Click here to switch to the map view.

The map label for this gene is edd [H]

Identifier: 238895427

GI number: 238895427

Start: 3312735

End: 3314546

Strand: Reverse

Name: edd [H]

Synonym: KP1_3495

Alternate gene names: 238895427

Gene position: 3314546-3312735 (Counterclockwise)

Preceding gene: 238895428

Following gene: 238895426

Centisome position: 63.15

GC content: 61.09

Gene sequence:

>1812_bases
ATGAATTCGACAATGTTACGGGTAACAAATCGCATTATCGAACGGTCGCGTGACACCCGCGCGGCTTACCTCGCAAGGAT
TAACCAGGCCAAAACCGACACCGTGCATCGTGCGCAACTGGCCTGCGGCAATCTGGCTCACGGATTCGCGGCCTGCCAGG
CTGACGACAAAGCCTCCCTGAAGAGCATGTTGCGCAACAACATTGCCATCATCACCTCCTACAACGACATGTTGTCCGCT
CACCAGCCCTATGAACACTACCCGGAGATCATCCGCAAAGCGCTGCACAGCGCCAATGCGGTCGGCCAGGTCGCCGGCGG
CGTGCCGGCGATGTGCGACGGCGTAACGCAGGGGCAGGACGGGATGGAGCTTTCACTCCTGAGCCGCGAGGTGATCGCTA
TGTCCGCCGCCATCGGCCTGTCGCATAACATGTTCGACGGGGCCCTGTATCTCGGGGTCTGCGATAAAATTGTTCCCGGT
CTGACCATGGCGGCGCTCTCATTTGGCCATCTGCCGTCGGTCTTTATTCCCTCCGGTCCGATGGCCAGCGGCCTGCCGAA
TAAAGAGAAGGTTCGCATTCGCCAGCTGTATGCAGAAGGGAAAGTTGACCGTATGGCGCTGCTGGAGTCCGAAGCCGCCT
CTTATCACGCGCCGGGGACCTGTACTTTCTACGGAACGGCGAACACCAACCAGATGGTGGTCGAATTTATGGGCATGCAG
CTGCCGGGCTCGTCCTTTGTCCATCCGGATGCTCCGCTGCGGGAAGCGCTGACCGCCGCCGCCGCGCGCCAGGTCACCCG
CATGACCGGCAACGGCAATGAGTGGATGCCGCTGGGCAAAATGTTTGACGAAAAAGTGGTGGTCAACGGCATCGTGGCGC
TGCTGGCGACCGGTGGCTCCACCAACCACACTATGCACCTGGTGGCGATGGCCCGCGCGGCGGGAATTATCATTAACTGG
GACGATTTCTCCGACCTGTCAGACGTGGTGCCGCTGCTGGCGCGCCTCTATCCCAACGGCCCGGCGGATATCAACCACTT
CCAGGCGGCAGGCGGCGTTCCGGTACTGGTGCGCGAGCTGCTGAAAGGCGGCCTGCTGCATGAGGATGTTCACACCGTGG
CCGGCTTTGGCCTGTCGCGCTACACCCTGGAGCCATGGCTGAATAACGGCGAGCTGGACTGGCGCGAAGGGGCGACAGCG
CCATTGGACGACCAGGTCATCGCGACCTTTGAAAAACCATTCTCCCGCCACGGCGGCACCAAGGTGCTGAGCGGCAACCT
GGGACGCGCGGTGATGAAAACTTCGGCGGTCCCGGTGGAGAACCAGGTGATTGAAGCGCCGGCGGTGGTATTCGAGAGCC
AGCACGACGTGTTGCCGGCCTTTGAAGCGGGGCTGCTGGACAAAGACTGCGTGGTGGTGGTCCGTCATCAGGGGCCAAAA
GCGAACGGGATGCCAGAATTACATAAACTTATGCCGCCACTTGGTGTATTATTGGACCGCCGTTTCAAAATAGCGCTGGT
GACCGATGGCCGACTTTCTGGCGCCTCCGGTAAAGTCCCGTCAGCCATTCACGTCACGCCTGAAGCGTATGATGGCGGCT
TGCTGGCGAAAGTGCGCGATGGCGATCTTATTCGCGTGAACGGACAGACGGGGGAACTGACGCTGCTGGTGGATGAGGCC
GAACTGGCGGCGCGTCAGCCGCATATCCCTGACCTCAGCGCGTCGCGCGTGGGAACCGGTCGGGAGATGTTTGGGGCGCT
GCGTGAGAAGCTCTCTGGCGCGGAGCAGGGCGCAACCTGCATCACTTTTTAA

Upstream 100 bases:

>100_bases
CCTGCAGACATTTTGCCCCTGAGCGCTGGTGTTTGTGGCCTTTACCACGTCAACACGTCATCACGCAGCGGCCGGACAGA
TAAAAATTTGAGGAGCCTTT

Downstream 100 bases:

>100_bases
GACGATTTAATTTCTAGATCTGGCGAGAGAAAATCCTGATGAAAAACTGGAAAACAACAGCAGAAGCAATCCTCACCTCC
GGTCCGGTTGTCCCGGTTAT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MNSTMLRVTNRIIERSRDTRAAYLARINQAKTDTVHRAQLACGNLAHGFAACQADDKASLKSMLRNNIAIITSYNDMLSA
HQPYEHYPEIIRKALHSANAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LTMAALSFGHLPSVFIPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDAPLREALTAAAARQVTRMTGNGNEWMPLGKMFDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGIIINW
DDFSDLSDVVPLLARLYPNGPADINHFQAAGGVPVLVRELLKGGLLHEDVHTVAGFGLSRYTLEPWLNNGELDWREGATA
PLDDQVIATFEKPFSRHGGTKVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVLPAFEAGLLDKDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRRFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDLIRVNGQTGELTLLVDEA
ELAARQPHIPDLSASRVGTGREMFGALREKLSGAEQGATCITF

Sequences:

>Translated_603_residues
MNSTMLRVTNRIIERSRDTRAAYLARINQAKTDTVHRAQLACGNLAHGFAACQADDKASLKSMLRNNIAIITSYNDMLSA
HQPYEHYPEIIRKALHSANAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LTMAALSFGHLPSVFIPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDAPLREALTAAAARQVTRMTGNGNEWMPLGKMFDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGIIINW
DDFSDLSDVVPLLARLYPNGPADINHFQAAGGVPVLVRELLKGGLLHEDVHTVAGFGLSRYTLEPWLNNGELDWREGATA
PLDDQVIATFEKPFSRHGGTKVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVLPAFEAGLLDKDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRRFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDLIRVNGQTGELTLLVDEA
ELAARQPHIPDLSASRVGTGREMFGALREKLSGAEQGATCITF
>Mature_603_residues
MNSTMLRVTNRIIERSRDTRAAYLARINQAKTDTVHRAQLACGNLAHGFAACQADDKASLKSMLRNNIAIITSYNDMLSA
HQPYEHYPEIIRKALHSANAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LTMAALSFGHLPSVFIPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDAPLREALTAAAARQVTRMTGNGNEWMPLGKMFDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGIIINW
DDFSDLSDVVPLLARLYPNGPADINHFQAAGGVPVLVRELLKGGLLHEDVHTVAGFGLSRYTLEPWLNNGELDWREGATA
PLDDQVIATFEKPFSRHGGTKVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVLPAFEAGLLDKDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRRFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDLIRVNGQTGELTLLVDEA
ELAARQPHIPDLSASRVGTGREMFGALREKLSGAEQGATCITF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=603, Percent_Identity=93.698175787728, Blast_Score=1174, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=540, Percent_Identity=29.6296296296296, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI2367371, Length=479, Percent_Identity=30.4801670146138, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1786464, Length=515, Percent_Identity=29.126213592233, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6322476, Length=480, Percent_Identity=30.625, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64568; Mature: 64568

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTMLRVTNRIIERSRDTRAAYLARINQAKTDTVHRAQLACGNLAHGFAACQADDKASL
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHH
KSMLRNNIAIITSYNDMLSAHQPYEHYPEIIRKALHSANAVGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMSAAIGLSHNMFDGALYLGVCDKIVPGLTMAALSFGHLPSVFIPSGP
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCC
LPGSSFVHPDAPLREALTAAAARQVTRMTGNGNEWMPLGKMFDEKVVVNGIVALLATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNHTMHLVAMARAAGIIINWDDFSDLSDVVPLLARLYPNGPADINHFQAAGGVPVLVREL
CCCHHHHEEHHHHCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
LKGGLLHEDVHTVAGFGLSRYTLEPWLNNGELDWREGATAPLDDQVIATFEKPFSRHGGT
HHCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
KVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVLPAFEAGLLDKDCVVVVRHQGPK
EEEECCCCHHHHHHCCCCCCHHHHHCCHHEECCCCCCCCHHHHCCCCCCCEEEEECCCCC
ANGMPELHKLMPPLGVLLDRRFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRD
CCCCHHHHHHCCCHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEECC
GDLIRVNGQTGELTLLVDEAELAARQPHIPDLSASRVGTGREMFGALREKLSGAEQGATC
CCEEEEECCCCEEEEEEECHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEE
ITF
ECC
>Mature Secondary Structure
MNSTMLRVTNRIIERSRDTRAAYLARINQAKTDTVHRAQLACGNLAHGFAACQADDKASL
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHH
KSMLRNNIAIITSYNDMLSAHQPYEHYPEIIRKALHSANAVGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMSAAIGLSHNMFDGALYLGVCDKIVPGLTMAALSFGHLPSVFIPSGP
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCC
LPGSSFVHPDAPLREALTAAAARQVTRMTGNGNEWMPLGKMFDEKVVVNGIVALLATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNHTMHLVAMARAAGIIINWDDFSDLSDVVPLLARLYPNGPADINHFQAAGGVPVLVREL
CCCHHHHEEHHHHCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
LKGGLLHEDVHTVAGFGLSRYTLEPWLNNGELDWREGATAPLDDQVIATFEKPFSRHGGT
HHCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
KVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVLPAFEAGLLDKDCVVVVRHQGPK
EEEECCCCHHHHHHCCCCCCHHHHHCCHHEECCCCCCCCHHHHCCCCCCCEEEEECCCCC
ANGMPELHKLMPPLGVLLDRRFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRD
CCCCHHHHHHCCCHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEECC
GDLIRVNGQTGELTLLVDEAELAARQPHIPDLSASRVGTGREMFGALREKLSGAEQGATC
CCEEEEECCCCEEEEEEECHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEE
ITF
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]