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The map label for this gene is ubiH [H]

Identifier: 238896452

GI number: 238896452

Start: 4432200

End: 4433378

Strand: Reverse

Name: ubiH [H]

Synonym: KP1_4630

Alternate gene names: 238896452

Gene position: 4433378-4432200 (Counterclockwise)

Preceding gene: 238896453

Following gene: 238896451

Centisome position: 84.47

GC content: 66.58

Gene sequence:

>1179_bases
ATGAGCGTGCTGATCGTCGGCGGCGGGATGACCGGGGCGACGCTCGCGCTGGCCATCTCCCGTTTGACCGGCGGCGCGCT
GCCGGTCCACCTCATTGAAGCGCAGGATCCGCATTCGTCACGCCACCCTGGCTTTGACGACCGGGCGATCGCCCTGGCTG
CGGGCACCTGCCAGCAGCTGGCGCGTATCGGTATCTGGCAACGCCTCGCCGAACGCGCGACGCCCATCCAGCGAGTACAC
GTCAGCGACCGCGGTCATGCCGGGTTTGTGAATCTGGCGGCCGCGGATTATGGCCTGTCGGCGCTGGGCCAGGTGGTTGA
ACTCCACGATGTCGGCCAGCGGCTGTTTGGTCTGCTGCGCGAGGCGCCGGGCGTCACGCTGCACTGTCCGGCGAAAGTGG
AAGCGGTCAGTCGCAGCCAGGAGAGCGTCAGCCTTACGCTTGAGGGCGGCGAAATCATTAACGGTAAGCTGCTGGTGGCG
GCGGACGGTTCCCGTTCGGCACTGGGCGCCCGCTGCGGCATCAGCTGGCAGCAGCAGCCGTATGAGCAGATAGCGATCAT
TGCTAACGTCAGCACCGCGTTGCCCCACGAAGGTCGCGCCTTCGAGCGCTTTACCGAGCATGGCCCGCTGGCGATGCTGC
CGATGTCGCAAGGGCGCTGCTCGCTGGTGTGGTGTCATCCGCAGTCGCGCCGCGATGAGGTGCAGAGCTGGTCTGACGAA
CGCTTTTGTCAGGAGCTGCAGCAGGCGTTCGGCTGGCGGCTGGGGCGTATTACCCACGCCGGGAAGCGCAGCGTCTATCC
GCTGGCCCTCACCACCGCCAGCCGCGCGGTGTCGCACCGCCTGGCGCTGGTCGGCAATGCGGCGCAGACGCTGCACCCGA
TCGCCGGGCAGGGCTTTAATCTCGGCCTGCGCGATGTGATGAGCCTGGCGGAATTACTCGCTGACGCCCATCTCAGCGGC
GAAGATGTCGGTCATTATCCGCTGCTGTGCCGCTATCAGGCGCGCAGGGCAGGGGATAAAGCCGCCACCATCGGCGTGAC
CGATGGGCTGGTGCATCTGTTTGCCAACCGTTGGGCGCCGCTGGTGGCGGGGCGCAACGTCGGTCTGATGGCGATGGAAT
TATTTACCCCGGCGCGCGATGCGCTGGCGCAGCGTACCCTCGGTTGGGTTCCCCGTTAA

Upstream 100 bases:

>100_bases
ATGACATCGTGATTACCGAAGACGGTAACGAAAATCTCACTGCCGGCGTGGTGAAGAAGGCGGATGAGATCGAGGCGCTG
ATGGCGGCGGCGCGCCAGTC

Downstream 100 bases:

>100_bases
GGAGTAGAACGTGCAAAGTGTTGATGTTGCCATTGTTGGCGGTGGAATGGTGGGGCTGGCGGTAGCCTGCGGTCTACAGG
GTAGCGGCCTGCGCGTCGCA

Product: 2-octaprenyl-6-methoxyphenyl hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSVLIVGGGMTGATLALAISRLTGGALPVHLIEAQDPHSSRHPGFDDRAIALAAGTCQQLARIGIWQRLAERATPIQRVH
VSDRGHAGFVNLAAADYGLSALGQVVELHDVGQRLFGLLREAPGVTLHCPAKVEAVSRSQESVSLTLEGGEIINGKLLVA
ADGSRSALGARCGISWQQQPYEQIAIIANVSTALPHEGRAFERFTEHGPLAMLPMSQGRCSLVWCHPQSRRDEVQSWSDE
RFCQELQQAFGWRLGRITHAGKRSVYPLALTTASRAVSHRLALVGNAAQTLHPIAGQGFNLGLRDVMSLAELLADAHLSG
EDVGHYPLLCRYQARRAGDKAATIGVTDGLVHLFANRWAPLVAGRNVGLMAMELFTPARDALAQRTLGWVPR

Sequences:

>Translated_392_residues
MSVLIVGGGMTGATLALAISRLTGGALPVHLIEAQDPHSSRHPGFDDRAIALAAGTCQQLARIGIWQRLAERATPIQRVH
VSDRGHAGFVNLAAADYGLSALGQVVELHDVGQRLFGLLREAPGVTLHCPAKVEAVSRSQESVSLTLEGGEIINGKLLVA
ADGSRSALGARCGISWQQQPYEQIAIIANVSTALPHEGRAFERFTEHGPLAMLPMSQGRCSLVWCHPQSRRDEVQSWSDE
RFCQELQQAFGWRLGRITHAGKRSVYPLALTTASRAVSHRLALVGNAAQTLHPIAGQGFNLGLRDVMSLAELLADAHLSG
EDVGHYPLLCRYQARRAGDKAATIGVTDGLVHLFANRWAPLVAGRNVGLMAMELFTPARDALAQRTLGWVPR
>Mature_391_residues
SVLIVGGGMTGATLALAISRLTGGALPVHLIEAQDPHSSRHPGFDDRAIALAAGTCQQLARIGIWQRLAERATPIQRVHV
SDRGHAGFVNLAAADYGLSALGQVVELHDVGQRLFGLLREAPGVTLHCPAKVEAVSRSQESVSLTLEGGEIINGKLLVAA
DGSRSALGARCGISWQQQPYEQIAIIANVSTALPHEGRAFERFTEHGPLAMLPMSQGRCSLVWCHPQSRRDEVQSWSDER
FCQELQQAFGWRLGRITHAGKRSVYPLALTTASRAVSHRLALVGNAAQTLHPIAGQGFNLGLRDVMSLAELLADAHLSGE
DVGHYPLLCRYQARRAGDKAATIGVTDGLVHLFANRWAPLVAGRNVGLMAMELFTPARDALAQRTLGWVPR

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=386, Percent_Identity=27.979274611399, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI32967307, Length=377, Percent_Identity=28.1167108753316, Blast_Score=128, Evalue=7e-30,
Organism=Escherichia coli, GI1789274, Length=392, Percent_Identity=76.0204081632653, Blast_Score=621, Evalue=1e-179,
Organism=Escherichia coli, GI1789273, Length=392, Percent_Identity=32.3979591836735, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1786883, Length=376, Percent_Identity=34.8404255319149, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25146631, Length=426, Percent_Identity=26.056338028169, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321694, Length=453, Percent_Identity=24.7240618101545, Blast_Score=106, Evalue=7e-24,
Organism=Drosophila melanogaster, GI19920760, Length=420, Percent_Identity=24.047619047619, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 42136; Mature: 42005

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLIVGGGMTGATLALAISRLTGGALPVHLIEAQDPHSSRHPGFDDRAIALAAGTCQQL
CEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHH
ARIGIWQRLAERATPIQRVHVSDRGHAGFVNLAAADYGLSALGQVVELHDVGQRLFGLLR
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHH
EAPGVTLHCPAKVEAVSRSQESVSLTLEGGEIINGKLLVAADGSRSALGARCGISWQQQP
HCCCCEEECCCHHHHHHCCCCEEEEEEECCEEECCEEEEEECCCCCCCHHHCCCCCCCCC
YEQIAIIANVSTALPHEGRAFERFTEHGPLAMLPMSQGRCSLVWCHPQSRRDEVQSWSDE
HHHEEEEEECHHHCCCCCCHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHHCCCHH
RFCQELQQAFGWRLGRITHAGKRSVYPLALTTASRAVSHRLALVGNAAQTLHPIAGQGFN
HHHHHHHHHHCCCHHHEECCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHHCCCCCCCCC
LGLRDVMSLAELLADAHLSGEDVGHYPLLCRYQARRAGDKAATIGVTDGLVHLFANRWAP
CCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHCCCCCEEEEEHHHHHHHHHHHCCCH
LVAGRNVGLMAMELFTPARDALAQRTLGWVPR
HHCCCCCCEEEHHHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVLIVGGGMTGATLALAISRLTGGALPVHLIEAQDPHSSRHPGFDDRAIALAAGTCQQL
EEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHH
ARIGIWQRLAERATPIQRVHVSDRGHAGFVNLAAADYGLSALGQVVELHDVGQRLFGLLR
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHH
EAPGVTLHCPAKVEAVSRSQESVSLTLEGGEIINGKLLVAADGSRSALGARCGISWQQQP
HCCCCEEECCCHHHHHHCCCCEEEEEEECCEEECCEEEEEECCCCCCCHHHCCCCCCCCC
YEQIAIIANVSTALPHEGRAFERFTEHGPLAMLPMSQGRCSLVWCHPQSRRDEVQSWSDE
HHHEEEEEECHHHCCCCCCHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHHCCCHH
RFCQELQQAFGWRLGRITHAGKRSVYPLALTTASRAVSHRLALVGNAAQTLHPIAGQGFN
HHHHHHHHHHCCCHHHEECCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHHCCCCCCCCC
LGLRDVMSLAELLADAHLSGEDVGHYPLLCRYQARRAGDKAATIGVTDGLVHLFANRWAP
CCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHCCCCCEEEEEHHHHHHHHHHHCCCH
LVAGRNVGLMAMELFTPARDALAQRTLGWVPR
HHCCCCCCEEEHHHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]