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The map label for this gene is uge [C]

Identifier: 238895614

GI number: 238895614

Start: 3519637

End: 3520641

Strand: Direct

Name: uge [C]

Synonym: KP1_3699

Alternate gene names: 238895614

Gene position: 3519637-3520641 (Clockwise)

Preceding gene: 238895606

Following gene: 238895635

Centisome position: 67.06

GC content: 55.32

Gene sequence:

>1005_bases
ATGAAGTTTTTGGTCACTGGTGCCGCAGGTTTTATCGGCTTCCATATCGCGCAGCGCCTGCTGAATGAAGGGCATGATGT
TGTCGGAATCGACAACATGAACGACTATTATGACGTCAGCCTGAAGCAGGCCCGTCTGGATCGCCTGGCATCTCCGGCAT
TCCATTTCCAGCAGCTGGATCTGGCCGACCGTGAAGGTATGGCAAAGCTGTTCGCCACAGAGCAATTTGACCGCGTGATC
CACCTGGCCGCCCAGGCCGGGGTGCGCTACTCGCTGGAAAACCCGTATGCCTACGCAGACGCTAACCTGATGGGGTACCT
GAACATTCTGGAAGGCTGCCGTCATACCAAGGTGAAACACCTGGTGTACGCCTCCTCCAGCTCGGTTTACGGCCTTAACC
GTAAAATGCCGTTCTCCACCGAAGATTCCGTCGATCATCCGGTCTCCCTGTATGCCGCCACCAAGAAAGCCAATGAGCTG
ATGGCGCATACCTATTCCCACCTGTACGGCATCCCGACCACCGGGCTGCGCTTCTTTACGGTTTATGGTCCGTGGGGTCG
CCCGGATATGGCGCTGTTCAAGTTCACGAAAGCGATGCTGGAAGGAAAAAGTATCGACGTTTACAACTACGGCAAAATGA
AGCGCGACTTCACCTATATCGACGACATCGTCGAGGCGGTGGTTCGGGTGCAGGATGTAATCCCGCAGGCCAATGCCGAC
TGGACCGTTGAGAGCGGTTCCCCGGCAACCAGTTCCGCGCCGTATCGGGTATATAACATTGGCAACAGCTCACCAGTGGA
ACTGATGGACTACATCACCGCTCTGGAAGAAGCGCTTGGAATGGAAGCGCAGAAGAATATGATGCCGATTCAGCCGGGCG
ATGTGCTGGACACCAGCGCAGACACCCAACCGCTGTATGACCTGGTGGGCTTTAGGCCGCAAACGTCAGTGAAGGAAGGC
GTGAAGAACTTCGTGGAGTGGTACAAGGATTACTATCAGATCTAG

Upstream 100 bases:

>100_bases
CTTGCATATCTTGTCATGGCAAAGCAAGTGATCCCAACCGCAAGCCAGTGTAAAATCGGCACTTATGTAGAACGGGATAT
CCACACCCCGGAGGAAAAAT

Downstream 100 bases:

>100_bases
TCCCCCTGCCCTGCCGCAATCGTCAGATTGCGGCACCTCTTCTATGGAACCTCCGTTATCCGGGCTATATGTCGACTGAA
TGCACATTCATTGTTTTATA

Product: uridine diphosphate galacturonate 4-epimerase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKFLVTGAAGFIGFHIAQRLLNEGHDVVGIDNMNDYYDVSLKQARLDRLASPAFHFQQLDLADREGMAKLFATEQFDRVI
HLAAQAGVRYSLENPYAYADANLMGYLNILEGCRHTKVKHLVYASSSSVYGLNRKMPFSTEDSVDHPVSLYAATKKANEL
MAHTYSHLYGIPTTGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIVEAVVRVQDVIPQANAD
WTVESGSPATSSAPYRVYNIGNSSPVELMDYITALEEALGMEAQKNMMPIQPGDVLDTSADTQPLYDLVGFRPQTSVKEG
VKNFVEWYKDYYQI

Sequences:

>Translated_334_residues
MKFLVTGAAGFIGFHIAQRLLNEGHDVVGIDNMNDYYDVSLKQARLDRLASPAFHFQQLDLADREGMAKLFATEQFDRVI
HLAAQAGVRYSLENPYAYADANLMGYLNILEGCRHTKVKHLVYASSSSVYGLNRKMPFSTEDSVDHPVSLYAATKKANEL
MAHTYSHLYGIPTTGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIVEAVVRVQDVIPQANAD
WTVESGSPATSSAPYRVYNIGNSSPVELMDYITALEEALGMEAQKNMMPIQPGDVLDTSADTQPLYDLVGFRPQTSVKEG
VKNFVEWYKDYYQI
>Mature_334_residues
MKFLVTGAAGFIGFHIAQRLLNEGHDVVGIDNMNDYYDVSLKQARLDRLASPAFHFQQLDLADREGMAKLFATEQFDRVI
HLAAQAGVRYSLENPYAYADANLMGYLNILEGCRHTKVKHLVYASSSSVYGLNRKMPFSTEDSVDHPVSLYAATKKANEL
MAHTYSHLYGIPTTGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIVEAVVRVQDVIPQANAD
WTVESGSPATSSAPYRVYNIGNSSPVELMDYITALEEALGMEAQKNMMPIQPGDVLDTSADTQPLYDLVGFRPQTSVKEG
VKNFVEWYKDYYQI

Specific function: DTDP-L-RHAMNOSE BIOSYNTHESIS WITHIN THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE BIOSYNTHESIS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=342, Percent_Identity=26.9005847953216, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI56237023, Length=351, Percent_Identity=23.6467236467236, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI56118217, Length=351, Percent_Identity=23.6467236467236, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI189083684, Length=351, Percent_Identity=23.6467236467236, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI42516563, Length=338, Percent_Identity=22.4852071005917, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1788353, Length=355, Percent_Identity=27.0422535211268, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI48994969, Length=349, Percent_Identity=27.5071633237822, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1786974, Length=346, Percent_Identity=24.2774566473988, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788589, Length=246, Percent_Identity=27.6422764227642, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788366, Length=205, Percent_Identity=29.2682926829268, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71982035, Length=351, Percent_Identity=26.4957264957265, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71982038, Length=353, Percent_Identity=26.3456090651558, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17568069, Length=232, Percent_Identity=29.7413793103448, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17539532, Length=339, Percent_Identity=24.188790560472, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17539422, Length=243, Percent_Identity=27.1604938271605, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133901788, Length=243, Percent_Identity=27.1604938271605, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133901786, Length=243, Percent_Identity=27.1604938271605, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133901790, Length=243, Percent_Identity=27.1604938271605, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539424, Length=243, Percent_Identity=27.5720164609054, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507723, Length=243, Percent_Identity=26.3374485596708, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532424, Length=342, Percent_Identity=22.5146198830409, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=345, Percent_Identity=27.2463768115942, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19923002, Length=347, Percent_Identity=25.6484149855908, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356223, Length=237, Percent_Identity=28.2700421940928, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 37580; Mature: 37580

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLVTGAAGFIGFHIAQRLLNEGHDVVGIDNMNDYYDVSLKQARLDRLASPAFHFQQLD
CEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHCC
LADREGMAKLFATEQFDRVIHLAAQAGVRYSLENPYAYADANLMGYLNILEGCRHTKVKH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHE
LVYASSSSVYGLNRKMPFSTEDSVDHPVSLYAATKKANELMAHTYSHLYGIPTTGLRFFT
EEEECCCCEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
VYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIVEAVVRVQDVIPQANAD
EECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
WTVESGSPATSSAPYRVYNIGNSSPVELMDYITALEEALGMEAQKNMMPIQPGDVLDTSA
EEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCC
DTQPLYDLVGFRPQTSVKEGVKNFVEWYKDYYQI
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFLVTGAAGFIGFHIAQRLLNEGHDVVGIDNMNDYYDVSLKQARLDRLASPAFHFQQLD
CEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHCC
LADREGMAKLFATEQFDRVIHLAAQAGVRYSLENPYAYADANLMGYLNILEGCRHTKVKH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHE
LVYASSSSVYGLNRKMPFSTEDSVDHPVSLYAATKKANELMAHTYSHLYGIPTTGLRFFT
EEEECCCCEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
VYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIVEAVVRVQDVIPQANAD
EECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
WTVESGSPATSSAPYRVYNIGNSSPVELMDYITALEEALGMEAQKNMMPIQPGDVLDTSA
EEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCC
DTQPLYDLVGFRPQTSVKEGVKNFVEWYKDYYQI
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.019 {NAD+}} 0.034 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: TDP; TTP [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7682279 [H]