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The map label for this gene is menB [H]

Identifier: 238895787

GI number: 238895787

Start: 3732227

End: 3733084

Strand: Reverse

Name: menB [H]

Synonym: KP1_3901

Alternate gene names: 238895787

Gene position: 3733084-3732227 (Counterclockwise)

Preceding gene: 238895788

Following gene: 238895786

Centisome position: 71.13

GC content: 58.97

Gene sequence:

>858_bases
ATGATCTCTCTTGATGAAGCAATGCTCTACGCCCCCGTTGAATGGCACGATTGCTCCGAAGGCTATACCGATATTCGCTA
TCACAAATCGACTGACGGGATTGCCAAAATCACCATTAATCGTCCGCAGGTGCGCAACGCCTTCCGCCCGCTGACCGTCA
AAGAGATGATCCAGGCGCTGGCGGATGCCCGGTATGACGACAATATCGGCGTCATCGTGCTGACCGGTGAAGGTGAGAAA
GCCTTCTGCGCCGGCGGCGACCAGAAAGTCCGCGGCGACTACGGCGGCTATCAGGACGACTCCGGCGTTCATCATCTTAA
CGTGCTCGACTTCCAGCGTCAGATCCGCACCTGCCCGAAACCGGTGGTCGCGATGGTGGCCGGCTACTCTATCGGCGGCG
GTCACGTGCTGCATATGATGTGCGATCTGACTATCGCGGCGGAAAACGCCATCTTCGGCCAGACCGGGCCAAAAGTCGGC
TCATTCGACGGCGGCTGGGGCGCCTCCTATATGGCGCGGATCGTCGGGCAGAAAAAAGCGCGCGAAATCTGGTTCCTGTG
CCGCCAGTATGACGCTCAGCAGGCGCTGGACATGGGGCTGGTGAATACCGTGGTACCGCTGGCGGATCTGGAAAAAGAGA
CCGTGCGCTGGTGTCGTGAAATGCTGCAGAACAGCCCGATGGCCTTGCGCTGCCTGAAAGCGGCGCTGAACGCCGACTGC
GACGGCCAGGCTGGTCTGCAGGAGCTGGCGGGCAACGCCACCATGCTGTTCTATATGACGGAAGAGGGGCAGGAAGGCCG
CAATGCCTTCAACCAAAAACGTCAGCCGGACTTCAGCAAATTTAAACGGAATCCATAA

Upstream 100 bases:

>100_bases
ATCTTATTCACCATGCCGGACACAACGCGCACCGGGACAACCCGGCGGCGGTGATTGCCTGTCTGGCGCAGATTCTGGCA
AGTTAACTGAAGGACATTCT

Downstream 100 bases:

>100_bases
TGCGCGTTTCGCAGGTTTACCGCTGGCAGATACCGATGGACGCGGGCGTGGTGCTGCGCGAGCGGCGGTTAAAAACCCGC
GACGGGCTGTTCATCCGCCT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MISLDEAMLYAPVEWHDCSEGYTDIRYHKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIVLTGEGEK
AFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP

Sequences:

>Translated_285_residues
MISLDEAMLYAPVEWHDCSEGYTDIRYHKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIVLTGEGEK
AFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP
>Mature_285_residues
MISLDEAMLYAPVEWHDCSEGYTDIRYHKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIVLTGEGEK
AFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=245, Percent_Identity=34.6938775510204, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI31542718, Length=252, Percent_Identity=30.5555555555556, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=29.1866028708134, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=29.1866028708134, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=29.1866028708134, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4502327, Length=253, Percent_Identity=28.4584980237154, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI157694516, Length=225, Percent_Identity=24.4444444444444, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI213417737, Length=225, Percent_Identity=24.4444444444444, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI70995211, Length=239, Percent_Identity=28.0334728033473, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI37594469, Length=142, Percent_Identity=28.8732394366197, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI37594471, Length=142, Percent_Identity=28.8732394366197, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1788597, Length=285, Percent_Identity=95.7894736842105, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI1787659, Length=247, Percent_Identity=33.6032388663968, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI87082183, Length=255, Percent_Identity=27.843137254902, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI221142681, Length=207, Percent_Identity=31.4009661835749, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787660, Length=257, Percent_Identity=29.5719844357977, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=255, Percent_Identity=32.9411764705882, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17554946, Length=248, Percent_Identity=32.258064516129, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=234, Percent_Identity=26.0683760683761, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=27.1428571428571, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=264, Percent_Identity=27.6515151515151, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=197, Percent_Identity=25.8883248730964, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=190, Percent_Identity=30, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=34.9397590361446, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=34.9397590361446, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653139, Length=278, Percent_Identity=27.6978417266187, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21357171, Length=251, Percent_Identity=29.0836653386454, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24654903, Length=184, Percent_Identity=28.2608695652174, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19922422, Length=202, Percent_Identity=27.7227722772277, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650670, Length=178, Percent_Identity=31.4606741573034, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31625; Mature: 31625

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLDEAMLYAPVEWHDCSEGYTDIRYHKSTDGIAKITINRPQVRNAFRPLTVKEMIQAL
CCCCCCCCEECCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHHHHCCCCCHHHHHHHH
ADARYDDNIGVIVLTGEGEKAFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPK
HCCCCCCCCEEEEEECCCCEEEECCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCH
PVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHCCCCCCHHHHHHHHHHHEEECCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHCCCC
>Mature Secondary Structure
MISLDEAMLYAPVEWHDCSEGYTDIRYHKSTDGIAKITINRPQVRNAFRPLTVKEMIQAL
CCCCCCCCEECCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHHHHCCCCCHHHHHHHH
ADARYDDNIGVIVLTGEGEKAFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPK
HCCCCCCCCEEEEEECCCCEEEECCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCH
PVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHCCCCCCHHHHHHHHHHHEEECCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]