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The map label for this gene is pepP [H]

Identifier: 238896453

GI number: 238896453

Start: 4433375

End: 4434691

Strand: Reverse

Name: pepP [H]

Synonym: KP1_4631

Alternate gene names: 238896453

Gene position: 4434691-4433375 (Counterclockwise)

Preceding gene: 238896454

Following gene: 238896452

Centisome position: 84.49

GC content: 58.62

Gene sequence:

>1317_bases
ATGACTCAGCAGGAATTTCTATCGCGTCGCCAGACGCTGTTGGCGCAGATGCAGCCAGGCAGCGCGGCGCTGATTTTCGC
CGCACCGGAAGCGGTGCGCAGTGCAGATTCGGAATATCCCTACCGGCAGAACAGCGATTTCTGGTACTTCACCGGCTTTA
ACGAACCGGAAGCGCTGCTGGTGTTGATTAAAAGCGATGAAACCCACAACCATAGCGTGCTGTTCAACCGGGTTCGCGAT
CTGACCGCTGAGATCTGGTTTGGACGCCGTCTGGGCCAGGAGGCCGCGCCGGCGAAGCTTGGCGTCGACCGGGCGCTGGC
GTTCAGCGAAATCAACCAGCAGCTGTATCAGCTGCTCAACGGTCTGGACGCGATCTACTTCGCCCAGGGTGAATATGCCT
ATGCCGATGAGATTGTGTTCAACGCCCTCGAAAAACTGCGCAAAGGCTCGCGCCAGAATCTGCAGGCGCCGAACTCGGTT
ATCGACTGGCGGCCCATTGTGCATGAGATGCGCCTGTTTAAATCTGCGGAAGAGCTTGCCGTGATGCGCCGCGCCGGGGA
GATCACCGCGCTGGCCCATACCCGGGCGATGGAAAAATGCCGCCCTGGCATGTTCGAATATCAGCTGGAAGGTGAAATTC
TCCATGAATTCAACCGCCACGGGGCACGTTTCCCCTCCTATAACACCATCGTTGGCGGCGGCGAAAACGGCTGTATTCTG
CACTACACCGAAAACGAATCTGAACTGCGCGACGGCGATTTAGTCCTGATTGACGCCGGCTGCGAGTATCGCGGCTATGC
CGGGGACATTACCCGCACCTTCCCGGTAAACGGTAAATTTACCCAGCCGCAGCGCGAGATCTACGACATTGTGCTCGAAT
CGCTGGAGACCGCGCTGAAACTCTATCGGCCGGGCACCTCGATCTGTCAGGTCAACCAGGAAGTGGTGCGCATTATGATT
ACCGGCCTGGTGCGGCTGGGGATCCTGAAAGGCGAGATTGACGAGCTTATCGCCAACAACGCCCACCGCCCGTACTTTAT
GCATGGCCTGAGCCACTGGCTGGGTCTGGATGTGCACGATGTCGGTAATTACGACACCGACCGTTCGCGCGTCCTGGAGC
CGGGAATGGTGCTGACCGTCGAGCCGGGACTGTATATCGCCACCGATGCCGACGTGCCGGCGCAGTATCGCGGCATCGGC
ATCCGTATTGAAGATGACATCGTGATTACCGAAGACGGTAACGAAAATCTCACTGCCGGCGTGGTGAAGAAGGCGGATGA
GATCGAGGCGCTGATGGCGGCGGCGCGCCAGTCATGA

Upstream 100 bases:

>100_bases
CCGCACTGCTGTGCCACGACACCTTTGCCCGTCAGCAGCCAACCGCACCGGAAGTCCGCAAACCGACATTACACTAACTA
AAATTCGTTCAGGGGGCGTC

Downstream 100 bases:

>100_bases
GCGTGCTGATCGTCGGCGGCGGGATGACCGGGGCGACGCTCGCGCTGGCCATCTCCCGTTTGACCGGCGGCGCGCTGCCG
GTCCACCTCATTGAAGCGCA

Product: proline aminopeptidase P II

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTQQEFLSRRQTLLAQMQPGSAALIFAAPEAVRSADSEYPYRQNSDFWYFTGFNEPEALLVLIKSDETHNHSVLFNRVRD
LTAEIWFGRRLGQEAAPAKLGVDRALAFSEINQQLYQLLNGLDAIYFAQGEYAYADEIVFNALEKLRKGSRQNLQAPNSV
IDWRPIVHEMRLFKSAEELAVMRRAGEITALAHTRAMEKCRPGMFEYQLEGEILHEFNRHGARFPSYNTIVGGGENGCIL
HYTENESELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTQPQREIYDIVLESLETALKLYRPGTSICQVNQEVVRIMI
TGLVRLGILKGEIDELIANNAHRPYFMHGLSHWLGLDVHDVGNYDTDRSRVLEPGMVLTVEPGLYIATDADVPAQYRGIG
IRIEDDIVITEDGNENLTAGVVKKADEIEALMAAARQS

Sequences:

>Translated_438_residues
MTQQEFLSRRQTLLAQMQPGSAALIFAAPEAVRSADSEYPYRQNSDFWYFTGFNEPEALLVLIKSDETHNHSVLFNRVRD
LTAEIWFGRRLGQEAAPAKLGVDRALAFSEINQQLYQLLNGLDAIYFAQGEYAYADEIVFNALEKLRKGSRQNLQAPNSV
IDWRPIVHEMRLFKSAEELAVMRRAGEITALAHTRAMEKCRPGMFEYQLEGEILHEFNRHGARFPSYNTIVGGGENGCIL
HYTENESELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTQPQREIYDIVLESLETALKLYRPGTSICQVNQEVVRIMI
TGLVRLGILKGEIDELIANNAHRPYFMHGLSHWLGLDVHDVGNYDTDRSRVLEPGMVLTVEPGLYIATDADVPAQYRGIG
IRIEDDIVITEDGNENLTAGVVKKADEIEALMAAARQS
>Mature_437_residues
TQQEFLSRRQTLLAQMQPGSAALIFAAPEAVRSADSEYPYRQNSDFWYFTGFNEPEALLVLIKSDETHNHSVLFNRVRDL
TAEIWFGRRLGQEAAPAKLGVDRALAFSEINQQLYQLLNGLDAIYFAQGEYAYADEIVFNALEKLRKGSRQNLQAPNSVI
DWRPIVHEMRLFKSAEELAVMRRAGEITALAHTRAMEKCRPGMFEYQLEGEILHEFNRHGARFPSYNTIVGGGENGCILH
YTENESELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTQPQREIYDIVLESLETALKLYRPGTSICQVNQEVVRIMIT
GLVRLGILKGEIDELIANNAHRPYFMHGLSHWLGLDVHDVGNYDTDRSRVLEPGMVLTVEPGLYIATDADVPAQYRGIGI
RIEDDIVITEDGNENLTAGVVKKADEIEALMAAARQS

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=447, Percent_Identity=34.675615212528, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI149589008, Length=462, Percent_Identity=32.034632034632, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI260593665, Length=309, Percent_Identity=36.8932038834951, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI260593663, Length=345, Percent_Identity=31.8840579710145, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI1789275, Length=437, Percent_Identity=85.58352402746, Blast_Score=791, Evalue=0.0,
Organism=Escherichia coli, GI1790282, Length=333, Percent_Identity=30.6306306306306, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1788728, Length=254, Percent_Identity=29.9212598425197, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17508215, Length=440, Percent_Identity=30.6818181818182, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71989583, Length=374, Percent_Identity=26.2032085561497, Blast_Score=138, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6320922, Length=437, Percent_Identity=32.2654462242563, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6321118, Length=463, Percent_Identity=29.8056155507559, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6323273, Length=330, Percent_Identity=20.9090909090909, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920384, Length=412, Percent_Identity=36.4077669902913, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI21357079, Length=455, Percent_Identity=32.0879120879121, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49321; Mature: 49190

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQEFLSRRQTLLAQMQPGSAALIFAAPEAVRSADSEYPYRQNSDFWYFTGFNEPEALL
CCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCCCCCCCCCEEEECCCCCCCEEE
VLIKSDETHNHSVLFNRVRDLTAEIWFGRRLGQEAAPAKLGVDRALAFSEINQQLYQLLN
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHHHHHHC
GLDAIYFAQGEYAYADEIVFNALEKLRKGSRQNLQAPNSVIDWRPIVHEMRLFKSAEELA
CCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VMRRAGEITALAHTRAMEKCRPGMFEYQLEGEILHEFNRHGARFPSYNTIVGGGENGCIL
HHHHCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCCCCCEEEECCCCCEEE
HYTENESELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTQPQREIYDIVLESLETALK
EEECCCCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
LYRPGTSICQVNQEVVRIMITGLVRLGILKGEIDELIANNAHRPYFMHGLSHWLGLDVHD
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHH
VGNYDTDRSRVLEPGMVLTVEPGLYIATDADVPAQYRGIGIRIEDDIVITEDGNENLTAG
CCCCCCCHHHHCCCCEEEEECCCEEEEECCCCCHHHCEEEEEEECCEEEECCCCCCCHHH
VVKKADEIEALMAAARQS
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQQEFLSRRQTLLAQMQPGSAALIFAAPEAVRSADSEYPYRQNSDFWYFTGFNEPEALL
CHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCCCCCCCCCEEEECCCCCCCEEE
VLIKSDETHNHSVLFNRVRDLTAEIWFGRRLGQEAAPAKLGVDRALAFSEINQQLYQLLN
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHHHHHHC
GLDAIYFAQGEYAYADEIVFNALEKLRKGSRQNLQAPNSVIDWRPIVHEMRLFKSAEELA
CCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VMRRAGEITALAHTRAMEKCRPGMFEYQLEGEILHEFNRHGARFPSYNTIVGGGENGCIL
HHHHCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCCCCCEEEECCCCCEEE
HYTENESELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTQPQREIYDIVLESLETALK
EEECCCCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
LYRPGTSICQVNQEVVRIMITGLVRLGILKGEIDELIANNAHRPYFMHGLSHWLGLDVHD
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHH
VGNYDTDRSRVLEPGMVLTVEPGLYIATDADVPAQYRGIGIRIEDDIVITEDGNENLTAG
CCCCCCCHHHHCCCCEEEEECCCEEEEECCCCCHHHCEEEEEEECCEEEECCCCCCCHHH
VVKKADEIEALMAAARQS
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]