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The map label for this gene is yfaU

Identifier: 238895777

GI number: 238895777

Start: 3721833

End: 3722636

Strand: Reverse

Name: yfaU

Synonym: KP1_3885

Alternate gene names: 238895777

Gene position: 3722636-3721833 (Counterclockwise)

Preceding gene: 238895778

Following gene: 238895773

Centisome position: 70.93

GC content: 61.94

Gene sequence:

>804_bases
ATGAACGCACTGTTATCTAACCCCTTCAAACGGGGATTATTACGCGGTGAGACGCAAATCGGCCTGTGGCTGAGCTCCAC
CTCATCCTACATGGCGGAGATCGCTGCGACGTCGGGATACGACTGGCTGCTGATCGACGGCGAGCATGCCCCGAACACCA
TTCAGGACCTTTATCATCAGCTGCAGGCGATTGCCCCCTATGCCAGCCAGCCGGTCATTCGCCCGGTCGAGGGCAACCGC
AGCCTGATAAAACAGGTGCTGGATATTGGCGCCAGAACCTTGCTGGTGCCGATGGTCGATACCGCCGAGCAGGCTCGGGA
GGTGGTCTCAGCGACCCGTTATCCCCCCATCGGGAGCCGCGGCGTTGGCGCCGGCGTGGCGAGAGCGGCGCGCTGGGGAA
GGGTGGAGAATTATATGGCGGAGGCAAATGACGAACTTTGTCTGCTGATTCAGGTCGAGAGCCGAACCGCGCTGGAGAAC
CTGGACGCTATTCTCGAGGTGGACGGCATTGACGGGGTGTTCATCGGTCCGGCGGATCTCTCCGCCTCGCTGGGCTACCC
GGACGATGCCGGTCACCCTGACGTGCAGCGGGTGATCGAGCAGAGCATCCGGCGCATTCGCGCGGCGGGGAAAGCGGCCG
GATTTCTGGCGGTCGACCCGGCGATGGCGGAAAAATGTCTTGCCTGGGGGGCCAACTTTGTCGCCGTCGGGGTGGATACC
ATGCTGTATACCCAGGCGCTGGACCGCCGGCTGGCGATGTTTAAATCTGACAGCGCCCAGCCGCAAGAGAAAACGAGCTA
TTGA

Upstream 100 bases:

>100_bases
CCGGCGTCGCCATTGTCGGGGTGGTCATTATCTTTTCATTGAGCCTTACCCGCGCGGTACCCCAGCGCGGCAGCGTACAG
CATTGAATAAAGGAATCGCT

Downstream 100 bases:

>100_bases
CGGCACAGGCTGGCGCTGGGCTCAGACGAGCGCCTGCGCCAGCACCGTCAGCGGATGCTCGCAGCGTTTGCTGGTGGACA
TCTCAATCTGCCATTTGCAG

Product: putative aldolase

Products: NA

Alternate protein names: KDR aldolase; 2-dehydro-3-deoxyrhamnonate aldolase

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MNALLSNPFKRGLLRGETQIGLWLSSTSSYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQLQAIAPYASQPVIRPVEGNR
SLIKQVLDIGARTLLVPMVDTAEQAREVVSATRYPPIGSRGVGAGVARAARWGRVENYMAEANDELCLLIQVESRTALEN
LDAILEVDGIDGVFIGPADLSASLGYPDDAGHPDVQRVIEQSIRRIRAAGKAAGFLAVDPAMAEKCLAWGANFVAVGVDT
MLYTQALDRRLAMFKSDSAQPQEKTSY

Sequences:

>Translated_267_residues
MNALLSNPFKRGLLRGETQIGLWLSSTSSYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQLQAIAPYASQPVIRPVEGNR
SLIKQVLDIGARTLLVPMVDTAEQAREVVSATRYPPIGSRGVGAGVARAARWGRVENYMAEANDELCLLIQVESRTALEN
LDAILEVDGIDGVFIGPADLSASLGYPDDAGHPDVQRVIEQSIRRIRAAGKAAGFLAVDPAMAEKCLAWGANFVAVGVDT
MLYTQALDRRLAMFKSDSAQPQEKTSY
>Mature_267_residues
MNALLSNPFKRGLLRGETQIGLWLSSTSSYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQLQAIAPYASQPVIRPVEGNR
SLIKQVLDIGARTLLVPMVDTAEQAREVVSATRYPPIGSRGVGAGVARAARWGRVENYMAEANDELCLLIQVESRTALEN
LDAILEVDGIDGVFIGPADLSASLGYPDDAGHPDVQRVIEQSIRRIRAAGKAAGFLAVDPAMAEKCLAWGANFVAVGVDT
MLYTQALDRRLAMFKSDSAQPQEKTSY

Specific function: Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde

COG id: COG3836

COG function: function code G; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily

Homologues:

Organism=Escherichia coli, GI1788578, Length=267, Percent_Identity=83.1460674157303, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1789514, Length=254, Percent_Identity=42.1259842519685, Blast_Score=215, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RHMA_KLEP7 (A6TBU6)

Other databases:

- EMBL:   CP000647
- RefSeq:   YP_001336297.1
- ProteinModelPortal:   A6TBU6
- SMR:   A6TBU6
- STRING:   A6TBU6
- GeneID:   5341826
- GenomeReviews:   CP000647_GR
- KEGG:   kpn:KPN_02650
- eggNOG:   COG3836
- HOGENOM:   HBG747616
- OMA:   SIGSELH
- ProtClustDB:   PRK10128
- HAMAP:   MF_01290
- InterPro:   IPR005000
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60

Pfam domain/function: PF03328 HpcH_HpaI; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 28917; Mature: 28917

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: ACT_SITE 49-49 BINDING 151-151 BINDING 178-178 BINDING 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALLSNPFKRGLLRGETQIGLWLSSTSSYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQ
CCCCCCCHHHHHHHCCCCEEEEEEECHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHH
LQAIAPYASQPVIRPVEGNRSLIKQVLDIGARTLLVPMVDTAEQAREVVSATRYPPIGSR
HHHHCCCCCCCCEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCC
GVGAGVARAARWGRVENYMAEANDELCLLIQVESRTALENLDAILEVDGIDGVFIGPADL
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHEEECCCCEEEECCCCC
SASLGYPDDAGHPDVQRVIEQSIRRIRAAGKAAGFLAVDPAMAEKCLAWGANFVAVGVDT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCEEEEHHHH
MLYTQALDRRLAMFKSDSAQPQEKTSY
HHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNALLSNPFKRGLLRGETQIGLWLSSTSSYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQ
CCCCCCCHHHHHHHCCCCEEEEEEECHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHH
LQAIAPYASQPVIRPVEGNRSLIKQVLDIGARTLLVPMVDTAEQAREVVSATRYPPIGSR
HHHHCCCCCCCCEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCC
GVGAGVARAARWGRVENYMAEANDELCLLIQVESRTALENLDAILEVDGIDGVFIGPADL
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHEEECCCCEEEECCCCC
SASLGYPDDAGHPDVQRVIEQSIRRIRAAGKAAGFLAVDPAMAEKCLAWGANFVAVGVDT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCEEEEHHHH
MLYTQALDRRLAMFKSDSAQPQEKTSY
HHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA