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The map label for this gene is fimE [H]

Identifier: 238896397

GI number: 238896397

Start: 4379512

End: 4380120

Strand: Direct

Name: fimE [H]

Synonym: KP1_4569

Alternate gene names: 238896397

Gene position: 4379512-4380120 (Clockwise)

Preceding gene: 238896396

Following gene: 238896398

Centisome position: 83.44

GC content: 53.2

Gene sequence:

>609_bases
GTGAACCGACGTCGTTTTCTAACCGCCAAAGAAGTTCAGGCCATGATGCAGGCTGCTCGTCAGGGCCCTACCGGCGAACG
GGACTACTGCCTCATTCTGCTGGCCTTTCGCCATGGCATGCGCATTAGCGAACTGCTGGATCTGCATTATCACGATCTGG
ATCTCCATGAAGGGCGGGTTAATGTGCGGCGATTAAAGAATGGTTTTTCGACGATTCATCCACTGCGTTTTGATGAGCGC
GAGGCGATTGAGCGCTGGAGCCTGGTCCGTGCCGGCTGGAAAGCGGCGGACAAAACGGACGCACTGTTTATCTCCCGCCG
CGGTACAGCGCTCTCCCGCCAGCAGGCGTATCGTATTATTCGCTCCGCCGGGGAAAATGCGGGTACCGTCACGCACACTC
ACCCCCATATGCTGCGTCACGCCTGCGGCTATGAACTGGCTGAAAGAGGGACAGATACGCGTTTGATACAGGATTATCTA
GGACATCGTAATATTCGTCACACAGTACGTTACACCGCCAGTAATGCGGCACGTTTCGCTGGCATCTGGGAAAGAAATAA
TCTTTTAGAGGAAAAAGACCAGAAGACGAAAAATGAAATAACTGATTGA

Upstream 100 bases:

>100_bases
TCTTCACCCTGTACCGTTTTAGCATTACAGAACCTACTTTCGTCATGGAGTATGGTTTCGCTGTGACGGTCATTCATACC
TATTTTCAGGAGCAACTATT

Downstream 100 bases:

>100_bases
TTTTAAATAATTAAAAAAATAACGAACAGGTCAATTGGGGCCAAACTGTTTATATCATAAAAATGTTTTGACATATTTTG
CAACTCACTGCGCCATATTT

Product: tyrosine recombinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MNRRRFLTAKEVQAMMQAARQGPTGERDYCLILLAFRHGMRISELLDLHYHDLDLHEGRVNVRRLKNGFSTIHPLRFDER
EAIERWSLVRAGWKAADKTDALFISRRGTALSRQQAYRIIRSAGENAGTVTHTHPHMLRHACGYELAERGTDTRLIQDYL
GHRNIRHTVRYTASNAARFAGIWERNNLLEEKDQKTKNEITD

Sequences:

>Translated_202_residues
MNRRRFLTAKEVQAMMQAARQGPTGERDYCLILLAFRHGMRISELLDLHYHDLDLHEGRVNVRRLKNGFSTIHPLRFDER
EAIERWSLVRAGWKAADKTDALFISRRGTALSRQQAYRIIRSAGENAGTVTHTHPHMLRHACGYELAERGTDTRLIQDYL
GHRNIRHTVRYTASNAARFAGIWERNNLLEEKDQKTKNEITD
>Mature_202_residues
MNRRRFLTAKEVQAMMQAARQGPTGERDYCLILLAFRHGMRISELLDLHYHDLDLHEGRVNVRRLKNGFSTIHPLRFDER
EAIERWSLVRAGWKAADKTDALFISRRGTALSRQQAYRIIRSAGENAGTVTHTHPHMLRHACGYELAERGTDTRLIQDYL
GHRNIRHTVRYTASNAARFAGIWERNNLLEEKDQKTKNEITD

Specific function: FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches f

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790768, Length=192, Percent_Identity=82.8125, Blast_Score=338, Evalue=1e-94,
Organism=Escherichia coli, GI1790767, Length=183, Percent_Identity=53.551912568306, Blast_Score=206, Evalue=8e-55,
Organism=Escherichia coli, GI1790244, Length=169, Percent_Identity=30.7692307692308, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 23504; Mature: 23504

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRRFLTAKEVQAMMQAARQGPTGERDYCLILLAFRHGMRISELLDLHYHDLDLHEGRV
CCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCH
NVRRLKNGFSTIHPLRFDEREAIERWSLVRAGWKAADKTDALFISRRGTALSRQQAYRII
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHH
RSAGENAGTVTHTHPHMLRHACGYELAERGTDTRLIQDYLGHRNIRHTVRYTASNAARFA
HHCCCCCCCEEECCHHHHHHHHCHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCCCHHHHH
GIWERNNLLEEKDQKTKNEITD
HHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNRRRFLTAKEVQAMMQAARQGPTGERDYCLILLAFRHGMRISELLDLHYHDLDLHEGRV
CCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCH
NVRRLKNGFSTIHPLRFDEREAIERWSLVRAGWKAADKTDALFISRRGTALSRQQAYRII
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHH
RSAGENAGTVTHTHPHMLRHACGYELAERGTDTRLIQDYLGHRNIRHTVRYTASNAARFA
HHCCCCCCCEEECCHHHHHHHHCHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCCCHHHHH
GIWERNNLLEEKDQKTKNEITD
HHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]