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The map label for this gene is hisM [H]

Identifier: 238895826

GI number: 238895826

Start: 3771083

End: 3771799

Strand: Reverse

Name: hisM [H]

Synonym: KP1_3943

Alternate gene names: 238895826

Gene position: 3771799-3771083 (Counterclockwise)

Preceding gene: 238895827

Following gene: 238895825

Centisome position: 71.86

GC content: 52.3

Gene sequence:

>717_bases
GTGATTGAAATTATTCAGGAGTACTGGAAATCACTACTGTGGACCGACGGCTATCGCTTTACCGGTGTGGCAATTACCTT
ATGGTTGCTGATCTCTTCAGTGGTAATGGGGGGCATCCTGGCGGTGTTTCTGGCCATCGGCCGCGTCTCGAGCAATAAGT
TTATCCAGTTCCCCATCTGGCTGTTCACTTACATATTTCGCGGTACGCCGCTGTATGTGCAACTGCTGGTTTTTTACTCC
GGCATGTATACCCTGGAAATCGTCAAAGGCACGGAGCTGTTGAACGCTTTTTTCCGCAGCGGGCTAAACTGCACGGTTCT
GGCGTTAACCCTGAATACTTGCGCCTATACCACTGAAATTTTCGCCGGCGCGATCCGTTCAGTACCCGCCGGAGAAATTG
AAGCAGCGCGGGCCTACGGCTTCTCGTCAGTCAAACTGTATCGCTGCATTATTCTGCCTTCCGCGCTGCGGATTGCACTG
CCGGCCTACAGTAACGAAGTGATCCTCATGCTGCACTCTACCGCGCTGGCGTTTACCGCTACGGTACCGGATCTGCTGAA
AATCGCCCGCGATATCAACTCGGCCACCTATCAGCCGTTCACCGCGTTTGGCATCGCCGCGGTGCTCTATTTAATTATCT
CGTATGTGCTGATTAGCTTGTTCCGTAAAGCGGAAAAGCGCTGGTTGCAGCATATCAAACCTTCTTCGACGCATTGA

Upstream 100 bases:

>100_bases
TCGTCTGCGGCCTGATTTATCTGGTGTTTACCACCGTTTCTAATGGCGTACTGCTGCTGCTCGAACGCCGCTATACCGTT
GGCGTGAAGAGGGCTGACCT

Downstream 100 bases:

>100_bases
GAACGCCATGTCCGACAATAAATTAAACGTTATCGATCTGCATAAACGCTATGGGGAACACGAGGTGCTGAAGGGCGTCT
CGCTGCAGGCGAAAGCCGGG

Product: histidine transport system permease component

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MIEIIQEYWKSLLWTDGYRFTGVAITLWLLISSVVMGGILAVFLAIGRVSSNKFIQFPIWLFTYIFRGTPLYVQLLVFYS
GMYTLEIVKGTELLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPAGEIEAARAYGFSSVKLYRCIILPSALRIAL
PAYSNEVILMLHSTALAFTATVPDLLKIARDINSATYQPFTAFGIAAVLYLIISYVLISLFRKAEKRWLQHIKPSSTH

Sequences:

>Translated_238_residues
MIEIIQEYWKSLLWTDGYRFTGVAITLWLLISSVVMGGILAVFLAIGRVSSNKFIQFPIWLFTYIFRGTPLYVQLLVFYS
GMYTLEIVKGTELLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPAGEIEAARAYGFSSVKLYRCIILPSALRIAL
PAYSNEVILMLHSTALAFTATVPDLLKIARDINSATYQPFTAFGIAAVLYLIISYVLISLFRKAEKRWLQHIKPSSTH
>Mature_238_residues
MIEIIQEYWKSLLWTDGYRFTGVAITLWLLISSVVMGGILAVFLAIGRVSSNKFIQFPIWLFTYIFRGTPLYVQLLVFYS
GMYTLEIVKGTELLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPAGEIEAARAYGFSSVKLYRCIILPSALRIAL
PAYSNEVILMLHSTALAFTATVPDLLKIARDINSATYQPFTAFGIAAVLYLIISYVLISLFRKAEKRWLQHIKPSSTH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=238, Percent_Identity=93.2773109243697, Blast_Score=456, Evalue=1e-130,
Organism=Escherichia coli, GI1788226, Length=213, Percent_Identity=35.2112676056338, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787086, Length=208, Percent_Identity=31.7307692307692, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788646, Length=225, Percent_Identity=32, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787030, Length=206, Percent_Identity=28.1553398058252, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787087, Length=221, Percent_Identity=26.6968325791855, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1786874, Length=203, Percent_Identity=28.0788177339901, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082239, Length=212, Percent_Identity=27.3584905660377, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786873, Length=211, Percent_Identity=27.9620853080569, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI48994930, Length=209, Percent_Identity=26.7942583732057, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26649; Mature: 26649

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEIIQEYWKSLLWTDGYRFTGVAITLWLLISSVVMGGILAVFLAIGRVSSNKFIQFPIW
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHH
LFTYIFRGTPLYVQLLVFYSGMYTLEIVKGTELLNAFFRSGLNCTVLALTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIRSVPAGEIEAARAYGFSSVKLYRCIILPSALRIALPAYSNEVILMLHSTALAFTA
HHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHH
TVPDLLKIARDINSATYQPFTAFGIAAVLYLIISYVLISLFRKAEKRWLQHIKPSSTH
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIEIIQEYWKSLLWTDGYRFTGVAITLWLLISSVVMGGILAVFLAIGRVSSNKFIQFPIW
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHH
LFTYIFRGTPLYVQLLVFYSGMYTLEIVKGTELLNAFFRSGLNCTVLALTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIRSVPAGEIEAARAYGFSSVKLYRCIILPSALRIALPAYSNEVILMLHSTALAFTA
HHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHH
TVPDLLKIARDINSATYQPFTAFGIAAVLYLIISYVLISLFRKAEKRWLQHIKPSSTH
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]