIETLQQELNA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=272, Percent_Identity=78.3088235294118, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1787983, Length=267, Percent_Identity=27.3408239700375, Blast_Score=79, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320332, Length=286, Percent_Identity=29.020979020979, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 29087; Mature: 29087

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METYAVFGNPIAHSKSPAIHQLFARQLGITHPYGRVLAPLDDFVSSLNQFFAEGGKGANV
CCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
TVPFKEEAFARADELTERAALAGAVNTLKRLEDGRLLGDNTDGIGLLSDLERLGFIKPRQ
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCCCC
RILLVGAGGASRGVLLPLLSLGCAVTIVNRTYSRARELATLFAHTGSVSAREMDTLSGET
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCE
FDLIVNATSSGIDGDVPAIPASIVNADVYCYDMFYQKGPTPFLHWCQQYGAVHCADGLGM
EEEEEECCCCCCCCCCCCCCHHHHCCCHHEEEHHHHCCCCHHHHHHHHHCCEEECCHHHH
LVAQAAHAVLLWHGVLPAIAPVIETLQQELNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
METYAVFGNPIAHSKSPAIHQLFARQLGITHPYGRVLAPLDDFVSSLNQFFAEGGKGANV
CCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
TVPFKEEAFARADELTERAALAGAVNTLKRLEDGRLLGDNTDGIGLLSDLERLGFIKPRQ
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCCCC
RILLVGAGGASRGVLLPLLSLGCAVTIVNRTYSRARELATLFAHTGSVSAREMDTLSGET
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCE
FDLIVNATSSGIDGDVPAIPASIVNADVYCYDMFYQKGPTPFLHWCQQYGAVHCADGLGM
EEEEEECCCCCCCCCCCCCCHHHHCCCHHEEEHHHHCCCCHHHHHHHHHCCEEECCHHHH
LVAQAAHAVLLWHGVLPAIAPVIETLQQELNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA