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The map label for this gene is ndk [H]

Identifier: 238895974

GI number: 238895974

Start: 3928467

End: 3928898

Strand: Reverse

Name: ndk [H]

Synonym: KP1_4100

Alternate gene names: 238895974

Gene position: 3928898-3928467 (Counterclockwise)

Preceding gene: 238895975

Following gene: 238895973

Centisome position: 74.86

GC content: 56.02

Gene sequence:

>432_bases
ATGGCTATTGAACGTACTTTTTCCATCATCAAACCAAACGCGGTGGCAAAAAACGTTATTGGCAGCATCTTTTCCCGCTT
TGAAGCTGCAGGGTTCAAAATCGTCGGCACCAAAATGCTGCACCTGACCGTTGAACAGGCTCGTGGTTTCTATGCTGAGC
ACGAAGGTCGCCCGTTCTTCGACGGTCTGGTTGAGTTCATGACCTCCGGCCCGATCGTGGTTTCCGTTCTGGAAGGCGAA
AATGCGGTACAGCGTCACCGTGACCTGCTGGGCGCCACCAATCCGGCAAACGCCCTGGCGGGTACCCTGCGCGCTGACTA
CGCTGACAGCTTCACCGAGAACGGCACCCACGGTTCTGACTCTGTAGAATCCGCTGCCCGCGAAATCGCGTTCTTCTTTG
CTGAAGGCGAGGTTTGCCCGCGCACTCGCTAA

Upstream 100 bases:

>100_bases
GTTACCTTCATCCGTAGGCAGGGGCGGGGATGCTCATTATAATGCGCGCCAGGCCATACAATCGTATGTGCAACAACAGA
ACATTTAATTAGAGGTAATC

Downstream 100 bases:

>100_bases
TCTCCTGCGTCTTTCACGCCACAGCATTGTTGGCTTCCTTCGCGCACCCCGGTCACATAGTTATCTATGCTCCCGGGGAT
TTGCGAACTCGCCGTCTCGC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MAIERTFSIIKPNAVAKNVIGSIFSRFEAAGFKIVGTKMLHLTVEQARGFYAEHEGRPFFDGLVEFMTSGPIVVSVLEGE
NAVQRHRDLLGATNPANALAGTLRADYADSFTENGTHGSDSVESAAREIAFFFAEGEVCPRTR

Sequences:

>Translated_143_residues
MAIERTFSIIKPNAVAKNVIGSIFSRFEAAGFKIVGTKMLHLTVEQARGFYAEHEGRPFFDGLVEFMTSGPIVVSVLEGE
NAVQRHRDLLGATNPANALAGTLRADYADSFTENGTHGSDSVESAAREIAFFFAEGEVCPRTR
>Mature_142_residues
AIERTFSIIKPNAVAKNVIGSIFSRFEAAGFKIVGTKMLHLTVEQARGFYAEHEGRPFFDGLVEFMTSGPIVVSVLEGEN
AVQRHRDLLGATNPANALAGTLRADYADSFTENGTHGSDSVESAAREIAFFFAEGEVCPRTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=47.4074074074074, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=44.8529411764706, Blast_Score=129, Evalue=8e-31,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=44.8529411764706, Blast_Score=129, Evalue=8e-31,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=44.8529411764706, Blast_Score=129, Evalue=8e-31,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=44.8529411764706, Blast_Score=129, Evalue=8e-31,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=44.8529411764706, Blast_Score=129, Evalue=8e-31,
Organism=Homo sapiens, GI4557797, Length=139, Percent_Identity=44.6043165467626, Blast_Score=127, Evalue=2e-30,
Organism=Homo sapiens, GI38045913, Length=139, Percent_Identity=44.6043165467626, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=38.9705882352941, Blast_Score=112, Evalue=8e-26,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=41.304347826087, Blast_Score=96, Evalue=9e-21,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=35.9712230215827, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=35.9712230215827, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI4505413, Length=145, Percent_Identity=38.6206896551724, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=34.8148148148148, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=32.8467153284672, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788866, Length=143, Percent_Identity=95.1048951048951, Blast_Score=282, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=41.4814814814815, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=44.1176470588235, Blast_Score=130, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=47.4820143884892, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=36.7647058823529, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15527; Mature: 15395

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSIIKPNAVAKNVIGSIFSRFEAAGFKIVGTKMLHLTVEQARGFYAEHEGRPFF
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEECHHHHEEEHHHHCCCCCCCCCCCHH
DGLVEFMTSGPIVVSVLEGENAVQRHRDLLGATNPANALAGTLRADYADSFTENGTHGSD
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
SVESAAREIAFFFAEGEVCPRTR
HHHHHHHHHHHHEECCCCCCCCC
>Mature Secondary Structure 
AIERTFSIIKPNAVAKNVIGSIFSRFEAAGFKIVGTKMLHLTVEQARGFYAEHEGRPFF
CCCHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEECHHHHEEEHHHHCCCCCCCCCCCHH
DGLVEFMTSGPIVVSVLEGENAVQRHRDLLGATNPANALAGTLRADYADSFTENGTHGSD
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
SVESAAREIAFFFAEGEVCPRTR
HHHHHHHHHHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA