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The map label for this gene is panF [H]

Identifier: 238896765

GI number: 238896765

Start: 4744824

End: 4746278

Strand: Direct

Name: panF [H]

Synonym: KP1_4985

Alternate gene names: 238896765

Gene position: 4744824-4746278 (Clockwise)

Preceding gene: 238896764

Following gene: 238896766

Centisome position: 90.4

GC content: 60.07

Gene sequence:

>1455_bases
ATGATGCAGTTTGAGGTCATTATTCCCCTGATCGCCTACCTGGTGGTGGTGTTCGGTTTATCCCTCTACGCCATGAGAAA
ACGCGCCTCAGGTAGCTTTCTTAATGAGTACTTTCTCGGCAGCCGCTCGATGGGCGGCTTCGTGCTGGCCATGACGCTAA
CCGCCACCTATATCAGCGCCAGCTCATTTATCGGCGGACCCGGCGCCGCCTATAAATACGGCCTGGGCTGGGTGCTGCTG
GCGATGATCCAGCTCCCCGCCATCTGGCTGTCGCTGGGCGTGCTGGGGAAAAAATTCGCCATCCTTGCGCGTCGCTATAA
TGCTGTCACCCTCAATGACATGCTGTTTGCGCGCTATCAGAGTCGCCTGCTGGTCTGGCTGGCCAGCCTGAGTCTGCTGG
TGGCCTTTGTCGGCGCCATGACCGTCCAGTTTATCGGCGGCGCCCGCCTGCTGGAGACGGCTGCCGGTATTCCTTACGAT
ACCGGCCTGCTGATCTTCGGGGTCAGCATCGCGCTGTATACCGCCTATGGCGGCTTTCGCGCCAGCGTGCTCAACGACAC
GATGCAGGGCATGGTAATGCTGATCGGCACGATCGTGCTGCTGGTAGGCGTGATCCACGCCGCCGGGGGGGTTGGCCATG
CGGTAGAGACGCTGCAGTCGATCGACGTCAAGCTGGTGTCCCCGCAGGGCGCGGAAGATATCCTCTCGCCAACCTTTATG
GCCTCGTTTTGGGTGCTGGTCTGCTTCGGCGTTATTGGTCTGCCACATACCGCAGTGCGCTGTATCTCCTACAAAGACAG
CAAAGCCGTGCATCGCGGCATCATTATCGGCACCATCGTGGTGGCGATCCTGATGTTTGGCATGCATCTGGCTGGGGCAT
TAGGCCGGGCGGTGATCCCCGATTTAACCGTGCCGGATCTGGTGATCCCGACGCTGATGGTTAAAGTGCTTCCGCCCTTT
GCCGCCGGGATCTTCCTTGCCGCGCCGATGGCGGCGATTATGTCGACGATCAATGCCCAACTTCTGCAAAGTTCCGCTAC
GATCATCAAAGATCTGTACCTGAACTGGCGGCCGGATCAGGCGACTAACGAAAAGCGGCTTAAACGCATGTCCGCCGGCA
TCACGCTCCTGCTGGGGGTCTTGTTGCTGCTCGCGGCCTGGCGGCCGCCGGAGATGATAATCTGGCTGAACCTGCTGGCC
TTCGGCGGCCTGGAAGCCGTCTTCCTGTGGCCGCTGGTGCTGGGCCTTTACTGGGAACGCGCCAACGCGGCTGGCGCGCT
GAGCGCGATGATCGTAGGCGGCGTCCTGTATGCCGTACTGGCCACGCTGAAAGTGCAGTTTCTGGGCTTTCACCCGATCG
TTCCCGCGCTGCTGCTGAGTTTGCTGGCGTTTGTGGCGGGGAACCGTTTCGGTCGTCCCGCCCCACAGTCCCCCATTTTG
ACTACTGATAAATAA

Upstream 100 bases:

>100_bases
CACTGGTTTGAAATGGCCTGCCTGCTGGTACCGCTGCTGTTCATTCTGCTGTGCTGGGCGATGGTCAAACTGATTTTCCG
CGATATTTCTCTGGAGGACG

Downstream 100 bases:

>100_bases
AGAGTTTTGCTATGCCATGGATCCAACTGAAACTAAATACCACCGGCGCGAACGCTGAAGATCTTAGCGATGCGCTGATG
GAGGCCGGATCGGTCTCGAT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MMQFEVIIPLIAYLVVVFGLSLYAMRKRASGSFLNEYFLGSRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLL
AMIQLPAIWLSLGVLGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYD
TGLLIFGVSIALYTAYGGFRASVLNDTMQGMVMLIGTIVLLVGVIHAAGGVGHAVETLQSIDVKLVSPQGAEDILSPTFM
ASFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPF
AAGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNWRPDQATNEKRLKRMSAGITLLLGVLLLLAAWRPPEMIIWLNLLA
FGGLEAVFLWPLVLGLYWERANAAGALSAMIVGGVLYAVLATLKVQFLGFHPIVPALLLSLLAFVAGNRFGRPAPQSPIL
TTDK

Sequences:

>Translated_484_residues
MMQFEVIIPLIAYLVVVFGLSLYAMRKRASGSFLNEYFLGSRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLL
AMIQLPAIWLSLGVLGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYD
TGLLIFGVSIALYTAYGGFRASVLNDTMQGMVMLIGTIVLLVGVIHAAGGVGHAVETLQSIDVKLVSPQGAEDILSPTFM
ASFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPF
AAGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNWRPDQATNEKRLKRMSAGITLLLGVLLLLAAWRPPEMIIWLNLLA
FGGLEAVFLWPLVLGLYWERANAAGALSAMIVGGVLYAVLATLKVQFLGFHPIVPALLLSLLAFVAGNRFGRPAPQSPIL
TTDK
>Mature_484_residues
MMQFEVIIPLIAYLVVVFGLSLYAMRKRASGSFLNEYFLGSRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLL
AMIQLPAIWLSLGVLGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYD
TGLLIFGVSIALYTAYGGFRASVLNDTMQGMVMLIGTIVLLVGVIHAAGGVGHAVETLQSIDVKLVSPQGAEDILSPTFM
ASFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPF
AAGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNWRPDQATNEKRLKRMSAGITLLLGVLLLLAAWRPPEMIIWLNLLA
FGGLEAVFLWPLVLGLYWERANAAGALSAMIVGGVLYAVLATLKVQFLGFHPIVPALLLSLLAFVAGNRFGRPAPQSPIL
TTDK

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=473, Percent_Identity=26.8498942917548, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI14140236, Length=478, Percent_Identity=23.8493723849372, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4507033, Length=407, Percent_Identity=25.3071253071253, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4507031, Length=473, Percent_Identity=24.5243128964059, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4507035, Length=399, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI110835708, Length=490, Percent_Identity=24.0816326530612, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI256985183, Length=425, Percent_Identity=22.5882352941176, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI157671931, Length=374, Percent_Identity=21.1229946524064, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI109659836, Length=486, Percent_Identity=24.0740740740741, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI87082237, Length=483, Percent_Identity=89.648033126294, Blast_Score=845, Evalue=0.0,
Organism=Escherichia coli, GI1787251, Length=482, Percent_Identity=26.7634854771784, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1790503, Length=495, Percent_Identity=24.040404040404, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790113, Length=476, Percent_Identity=23.7394957983193, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51862; Mature: 51862

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCC
>Mature Secondary Structure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CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]