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The map label for this gene is hisQ [H]

Identifier: 238895827

GI number: 238895827

Start: 3771796

End: 3772482

Strand: Reverse

Name: hisQ [H]

Synonym: KP1_3944

Alternate gene names: 238895827

Gene position: 3772482-3771796 (Counterclockwise)

Preceding gene: 238895828

Following gene: 238895826

Centisome position: 71.88

GC content: 58.52

Gene sequence:

>687_bases
ATGCTGTATGGGTTTTCACAGGTTATTTTGCAGGGTGCGCTCGTCACCCTGGAGCTTGCGCTCAGCTCGGTCGTTCTCGC
CGTCCTGATTGGGCTGGCGGGCGCTGGCGCAAAGTTATCGAGCAACCGTCCACTGGCGCTGGTGTTTGAAGGCTATACCA
CTCTTATCCGCGGCGTGCCCGATCTGGTGCTGATGCTGCTGATTTTCTACGGCCTGCAGATTGCGCTAAACAGCGTTACC
GACGCGCTGGGTATGGCCCAGTTTGATATCGATCCGATGATCGCCGGGATTATTACCCTTGGCTTTATCTATGGCGCCTA
TTTTACGGAAACCTTCCGCGGCGCCTACCTGGCGGTGCCGAAGGGGCATATCGAAGCGGCTACCGCCTTTGGCTTTAGCG
GCGGGCAGACGTTCCGGCGTATTCTCTTCCCGGCGATGATGCGCTACGCGCTGCCGGGGATAGGCAACAACTGGCAGGTT
ATCCTCAAGGCGACGGCGCTGGTCTCGTTGCTGGGGCTGGAGGATGTGGTCAAAGCCACGCAGCTGGCCGGGAAAAGCAC
CTGGCAGCCGTTCTACTTCGCCATCGTCTGCGGCCTGATTTATCTGGTGTTTACCACCGTTTCTAATGGCGTACTGCTGC
TGCTCGAACGCCGCTATACCGTTGGCGTGAAGAGGGCTGACCTGTGA

Upstream 100 bases:

>100_bases
AAAAAATATTTCGATTTTAACGTATACGGCGAATAATTCTCACGCCTCGCCATTGCGTGCGTTTCGCGCGCAATGGTGAA
TGACAGACAGGGTAGGCAGC

Downstream 100 bases:

>100_bases
TTGAAATTATTCAGGAGTACTGGAAATCACTACTGTGGACCGACGGCTATCGCTTTACCGGTGTGGCAATTACCTTATGG
TTGCTGATCTCTTCAGTGGT

Product: histidine transport system permease component

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MLYGFSQVILQGALVTLELALSSVVLAVLIGLAGAGAKLSSNRPLALVFEGYTTLIRGVPDLVLMLLIFYGLQIALNSVT
DALGMAQFDIDPMIAGIITLGFIYGAYFTETFRGAYLAVPKGHIEAATAFGFSGGQTFRRILFPAMMRYALPGIGNNWQV
ILKATALVSLLGLEDVVKATQLAGKSTWQPFYFAIVCGLIYLVFTTVSNGVLLLLERRYTVGVKRADL

Sequences:

>Translated_228_residues
MLYGFSQVILQGALVTLELALSSVVLAVLIGLAGAGAKLSSNRPLALVFEGYTTLIRGVPDLVLMLLIFYGLQIALNSVT
DALGMAQFDIDPMIAGIITLGFIYGAYFTETFRGAYLAVPKGHIEAATAFGFSGGQTFRRILFPAMMRYALPGIGNNWQV
ILKATALVSLLGLEDVVKATQLAGKSTWQPFYFAIVCGLIYLVFTTVSNGVLLLLERRYTVGVKRADL
>Mature_228_residues
MLYGFSQVILQGALVTLELALSSVVLAVLIGLAGAGAKLSSNRPLALVFEGYTTLIRGVPDLVLMLLIFYGLQIALNSVT
DALGMAQFDIDPMIAGIITLGFIYGAYFTETFRGAYLAVPKGHIEAATAFGFSGGQTFRRILFPAMMRYALPGIGNNWQV
ILKATALVSLLGLEDVVKATQLAGKSTWQPFYFAIVCGLIYLVFTTVSNGVLLLLERRYTVGVKRADL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=228, Percent_Identity=87.280701754386, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1787087, Length=224, Percent_Identity=34.8214285714286, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788645, Length=216, Percent_Identity=31.4814814814815, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1788226, Length=201, Percent_Identity=29.8507462686567, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1787030, Length=218, Percent_Identity=29.8165137614679, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1786873, Length=210, Percent_Identity=26.1904761904762, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787086, Length=210, Percent_Identity=27.1428571428571, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786874, Length=218, Percent_Identity=27.5229357798165, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24540; Mature: 24540

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYGFSQVILQGALVTLELALSSVVLAVLIGLAGAGAKLSSNRPLALVFEGYTTLIRGVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHCCH
DLVLMLLIFYGLQIALNSVTDALGMAQFDIDPMIAGIITLGFIYGAYFTETFRGAYLAVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
KGHIEAATAFGFSGGQTFRRILFPAMMRYALPGIGNNWQVILKATALVSLLGLEDVVKAT
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAGKSTWQPFYFAIVCGLIYLVFTTVSNGVLLLLERRYTVGVKRADL
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHCCCCCCC
>Mature Secondary Structure
MLYGFSQVILQGALVTLELALSSVVLAVLIGLAGAGAKLSSNRPLALVFEGYTTLIRGVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHCCH
DLVLMLLIFYGLQIALNSVTDALGMAQFDIDPMIAGIITLGFIYGAYFTETFRGAYLAVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
KGHIEAATAFGFSGGQTFRRILFPAMMRYALPGIGNNWQVILKATALVSLLGLEDVVKAT
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAGKSTWQPFYFAIVCGLIYLVFTTVSNGVLLLLERRYTVGVKRADL
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]