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The map label for this gene is csrD [H]

Identifier: 238896757

GI number: 238896757

Start: 4737909

End: 4739849

Strand: Reverse

Name: csrD [H]

Synonym: KP1_4976

Alternate gene names: 238896757

Gene position: 4739849-4737909 (Counterclockwise)

Preceding gene: 238896758

Following gene: 238896756

Centisome position: 90.31

GC content: 57.29

Gene sequence:

>1941_bases
ATGCGATTAACGACGAAGTTCTCAGCCTTTATTACGCTGCTAACTAGCCTGACCATCTTTGTCACGCTGATTGGCGCTTC
GCTGAGTTTTTATAACGGCATTGAGAACAAGGTCGAAAACCGCGTTCAGGCGGTGGCGACCATGCTGGATAACCGGCTCA
TCACCACCTCTTTCGATAAGCTTGAACCGCAGTTGGATGAGCTGATGACGCCGATCGAGATCGTGCATATCGATTTCATG
CTCAACGGCAAACCGCTCTACAGCCATTCCCGACCCGATAGCTATCGCCCGCTCGGCAGCCATGAGCAATTCCGTGAGAT
CACGGTTCAGTCGCTTAAACATCCTGGTATTACGCTGCATCTGGTCTACGTTGACCCGATGGTGAACTATTTCCGTTCGC
TGTCGATCACTGCCCCGCTGTCGATCTCCATTGGCTTCATGGTGGTAATTATTTTCTTCGCCGTCCGCTGGATCCGCCGC
CAGCTGGCCGGCCAGGAGCTGCTGGAGCTGCGTTCCACGCGTATCCTGAGCGGCGAGCGCGGGCCGCAGGTGCGCGGGTC
GGTCTATGAATGGCCGGCCAGCACCAGCAGCGCGCTGGATATGCTGCTGTCGGAGCTGCAGTTCGCCAGCGATCAGCGCA
GCCGGATGGATACGCTTATTCGCTCCTACGCGGCGCAGGATTCGAAAACCGGACTGAATAACCGCCTGTTTTTTGACAAT
CAGCTGGCCACGCTGCTGGAAGACCAGGAGAAGGTGGGAGCCTACGGCATCGTGATGATGATCCGTCTGCCGGAGTTTGA
TCTGCTACGGGACAACTGGGGACGGGCGGCGGCCGAAGAACATTACTTTACGCTTATCAACCTGCTCTCTACCTTTATTA
TGCGTTACCCCGGCGCGCTGTTGGCGCGCTATCACCGTAGCGACTTCGCCGTGCTGCTGCCGCACCGTACGTTGAAAGAG
GCGGATAGTATCGCCGGCCTGTTGCTGAAGGCGATGGATGCGCTGCCTCCAACGCGTATCCTCGATCGCGACGATATGAT
GCATATCGGCATCTGTTCTTTCCGCAGCGGGCAATCGGCGGCGCAGGTGATGGAACATGCGGAAGCGGCAACGCGCAACG
CGGTGCTGCAGGGCAGCAACAGCTGGTCGGTCTATGATGACACCCTTCCGGAGAAAGGTCGCGGCAACGTTCGCTGGCGA
ACGCTGATCGAACAGATGCTGAGCCGCGGCGGGCCGCGGTTGTACCAAAAACCAGCTGTCACCCGCGACGGGCGGGTACA
TCATCGTGAACTGATGTCGCGGATGTACGACGGTAAAGAAGAGGTGATTGCAGCGGAATACATGCCGATGGTGCTGCAGT
TTGGCCTGGCGGAGGAGTATGACCGCCTGCAGGTAACGCGCCTGCTGCCGTTTTTAGGCTTCTGGCCCGAGGAGAATCTG
GCGCTCCAGCTGTCGGTGGAGTCGCTGATCCGTCCGCGTTTCCAGCGCTGGCTGCGCGATGCCTTGATGCAGTGTGAAAA
ATCGCAGCGTCAGCGGATTATTTTTGAACTTGCAGAGGCAGATGTTTGTCAATATATCGGCCGTCTGCAGCCGGTTATGC
GATTGGTTAACGCTCTGGGCGTTCGGGTGGCAGTGGTTCAGGCGGGGTTAACCCTGGTTGGAACCAGCTGGATCAAGCAG
CTGGATGCGGAGCTGATCAAACTGCATCCGGGTCTGGCGCGCAACATCGAAAAGCGCAGCGAGAACCAACTGCTGGTGCA
AAGCCTGGTGGAAGCCTGTAAAGGCATGCCTATGCAAGTTTTTGCGACGGGCGTACGCAGCCGCAGCGAGTGGTTGGTAC
TGTCCCAATGCGGTGTCACGGGCGGGCAGGGGGAATTTTTTGCCGCCTCACAGCCACTTGACACAAATGTGAAAAAATAT
TCGCAAAGATACTCGGTTTGA

Upstream 100 bases:

>100_bases
CGTCGCGCTTTAAAAGGTTAATGCTTGCGGCAAGGTGCGCGCCGGCACGGGAGCCTGATGGTTCATCGGGTAGTCATTCA
CTCGCGGAGTTAACACAGGG

Downstream 100 bases:

>100_bases
TCTGCCGTTTAGCGTGATTTCACGTAGAATAACGCGCGCCATCGTGAAGGGGGTGTGCTTGTCTACCTGCCGGATCATCG
CAATGTAAATGCCAGTGACC

Product: regulatory protein CsrD

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MRLTTKFSAFITLLTSLTIFVTLIGASLSFYNGIENKVENRVQAVATMLDNRLITTSFDKLEPQLDELMTPIEIVHIDFM
LNGKPLYSHSRPDSYRPLGSHEQFREITVQSLKHPGITLHLVYVDPMVNYFRSLSITAPLSISIGFMVVIIFFAVRWIRR
QLAGQELLELRSTRILSGERGPQVRGSVYEWPASTSSALDMLLSELQFASDQRSRMDTLIRSYAAQDSKTGLNNRLFFDN
QLATLLEDQEKVGAYGIVMMIRLPEFDLLRDNWGRAAAEEHYFTLINLLSTFIMRYPGALLARYHRSDFAVLLPHRTLKE
ADSIAGLLLKAMDALPPTRILDRDDMMHIGICSFRSGQSAAQVMEHAEAATRNAVLQGSNSWSVYDDTLPEKGRGNVRWR
TLIEQMLSRGGPRLYQKPAVTRDGRVHHRELMSRMYDGKEEVIAAEYMPMVLQFGLAEEYDRLQVTRLLPFLGFWPEENL
ALQLSVESLIRPRFQRWLRDALMQCEKSQRQRIIFELAEADVCQYIGRLQPVMRLVNALGVRVAVVQAGLTLVGTSWIKQ
LDAELIKLHPGLARNIEKRSENQLLVQSLVEACKGMPMQVFATGVRSRSEWLVLSQCGVTGGQGEFFAASQPLDTNVKKY
SQRYSV

Sequences:

>Translated_646_residues
MRLTTKFSAFITLLTSLTIFVTLIGASLSFYNGIENKVENRVQAVATMLDNRLITTSFDKLEPQLDELMTPIEIVHIDFM
LNGKPLYSHSRPDSYRPLGSHEQFREITVQSLKHPGITLHLVYVDPMVNYFRSLSITAPLSISIGFMVVIIFFAVRWIRR
QLAGQELLELRSTRILSGERGPQVRGSVYEWPASTSSALDMLLSELQFASDQRSRMDTLIRSYAAQDSKTGLNNRLFFDN
QLATLLEDQEKVGAYGIVMMIRLPEFDLLRDNWGRAAAEEHYFTLINLLSTFIMRYPGALLARYHRSDFAVLLPHRTLKE
ADSIAGLLLKAMDALPPTRILDRDDMMHIGICSFRSGQSAAQVMEHAEAATRNAVLQGSNSWSVYDDTLPEKGRGNVRWR
TLIEQMLSRGGPRLYQKPAVTRDGRVHHRELMSRMYDGKEEVIAAEYMPMVLQFGLAEEYDRLQVTRLLPFLGFWPEENL
ALQLSVESLIRPRFQRWLRDALMQCEKSQRQRIIFELAEADVCQYIGRLQPVMRLVNALGVRVAVVQAGLTLVGTSWIKQ
LDAELIKLHPGLARNIEKRSENQLLVQSLVEACKGMPMQVFATGVRSRSEWLVLSQCGVTGGQGEFFAASQPLDTNVKKY
SQRYSV
>Mature_646_residues
MRLTTKFSAFITLLTSLTIFVTLIGASLSFYNGIENKVENRVQAVATMLDNRLITTSFDKLEPQLDELMTPIEIVHIDFM
LNGKPLYSHSRPDSYRPLGSHEQFREITVQSLKHPGITLHLVYVDPMVNYFRSLSITAPLSISIGFMVVIIFFAVRWIRR
QLAGQELLELRSTRILSGERGPQVRGSVYEWPASTSSALDMLLSELQFASDQRSRMDTLIRSYAAQDSKTGLNNRLFFDN
QLATLLEDQEKVGAYGIVMMIRLPEFDLLRDNWGRAAAEEHYFTLINLLSTFIMRYPGALLARYHRSDFAVLLPHRTLKE
ADSIAGLLLKAMDALPPTRILDRDDMMHIGICSFRSGQSAAQVMEHAEAATRNAVLQGSNSWSVYDDTLPEKGRGNVRWR
TLIEQMLSRGGPRLYQKPAVTRDGRVHHRELMSRMYDGKEEVIAAEYMPMVLQFGLAEEYDRLQVTRLLPFLGFWPEENL
ALQLSVESLIRPRFQRWLRDALMQCEKSQRQRIIFELAEADVCQYIGRLQPVMRLVNALGVRVAVVQAGLTLVGTSWIKQ
LDAELIKLHPGLARNIEKRSENQLLVQSLVEACKGMPMQVFATGVRSRSEWLVLSQCGVTGGQGEFFAASQPLDTNVKKY
SQRYSV

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=646, Percent_Identity=73.9938080495356, Blast_Score=1011, Evalue=0.0,
Organism=Escherichia coli, GI1788849, Length=236, Percent_Identity=24.1525423728814, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787410, Length=121, Percent_Identity=26.4462809917355, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787541, Length=445, Percent_Identity=22.4719101123595, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 73418; Mature: 73418

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTTKFSAFITLLTSLTIFVTLIGASLSFYNGIENKVENRVQAVATMLDNRLITTSFDK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHH
LEPQLDELMTPIEIVHIDFMLNGKPLYSHSRPDSYRPLGSHEQFREITVQSLKHPGITLH
HCHHHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
LVYVDPMVNYFRSLSITAPLSISIGFMVVIIFFAVRWIRRQLAGQELLELRSTRILSGER
EEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GPQVRGSVYEWPASTSSALDMLLSELQFASDQRSRMDTLIRSYAAQDSKTGLNNRLFFDN
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECH
QLATLLEDQEKVGAYGIVMMIRLPEFDLLRDNWGRAAAEEHYFTLINLLSTFIMRYPGAL
HHHHHHHHHHHHCCEEEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHH
LARYHRSDFAVLLPHRTLKEADSIAGLLLKAMDALPPTRILDRDDMMHIGICSFRSGQSA
HHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCCCCHH
AQVMEHAEAATRNAVLQGSNSWSVYDDTLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
HHHHHHHHHHHHHHEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
TRDGRVHHRELMSRMYDGKEEVIAAEYMPMVLQFGLAEEYDRLQVTRLLPFLGFWPEENL
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
ALQLSVESLIRPRFQRWLRDALMQCEKSQRQRIIFELAEADVCQYIGRLQPVMRLVNALG
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRVAVVQAGLTLVGTSWIKQLDAELIKLHPGLARNIEKRSENQLLVQSLVEACKGMPMQV
HHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FATGVRSRSEWLVLSQCGVTGGQGEFFAASQPLDTNVKKYSQRYSV
HHHHHCCCCCEEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MRLTTKFSAFITLLTSLTIFVTLIGASLSFYNGIENKVENRVQAVATMLDNRLITTSFDK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHH
LEPQLDELMTPIEIVHIDFMLNGKPLYSHSRPDSYRPLGSHEQFREITVQSLKHPGITLH
HCHHHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
LVYVDPMVNYFRSLSITAPLSISIGFMVVIIFFAVRWIRRQLAGQELLELRSTRILSGER
EEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GPQVRGSVYEWPASTSSALDMLLSELQFASDQRSRMDTLIRSYAAQDSKTGLNNRLFFDN
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECH
QLATLLEDQEKVGAYGIVMMIRLPEFDLLRDNWGRAAAEEHYFTLINLLSTFIMRYPGAL
HHHHHHHHHHHHCCEEEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHH
LARYHRSDFAVLLPHRTLKEADSIAGLLLKAMDALPPTRILDRDDMMHIGICSFRSGQSA
HHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCCCCHH
AQVMEHAEAATRNAVLQGSNSWSVYDDTLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
HHHHHHHHHHHHHHEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
TRDGRVHHRELMSRMYDGKEEVIAAEYMPMVLQFGLAEEYDRLQVTRLLPFLGFWPEENL
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
ALQLSVESLIRPRFQRWLRDALMQCEKSQRQRIIFELAEADVCQYIGRLQPVMRLVNALG
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRVAVVQAGLTLVGTSWIKQLDAELIKLHPGLARNIEKRSENQLLVQSLVEACKGMPMQV
HHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FATGVRSRSEWLVLSQCGVTGGQGEFFAASQPLDTNVKKYSQRYSV
HHHHHCCCCCEEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]