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The map label for this gene is zwf [H]

Identifier: 238895428

GI number: 238895428

Start: 3314769

End: 3316244

Strand: Reverse

Name: zwf [H]

Synonym: KP1_3496

Alternate gene names: 238895428

Gene position: 3316244-3314769 (Counterclockwise)

Preceding gene: 238895429

Following gene: 238895427

Centisome position: 63.18

GC content: 56.98

Gene sequence:

>1476_bases
ATGGCGGTAACGCAAACGGCCCAGGCATGCGACCTGGTCATTTTCGGCGCGAAGGGCGACCTGGCGCGGCGTAAATTGTT
GCCTTCCCTGTATCAGCTTGAAAAGGCGGGCCAGATCCACGCTGACACCAGAATCATTGGCGTCGGCCGTGCCGACTGGG
ATAAAGCGGCTTATACCAAAGTCGTGCGCGAAGCGCTGGAAACCTTCATGAAGGAAAAAATTGATGAAGGTTTGTGGGAT
ACCCTGAGCGGACGCCTGGAGTTCTGTAATCTTGACGTCAATGACACCAGCGGCTTCACCCGCCTGGGTGAGATGCTGGA
TCAAAAGAACCGTGTCACCATCAACTATTTCGCTATGCCGCCGAGCACCTTTGGCGCGATCTGTAAAGGGCTGGGCGAAG
CGAAGCTTAATGCCAAGCCTGCGCGCGTGGTCATGGAAAAACCGCTCGGCACCTCGCTGGAAACCTCCCGTGAAATCAAC
GACCAGGTCGGCGAGTTTTTTGAAGAGTGTCAGGTCTACCGTATCGACCACTATCTCGGTAAAGAGACGGTCCTCAACCT
GCTGGCGCTGCGCTTCGCCAACTCCCTGTTCGTCAATAACTGGGACTGCCGCACCATCGATCACGTCGAAATCACCGTCG
CGGAAGAGGTGGGTATTGAAGGGCGCTGGGGTTACTTCGACCAGGCCGGGCAGATGCGCGACATGATCCAGAACCACCTG
CTGCAGATCCTGTGCATGATTGCCATGTCGCCGCCGTCCGATCTCAGCGCCGACAGCATCCGTGATGAAAAGGTCAAGGT
GCTGAAATCCCTGCGCCGTATTGACCGCTCCAACGTGCGCGAGAAAACCGTTCGCGGCCAGTATACCGCCGGCTTTGCCC
AGGGCAAAAAAGTGCCTGGCTATCTCGAAGAGGAGGGGGCCAACAAGACCAGCAACACCGAAACCTTCGTGGCGATCCGC
GTCGATATCGATAACTGGCGCTGGGCTGGCGTACCGTTCTATCTGCGCACCGGCAAACGTCTGCCGACCAAATGCTCAGA
GGTAGTGGTTTACTTCAAAACCCCGGAACTGAATCTGTTTAAAGAGACCTGGCAGGAGCTGCCGCAGAACAAGCTGACCA
TTCGCCTGCAGCCGGACGAAGGGGTAGATATCCAGGTACTGAACAAAGTGCCGGGCCTCGATCATAAACATAACCTGCAG
ATCACTAAACTGGATCTGAGCTACTCCGAAACCTTCAACCAGACGCACCTGGCCGATGCCTATGAACGTCTGCTGCTGGA
GACCATGCGTGGCATCCAGGCGCTGTTCGTTCGCCGCGACGAAGTAGAAGAGGCGTGGAAATGGGTTGACTCCATTACCG
AAGCCTGGGCAGCCGACCGCGATGCGCCGAAACCGTATCAGGCCGGGACCTGGGGACCGGTTGCGTCGGTGGCCATGATC
ACTCGCGACGGTCGTTCATGGAACGAGTTCGAGTAA

Upstream 100 bases:

>100_bases
GAAGGCTTTCGGGAAATACGTAAACACAGTACAGTGCAGTGTAAGAAAATTACAAATATAGCCTGGCAAAAGCACCAGAC
TATCAACTGAGGAGAATGAC

Downstream 100 bases:

>100_bases
GGCTGGAGGCTAATCCGTCAGGGTTATTTTACCGGTAACATGATCTGACGCAGAAAGTCGCACGCTTTTTAATCTTTTAA
GCCCCGTGAGGATTCACCCA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGLWD
TLSGRLEFCNLDVNDTSGFTRLGEMLDQKNRVTINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLETSREIN
DQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKTSNTETFVAIR
VDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQELPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQ
ITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWGPVASVAMI
TRDGRSWNEFE

Sequences:

>Translated_491_residues
MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGLWD
TLSGRLEFCNLDVNDTSGFTRLGEMLDQKNRVTINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLETSREIN
DQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKTSNTETFVAIR
VDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQELPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQ
ITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWGPVASVAMI
TRDGRSWNEFE
>Mature_490_residues
AVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGLWDT
LSGRLEFCNLDVNDTSGFTRLGEMLDQKNRVTINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLETSREIND
QVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHLL
QILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKTSNTETFVAIRV
DIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQELPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQI
TKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWGPVASVAMIT
RDGRSWNEFE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=36.2886597938144, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=36.2886597938144, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI52145310, Length=496, Percent_Identity=26.8145161290323, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=95.7230142566191, Blast_Score=985, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=36.4948453608247, Blast_Score=307, Evalue=9e-84,
Organism=Saccharomyces cerevisiae, GI6324088, Length=475, Percent_Identity=33.6842105263158, Blast_Score=271, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24643350, Length=478, Percent_Identity=36.4016736401674, Blast_Score=283, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24643352, Length=478, Percent_Identity=36.4016736401674, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI221513548, Length=488, Percent_Identity=27.8688524590164, Blast_Score=178, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55872; Mature: 55741

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTK
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCHHHHHHH
VVREALETFMKEKIDEGLWDTLSGRLEFCNLDVNDTSGFTRLGEMLDQKNRVTINYFAMP
HHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECC
PSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLETSREINDQVGEFFEECQVYRIDHYLG
CHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHHHC
KETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
HHHHHHHHHHHHHHHHHCCCCCCCEECCEEEEEHHHCCCCCCCCCHHCCHHHHHHHHHHH
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCC
YLEEEGANKTSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLF
CHHHCCCCCCCCCEEEEEEEEEECCCEECCCCEEEECCCCCCCCCCCEEEEEECCCCHHH
KETWQELPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQITKLDLSYSETFNQTHLADA
HHHHHHCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHH
YERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWGPVASVAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEE
TRDGRSWNEFE
EECCCCCCCCC
>Mature Secondary Structure 
AVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTK
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCHHHHHHH
VVREALETFMKEKIDEGLWDTLSGRLEFCNLDVNDTSGFTRLGEMLDQKNRVTINYFAMP
HHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECC
PSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLETSREINDQVGEFFEECQVYRIDHYLG
CHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHHHC
KETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
HHHHHHHHHHHHHHHHHCCCCCCCEECCEEEEEHHHCCCCCCCCCHHCCHHHHHHHHHHH
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCC
YLEEEGANKTSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLF
CHHHCCCCCCCCCEEEEEEEEEECCCEECCCCEEEECCCCCCCCCCCEEEEEECCCCHHH
KETWQELPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQITKLDLSYSETFNQTHLADA
HHHHHHCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHH
YERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWGPVASVAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEE
TRDGRSWNEFE
EECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]