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The map label for this gene is emrA [H]

Identifier: 238896138

GI number: 238896138

Start: 4108112

End: 4109284

Strand: Direct

Name: emrA [H]

Synonym: KP1_4279

Alternate gene names: 238896138

Gene position: 4108112-4109284 (Clockwise)

Preceding gene: 238896137

Following gene: 238896139

Centisome position: 78.27

GC content: 59.08

Gene sequence:

>1173_bases
ATGAGTGCAAATGCGGAGAGCCAAACCCCGCAGCAACCAGGCAGCAAAAAAGGAAAGCGTAAAGGCGCCCTTCTGTTGCT
GACATTGCTCTTCATTATTATTGCCGTGGCATATGGGATTTACTGGTTTCTGGTACTGCGTCACTACGAAGAGACCGACG
ATGCCTACGTGGCAGGGAATCAGGTACAAATTATGGCTCAGGTCGCGGGCAGCGTGACCAAAGTCTGGGCTGACAACACG
GACTACGTGCAGAAAGGCGATCCGCTGGTCACGCTCGATCGGACCGATGCCCAACAGGCGTTTGAAAAGGCTAAGACCCA
ACTGGCCGCCAGCGTGCGTCAGACCCGCCAGCAGATGATCAACAGCAAGCAATTGCAGGCGAACATCGACGTCAAAAAAA
CCGCCCTTGCCCAGGCGCAGGCTGACCTGAACCGCCGCATCCCGCTGGGCGCCGCGAACCTCATTGGCCGCGAAGAGCTG
CAGCACGCCCGCGATACCGTCGCCAGCGCACAGGCCGAACTCGACGTGGCAATCCAGCAGTACAACGCCAACCAGGCGAT
CGTGCTGGGCACCAGGCTGGAACAGCAGCCGGCGGTGCTCCAGGCGGCCACTGAAGTGCGTAACGCCTGGCTGGCCCTGC
AGCGTACGCAGATCGTCAGCCCGATTAGCGGCTACGTTTCCCGTCGCTCGGTACAGCCTGGCGCGCAGATCGGCACCACC
ACGCCGCTGATGGCGGTGGTCCCGGCGACCAACCTGTGGATCGATGCTAACTTTAAAGAGACTCAGCTGGCGCATATGCG
TATCGGCCAGCCGGCCACCGTGATCAGCGATATCTATGGCGATGACGTGAAATACACCGGTAAAGTGGTCGGTCTGGATA
TGGGCACCGGCAGCGCCTTCTCTCTGCTGCCGGCGCAGAATGCTACCGGCAACTGGATCAAAGTGGTACAGCGTCTGCCG
GTTCGTATCGAGCTGGATGAAAAACAACTAGCGGAACACCCGCTGCGCATCGGCCTCTCGACGCTGGTGGAAGTCAACAC
CACCGATCGCGATGGTGAAATGCTGGCAAGCCAGGTGCGGAGCTCCCCGGTTTACGAGAGCAATGCCCGTGAAATCGCTC
TCGATCCGGTTAATAAGCTGATAGACGAGATCATTCAGGCCAACGCCGGATAA

Upstream 100 bases:

>100_bases
ACGTTGCAAGGAAAACAGCCAGGCCAGCAGATCTCTGCTGGCCTTTCTGATAAACAGGTCGGCTCAGCCGATGTGAAATA
ATAAGATCGTGGAGAATAAC

Downstream 100 bases:

>100_bases
TTCGGGGTGAGTGTAATGCAACAGCAAAAACCGCTGGAAGGCGCGCAGCTGGTCATTATGACCATTGCGCTGTCGCTCGC
GACGTTCATGCAGGTGCTGG

Product: multidrug resistance secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNT
DYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALAQAQADLNRRIPLGAANLIGREEL
QHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTT
TPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP
VRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG

Sequences:

>Translated_390_residues
MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNT
DYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALAQAQADLNRRIPLGAANLIGREEL
QHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTT
TPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP
VRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG
>Mature_389_residues
SANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTD
YVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALAQAQADLNRRIPLGAANLIGREELQ
HARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTT
PLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPV
RIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=390, Percent_Identity=81.5384615384615, Blast_Score=648, Evalue=0.0,
Organism=Escherichia coli, GI1788711, Length=374, Percent_Identity=50.5347593582888, Blast_Score=363, Evalue=1e-102,
Organism=Escherichia coli, GI87081951, Length=305, Percent_Identity=27.8688524590164, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790519, Length=305, Percent_Identity=25.9016393442623, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789637, Length=341, Percent_Identity=26.099706744868, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42586; Mature: 42455

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGN
CCCCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
QVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMI
CEEEHHHHHCCHHEEECCCCCHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
NSKQLQANIDVKKTALAQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQ
CCHHHEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTT
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAF
CCEEEEECCCEEEEECCCCHHHHHHHHCCCCHHHHHHHCCCCCEECCEEEEEECCCCCCE
SLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVR
EEECCCCCCCHHHHHHHHCCCEEEECHHHHHHCHHHHCHHHEEEECCCCCCHHHHHHHHH
SSPVYESNAREIALDPVNKLIDEIIQANAG
CCCCCCCCCCEEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGN
CCCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
QVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMI
CEEEHHHHHCCHHEEECCCCCHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
NSKQLQANIDVKKTALAQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQ
CCHHHEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTT
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAF
CCEEEEECCCEEEEECCCCHHHHHHHHCCCCHHHHHHHCCCCCEECCEEEEEECCCCCCE
SLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVR
EEECCCCCCCHHHHHHHHCCCEEEECHHHHHHCHHHHCHHHEEEECCCCCCHHHHHHHHH
SSPVYESNAREIALDPVNKLIDEIIQANAG
CCCCCCCCCCEEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]