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The map label for this gene is cobQ [H]

Identifier: 238896288

GI number: 238896288

Start: 4270671

End: 4272194

Strand: Reverse

Name: cobQ [H]

Synonym: KP1_4449

Alternate gene names: 238896288

Gene position: 4272194-4270671 (Counterclockwise)

Preceding gene: 238896289

Following gene: 238896287

Centisome position: 81.4

GC content: 64.11

Gene sequence:

>1524_bases
ATGACGCTGGCAGTGATGTTGCAGGGCACGGCTTCCGACGTGGGGAAAAGCGTACTGGTGGCGGGACTGTGCCGCATTTT
TCATCAGGATGGGCTGCGTACCGCGCCGTTTAAATCACAGAATATGGCGCTGAACTCCGGCATTACGCCGGATGGCAAAG
AGATGGGCCGGGCGCAGATTTTCCAGGCCGAAGCGGCCGGGATTGCGCCGGATGTCCGCATGAATCCGGTTTTGCTCAAG
CCCACCAGCGACCGTCAGGCGCAGGTGGTCCTGATGGGGCAGGTGGCGACCAGCATGGACGCGGTGAGCTATCACCAGTA
CAAGCCGCGCCTGCGCGAGCAGATCCTCGCGGTCTACCAGAGCCTGGCCGGAGAGTATGAGGCGCTGGTGCTGGAAGGCG
CCGGCAGTCCGGCGGAGATTAACCTGCGCGACCGCGATATCGTCAATATGGGCATGGCCGAGATGGCGCAATGCCCGGTG
ATCCTGGTGGCCGATATCGACCGCGGCGGGGTGTTTGCCGCGATTTACGGCACGCTGGCGCTGCTGCAGCCTCAGGAGCG
GGCGCGGGTGAAAGGGGTGATTATCAATAAATTCCGCGGCGATGTGGCGCTCCTGCGCTCCGGGATAGAGCAGATCGAGG
CGTTGACCGGGGTGCCGGTGCTGGGCGTTATGCCGTGGCTTGATGTGGATCTGGAGGATGAGGACGGCGTCGCGCTGCAG
GCCGGGAAATACCATCGCACCGACCGGCGCGATATCGACATCGCCGTGGTTCACCTGCCGCATATCGCCAATTTTACCGA
CTTTAACGCCCTGGCGGCACAGCCAGACGTCCGGGTGCGCTATGTCCGCGATCCGCAGGCGCTGGCCGACGCCGACCTGG
TCATTCTCCCGGGCAGTAAAAATACCCTCGGCGATCTGTGCTGGCTGCGCGAGAGCGGCATGGCGCACGCGGTCGAGCAG
GCCCGGCAGCGCAAGGTGCCGCTGCTGGGGATCTGCGGCGGCTATCAGATGCTGGGCGAAACCATTATCGATGAGGTGGA
GTCTGGCCTTGGCGCCCAGCCCGGGCTGGGGGTGCTGAAGACCGTGACCCACTTCGCCCAGCACAAAACCACCACCCAGG
TGCAGGCGACCCTGGGGTCTGCGCTCCCGGAATGGTTAGCCGACGCGGCGGGGCTGGGCGTCAGTGGCTATGAAATTCAT
ATGGGCGAGACGCGCCGCGAGGCAGGCTGCCCGCCGCTGCTGCAGCTGCATAAAGCGGGGCAGGCAGTGGACGACGGGGC
GATAAGCGACGACGGCCTGGCGTTCGGCACCTATCTCCATGGCCTGTTCGACAGCGATGCCTTTACCCGGGCGCTGCTCA
ACGGCCTGCGCCAGCGCAAAGGGCTGGCGCCGCTGGACAGCGCCCTGGAGTATGCCCGCTATAAAACCCGCCAGTTTGAT
CGGCTGGCCGAGGCCATGCGCGAACATATCGCCATCGATAAAATTTACGCCATCATGCGCCAACATCAGGAGCCCCTATG
CTGA

Upstream 100 bases:

>100_bases
TGAAACTTCATAGCGAACTGGGGCTGCCGCTGTGTAAAACCGAGGCGGAGTTTTTTCAGCGGATGCACAACAACGCGATA
GGCGCGATAAAGGAGGCGTC

Downstream 100 bases:

>100_bases
CTCTGGTTACCGGCGGCGCGCGCAGCGGCAAAAGTCGCCATGCCGAGGCGCTGATTGCCGATGCGCCGCAGGTGTTATAT
ATCGCCACCTCGCAAATCTT

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MTLAVMLQGTASDVGKSVLVAGLCRIFHQDGLRTAPFKSQNMALNSGITPDGKEMGRAQIFQAEAAGIAPDVRMNPVLLK
PTSDRQAQVVLMGQVATSMDAVSYHQYKPRLREQILAVYQSLAGEYEALVLEGAGSPAEINLRDRDIVNMGMAEMAQCPV
ILVADIDRGGVFAAIYGTLALLQPQERARVKGVIINKFRGDVALLRSGIEQIEALTGVPVLGVMPWLDVDLEDEDGVALQ
AGKYHRTDRRDIDIAVVHLPHIANFTDFNALAAQPDVRVRYVRDPQALADADLVILPGSKNTLGDLCWLRESGMAHAVEQ
ARQRKVPLLGICGGYQMLGETIIDEVESGLGAQPGLGVLKTVTHFAQHKTTTQVQATLGSALPEWLADAAGLGVSGYEIH
MGETRREAGCPPLLQLHKAGQAVDDGAISDDGLAFGTYLHGLFDSDAFTRALLNGLRQRKGLAPLDSALEYARYKTRQFD
RLAEAMREHIAIDKIYAIMRQHQEPLC

Sequences:

>Translated_507_residues
MTLAVMLQGTASDVGKSVLVAGLCRIFHQDGLRTAPFKSQNMALNSGITPDGKEMGRAQIFQAEAAGIAPDVRMNPVLLK
PTSDRQAQVVLMGQVATSMDAVSYHQYKPRLREQILAVYQSLAGEYEALVLEGAGSPAEINLRDRDIVNMGMAEMAQCPV
ILVADIDRGGVFAAIYGTLALLQPQERARVKGVIINKFRGDVALLRSGIEQIEALTGVPVLGVMPWLDVDLEDEDGVALQ
AGKYHRTDRRDIDIAVVHLPHIANFTDFNALAAQPDVRVRYVRDPQALADADLVILPGSKNTLGDLCWLRESGMAHAVEQ
ARQRKVPLLGICGGYQMLGETIIDEVESGLGAQPGLGVLKTVTHFAQHKTTTQVQATLGSALPEWLADAAGLGVSGYEIH
MGETRREAGCPPLLQLHKAGQAVDDGAISDDGLAFGTYLHGLFDSDAFTRALLNGLRQRKGLAPLDSALEYARYKTRQFD
RLAEAMREHIAIDKIYAIMRQHQEPLC
>Mature_506_residues
TLAVMLQGTASDVGKSVLVAGLCRIFHQDGLRTAPFKSQNMALNSGITPDGKEMGRAQIFQAEAAGIAPDVRMNPVLLKP
TSDRQAQVVLMGQVATSMDAVSYHQYKPRLREQILAVYQSLAGEYEALVLEGAGSPAEINLRDRDIVNMGMAEMAQCPVI
LVADIDRGGVFAAIYGTLALLQPQERARVKGVIINKFRGDVALLRSGIEQIEALTGVPVLGVMPWLDVDLEDEDGVALQA
GKYHRTDRRDIDIAVVHLPHIANFTDFNALAAQPDVRVRYVRDPQALADADLVILPGSKNTLGDLCWLRESGMAHAVEQA
RQRKVPLLGICGGYQMLGETIIDEVESGLGAQPGLGVLKTVTHFAQHKTTTQVQATLGSALPEWLADAAGLGVSGYEIHM
GETRREAGCPPLLQLHKAGQAVDDGAISDDGLAFGTYLHGLFDSDAFTRALLNGLRQRKGLAPLDSALEYARYKTRQFDR
LAEAMREHIAIDKIYAIMRQHQEPLC

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 55000; Mature: 54869

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAVMLQGTASDVGKSVLVAGLCRIFHQDGLRTAPFKSQNMALNSGITPDGKEMGRAQI
CEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHCHHHE
FQAEAAGIAPDVRMNPVLLKPTSDRQAQVVLMGQVATSMDAVSYHQYKPRLREQILAVYQ
EHHHHCCCCCCCCCCCEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAGEYEALVLEGAGSPAEINLRDRDIVNMGMAEMAQCPVILVADIDRGGVFAAIYGTLA
HHCCCEEEEEEECCCCCCEEECCCCHHHHCCHHHHHCCCEEEEEECCCCCCHHHHHHHHH
LLQPQERARVKGVIINKFRGDVALLRSGIEQIEALTGVPVLGVMPWLDVDLEDEDGVALQ
HCCCHHHHHHCEEEEEHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCEEE
AGKYHRTDRRDIDIAVVHLPHIANFTDFNALAAQPDVRVRYVRDPQALADADLVILPGSK
CCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCEEEEECCCHHHCCCCEEEECCCC
NTLGDLCWLRESGMAHAVEQARQRKVPLLGICGGYQMLGETIIDEVESGLGAQPGLGVLK
CCHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHH
TVTHFAQHKTTTQVQATLGSALPEWLADAAGLGVSGYEIHMGETRREAGCPPLLQLHKAG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCHHHHHHHCC
QAVDDGAISDDGLAFGTYLHGLFDSDAFTRALLNGLRQRKGLAPLDSALEYARYKTRQFD
CCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RLAEAMREHIAIDKIYAIMRQHQEPLC
HHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLAVMLQGTASDVGKSVLVAGLCRIFHQDGLRTAPFKSQNMALNSGITPDGKEMGRAQI
EEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHCHHHE
FQAEAAGIAPDVRMNPVLLKPTSDRQAQVVLMGQVATSMDAVSYHQYKPRLREQILAVYQ
EHHHHCCCCCCCCCCCEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAGEYEALVLEGAGSPAEINLRDRDIVNMGMAEMAQCPVILVADIDRGGVFAAIYGTLA
HHCCCEEEEEEECCCCCCEEECCCCHHHHCCHHHHHCCCEEEEEECCCCCCHHHHHHHHH
LLQPQERARVKGVIINKFRGDVALLRSGIEQIEALTGVPVLGVMPWLDVDLEDEDGVALQ
HCCCHHHHHHCEEEEEHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCEEE
AGKYHRTDRRDIDIAVVHLPHIANFTDFNALAAQPDVRVRYVRDPQALADADLVILPGSK
CCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCEEEEECCCHHHCCCCEEEECCCC
NTLGDLCWLRESGMAHAVEQARQRKVPLLGICGGYQMLGETIIDEVESGLGAQPGLGVLK
CCHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHH
TVTHFAQHKTTTQVQATLGSALPEWLADAAGLGVSGYEIHMGETRREAGCPPLLQLHKAG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCHHHHHHHCC
QAVDDGAISDDGLAFGTYLHGLFDSDAFTRALLNGLRQRKGLAPLDSALEYARYKTRQFD
CCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RLAEAMREHIAIDKIYAIMRQHQEPLC
HHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA