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The map label for this gene is cobD [H]

Identifier: 238896330

GI number: 238896330

Start: 4304575

End: 4305651

Strand: Reverse

Name: cobD [H]

Synonym: KP1_4493

Alternate gene names: 238896330

Gene position: 4305651-4304575 (Counterclockwise)

Preceding gene: 238896331

Following gene: 238896308

Centisome position: 82.04

GC content: 64.44

Gene sequence:

>1077_bases
ATGGCCTTACTGAAAAGCGCCCATGGCGGCAATATCCGCGAGGCCGCCGCCCTGCTGGGCATAGCCCCCGGCGAGCTGCT
GGATTTTAGCGCCAACATCAATCCGCTGGGGATGCCTGCCTCGCTCAGGCAGGCGATCGTTGACAACCCAGGCTGCGCCG
AACGCTACCCTGACGTCGAGTATCAACAGCTGCATCAGGCGCTGGCTGCCCACCATCAGTTGCCGGCGGCGCATATCCTC
GCCGGCAACGGCGAAACTGAATCGATCTTCACCCTCGTCCACGGCCTTAAGCCGCGGCGGGCGATGATCGTCATTCCCGG
TTTTGCGGAGTACCGGCGGGCGCTGCAGACGGTGGACTGTGAGGTGGTGGAGTATGCCCTGCGGGAGCGCGATGGCTGGC
AGCTGACCGACGCGATCCTCGATGCCCTGACTCCGGCGCTGGACTGCCTGTTTCTCTGCACCCCGAACAACCCCACCGGC
CTGCTGCCGGAGCGGGGCCTGCTGGAAGCCATTGCGCAGCGCTGCCGGGCGCTGAACATCAGCCTGATCCTCGATGAGGC
CTTCCTCGACTTTATCCCCGACCAGCCGGGGTTTATTCCTCTGCTGGCGCAGCATCCGCACGTCTGGGTTTTGCGATCGC
TGACCAAATTTTATGCCATTCCGGGGCTGCGTCTCGGCTACCTGCTGAACGCTGATGTCCAGGCGGTGGCCCGACTGCGC
GCGCGACAAATGCCGTGGTCCATCAACGCCTATGCCGCCCTGGCCGGGGAAATTATTCTCCAGGATCGGGCGTATCAGCG
GGCCACCTGGCAGTGGCTGCAGGAGGAGGGAGCGCGTTTCTATGCGCAGCTGCAGGAGATGGCCGGGCTGACCGTGTGGC
CCGGGCGTGCTAACTACCTGTTCTTGCGCTGCGACAGAGCCGATTTTGACCTGCAATATGCCCTGCTGCGCCAGCATGTG
CTGATCCGCAGCTGCGCCAACTACCCGGGGCTGGATAGCCGCTATTTCCGGGTGGCGATCCGCAGCGCCGAGGAAAACGA
CCAGCTGCTGGCGGCGTTGCGCCGGGTGCTGGCCTGA

Upstream 100 bases:

>100_bases
TCCAGCAGGAGGTGGCCGAGTCGATCCTCGCCGGGATTAAAGCCTACTTCGCCGACGGCGCGACGCTGGCCCGCCGCGGA
TAACCACACAGGAAAGGGAC

Downstream 100 bases:

>100_bases
GGCCTACTGCAGGATGACGCCCCCGGGCACCATCGCCAACAGATGCTGCTGCGGCCAGTGGGCGGCGATGTCGCTGTCTG
CCAGCCGCCATTGCAGAAAT

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MALLKSAHGGNIREAAALLGIAPGELLDFSANINPLGMPASLRQAIVDNPGCAERYPDVEYQQLHQALAAHHQLPAAHIL
AGNGETESIFTLVHGLKPRRAMIVIPGFAEYRRALQTVDCEVVEYALRERDGWQLTDAILDALTPALDCLFLCTPNNPTG
LLPERGLLEAIAQRCRALNISLILDEAFLDFIPDQPGFIPLLAQHPHVWVLRSLTKFYAIPGLRLGYLLNADVQAVARLR
ARQMPWSINAYAALAGEIILQDRAYQRATWQWLQEEGARFYAQLQEMAGLTVWPGRANYLFLRCDRADFDLQYALLRQHV
LIRSCANYPGLDSRYFRVAIRSAEENDQLLAALRRVLA

Sequences:

>Translated_358_residues
MALLKSAHGGNIREAAALLGIAPGELLDFSANINPLGMPASLRQAIVDNPGCAERYPDVEYQQLHQALAAHHQLPAAHIL
AGNGETESIFTLVHGLKPRRAMIVIPGFAEYRRALQTVDCEVVEYALRERDGWQLTDAILDALTPALDCLFLCTPNNPTG
LLPERGLLEAIAQRCRALNISLILDEAFLDFIPDQPGFIPLLAQHPHVWVLRSLTKFYAIPGLRLGYLLNADVQAVARLR
ARQMPWSINAYAALAGEIILQDRAYQRATWQWLQEEGARFYAQLQEMAGLTVWPGRANYLFLRCDRADFDLQYALLRQHV
LIRSCANYPGLDSRYFRVAIRSAEENDQLLAALRRVLA
>Mature_357_residues
ALLKSAHGGNIREAAALLGIAPGELLDFSANINPLGMPASLRQAIVDNPGCAERYPDVEYQQLHQALAAHHQLPAAHILA
GNGETESIFTLVHGLKPRRAMIVIPGFAEYRRALQTVDCEVVEYALRERDGWQLTDAILDALTPALDCLFLCTPNNPTGL
LPERGLLEAIAQRCRALNISLILDEAFLDFIPDQPGFIPLLAQHPHVWVLRSLTKFYAIPGLRLGYLLNADVQAVARLRA
RQMPWSINAYAALAGEIILQDRAYQRATWQWLQEEGARFYAQLQEMAGLTVWPGRANYLFLRCDRADFDLQYALLRQHVL
IRSCANYPGLDSRYFRVAIRSAEENDQLLAALRRVLA

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=345, Percent_Identity=27.2463768115942, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322075, Length=338, Percent_Identity=26.0355029585799, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 40026; Mature: 39894

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLKSAHGGNIREAAALLGIAPGELLDFSANINPLGMPASLRQAIVDNPGCAERYPDVE
CCCCCCCCCCCHHHHHHHHCCCCCHHEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCH
YQQLHQALAAHHQLPAAHILAGNGETESIFTLVHGLKPRRAMIVIPGFAEYRRALQTVDC
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHH
EVVEYALRERDGWQLTDAILDALTPALDCLFLCTPNNPTGLLPERGLLEAIAQRCRALNI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCH
SLILDEAFLDFIPDQPGFIPLLAQHPHVWVLRSLTKFYAIPGLRLGYLLNADVQAVARLR
HEEEHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHEECCCHHHHHHHH
ARQMPWSINAYAALAGEIILQDRAYQRATWQWLQEEGARFYAQLQEMAGLTVWPGRANYL
HHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEE
FLRCDRADFDLQYALLRQHVLIRSCANYPGLDSRYFRVAIRSAEENDQLLAALRRVLA
EEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
ALLKSAHGGNIREAAALLGIAPGELLDFSANINPLGMPASLRQAIVDNPGCAERYPDVE
CCCCCCCCCCHHHHHHHHCCCCCHHEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCH
YQQLHQALAAHHQLPAAHILAGNGETESIFTLVHGLKPRRAMIVIPGFAEYRRALQTVDC
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHH
EVVEYALRERDGWQLTDAILDALTPALDCLFLCTPNNPTGLLPERGLLEAIAQRCRALNI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCH
SLILDEAFLDFIPDQPGFIPLLAQHPHVWVLRSLTKFYAIPGLRLGYLLNADVQAVARLR
HEEEHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHEECCCHHHHHHHH
ARQMPWSINAYAALAGEIILQDRAYQRATWQWLQEEGARFYAQLQEMAGLTVWPGRANYL
HHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEE
FLRCDRADFDLQYALLRQHVLIRSCANYPGLDSRYFRVAIRSAEENDQLLAALRRVLA
EEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]