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The map label for this gene is gcvT [H]

Identifier: 238896450

GI number: 238896450

Start: 4429470

End: 4430564

Strand: Reverse

Name: gcvT [H]

Synonym: KP1_4628

Alternate gene names: 238896450

Gene position: 4430564-4429470 (Counterclockwise)

Preceding gene: 238896451

Following gene: 238896449

Centisome position: 84.42

GC content: 59.91

Gene sequence:

>1095_bases
ATGGCTCAACAGACTCCGTTGTATGAACAACACACGCTGTGCGGCGCGCGCATGGTGGATTTCCATGGCTGGATGATGCC
GCTGCATTACGGGTCCCAGATTGATGAGCACCATGCGGTGCGCGGCGATGCAGGGATGTTCGATGTGTCGCATATGACCA
TCGTCGATTTCCACGGCAGCCGGATCCGCGAGTTCTTGCGCTATTTGCTGGCCAACGATGTGGCGAAGCTCACCACCCCG
GGCAAAGCGCTCTACACGGGAATGCTTACCGCCTCCGCCGGCGTCATCGATGACCTGATTGTCTATTTCCTTTCTGAAGA
TTATTTCCGCCTCGTTGTTAACTCCGCCACCCGCGAAAAAGACCTCGCCTGGATCTCCGAACAAGCTGAACCTTACGGCC
TTGAAATTACCGTTCGCGACGATCTGTCGCTGATCGCGGTGCAGGGCCCCCAGGCGAAAGCGAAGGCGGCGACGCTGTTT
ACCGACGCTCAGCGTCAGGCCGTGGAAGGCATGAAGCCGTTCTTCGGCGTGCAGGCCGGCGACCTGTTTATCGCCACCAC
CGGCTATACCGGCGAAGCGGGTTATGAAATTGCGATGCCGAACGAGCAGGCGGCTGATTTCTGGCGCGGTCTGCTGGACG
CTGGCGTTAAGCCGTGCGGTCTTGGCGCGCGCGACACCCTGCGCCTGGAGGCCGGGATGAACTTGTACGGCCAGGAGATG
GACGAAGGCGTTTCCCCGCTGGCGGCGAACATGGGCTGGACTATCGCCTGGGAGCCCGCCGATCGTAACTTCATCGGCCG
CGAAGCGCTGGAGATGCAGCGCGAAAAAGGCACCGAGCAGCTGGTTGGCCTGGTGATGACCGAGAAAGGCGTCCTGCGCG
GTGGTCTGCCGGTCCGTTTTACCGATAGCGACGGTAATCAAAAAGAAGGCATTATCACCAGCGGCACCTTCTCGCCGACG
CTGGGCTACAGCATCGCGCTGGCTCGCGTGCCGGCCGGGATTGGCGACACCGCGGTGGTGCAAATCCGTAACCGTGAAAT
GCCGGTAAAAGTGACTAAACCTGGTTTTGTACGCAATGGCAAAGCCATTGTGTGA

Upstream 100 bases:

>100_bases
CGTTTGCGTCGGCGTCCGTCAGCGATGCCGACGCCGAATTTCGTGGCGCAAAATCGCCGACAATTTCGTGGCTGGTTCCG
TTTTATTCGATGAGGAAAAG

Downstream 100 bases:

>100_bases
TTTCCCTTTTTTGGAGATGAATTGATGAGCAACGTACCAGCAGAACTGAAATACAGCAAAGAACACGAGTGGCTGCGTAA
AGAAGCGGACGGTACCTATA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQIDEHHAVRGDAGMFDVSHMTIVDFHGSRIREFLRYLLANDVAKLTTP
GKALYTGMLTASAGVIDDLIVYFLSEDYFRLVVNSATREKDLAWISEQAEPYGLEITVRDDLSLIAVQGPQAKAKAATLF
TDAQRQAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIAMPNEQAADFWRGLLDAGVKPCGLGARDTLRLEAGMNLYGQEM
DEGVSPLAANMGWTIAWEPADRNFIGREALEMQREKGTEQLVGLVMTEKGVLRGGLPVRFTDSDGNQKEGIITSGTFSPT
LGYSIALARVPAGIGDTAVVQIRNREMPVKVTKPGFVRNGKAIV

Sequences:

>Translated_364_residues
MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQIDEHHAVRGDAGMFDVSHMTIVDFHGSRIREFLRYLLANDVAKLTTP
GKALYTGMLTASAGVIDDLIVYFLSEDYFRLVVNSATREKDLAWISEQAEPYGLEITVRDDLSLIAVQGPQAKAKAATLF
TDAQRQAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIAMPNEQAADFWRGLLDAGVKPCGLGARDTLRLEAGMNLYGQEM
DEGVSPLAANMGWTIAWEPADRNFIGREALEMQREKGTEQLVGLVMTEKGVLRGGLPVRFTDSDGNQKEGIITSGTFSPT
LGYSIALARVPAGIGDTAVVQIRNREMPVKVTKPGFVRNGKAIV
>Mature_363_residues
AQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQIDEHHAVRGDAGMFDVSHMTIVDFHGSRIREFLRYLLANDVAKLTTPG
KALYTGMLTASAGVIDDLIVYFLSEDYFRLVVNSATREKDLAWISEQAEPYGLEITVRDDLSLIAVQGPQAKAKAATLFT
DAQRQAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIAMPNEQAADFWRGLLDAGVKPCGLGARDTLRLEAGMNLYGQEMD
EGVSPLAANMGWTIAWEPADRNFIGREALEMQREKGTEQLVGLVMTEKGVLRGGLPVRFTDSDGNQKEGIITSGTFSPTL
GYSIALARVPAGIGDTAVVQIRNREMPVKVTKPGFVRNGKAIV

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=375, Percent_Identity=32.8, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI257796258, Length=344, Percent_Identity=33.7209302325581, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI257796254, Length=368, Percent_Identity=29.8913043478261, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI257796256, Length=318, Percent_Identity=31.4465408805031, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI24797151, Length=360, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI197927446, Length=296, Percent_Identity=27.7027027027027, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI21361378, Length=296, Percent_Identity=27.7027027027027, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI1789272, Length=363, Percent_Identity=87.8787878787879, Blast_Score=675, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17560118, Length=374, Percent_Identity=34.2245989304813, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI32563613, Length=259, Percent_Identity=25.4826254826255, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994052, Length=338, Percent_Identity=22.7810650887574, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994045, Length=338, Percent_Identity=22.7810650887574, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320222, Length=376, Percent_Identity=32.4468085106383, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20129441, Length=377, Percent_Identity=33.42175066313, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28571104, Length=265, Percent_Identity=29.4339622641509, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI20130091, Length=363, Percent_Identity=25.3443526170799, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39788; Mature: 39657

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQIDEHHAVRGDAGMFDVSHMTIVDFHGS
CCCCCCCHHHHHHCCCEEEECCCEEEEECCCCCCCHHHCCCCCCCEEEECEEEEEECCCH
RIREFLRYLLANDVAKLTTPGKALYTGMLTASAGVIDDLIVYFLSEDYFRLVVNSATREK
HHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCHH
DLAWISEQAEPYGLEITVRDDLSLIAVQGPQAKAKAATLFTDAQRQAVEGMKPFFGVQAG
HHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCC
DLFIATTGYTGEAGYEIAMPNEQAADFWRGLLDAGVKPCGLGARDTLRLEAGMNLYGQEM
CEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHH
DEGVSPLAANMGWTIAWEPADRNFIGREALEMQREKGTEQLVGLVMTEKGVLRGGLPVRF
HCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHEECCCHHCCCCEEEE
TDSDGNQKEGIITSGTFSPTLGYSIALARVPAGIGDTAVVQIRNREMPVKVTKPGFVRNG
ECCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCEEECCCCCCCCC
KAIV
CCCC
>Mature Secondary Structure 
AQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQIDEHHAVRGDAGMFDVSHMTIVDFHGS
CCCCCCHHHHHHCCCEEEECCCEEEEECCCCCCCHHHCCCCCCCEEEECEEEEEECCCH
RIREFLRYLLANDVAKLTTPGKALYTGMLTASAGVIDDLIVYFLSEDYFRLVVNSATREK
HHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCHH
DLAWISEQAEPYGLEITVRDDLSLIAVQGPQAKAKAATLFTDAQRQAVEGMKPFFGVQAG
HHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCC
DLFIATTGYTGEAGYEIAMPNEQAADFWRGLLDAGVKPCGLGARDTLRLEAGMNLYGQEM
CEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHH
DEGVSPLAANMGWTIAWEPADRNFIGREALEMQREKGTEQLVGLVMTEKGVLRGGLPVRF
HCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHEECCCHHCCCCEEEE
TDSDGNQKEGIITSGTFSPTLGYSIALARVPAGIGDTAVVQIRNREMPVKVTKPGFVRNG
ECCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCEEECCCCCCCCC
KAIV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA