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The map label for this gene is yqeF [H]

Identifier: 238896378

GI number: 238896378

Start: 4360586

End: 4361764

Strand: Reverse

Name: yqeF [H]

Synonym: KP1_4545

Alternate gene names: 238896378

Gene position: 4361764-4360586 (Counterclockwise)

Preceding gene: 238896379

Following gene: 238896377

Centisome position: 83.1

GC content: 64.72

Gene sequence:

>1179_bases
ATGAAGGATGTCGTGATCGTCGGCGCGCTGCGAACGCCGATTGGCTGCTTTCAGGGCGCATTATCGCGCCATTCAGCCGT
CGAGCTGGGGAGCGTGGTGGTGAAGGCGCTGGTGGAGAAGACGGGAATCGATCCGCACAGCGTGGATGAGGTGATCCTCG
GCCAGGTGCTGACCGCGGGGACCGGACAAAATCCGGCGCGTCAGTCCGCTATTCGCGGTGGGCTGCCTAACACCGTATCG
GCTATCACCATTAACGATGTCTGCGGTTCCGGCCTGAAGGCTCTGCACCTCGCTACCCAGGCGATCCAGTGCGGGGAAGC
GGACGTGGTGATCGCTGGCGGCCAGGAGAATATGAGCCGCGCTCCGCATGTGCTTACCGACAGCCGCACCGGCGCCCAGC
TGGGCAACAGCCAGCTGATTGACAGTCTGGTGCATGATGGGCTGTGGGATGCTTTCAACGATTATCATATGGGCGTCACG
GCGGAAAACCTGGCCCGGGAATTTGGCATCAGTCGCGAGCTGCAGGACGCCTGGGCGCTCAGCTCACAGCATAAGGCGCG
CAAGGCGATTGATTCCGGTCGCTTTCGCGATGAGATCGTCCCGGTTGTCACCGAGCATAACGGCGCGGCGCGCACCGTGG
ATACCGATGAACAACCGCGGGTGGATGCCAGCGCGGAAGGGCTGGCCAGCCTGCAGCCCACCTTCGATCGCCTTGGATCG
GTGACCGCCGGCAACGCCTCAAGCATCAATGACGGCGCGGCGGCGGTAATGATGATGAGCGAGGCTAAAGCGCTGGAGCT
GGGGCTGCCGATCCTTGCGCGGATCCGCGCCTTCGCCAGCGTCGGCGTCGATCCGGCGCTGATGGGCATTGCCCCGGTGC
ATGCCACCCGTCGCTGTCTGGAGCGGGCCGGCTGGCGGCTGGACGACGTCGATCTGATCGAAGCCAATGAGGCCTTTGCC
GCTCAGGCGATCTCGGTTGGCCGGGTACTGGAGTGGGATGAGCGCCGGGTCAACGTCAACGGCGGCGCGATCGCCCTCGG
CCACCCCATCGGCGCCTCCGGCTGCCGGATTCTGGTGTCGCTGGTGCATGAAATGATCAAGCGCGATGCCCGCAAAGGTC
TGGCGACGCTGTGCATTGGCGGCGGTCAGGGCGTGGCGCTGGCGGTAGAACGCGCATAG

Upstream 100 bases:

>100_bases
TGATTGGCTTCACTTTTTTTAAACAATTACAAAGTTTTTTGATAACAATTATCTAGTATATCGCTGTTTCTTTGCGCAAA
TGCATGGGCAGGGGTAGAGG

Downstream 100 bases:

>100_bases
CGCTATACCTCGATTTCCATGGCCTCCTGCGGGAGGCCTTTTTTATGCGCCGTGCTTTGCCGAACCCTTATTTTTTCCCC
TCCCTCTTTCACTCTCCCCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKDVVIVGALRTPIGCFQGALSRHSAVELGSVVVKALVEKTGIDPHSVDEVILGQVLTAGTGQNPARQSAIRGGLPNTVS
AITINDVCGSGLKALHLATQAIQCGEADVVIAGGQENMSRAPHVLTDSRTGAQLGNSQLIDSLVHDGLWDAFNDYHMGVT
AENLAREFGISRELQDAWALSSQHKARKAIDSGRFRDEIVPVVTEHNGAARTVDTDEQPRVDASAEGLASLQPTFDRLGS
VTAGNASSINDGAAAVMMMSEAKALELGLPILARIRAFASVGVDPALMGIAPVHATRRCLERAGWRLDDVDLIEANEAFA
AQAISVGRVLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMIKRDARKGLATLCIGGGQGVALAVERA

Sequences:

>Translated_392_residues
MKDVVIVGALRTPIGCFQGALSRHSAVELGSVVVKALVEKTGIDPHSVDEVILGQVLTAGTGQNPARQSAIRGGLPNTVS
AITINDVCGSGLKALHLATQAIQCGEADVVIAGGQENMSRAPHVLTDSRTGAQLGNSQLIDSLVHDGLWDAFNDYHMGVT
AENLAREFGISRELQDAWALSSQHKARKAIDSGRFRDEIVPVVTEHNGAARTVDTDEQPRVDASAEGLASLQPTFDRLGS
VTAGNASSINDGAAAVMMMSEAKALELGLPILARIRAFASVGVDPALMGIAPVHATRRCLERAGWRLDDVDLIEANEAFA
AQAISVGRVLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMIKRDARKGLATLCIGGGQGVALAVERA
>Mature_392_residues
MKDVVIVGALRTPIGCFQGALSRHSAVELGSVVVKALVEKTGIDPHSVDEVILGQVLTAGTGQNPARQSAIRGGLPNTVS
AITINDVCGSGLKALHLATQAIQCGEADVVIAGGQENMSRAPHVLTDSRTGAQLGNSQLIDSLVHDGLWDAFNDYHMGVT
AENLAREFGISRELQDAWALSSQHKARKAIDSGRFRDEIVPVVTEHNGAARTVDTDEQPRVDASAEGLASLQPTFDRLGS
VTAGNASSINDGAAAVMMMSEAKALELGLPILARIRAFASVGVDPALMGIAPVHATRRCLERAGWRLDDVDLIEANEAFA
AQAISVGRVLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMIKRDARKGLATLCIGGGQGVALAVERA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=48.7179487179487, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=42.1319796954315, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=41.7721518987342, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=40.1515151515151, Blast_Score=254, Evalue=7e-68,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=31.8604651162791, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI194353979, Length=396, Percent_Identity=30.050505050505, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=86.7007672634271, Blast_Score=700, Evalue=0.0,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=57.1428571428571, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=45.25, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=40.6483790523691, Blast_Score=264, Evalue=9e-72,
Organism=Escherichia coli, GI1788683, Length=408, Percent_Identity=31.6176470588235, Blast_Score=178, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=41.9437340153453, Blast_Score=308, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=41.2820512820513, Blast_Score=289, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=39.5408163265306, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=33.0788804071247, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=30.5164319248826, Blast_Score=182, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=43.1818181818182, Blast_Score=295, Evalue=7e-81,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=36.6412213740458, Blast_Score=220, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=50.8951406649616, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=42.5641025641026, Blast_Score=304, Evalue=6e-83,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=41.6879795396419, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.7647058823529, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41079; Mature: 41079

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVVIVGALRTPIGCFQGALSRHSAVELGSVVVKALVEKTGIDPHSVDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
TGQNPARQSAIRGGLPNTVSAITINDVCGSGLKALHLATQAIQCGEADVVIAGGQENMSR
CCCCHHHHHHHHCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCHHHCC
APHVLTDSRTGAQLGNSQLIDSLVHDGLWDAFNDYHMGVTAENLAREFGISRELQDAWAL
CCCEEECCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHH
SSQHKARKAIDSGRFRDEIVPVVTEHNGAARTVDTDEQPRVDASAEGLASLQPTFDRLGS
HHHHHHHHHHHCCCCHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHCC
VTAGNASSINDGAAAVMMMSEAKALELGLPILARIRAFASVGVDPALMGIAPVHATRRCL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERAGWRLDDVDLIEANEAFAAQAISVGRVLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHCCCCCCCCEEEECCHHHHHHHHHHHHHEECCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMIKRDARKGLATLCIGGGQGVALAVERA
HHHHHHHHHHHCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure
MKDVVIVGALRTPIGCFQGALSRHSAVELGSVVVKALVEKTGIDPHSVDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
TGQNPARQSAIRGGLPNTVSAITINDVCGSGLKALHLATQAIQCGEADVVIAGGQENMSR
CCCCHHHHHHHHCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCHHHCC
APHVLTDSRTGAQLGNSQLIDSLVHDGLWDAFNDYHMGVTAENLAREFGISRELQDAWAL
CCCEEECCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHH
SSQHKARKAIDSGRFRDEIVPVVTEHNGAARTVDTDEQPRVDASAEGLASLQPTFDRLGS
HHHHHHHHHHHCCCCHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHCC
VTAGNASSINDGAAAVMMMSEAKALELGLPILARIRAFASVGVDPALMGIAPVHATRRCL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERAGWRLDDVDLIEANEAFAAQAISVGRVLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHCCCCCCCCEEEECCHHHHHHHHHHHHHEECCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMIKRDARKGLATLCIGGGQGVALAVERA
HHHHHHHHHHHCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]