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The map label for this gene is gatD [H]

Identifier: 238896650

GI number: 238896650

Start: 4629462

End: 4630505

Strand: Direct

Name: gatD [H]

Synonym: KP1_4855

Alternate gene names: 238896650

Gene position: 4629462-4630505 (Clockwise)

Preceding gene: 238896649

Following gene: 238896651

Centisome position: 88.21

GC content: 59.0

Gene sequence:

>1044_bases
ATGAAATCAGTGGTAATCCATGCTGAGGGGAACGTCTGCGTTGAAGAACGCCCTATCCCCACGCTGCAAACGGAAAACGA
TGTCCTGGTCAAAGTGGTCAGTTCCGGGTTATGCGGCTCCGATATCCCGCGCATTTTCGCCAAAGGGGCGCATTACTACC
CTATTACGCTGGGGCACGAATTCAGCGGTTATGTGGAATCCTACGGCGCGGCGGTAACCGACCTGCAGCCCGGCGATGCC
GTCGCCTGCGTGCCGCTGCTGCCTTGCTTCCAGTGCCCGCAATGCCAGCGCGAGTATTTCTCTTTATGTAAACAGTATCA
GTTCGTCGGCTCACGCAGCGAAGGCGGCAACGCCGAATATGTGGTGGTAAAGCGCGCCAACCTGTTCCGCCTGCCGGACC
AGATGCCAATTGATGATGGCGCGTTTATAGAACCGATAACCGTTGGCCTGCACGCTTTTCATCTGGCGCAGGGCTGTGAA
GGTAAAAACGTGATTATTATCGGCGCCGGCACCATCGGCCTGCTGGCGCTACAGTGCGCCCGCGAACTGGGCGCCAACAG
CGTCACGGCGATCGATATCAATCCGCAGAAGCTGGAGCTGGCCAAAACCCTTGGCGCAACCCATGTGTTCAACAGTCGCG
AGATGAGCGGCCAGGCGATTCAGCAGGCGCTGGAAGCCATTCAGTTCGATCAGTTAGTCCTCGAGACCGCCGGTACGCCG
CAGACCGTCGCGCTGGCGATTGAGGCCGCCGGTCCGCGGGCGCAGCTGACGCTGGTTGGCACGCTTCATCATGATTTAAC
CCTCCCGGCAGCCACCTTCGGGCAGATTCTGCGTAAGGAGTTGAATATTGTGGGTAGCTGGATGAACTACTCTGGCCCGT
GGCCGGGAGAAGAGTGGCAAACGGCCACCCGTCTGCTGACTGAAAAACGCCTGCAGCTGGCGCCGCTGATCGCCCATCGT
GGCGACGCAGAAAGCTTCGCTCGTGCAGTGCAGGCGCTCAACGGCGCGCCAATGCAAGGCAAAATCCTGCTCAAACTCTC
TTGA

Upstream 100 bases:

>100_bases
GAAAAAGCAGAAAAAAGCGCTGCCCCGCAACAAAGTACAGGCATGTCTTGATCTAAAAGGGGAGCGTTCGCTCCCCTGAA
TCTTATAGCTGGAGAATGTT

Downstream 100 bases:

>100_bases
CCGCCCGAGCCAGCCATCAGCGCTGGCTCATCCAACCTTTCGAAAATTATCGTTCACCTTTCGTTACCCTTCGATTACAC
TGAGATGAGTTAATTATCAG

Product: galactitol-1-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKSVVIHAEGNVCVEERPIPTLQTENDVLVKVVSSGLCGSDIPRIFAKGAHYYPITLGHEFSGYVESYGAAVTDLQPGDA
VACVPLLPCFQCPQCQREYFSLCKQYQFVGSRSEGGNAEYVVVKRANLFRLPDQMPIDDGAFIEPITVGLHAFHLAQGCE
GKNVIIIGAGTIGLLALQCARELGANSVTAIDINPQKLELAKTLGATHVFNSREMSGQAIQQALEAIQFDQLVLETAGTP
QTVALAIEAAGPRAQLTLVGTLHHDLTLPAATFGQILRKELNIVGSWMNYSGPWPGEEWQTATRLLTEKRLQLAPLIAHR
GDAESFARAVQALNGAPMQGKILLKLS

Sequences:

>Translated_347_residues
MKSVVIHAEGNVCVEERPIPTLQTENDVLVKVVSSGLCGSDIPRIFAKGAHYYPITLGHEFSGYVESYGAAVTDLQPGDA
VACVPLLPCFQCPQCQREYFSLCKQYQFVGSRSEGGNAEYVVVKRANLFRLPDQMPIDDGAFIEPITVGLHAFHLAQGCE
GKNVIIIGAGTIGLLALQCARELGANSVTAIDINPQKLELAKTLGATHVFNSREMSGQAIQQALEAIQFDQLVLETAGTP
QTVALAIEAAGPRAQLTLVGTLHHDLTLPAATFGQILRKELNIVGSWMNYSGPWPGEEWQTATRLLTEKRLQLAPLIAHR
GDAESFARAVQALNGAPMQGKILLKLS
>Mature_347_residues
MKSVVIHAEGNVCVEERPIPTLQTENDVLVKVVSSGLCGSDIPRIFAKGAHYYPITLGHEFSGYVESYGAAVTDLQPGDA
VACVPLLPCFQCPQCQREYFSLCKQYQFVGSRSEGGNAEYVVVKRANLFRLPDQMPIDDGAFIEPITVGLHAFHLAQGCE
GKNVIIIGAGTIGLLALQCARELGANSVTAIDINPQKLELAKTLGATHVFNSREMSGQAIQQALEAIQFDQLVLETAGTP
QTVALAIEAAGPRAQLTLVGTLHHDLTLPAATFGQILRKELNIVGSWMNYSGPWPGEEWQTATRLLTEKRLQLAPLIAHR
GDAESFARAVQALNGAPMQGKILLKLS

Specific function: Converts galactitol 1-phosphate to tagatose 6-phosphate [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=359, Percent_Identity=30.3621169916435, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI156523966, Length=352, Percent_Identity=25.2840909090909, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4501939, Length=342, Percent_Identity=25.1461988304094, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4501929, Length=223, Percent_Identity=26.9058295964126, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI71743840, Length=235, Percent_Identity=24.6808510638298, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI262073058, Length=235, Percent_Identity=24.6808510638298, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI34577061, Length=229, Percent_Identity=26.6375545851528, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4501933, Length=228, Percent_Identity=27.1929824561404, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI71565154, Length=223, Percent_Identity=26.457399103139, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1788407, Length=344, Percent_Identity=67.1511627906977, Blast_Score=493, Evalue=1e-141,
Organism=Escherichia coli, GI1788073, Length=325, Percent_Identity=31.6923076923077, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1790045, Length=343, Percent_Identity=26.530612244898, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1787863, Length=339, Percent_Identity=29.2035398230088, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1790718, Length=334, Percent_Identity=28.4431137724551, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI226510992, Length=322, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI87082125, Length=356, Percent_Identity=24.7191011235955, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788075, Length=319, Percent_Identity=26.6457680250784, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1786825, Length=305, Percent_Identity=27.2131147540984, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1786552, Length=253, Percent_Identity=28.0632411067194, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081918, Length=227, Percent_Identity=29.5154185022026, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=350, Percent_Identity=30.8571428571429, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17562878, Length=343, Percent_Identity=29.1545189504373, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25146526, Length=349, Percent_Identity=25.5014326647564, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=321, Percent_Identity=26.1682242990654, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=230, Percent_Identity=28.695652173913, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=225, Percent_Identity=29.3333333333333, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=338, Percent_Identity=29.8816568047337, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322619, Length=338, Percent_Identity=29.8816568047337, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323099, Length=350, Percent_Identity=29.7142857142857, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319258, Length=250, Percent_Identity=29.6, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319257, Length=235, Percent_Identity=25.9574468085106, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=242, Percent_Identity=26.4462809917355, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137530, Length=340, Percent_Identity=30.2941176470588, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI17737897, Length=349, Percent_Identity=30.0859598853868, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI17737895, Length=255, Percent_Identity=27.4509803921569, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45550770, Length=297, Percent_Identity=24.2424242424242, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221457811, Length=297, Percent_Identity=24.2424242424242, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551930, Length=297, Percent_Identity=24.2424242424242, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.251 [H]

Molecular weight: Translated: 37397; Mature: 37397

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVVIHAEGNVCVEERPIPTLQTENDVLVKVVSSGLCGSDIPRIFAKGAHYYPITLGHE
CCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCC
FSGYVESYGAAVTDLQPGDAVACVPLLPCFQCPQCQREYFSLCKQYQFVGSRSEGGNAEY
HHHHHHHHCCEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
VVVKRANLFRLPDQMPIDDGAFIEPITVGLHAFHLAQGCEGKNVIIIGAGTIGLLALQCA
EEEEECCEEECCCCCCCCCCCEECHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHH
RELGANSVTAIDINPQKLELAKTLGATHVFNSREMSGQAIQQALEAIQFDQLVLETAGTP
HHHCCCCEEEEECCHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
QTVALAIEAAGPRAQLTLVGTLHHDLTLPAATFGQILRKELNIVGSWMNYSGPWPGEEWQ
CEEEEEEECCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
TATRLLTEKRLQLAPLIAHRGDAESFARAVQALNGAPMQGKILLKLS
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure
MKSVVIHAEGNVCVEERPIPTLQTENDVLVKVVSSGLCGSDIPRIFAKGAHYYPITLGHE
CCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCC
FSGYVESYGAAVTDLQPGDAVACVPLLPCFQCPQCQREYFSLCKQYQFVGSRSEGGNAEY
HHHHHHHHCCEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
VVVKRANLFRLPDQMPIDDGAFIEPITVGLHAFHLAQGCEGKNVIIIGAGTIGLLALQCA
EEEEECCEEECCCCCCCCCCCEECHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHH
RELGANSVTAIDINPQKLELAKTLGATHVFNSREMSGQAIQQALEAIQFDQLVLETAGTP
HHHCCCCEEEEECCHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
QTVALAIEAAGPRAQLTLVGTLHHDLTLPAATFGQILRKELNIVGSWMNYSGPWPGEEWQ
CEEEEEEECCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
TATRLLTEKRLQLAPLIAHRGDAESFARAVQALNGAPMQGKILLKLS
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]