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The map label for this gene is ipdC [H]

Identifier: 238895871

GI number: 238895871

Start: 3815963

End: 3817624

Strand: Reverse

Name: ipdC [H]

Synonym: KP1_3993

Alternate gene names: 238895871

Gene position: 3817624-3815963 (Counterclockwise)

Preceding gene: 238895874

Following gene: 238895869

Centisome position: 72.74

GC content: 62.15

Gene sequence:

>1662_bases
ATGCAACCGACCTACACTATTGGGGATTATCTGCTGGATCGCCTTGTCGACTGCGGTATTGACCGCTTGTTCGGCGTGCC
GGGAGATTACAACTTACAGTTTCTCGATCGCGTCATCGCGCACAGCGCCTTGGGGTGGGTCGGCTGCGCCAACGAGCTGA
ATGCGGCATATGCCGCTGACGGCTATGCGCGCATCAAAGGAGCCGGTGCGCTGCTGACCACTTACGGCGTCGGCGAATTG
AGCGCGCTGAACGGCATTGCGGGTAGCTATGCGGAACATATTCCGGTATTGCATATCGTCGGTGCGCCCTCTACCGGCGC
CCAGCAGCGCGGCGAACTGCTGCACCATACCCTCGGCGATGGCGATTTTCGCCATTTCGCCCGCATGAGCGAGCAGATCA
CCTGTAGCCAGGCGCTGCTGACCGCCGGCAACGCCTGCCATGAAATCGACCGTGTGCTGCGCGATATGTTGACGCATCAT
CGCCCCGGCTATTTGATGCTGCCAGCCGATGTCGCCAGAGCGGCAGCGATTGCCCCAGCCCAGCGCTTGCTGGTGGAGCC
CGCTCCGGCGGATGAAAACCAGCTTGCCGGGTTCTGCGAACATGCCAGCCGCCTGCTGCGGGGCAGCCGACGCATTTCCC
TGCTGGCGGACTTCCTGGCGCAACGTTATGGCCTGCAGAAGACGCTCCGGGAGTGGGTGGCGAAAACGCCTGTCGCCCAT
GCGACGATGCTCATGGGCAAGGGATTGTTTGATGAGCAGCAGAGCGGGTTTGTCGGCACCTACAGCGGGATTGCCAGCGC
GCCGCAGACCCGGGAGGCGATTGAAAACGCCGACACCATCATCTGCATTGGCACGCGCTTCACCGACACCATCACCGCAG
GATTTACCCAACATCTGGCGCGGGAAAAGACTATTGAGATCCAGCCCTTCGCCGTCAGGGTGGGCGATCACTGGTTCAGC
GGGGTGCCGATGGATAAGGCCCTGGCCGCGCTGATGACGCTTTCCGCCCCGCTGGCGGCGGAGTGGGCTACGCCTCAGGT
CGTGGCGCCGGAGGCTGAGGAGGGCGCTGAAGGCGAGTTGACCCAGAAAAATTTCTGGGCGACGGTGCAGGGCGCCCTGC
GTCCGGGGGATATTATTCTCGCCGATCAGGGGACGGCCGCCTTTGGTATTGCGGCGCTGAAGCTGCCCTCTGAAGCATCG
CTGATCGTCCAGCCGCTGTGGGGCTCGATTGGTTTTACTCTCCCGGCCGCCTATGGCGCACAAACCGCGGCGGCGGAGCG
GCGGGTGGTGCTAATTGTCGGCGATGGCGCGGCCCAACTGACCATTCAGGAGATGGGCTCCATGCTGCGTGATAAGCAAA
AGCCGCTTATTCTGCTGCTGAATAACGAAGGGTATACCGTGGAACGGGCGATTCATGGTCCAGAGCAGCGCTACAATGAC
ATCGCTCTGTGGGACTGGCAGCGGCTGCCGGAAGCCTTCGCCCCTGACGTTGCTTCGCGCTGCCGGCGGGTCACTCAGAC
GTCTGAACTGCGGGAGGCGATGACGGAGAGCATCACCTCCGATACCCTCACCCTGGTAGAAGTGATGCTGCCGAAAATGG
ATATCCCCGATTTCCTGCGCGCGGTGACGCAGGCCCTTGAGGAGCGAAACAGCCGCGTTTAA

Upstream 100 bases:

>100_bases
TAATTATTGCTTTACACTGCCATTATCACCTCCCATCTGGACAGGCGGATCGCTTATTCAATACTCAAATTACACCTGCA
CCAAAATGAGGATAATGGAT

Downstream 100 bases:

>100_bases
TCGTTATGCCGTTTGGCAATCATCAACGGTCTCCCGGCCAGCAGCAGCCAGGCCGGGAGCATCACCATACACAACAGCGG
CAGCAGAGTCGTATCCGGGA

Product: putative pyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MQPTYTIGDYLLDRLVDCGIDRLFGVPGDYNLQFLDRVIAHSALGWVGCANELNAAYAADGYARIKGAGALLTTYGVGEL
SALNGIAGSYAEHIPVLHIVGAPSTGAQQRGELLHHTLGDGDFRHFARMSEQITCSQALLTAGNACHEIDRVLRDMLTHH
RPGYLMLPADVARAAAIAPAQRLLVEPAPADENQLAGFCEHASRLLRGSRRISLLADFLAQRYGLQKTLREWVAKTPVAH
ATMLMGKGLFDEQQSGFVGTYSGIASAPQTREAIENADTIICIGTRFTDTITAGFTQHLAREKTIEIQPFAVRVGDHWFS
GVPMDKALAALMTLSAPLAAEWATPQVVAPEAEEGAEGELTQKNFWATVQGALRPGDIILADQGTAAFGIAALKLPSEAS
LIVQPLWGSIGFTLPAAYGAQTAAAERRVVLIVGDGAAQLTIQEMGSMLRDKQKPLILLLNNEGYTVERAIHGPEQRYND
IALWDWQRLPEAFAPDVASRCRRVTQTSELREAMTESITSDTLTLVEVMLPKMDIPDFLRAVTQALEERNSRV

Sequences:

>Translated_553_residues
MQPTYTIGDYLLDRLVDCGIDRLFGVPGDYNLQFLDRVIAHSALGWVGCANELNAAYAADGYARIKGAGALLTTYGVGEL
SALNGIAGSYAEHIPVLHIVGAPSTGAQQRGELLHHTLGDGDFRHFARMSEQITCSQALLTAGNACHEIDRVLRDMLTHH
RPGYLMLPADVARAAAIAPAQRLLVEPAPADENQLAGFCEHASRLLRGSRRISLLADFLAQRYGLQKTLREWVAKTPVAH
ATMLMGKGLFDEQQSGFVGTYSGIASAPQTREAIENADTIICIGTRFTDTITAGFTQHLAREKTIEIQPFAVRVGDHWFS
GVPMDKALAALMTLSAPLAAEWATPQVVAPEAEEGAEGELTQKNFWATVQGALRPGDIILADQGTAAFGIAALKLPSEAS
LIVQPLWGSIGFTLPAAYGAQTAAAERRVVLIVGDGAAQLTIQEMGSMLRDKQKPLILLLNNEGYTVERAIHGPEQRYND
IALWDWQRLPEAFAPDVASRCRRVTQTSELREAMTESITSDTLTLVEVMLPKMDIPDFLRAVTQALEERNSRV
>Mature_553_residues
MQPTYTIGDYLLDRLVDCGIDRLFGVPGDYNLQFLDRVIAHSALGWVGCANELNAAYAADGYARIKGAGALLTTYGVGEL
SALNGIAGSYAEHIPVLHIVGAPSTGAQQRGELLHHTLGDGDFRHFARMSEQITCSQALLTAGNACHEIDRVLRDMLTHH
RPGYLMLPADVARAAAIAPAQRLLVEPAPADENQLAGFCEHASRLLRGSRRISLLADFLAQRYGLQKTLREWVAKTPVAH
ATMLMGKGLFDEQQSGFVGTYSGIASAPQTREAIENADTIICIGTRFTDTITAGFTQHLAREKTIEIQPFAVRVGDHWFS
GVPMDKALAALMTLSAPLAAEWATPQVVAPEAEEGAEGELTQKNFWATVQGALRPGDIILADQGTAAFGIAALKLPSEAS
LIVQPLWGSIGFTLPAAYGAQTAAAERRVVLIVGDGAAQLTIQEMGSMLRDKQKPLILLLNNEGYTVERAIHGPEQRYND
IALWDWQRLPEAFAPDVASRCRRVTQTSELREAMTESITSDTLTLVEVMLPKMDIPDFLRAVTQALEERNSRV

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1787096, Length=567, Percent_Identity=23.8095238095238, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790104, Length=483, Percent_Identity=24.223602484472, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323163, Length=562, Percent_Identity=39.8576512455516, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323073, Length=550, Percent_Identity=39.8181818181818, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321524, Length=562, Percent_Identity=38.9679715302491, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320123, Length=558, Percent_Identity=32.7956989247312, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6320588, Length=608, Percent_Identity=31.9078947368421, Blast_Score=304, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6323755, Length=309, Percent_Identity=23.6245954692557, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 59989; Mature: 59989

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPTYTIGDYLLDRLVDCGIDRLFGVPGDYNLQFLDRVIAHSALGWVGCANELNAAYAAD
CCCCEEHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHCCHHHCC
GYARIKGAGALLTTYGVGELSALNGIAGSYAEHIPVLHIVGAPSTGAQQRGELLHHTLGD
CCCEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCC
GDFRHFARMSEQITCSQALLTAGNACHEIDRVLRDMLTHHRPGYLMLPADVARAAAIAPA
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHH
QRLLVEPAPADENQLAGFCEHASRLLRGSRRISLLADFLAQRYGLQKTLREWVAKTPVAH
HHHEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHH
ATMLMGKGLFDEQQSGFVGTYSGIASAPQTREAIENADTIICIGTRFTDTITAGFTQHLA
HHHHHCCCCCCHHCCCCEEECHHHCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
REKTIEIQPFAVRVGDHWFSGVPMDKALAALMTLSAPLAAEWATPQVVAPEAEEGAEGEL
HCCCEEECEEEEEECCHHCCCCCHHHHHHHHHHHCCCHHHCCCCCCEECCCCCCCCCCCC
TQKNFWATVQGALRPGDIILADQGTAAFGIAALKLPSEASLIVQPLWGSIGFTLPAAYGA
CCCHHHHEEECCCCCCCEEEECCCCCHHEEEEEECCCCCCEEEEEHHCCCCCCCCHHHCC
QTAAAERRVVLIVGDGAAQLTIQEMGSMLRDKQKPLILLLNNEGYTVERAIHGPEQRYND
HHHHCCCEEEEEEECCCCEEEHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCHHHCCC
IALWDWQRLPEAFAPDVASRCRRVTQTSELREAMTESITSDTLTLVEVMLPKMDIPDFLR
CEEECHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
AVTQALEERNSRV
HHHHHHHHHCCCC
>Mature Secondary Structure
MQPTYTIGDYLLDRLVDCGIDRLFGVPGDYNLQFLDRVIAHSALGWVGCANELNAAYAAD
CCCCEEHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHCCHHHCC
GYARIKGAGALLTTYGVGELSALNGIAGSYAEHIPVLHIVGAPSTGAQQRGELLHHTLGD
CCCEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCC
GDFRHFARMSEQITCSQALLTAGNACHEIDRVLRDMLTHHRPGYLMLPADVARAAAIAPA
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHH
QRLLVEPAPADENQLAGFCEHASRLLRGSRRISLLADFLAQRYGLQKTLREWVAKTPVAH
HHHEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHH
ATMLMGKGLFDEQQSGFVGTYSGIASAPQTREAIENADTIICIGTRFTDTITAGFTQHLA
HHHHHCCCCCCHHCCCCEEECHHHCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
REKTIEIQPFAVRVGDHWFSGVPMDKALAALMTLSAPLAAEWATPQVVAPEAEEGAEGEL
HCCCEEECEEEEEECCHHCCCCCHHHHHHHHHHHCCCHHHCCCCCCEECCCCCCCCCCCC
TQKNFWATVQGALRPGDIILADQGTAAFGIAALKLPSEASLIVQPLWGSIGFTLPAAYGA
CCCHHHHEEECCCCCCCEEEECCCCCHHEEEEEECCCCCCEEEEEHHCCCCCCCCHHHCC
QTAAAERRVVLIVGDGAAQLTIQEMGSMLRDKQKPLILLLNNEGYTVERAIHGPEQRYND
HHHHCCCEEEEEEECCCCEEEHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCHHHCCC
IALWDWQRLPEAFAPDVASRCRRVTQTSELREAMTESITSDTLTLVEVMLPKMDIPDFLR
CEEECHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
AVTQALEERNSRV
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]