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The map label for this gene is dapA

Identifier: 238895938

GI number: 238895938

Start: 3887568

End: 3888446

Strand: Reverse

Name: dapA

Synonym: KP1_4063

Alternate gene names: 238895938

Gene position: 3888446-3887568 (Counterclockwise)

Preceding gene: 238895941

Following gene: 238895937

Centisome position: 74.09

GC content: 54.27

Gene sequence:

>879_bases
ATGTTCACGGGAAGTATTGTAGCGCTTGTCACGCCGATGGATGAAAACGGTAATGTCTGCCGGACAAGCCTGAAAAAACT
GATTGATTACCATGTCGCCAACGGAACCTCGGCGATCGTTTCGGTAGGGACTACCGGTGAATCCGCAACGCTGAGCCATG
AAGAGCATGGCGACGTGGTGATGATGACGCTGGAGCTGGCCGACGGGCGTATTCCGGTTATCGCTGGAACGGGAGCCAAT
GCAACCGCAGAGGCGATTAGCCTGACCAAACGTTTTAACGATAGCGGTGTTGTTGGCTGCCTGACGGTCACTCCTTATTA
TAACCGTCCGACCCAGGAAGGCCTGTTCCAGCACTTTAAAGCTATCGCCGAGCATACTGACCTGCCGCAAATTCTGTATA
ATGTGCCGTCCCGTACCGGTTGCGATATGCTGCCGGAAACCGTTGGCCGTCTGGCGGAAATTAAAAATATTGTCGGTATT
AAGGAAGCAACAGGGAACTTAAGTCGCGTTCACCAGATCAAAGAGCTGGTTTCAGACGACTTTATTCTGCTGAGCGGTGA
CGATGCGACCGGTATGGACTTCATGCAGCTCGGCGGCGTAGGCGTGATTTCTGTTACGGCCAACGTGGCGGCGCGCGAAA
TGGCCGACATGTGCCGTCTGGCGCTGGCGGGTCAATTTGCCGAAGCTCGTGCGATTAACCAGCGTCTGATGCCACTGCAT
ACAAAATTATTTGTCGAACCCAATCCTATCCCGGTGAAATGGGGATGCAAGGCGTTGGGTCTTGTGGCGACCGATACGCT
GCGCTTGCCGATGACGCCTATCACCGATCATGGTCGTGAAGCCGTCACTGCCGCGCTGAAGCATGCCGGTTTGCTGTAA

Upstream 100 bases:

>100_bases
CGCCATACAACATCCCTGATGGCGTCGGGTCTCTTGCTTTTATTACAGCTCCAAACGTAACATTGAGAATCTTGTCGCAC
TTCTGCTCTGAGGATGGCCC

Downstream 100 bases:

>100_bases
AGTTTAGGGAGATTTGATGGCTTACTCAGTACAGAAGTCGCGCCTGGCGAAGGTTGCGGGTGTTTCGCTGGTTCTACTCC
TCGCGGCCTGTAGTTCTGAC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MFTGSIVALVTPMDENGNVCRTSLKKLIDYHVANGTSAIVSVGTTGESATLSHEEHGDVVMMTLELADGRIPVIAGTGAN
ATAEAISLTKRFNDSGVVGCLTVTPYYNRPTQEGLFQHFKAIAEHTDLPQILYNVPSRTGCDMLPETVGRLAEIKNIVGI
KEATGNLSRVHQIKELVSDDFILLSGDDATGMDFMQLGGVGVISVTANVAAREMADMCRLALAGQFAEARAINQRLMPLH
TKLFVEPNPIPVKWGCKALGLVATDTLRLPMTPITDHGREAVTAALKHAGLL

Sequences:

>Translated_292_residues
MFTGSIVALVTPMDENGNVCRTSLKKLIDYHVANGTSAIVSVGTTGESATLSHEEHGDVVMMTLELADGRIPVIAGTGAN
ATAEAISLTKRFNDSGVVGCLTVTPYYNRPTQEGLFQHFKAIAEHTDLPQILYNVPSRTGCDMLPETVGRLAEIKNIVGI
KEATGNLSRVHQIKELVSDDFILLSGDDATGMDFMQLGGVGVISVTANVAAREMADMCRLALAGQFAEARAINQRLMPLH
TKLFVEPNPIPVKWGCKALGLVATDTLRLPMTPITDHGREAVTAALKHAGLL
>Mature_292_residues
MFTGSIVALVTPMDENGNVCRTSLKKLIDYHVANGTSAIVSVGTTGESATLSHEEHGDVVMMTLELADGRIPVIAGTGAN
ATAEAISLTKRFNDSGVVGCLTVTPYYNRPTQEGLFQHFKAIAEHTDLPQILYNVPSRTGCDMLPETVGRLAEIKNIVGI
KEATGNLSRVHQIKELVSDDFILLSGDDATGMDFMQLGGVGVISVTANVAAREMADMCRLALAGQFAEARAINQRLMPLH
TKLFVEPNPIPVKWGCKALGLVATDTLRLPMTPITDHGREAVTAALKHAGLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=216, Percent_Identity=29.1666666666667, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI13540533, Length=245, Percent_Identity=27.3469387755102, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=87.6712328767123, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI87082415, Length=296, Percent_Identity=28.3783783783784, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786463, Length=242, Percent_Identity=29.7520661157025, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1789620, Length=207, Percent_Identity=28.5024154589372, Blast_Score=97, Evalue=9e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_KLEP7 (A6TCA1)

Other databases:

- EMBL:   CP000647
- RefSeq:   YP_001336452.1
- ProteinModelPortal:   A6TCA1
- SMR:   A6TCA1
- STRING:   A6TCA1
- GeneID:   5339506
- GenomeReviews:   CP000647_GR
- KEGG:   kpn:KPN_02812
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31162; Mature: 31162

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 161-161 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGSIVALVTPMDENGNVCRTSLKKLIDYHVANGTSAIVSVGTTGESATLSHEEHGDVV
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCCCCEE
MMTLELADGRIPVIAGTGANATAEAISLTKRFNDSGVVGCLTVTPYYNRPTQEGLFQHFK
EEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHH
AIAEHTDLPQILYNVPSRTGCDMLPETVGRLAEIKNIVGIKEATGNLSRVHQIKELVSDD
HHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHCCC
FILLSGDDATGMDFMQLGGVGVISVTANVAAREMADMCRLALAGQFAEARAINQRLMPLH
EEEEECCCCCCCHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEE
TKLFVEPNPIPVKWGCKALGLVATDTLRLPMTPITDHGREAVTAALKHAGLL
EEEEECCCCCCEECCCCEECEEEECCEECCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MFTGSIVALVTPMDENGNVCRTSLKKLIDYHVANGTSAIVSVGTTGESATLSHEEHGDVV
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCCCCEE
MMTLELADGRIPVIAGTGANATAEAISLTKRFNDSGVVGCLTVTPYYNRPTQEGLFQHFK
EEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHH
AIAEHTDLPQILYNVPSRTGCDMLPETVGRLAEIKNIVGIKEATGNLSRVHQIKELVSDD
HHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHCCC
FILLSGDDATGMDFMQLGGVGVISVTANVAAREMADMCRLALAGQFAEARAINQRLMPLH
EEEEECCCCCCCHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEE
TKLFVEPNPIPVKWGCKALGLVATDTLRLPMTPITDHGREAVTAALKHAGLL
EEEEECCCCCCEECCCCEECEEEECCEECCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA