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The map label for this gene is flk [H]

Identifier: 238895842

GI number: 238895842

Start: 3784574

End: 3785551

Strand: Direct

Name: flk [H]

Synonym: KP1_3961

Alternate gene names: 238895842

Gene position: 3784574-3785551 (Clockwise)

Preceding gene: 238895824

Following gene: 238895845

Centisome position: 72.11

GC content: 64.62

Gene sequence:

>978_bases
ATGACGCACCCCCTTGCTGATATGCCAGACCGTCCTCCAGGGCGAGGCCCATCAGGCACTGCCGCCACCGGCGAACCTTC
GCTTTCCATGCAGCAACGCACCGTTCTGGAGCGACTGATCACGCGCCTGGTGGCGCTGACCTCGCAGCAGAACGCGGAAG
TGTGGGCCTGCGTCAAACATGACCTCGGACTGAAAGGCGACTCGCCCCTGCTGGCCTGCCATTTCAACGCCGCGGAGGCC
AGTCTCAACCAGCGCTTAGCCGCCGCTCAGGATAATCATCATCATCGCCAGACCTTAGCGCAGCTCAGCGATCTGCTCGG
TCAGGGCAATAACCGCCAGGCGGTGAGCGATTATATTCGTCAGCATTATGGGCAAACGGCGCTGCATGCCCTTAGCCAGA
CGCAGCTGGAGACCATTCTGCATCTGCTGCAGCATGGCCAGCTGTCGATCCCGCAGCCGCAGCAGCGCCCGCCGACCCTG
CGCCCGCTGTTGCCAGCCGAGCATAATACGCTCAATCAGCTGGTGACTAAGCTGGCGGCCGCCACCGGCGAACCAAGCAA
GCTGATTTGGCAATCCATGCTGGAGCTTTGCGGCGTCAAGTCCGGGGAGCTGATCCCGGCGACGCACTTCCTGCCGCTTT
CGTACTGGCTGCAGGCGCGGCAAACGCTGAGTGCGCAAAGCGCGCCGACGCTCACCTCGCTGCAGGGAGCGCTCAAGCAG
CCGCTGGAGGCCGCGGAGTGGCAGAAAATTGTCGACTTTGCCCGTCGCAGCTGGCAGGTCACGCCGCAGACCACGCTGAG
CCCGGCGCAGATCCTGGCGCTGCTGAACAAGGTGTTTGTGCTGCGGGTGGCCCGCGCCCAGGAGACGCTGGCCATCCCGC
AGGAGGAGCCAGTCGCCAGGCGGACGTGGAGCGCTAAGCCGTGGCAGCTGGCGCTGGGCGCGGTTGTCCTGCTCCTTGTG
CTGTGGCTCCTGCTGTAG

Upstream 100 bases:

>100_bases
CTGTCTGAGAACGAGAGTTAACTGGGGAAGTGTGCCATAATCTGGCCGCCAGGCATACTCATCACCTGGTTCCAGCACCG
CGATATCGAAAGGATGAATC

Downstream 100 bases:

>100_bases
CCCAGCAGCCACCAGCGGCGTTTACGGCTCCCTTTCATGCCAAACGCCGCGGTGTTTCCTACAGCGATTTCAGACCGGAC
AATAACCTAGCGGCGAAATG

Product: flagella biosynthesis regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTHPLADMPDRPPGRGPSGTAATGEPSLSMQQRTVLERLITRLVALTSQQNAEVWACVKHDLGLKGDSPLLACHFNAAEA
SLNQRLAAAQDNHHHRQTLAQLSDLLGQGNNRQAVSDYIRQHYGQTALHALSQTQLETILHLLQHGQLSIPQPQQRPPTL
RPLLPAEHNTLNQLVTKLAAATGEPSKLIWQSMLELCGVKSGELIPATHFLPLSYWLQARQTLSAQSAPTLTSLQGALKQ
PLEAAEWQKIVDFARRSWQVTPQTTLSPAQILALLNKVFVLRVARAQETLAIPQEEPVARRTWSAKPWQLALGAVVLLLV
LWLLL

Sequences:

>Translated_325_residues
MTHPLADMPDRPPGRGPSGTAATGEPSLSMQQRTVLERLITRLVALTSQQNAEVWACVKHDLGLKGDSPLLACHFNAAEA
SLNQRLAAAQDNHHHRQTLAQLSDLLGQGNNRQAVSDYIRQHYGQTALHALSQTQLETILHLLQHGQLSIPQPQQRPPTL
RPLLPAEHNTLNQLVTKLAAATGEPSKLIWQSMLELCGVKSGELIPATHFLPLSYWLQARQTLSAQSAPTLTSLQGALKQ
PLEAAEWQKIVDFARRSWQVTPQTTLSPAQILALLNKVFVLRVARAQETLAIPQEEPVARRTWSAKPWQLALGAVVLLLV
LWLLL
>Mature_324_residues
THPLADMPDRPPGRGPSGTAATGEPSLSMQQRTVLERLITRLVALTSQQNAEVWACVKHDLGLKGDSPLLACHFNAAEAS
LNQRLAAAQDNHHHRQTLAQLSDLLGQGNNRQAVSDYIRQHYGQTALHALSQTQLETILHLLQHGQLSIPQPQQRPPTLR
PLLPAEHNTLNQLVTKLAAATGEPSKLIWQSMLELCGVKSGELIPATHFLPLSYWLQARQTLSAQSAPTLTSLQGALKQP
LEAAEWQKIVDFARRSWQVTPQTTLSPAQILALLNKVFVLRVARAQETLAIPQEEPVARRTWSAKPWQLALGAVVLLLVL
WLLL

Specific function: Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor flgM upon sensing ring completion or hook elongation. Flk could inhibit flgM secretion by acting as a braking system for the flagellar- associated ty

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the flk family [H]

Homologues:

Organism=Escherichia coli, GI1788661, Length=313, Percent_Identity=54.3130990415335, Blast_Score=288, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 35814; Mature: 35683

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPLADMPDRPPGRGPSGTAATGEPSLSMQQRTVLERLITRLVALTSQQNAEVWACVKH
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
DLGLKGDSPLLACHFNAAEASLNQRLAAAQDNHHHRQTLAQLSDLLGQGNNRQAVSDYIR
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QHYGQTALHALSQTQLETILHLLQHGQLSIPQPQQRPPTLRPLLPAEHNTLNQLVTKLAA
HHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ATGEPSKLIWQSMLELCGVKSGELIPATHFLPLSYWLQARQTLSAQSAPTLTSLQGALKQ
HCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
PLEAAEWQKIVDFARRSWQVTPQTTLSPAQILALLNKVFVLRVARAQETLAIPQEEPVAR
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
RTWSAKPWQLALGAVVLLLVLWLLL
HCCCCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
THPLADMPDRPPGRGPSGTAATGEPSLSMQQRTVLERLITRLVALTSQQNAEVWACVKH
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
DLGLKGDSPLLACHFNAAEASLNQRLAAAQDNHHHRQTLAQLSDLLGQGNNRQAVSDYIR
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QHYGQTALHALSQTQLETILHLLQHGQLSIPQPQQRPPTLRPLLPAEHNTLNQLVTKLAA
HHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ATGEPSKLIWQSMLELCGVKSGELIPATHFLPLSYWLQARQTLSAQSAPTLTSLQGALKQ
HCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
PLEAAEWQKIVDFARRSWQVTPQTTLSPAQILALLNKVFVLRVARAQETLAIPQEEPVAR
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
RTWSAKPWQLALGAVVLLLVLWLLL
HCCCCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9079927; 11677609 [H]