| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is pbpC [H]
Identifier: 238895975
GI number: 238895975
Start: 3929059
End: 3931383
Strand: Reverse
Name: pbpC [H]
Synonym: KP1_4101
Alternate gene names: 238895975
Gene position: 3931383-3929059 (Counterclockwise)
Preceding gene: 238895976
Following gene: 238895974
Centisome position: 74.9
GC content: 66.28
Gene sequence:
>2325_bases ATGCGCGTATTGCCTCGGGTAAAACGCCGCTGGCGCTGGCTGGCGGCGTTTATTTTTCTGCTGTGGCTGGCGGTGCTGGC GGCCGATCGCCTGTGGCCGCTGCCGCTGCATGACGTCACGCCTGCCCGTGTGGTGGTGGCGGAAGACGGGACGCCGCTGT GGCGGTTTGCCGACGCGCAGGGCGTCTGGCGTTATCCGGTCACGCTCGCCGACGTGTCGCCGCGCTATCTGCAGGCGCTC ATCCAGTATGAAGACCGCTGGTTCTGGCGCCATCCGGGGGTCAATCCCTTCGCGGTGCTGCGCGCCGCCTGGCAGGATCT TACTTCCGGGCGAGTTATCTCGGGCGGCAGCACGCTTACCATGCAGGTGGCACGCCTGCTTGATCCCCATCCACGCACCT TCGGCGGCAAGCTGCGCCAGCTGTGGCGAGCGCTGCAGCTGGAGTGGCATCTGTCAAAAAGCGACATTCTAACCCTCTAT TTGAACCGCGCGCCGTTTGGCGGCACCCTGCAGGGGATCGGCGCGGCCAGCTGGGCCTATCTCGGTAAGCCGCCTGCCAG GCTTAGCTACGGCGAGGCGGCGCTGCTGGCGGTACTTCCCCAGGCGCCCAGTCGTTTACGTCCGGACCGCTGGCCGCAGC GGGCCCAGGCGGCGCGTGATAAAGTGCTTACGCGAATGGTCAGCCAGGGCGTCTGGCCGGAGCAGGCGGTAAAGGAAGCG ATGGAGGAGCCAGTATGGCTGTTTCCGCGCCAGATGCCGCAGCTGGCGCCGCTTTTTTCACGCCGCGCGCTGGCGACCAG TCGTGATGAAAAGGTGGTGACGACTCTGGATGCCGGACTGCAGCGGCAACTGGAAGATCTGGCGCTGAACTGGAAATCGC GCCTGCCGCCGCGCAGTTCGCTGGCGATGGTCGTCGTCGACCACACGGATATGAAAGTTCGCGGCTGGGTGGGCTCGGCG GATATCACCGACGACAGCCGCTTCGGCCATATTGATATGGTCTCGGCGGTACGCTCGCCGGGGTCGGTGCTGAAACCCTT TATCTACGCGATGGCGATGGATGAGGGGCTGATTCACCCGGCATCGCTATTACAGGATGTGCCACGGCGTTTTAGCGATT ATCGCCCCGGTAATTTCGACAGCGGGTTTCATGGCCCGGTGAGCGCCAGCGAGGCGCTGGTTCGGTCGCTGAATCTGCCG GCGGTGCAGGTGCTCGAAGCCTATGGACCAAAACGCTTTGCGGCTAATTTACGCAACGCCGGGCTGCCCCTGACGCTGCC CGCTGGCGCAGAGCCGAATCTGTCGCTAATCCTCGGCGGCGCCGGGGCGCGGCTGGAAGATATTGTCGCGGCGTACAGCG CCTTCGCCCGCCATGGCAAGGCGGCGCGGCTGCGCCTGAAGCCGAGCGATCCATTGACCGAGCGCGCGCTGATGTCGCCC GGGGCGGCATGGATCGTCCGGCGTATTTTGGCCGGCGAAGCGCAACCGGTTCCCGATGCCTCGCTGCCGCAGGCGGTGCC GCTGGCGTGGAAAACCGGCACCAGCTACGGCTATCGCGACGCGTGGGCGGTCGGCCTCAATGCGCGATATCTGATAGGCA TCTGGACCGGGCGCCCGGACGGTACGCCGGTGGTGGGCCAGTTTGGCTTCGCCAGCGCCGTGCCGCTGCTCAACCAGGTC AATAATCTGCTGCTGGCCCGCCCGGCGATGAGCCGCGGCGGGCTGCCGAGCGATCCGCGCCCGGCAACGGTCAGCCAGGG GACAATCTGCTGGCCTGGCGGGCAGGATCTGCCGGCGGGCGACAGCAACTGTCGTCGTCGCCTGGCCAGCTGGCTTTTGG ATGCCAGCCAGCCGCCGACTCTGCTGCTGCCGGGGCAGGAGAGCGTACGCGGGATCCGCTTCCCGGTGTGGCGCAATGAA CACGGCGAACGGGTGGCGGCGGATTGTCCCGGCGCTCGGGAAAGCCAGGTCGAAGTCTGGCCGCTGCCGCTGGATCCCTG GCTGCCGGCCAGCGAAAGGCGGCGCGCGCGCCTGGGACCGGCATCGGAGTCATGCCCGCCGTTACAGACTCAGGATACCG CGCCGCTGGTGCTGTCCGGCATCCGTGATGGGGCGGTGATAAAACGTCTCCCGGGTGAGGCGCGGGTGATGTTGCCGCTA CAAACCAGCGGTGGGGAGGGGCGGCGCTGGTGGTTTATTAATGGCGAACCGTTAGAGGCCGCCGGCGCAAGAACCACGCT AATGCTGGATAAACCCGGCGAGTGGCAGTTGGTAGTGATGGATGAAGCGGGTCAGACGGCGGCCGCCAGCTTCACCCTGC AATAA
Upstream 100 bases:
>100_bases GGGCACTTATCAGGTCCCGCAGCCGCAGGTGGAATCGATGTATGCGCCGCAGTGGCGGGCGACAGGAGCGGCCAGCGGTC CGCTCACCGTGACGCCGTAA
Downstream 100 bases:
>100_bases CCAGGGTGAATTTGTTGTTGGCGGTTTGTGTTTTCAATACTCATCTTATTTTAACAAAATGTTACCTTCATCCGTAGGCA GGGGCGGGGATGCTCATTAT
Product: penicillin-binding protein 1C
Products: NA
Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]
Number of amino acids: Translated: 774; Mature: 774
Protein sequence:
>774_residues MRVLPRVKRRWRWLAAFIFLLWLAVLAADRLWPLPLHDVTPARVVVAEDGTPLWRFADAQGVWRYPVTLADVSPRYLQAL IQYEDRWFWRHPGVNPFAVLRAAWQDLTSGRVISGGSTLTMQVARLLDPHPRTFGGKLRQLWRALQLEWHLSKSDILTLY LNRAPFGGTLQGIGAASWAYLGKPPARLSYGEAALLAVLPQAPSRLRPDRWPQRAQAARDKVLTRMVSQGVWPEQAVKEA MEEPVWLFPRQMPQLAPLFSRRALATSRDEKVVTTLDAGLQRQLEDLALNWKSRLPPRSSLAMVVVDHTDMKVRGWVGSA DITDDSRFGHIDMVSAVRSPGSVLKPFIYAMAMDEGLIHPASLLQDVPRRFSDYRPGNFDSGFHGPVSASEALVRSLNLP AVQVLEAYGPKRFAANLRNAGLPLTLPAGAEPNLSLILGGAGARLEDIVAAYSAFARHGKAARLRLKPSDPLTERALMSP GAAWIVRRILAGEAQPVPDASLPQAVPLAWKTGTSYGYRDAWAVGLNARYLIGIWTGRPDGTPVVGQFGFASAVPLLNQV NNLLLARPAMSRGGLPSDPRPATVSQGTICWPGGQDLPAGDSNCRRRLASWLLDASQPPTLLLPGQESVRGIRFPVWRNE HGERVAADCPGARESQVEVWPLPLDPWLPASERRRARLGPASESCPPLQTQDTAPLVLSGIRDGAVIKRLPGEARVMLPL QTSGGEGRRWWFINGEPLEAAGARTTLMLDKPGEWQLVVMDEAGQTAAASFTLQ
Sequences:
>Translated_774_residues MRVLPRVKRRWRWLAAFIFLLWLAVLAADRLWPLPLHDVTPARVVVAEDGTPLWRFADAQGVWRYPVTLADVSPRYLQAL IQYEDRWFWRHPGVNPFAVLRAAWQDLTSGRVISGGSTLTMQVARLLDPHPRTFGGKLRQLWRALQLEWHLSKSDILTLY LNRAPFGGTLQGIGAASWAYLGKPPARLSYGEAALLAVLPQAPSRLRPDRWPQRAQAARDKVLTRMVSQGVWPEQAVKEA MEEPVWLFPRQMPQLAPLFSRRALATSRDEKVVTTLDAGLQRQLEDLALNWKSRLPPRSSLAMVVVDHTDMKVRGWVGSA DITDDSRFGHIDMVSAVRSPGSVLKPFIYAMAMDEGLIHPASLLQDVPRRFSDYRPGNFDSGFHGPVSASEALVRSLNLP AVQVLEAYGPKRFAANLRNAGLPLTLPAGAEPNLSLILGGAGARLEDIVAAYSAFARHGKAARLRLKPSDPLTERALMSP GAAWIVRRILAGEAQPVPDASLPQAVPLAWKTGTSYGYRDAWAVGLNARYLIGIWTGRPDGTPVVGQFGFASAVPLLNQV NNLLLARPAMSRGGLPSDPRPATVSQGTICWPGGQDLPAGDSNCRRRLASWLLDASQPPTLLLPGQESVRGIRFPVWRNE HGERVAADCPGARESQVEVWPLPLDPWLPASERRRARLGPASESCPPLQTQDTAPLVLSGIRDGAVIKRLPGEARVMLPL QTSGGEGRRWWFINGEPLEAAGARTTLMLDKPGEWQLVVMDEAGQTAAASFTLQ >Mature_774_residues MRVLPRVKRRWRWLAAFIFLLWLAVLAADRLWPLPLHDVTPARVVVAEDGTPLWRFADAQGVWRYPVTLADVSPRYLQAL IQYEDRWFWRHPGVNPFAVLRAAWQDLTSGRVISGGSTLTMQVARLLDPHPRTFGGKLRQLWRALQLEWHLSKSDILTLY LNRAPFGGTLQGIGAASWAYLGKPPARLSYGEAALLAVLPQAPSRLRPDRWPQRAQAARDKVLTRMVSQGVWPEQAVKEA MEEPVWLFPRQMPQLAPLFSRRALATSRDEKVVTTLDAGLQRQLEDLALNWKSRLPPRSSLAMVVVDHTDMKVRGWVGSA DITDDSRFGHIDMVSAVRSPGSVLKPFIYAMAMDEGLIHPASLLQDVPRRFSDYRPGNFDSGFHGPVSASEALVRSLNLP AVQVLEAYGPKRFAANLRNAGLPLTLPAGAEPNLSLILGGAGARLEDIVAAYSAFARHGKAARLRLKPSDPLTERALMSP GAAWIVRRILAGEAQPVPDASLPQAVPLAWKTGTSYGYRDAWAVGLNARYLIGIWTGRPDGTPVVGQFGFASAVPLLNQV NNLLLARPAMSRGGLPSDPRPATVSQGTICWPGGQDLPAGDSNCRRRLASWLLDASQPPTLLLPGQESVRGIRFPVWRNE HGERVAADCPGARESQVEVWPLPLDPWLPASERRRARLGPASESCPPLQTQDTAPLVLSGIRDGAVIKRLPGEARVMLPL QTSGGEGRRWWFINGEPLEAAGARTTLMLDKPGEWQLVVMDEAGQTAAASFTLQ
Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]
COG id: COG4953
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1788867, Length=764, Percent_Identity=76.4397905759162, Blast_Score=1206, Evalue=0.0, Organism=Escherichia coli, GI87082258, Length=203, Percent_Identity=36.4532019704434, Blast_Score=127, Evalue=3e-30, Organism=Escherichia coli, GI1786343, Length=514, Percent_Identity=27.0428015564202, Blast_Score=118, Evalue=2e-27,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011815 - InterPro: IPR009647 - InterPro: IPR001460 [H]
Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-
Molecular weight: Translated: 85146; Mature: 85146
Theoretical pI: Translated: 10.48; Mature: 10.48
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRVLPRVKRRWRWLAAFIFLLWLAVLAADRLWPLPLHDVTPARVVVAEDGTPLWRFADAQ CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEECCC GVWRYPVTLADVSPRYLQALIQYEDRWFWRHPGVNPFAVLRAAWQDLTSGRVISGGSTLT CEEECCEEEECCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCEEECCCCHHH MQVARLLDPHPRTFGGKLRQLWRALQLEWHLSKSDILTLYLNRAPFGGTLQGIGAASWAY HHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHH LGKPPARLSYGEAALLAVLPQAPSRLRPDRWPQRAQAARDKVLTRMVSQGVWPEQAVKEA CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH MEEPVWLFPRQMPQLAPLFSRRALATSRDEKVVTTLDAGLQRQLEDLALNWKSRLPPRSS HHCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCC LAMVVVDHTDMKVRGWVGSADITDDSRFGHIDMVSAVRSPGSVLKPFIYAMAMDEGLIHP EEEEEEECCCEEEEEEECCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCH ASLLQDVPRRFSDYRPGNFDSGFHGPVSASEALVRSLNLPAVQVLEAYGPKRFAANLRNA HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHCC GLPLTLPAGAEPNLSLILGGAGARLEDIVAAYSAFARHGKAARLRLKPSDPLTERALMSP CCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCC GAAWIVRRILAGEAQPVPDASLPQAVPLAWKTGTSYGYRDAWAVGLNARYLIGIWTGRPD CHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCEEEEEEEECCCC GTPVVGQFGFASAVPLLNQVNNLLLARPAMSRGGLPSDPRPATVSQGTICWPGGQDLPAG CCCEEECCCHHHHHHHHHHHHHHEEECCCHHCCCCCCCCCCCCCCCCCEECCCCCCCCCC DSNCRRRLASWLLDASQPPTLLLPGQESVRGIRFPVWRNEHGERVAADCPGARESQVEVW CHHHHHHHHHHHHCCCCCCEEEECCHHHCCCEECCCCCCCCCCEEECCCCCCCCCCEEEE PLPLDPWLPASERRRARLGPASESCPPLQTQDTAPLVLSGIRDGAVIKRLPGEARVMLPL ECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHCCCCCCEEEEEE QTSGGEGRRWWFINGEPLEAAGARTTLMLDKPGEWQLVVMDEAGQTAAASFTLQ ECCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCEEEECC >Mature Secondary Structure MRVLPRVKRRWRWLAAFIFLLWLAVLAADRLWPLPLHDVTPARVVVAEDGTPLWRFADAQ CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEECCC GVWRYPVTLADVSPRYLQALIQYEDRWFWRHPGVNPFAVLRAAWQDLTSGRVISGGSTLT CEEECCEEEECCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCEEECCCCHHH MQVARLLDPHPRTFGGKLRQLWRALQLEWHLSKSDILTLYLNRAPFGGTLQGIGAASWAY HHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHH LGKPPARLSYGEAALLAVLPQAPSRLRPDRWPQRAQAARDKVLTRMVSQGVWPEQAVKEA CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH MEEPVWLFPRQMPQLAPLFSRRALATSRDEKVVTTLDAGLQRQLEDLALNWKSRLPPRSS HHCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCC LAMVVVDHTDMKVRGWVGSADITDDSRFGHIDMVSAVRSPGSVLKPFIYAMAMDEGLIHP EEEEEEECCCEEEEEEECCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCH ASLLQDVPRRFSDYRPGNFDSGFHGPVSASEALVRSLNLPAVQVLEAYGPKRFAANLRNA HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHCC GLPLTLPAGAEPNLSLILGGAGARLEDIVAAYSAFARHGKAARLRLKPSDPLTERALMSP CCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCC GAAWIVRRILAGEAQPVPDASLPQAVPLAWKTGTSYGYRDAWAVGLNARYLIGIWTGRPD CHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCEEEEEEEECCCC GTPVVGQFGFASAVPLLNQVNNLLLARPAMSRGGLPSDPRPATVSQGTICWPGGQDLPAG CCCEEECCCHHHHHHHHHHHHHHEEECCCHHCCCCCCCCCCCCCCCCCEECCCCCCCCCC DSNCRRRLASWLLDASQPPTLLLPGQESVRGIRFPVWRNEHGERVAADCPGARESQVEVW CHHHHHHHHHHHHCCCCCCEEEECCHHHCCCEECCCCCCCCCCEEECCCCCCCCCCEEEE PLPLDPWLPASERRRARLGPASESCPPLQTQDTAPLVLSGIRDGAVIKRLPGEARVMLPL ECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHCCCCCCEEEEEE QTSGGEGRRWWFINGEPLEAAGARTTLMLDKPGEWQLVVMDEAGQTAAASFTLQ ECCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10542235; 9205837; 9278503; 9841666 [H]