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The map label for this gene is maeB [H]

Identifier: 238895923

GI number: 238895923

Start: 3866727

End: 3869006

Strand: Reverse

Name: maeB [H]

Synonym: KP1_4048

Alternate gene names: 238895923

Gene position: 3869006-3866727 (Counterclockwise)

Preceding gene: 238895926

Following gene: 238895922

Centisome position: 73.72

GC content: 60.53

Gene sequence:

>2280_bases
ATGGATGAGCAGTTAAAACAGAGCGCCCTCGACTTCCACGAATTTCCGGTTCCCGGAAAAATCCAGGTCTCGCCGACCAA
ACCTCTCGCCACCCAGCGCGATCTGGCGCTGGCCTACTCGCCGGGCGTCGCAGCCCCCTGCCTGGAAATCGAAAAAGATC
CGCTGGCCGCCTACAAATACACTGCCCGCGGCAACCTGGTGGCGGTCGTCTCCAACGGCACCGCGGTGCTGGGGCTCGGC
AACATCGGCGCGCTGGCCGGTAAGCCGGTAATGGAGGGCAAAGGCGTCCTGTTTAAGAAATTTGCCGGTATCGATGTGTT
TGATATCGAAGTCGATGAGCTGGATCCGGACAAATTCATTAACGTCGTCGCCGCCCTCGAACCAACCTTCGGCGGTATCA
ACCTGGAAGATATTAAAGCGCCGGAGTGTTTCTACATCGAGCAGCAGCTGCGCGAGCGGATGAATATCCCGGTCTTCCAT
GACGATCAGCACGGCACGGCGATCATCAGCACCGCGGCGATCCTCAACGGTCTGCGCGTCGTCGAGAAGAATCTGTCCGA
CGTGCGGATGGTGGTCTCCGGCGCGGGCGCGGCGGCGATCGCCTGTATGAATCTGCTGGTGGCGCTGGGGATGCAAAAGC
ACAACATCGTGGTCTGCGATTCGAAAGGCGTTATCTATAAAGACCGTGAGCCGAACATGGCGGAAACCAAAGCGGCCTAT
GCGGTGGAAGACGACGGCAAACGCACCCTCGATGACGTGATCGACGGCGCCGACATTTTCCTCGGCTGCTCCGGTCCGAA
AGTGCTGACTCAGGAGATGGTGAAGAAGATGGCGCGGGCGCCGCTGATCCTCGCCCTGGCCAACCCGGAGCCGGAAATCC
TGCCGCCGCTGGCGAAGCAGGTCCGCGATGACGCCATCATCTGTACCGGCCGCTCCGACTACCCTAACCAGGTCAACAAC
GTGCTCTGCTTCCCGTTCATCTTCCGCGGCGCGCTGGACGTCGGCGCGACGGCGATCAACGAAGAGATGAAGCTGGCGGC
GGTGCATGCGATTGCCGAGCTGGCCCATGCCGAGCAGAGCGAAGTGGTGGCCTCCGCCTACGGCGATCAGGATTTAAGCT
TTGGTCCGGAGTACATCATTCCGAAACCGTTCGACCCGCGGCTGATCGTCAAGATAGCCCCTGCGGTGGCGAAGGCGGCG
ATGGATTCCGGCGTGGCAACGCGCCCCATCGCTGATTTTGACGCCTATATCGAGAAGCTGAGCGAGTTCGTCTATAAAAC
CAACCTGTTTATGAAGCCTATCTTCTCTCAGGCGCGCAAAGAGCCGAAGCGCGTGGTGCTGGCGGAAGGGGAGGAGACTC
GGGTGCTGCACGCCACCCAGGAGCTGGTGTCTCTGGGACTGGCCAAACCGATTCTGGTGGGGCGCCCGAGCGTGATTGAA
ATGCGCATCCAGAAGCTGGGCCTGCAGATCAAGGCCGGCGTTGACTTTGAGATCGTCAATAATGAATCCGACCCGCGGTT
TAAAGAGTACTGGAGCGAGTACTACCAGCTGATGAAGCGCCGCGGCATTACCCAGGAGCAGGCGCAGCGGGCGGTGATTA
GCAACACCACGGTGATTGGCGCCATCATGGTTCATCGCGGTGAAGCGGATGCGATGATCTGCGGGACTATTGGCGAGTAC
CACGATCACTACCGCGTGGTGCAGCCGCTGTTTGGCTATCGCGACGGCGTCAGCACCGCCGGGGCGATGAATGCGCTGCT
GCTGCCGAGCGGCAACACCTTTATCGCCGATACCTATGTCAATCACGATCCGTCGCCGGAAGAGCTGGCGGAGATCACCC
TGATGGCGGCGGAAAGCGTGCGACGCTTTGGTATTGAACCGCGCGTGGCGTTGCTGTCGCACTCCAACTTTGGCTCTGCC
GACTGTCCGTCAGCCAGTAAAATGCGTAAAACCCTGGAGCTGGTGAAGGCGCGCGCCCCGGAGCTGATGATCGATGGCGA
AATGCATGGCGACGCCGCGCTGGTGGAAAGCATCCGCAACGATCGCATGCCGGACAGCCCGCTGAAGGGGGCGGCCAATA
TTCTGGTGATGCCGAATATGGAAGCCGCCCGGATCAGCTATAACCTGCTGCGCGTCTCCAGTTCGGAAGGGGTGACCGTC
GGGCCGGTGCTGATGGGGGTGGCGAAGCCGGTGCATATTCTGACGCCGATCGCCTCCGTACGCCGGATCGTTAATATGGT
GGCGCTGGCGGTTGTTGAAGCGCAAACCGAACCGCTGTAA

Upstream 100 bases:

>100_bases
GCCCCGCCAGGAGGGATACTGTCTGCCACTGAAAGGTGAACGACAGGATGGTCATCACGCTTTTCCCCTACGAACGATAC
GTGAAAGAAAGGAATAGAAA

Downstream 100 bases:

>100_bases
TTTTCTATTTCCCCCGTTAACGCGCGGATCCGTTTCCGCGCGCAATATCAGGCAGGCCGGTGAGTAAAAAACGCTGAGCC
TGCCTTTTTAATTCCGCCGC

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MDEQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLAAYKYTARGNLVAVVSNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFINVVAALEPTFGGINLEDIKAPECFYIEQQLRERMNIPVFH
DDQHGTAIISTAAILNGLRVVEKNLSDVRMVVSGAGAAAIACMNLLVALGMQKHNIVVCDSKGVIYKDREPNMAETKAAY
AVEDDGKRTLDDVIDGADIFLGCSGPKVLTQEMVKKMARAPLILALANPEPEILPPLAKQVRDDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATAINEEMKLAAVHAIAELAHAEQSEVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MDSGVATRPIADFDAYIEKLSEFVYKTNLFMKPIFSQARKEPKRVVLAEGEETRVLHATQELVSLGLAKPILVGRPSVIE
MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWSEYYQLMKRRGITQEQAQRAVISNTTVIGAIMVHRGEADAMICGTIGEY
HDHYRVVQPLFGYRDGVSTAGAMNALLLPSGNTFIADTYVNHDPSPEELAEITLMAAESVRRFGIEPRVALLSHSNFGSA
DCPSASKMRKTLELVKARAPELMIDGEMHGDAALVESIRNDRMPDSPLKGAANILVMPNMEAARISYNLLRVSSSEGVTV
GPVLMGVAKPVHILTPIASVRRIVNMVALAVVEAQTEPL

Sequences:

>Translated_759_residues
MDEQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLAAYKYTARGNLVAVVSNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFINVVAALEPTFGGINLEDIKAPECFYIEQQLRERMNIPVFH
DDQHGTAIISTAAILNGLRVVEKNLSDVRMVVSGAGAAAIACMNLLVALGMQKHNIVVCDSKGVIYKDREPNMAETKAAY
AVEDDGKRTLDDVIDGADIFLGCSGPKVLTQEMVKKMARAPLILALANPEPEILPPLAKQVRDDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATAINEEMKLAAVHAIAELAHAEQSEVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MDSGVATRPIADFDAYIEKLSEFVYKTNLFMKPIFSQARKEPKRVVLAEGEETRVLHATQELVSLGLAKPILVGRPSVIE
MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWSEYYQLMKRRGITQEQAQRAVISNTTVIGAIMVHRGEADAMICGTIGEY
HDHYRVVQPLFGYRDGVSTAGAMNALLLPSGNTFIADTYVNHDPSPEELAEITLMAAESVRRFGIEPRVALLSHSNFGSA
DCPSASKMRKTLELVKARAPELMIDGEMHGDAALVESIRNDRMPDSPLKGAANILVMPNMEAARISYNLLRVSSSEGVTV
GPVLMGVAKPVHILTPIASVRRIVNMVALAVVEAQTEPL
>Mature_759_residues
MDEQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLAAYKYTARGNLVAVVSNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFINVVAALEPTFGGINLEDIKAPECFYIEQQLRERMNIPVFH
DDQHGTAIISTAAILNGLRVVEKNLSDVRMVVSGAGAAAIACMNLLVALGMQKHNIVVCDSKGVIYKDREPNMAETKAAY
AVEDDGKRTLDDVIDGADIFLGCSGPKVLTQEMVKKMARAPLILALANPEPEILPPLAKQVRDDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATAINEEMKLAAVHAIAELAHAEQSEVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MDSGVATRPIADFDAYIEKLSEFVYKTNLFMKPIFSQARKEPKRVVLAEGEETRVLHATQELVSLGLAKPILVGRPSVIE
MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWSEYYQLMKRRGITQEQAQRAVISNTTVIGAIMVHRGEADAMICGTIGEY
HDHYRVVQPLFGYRDGVSTAGAMNALLLPSGNTFIADTYVNHDPSPEELAEITLMAAESVRRFGIEPRVALLSHSNFGSA
DCPSASKMRKTLELVKARAPELMIDGEMHGDAALVESIRNDRMPDSPLKGAANILVMPNMEAARISYNLLRVSSSEGVTV
GPVLMGVAKPVHILTPIASVRRIVNMVALAVVEAQTEPL

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=402, Percent_Identity=25.8706467661692, Blast_Score=82, Evalue=3e-15,
Organism=Escherichia coli, GI1788806, Length=759, Percent_Identity=92.4901185770751, Blast_Score=1451, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=346, Percent_Identity=31.2138728323699, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI1788800, Length=326, Percent_Identity=33.1288343558282, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI87081919, Length=299, Percent_Identity=25.4180602006689, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17537199, Length=398, Percent_Identity=25.6281407035176, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=29.1044776119403, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI78707242, Length=442, Percent_Identity=26.4705882352941, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI78707238, Length=442, Percent_Identity=26.4705882352941, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24646388, Length=345, Percent_Identity=27.8260869565217, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646386, Length=345, Percent_Identity=27.8260869565217, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI78707240, Length=349, Percent_Identity=26.3610315186246, Blast_Score=83, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21356279, Length=474, Percent_Identity=24.8945147679325, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281362674, Length=474, Percent_Identity=24.8945147679325, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281362672, Length=474, Percent_Identity=24.8945147679325, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82373; Mature: 82373

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLAAYKY
CCHHHHHHHCCHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
TARGNLVAVVSNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEECCCCHHHHH
NVVAALEPTFGGINLEDIKAPECFYIEQQLRERMNIPVFHDDQHGTAIISTAAILNGLRV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
VEKNLSDVRMVVSGAGAAAIACMNLLVALGMQKHNIVVCDSKGVIYKDREPNMAETKAAY
HHHCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCHHHHEEE
AVEDDGKRTLDDVIDGADIFLGCSGPKVLTQEMVKKMARAPLILALANPEPEILPPLAKQ
EECCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHH
VRDDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATAINEEMKLAAVHAIAELAHAEQS
HCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHH
EVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMDSGVATRPIADFDAYIEKL
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
SEFVYKTNLFMKPIFSQARKEPKRVVLAEGEETRVLHATQELVSLGLAKPILVGRPSVIE
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCHHHH
MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWSEYYQLMKRRGITQEQAQRAVISNTTVIG
HHHHHCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEE
AIMVHRGEADAMICGTIGEYHDHYRVVQPLFGYRDGVSTAGAMNALLLPSGNTFIADTYV
EEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEEEECC
NHDPSPEELAEITLMAAESVRRFGIEPRVALLSHSNFGSADCPSASKMRKTLELVKARAP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
ELMIDGEMHGDAALVESIRNDRMPDSPLKGAANILVMPNMEAARISYNLLRVSSSEGVTV
CEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHEEEEEEEEECCCCCEE
GPVLMGVAKPVHILTPIASVRRIVNMVALAVVEAQTEPL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDEQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLAAYKY
CCHHHHHHHCCHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
TARGNLVAVVSNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEECCCCHHHHH
NVVAALEPTFGGINLEDIKAPECFYIEQQLRERMNIPVFHDDQHGTAIISTAAILNGLRV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
VEKNLSDVRMVVSGAGAAAIACMNLLVALGMQKHNIVVCDSKGVIYKDREPNMAETKAAY
HHHCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCHHHHEEE
AVEDDGKRTLDDVIDGADIFLGCSGPKVLTQEMVKKMARAPLILALANPEPEILPPLAKQ
EECCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHH
VRDDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATAINEEMKLAAVHAIAELAHAEQS
HCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHH
EVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMDSGVATRPIADFDAYIEKL
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
SEFVYKTNLFMKPIFSQARKEPKRVVLAEGEETRVLHATQELVSLGLAKPILVGRPSVIE
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCHHHH
MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWSEYYQLMKRRGITQEQAQRAVISNTTVIG
HHHHHCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEE
AIMVHRGEADAMICGTIGEYHDHYRVVQPLFGYRDGVSTAGAMNALLLPSGNTFIADTYV
EEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEEEECC
NHDPSPEELAEITLMAAESVRRFGIEPRVALLSHSNFGSADCPSASKMRKTLELVKARAP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
ELMIDGEMHGDAALVESIRNDRMPDSPLKGAANILVMPNMEAARISYNLLRVSSSEGVTV
CEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHEEEEEEEEECCCCCEE
GPVLMGVAKPVHILTPIASVRRIVNMVALAVVEAQTEPL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]