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The map label for this gene is ptrB [H]

Identifier: 238895422

GI number: 238895422

Start: 3307347

End: 3309407

Strand: Reverse

Name: ptrB [H]

Synonym: KP1_3489

Alternate gene names: 238895422

Gene position: 3309407-3307347 (Counterclockwise)

Preceding gene: 238895423

Following gene: 238895419

Centisome position: 63.05

GC content: 57.5

Gene sequence:

>2061_bases
ATGCCACCTAAAGCTAAACGGATCCCTCACGCCATGACCTTGCATGGCGATACACGCATCGATAATTATTACTGGCTGCG
CGACGATGAGCGCGCGCGACCTGACGTGCTGGAGTATCTGCACGCGGAGAACGCTTACGGCAAGCAAGTGATGGATTCGC
AGCTCAGCCTGCAGGAGCGTCTGCTGAAGGAGATTATCGACCGCATTCCGCAGCGGGAAGTCTCTGCCCCCTACAGTAAA
AACGGCTTTCGCTACCGTCAGGTGTATGAGCCGGGCTGCGAATACGCTATCTACCAGCGGCAGTCGGTGCTGAAAGAAGA
GTGGGATGAGTGGGAGATCCTGCTCGACGCCAACCAGCGGGCGGCGAAGAGCGAGTTCTACACCCTGGGCGGACTGGGCA
TTGCGCCCAACAACCAGCTAATGGCGGTGGCGGAAGATTACCTTTCCCGCCGTCAGTACGGCCTGCGCTTTTGCGACCTC
AGCAACGGCGAGTGGTACCCGGAAATCCTCGAAAATGTCACCTCCGGCTTTGCCTGGAGCAACGATTCACGCTTTGTTTG
GTATGTGCGTAAACATCCCACCACGCTGCTCCCTTATCAGGTCTGGCGCCACACCGTCGGGACACCGGCGCAGAGCGACG
CGCTGGTCTACGAGGAAAAAGATGAGACCTTCTACGTCAGCGTGCATAAAACCACCTCCCAGCAGTTCGTGGTAATTTAT
CTCTCCAGCGCCACCACCAGCGAAGTGCTGCTGCTCAACGCCGAACTGCCAGACGCCGAGCCGGTCTGCTTTCTGCCACG
GCGTAAAGATCATGAATACAGTCTTGATCACTATCAGCACGCTTTCTATCTTCGTTCCAACCGGGAGGGGAAGAATTTCG
GCCTCTACCGTACCGTGCTGCGTGATGAAGAACAGTGGACCACGCTGATCCCGCCGCGTCACGACGTGATGCTCGAAGGA
TTTACCCTGTTTACCGACTGGCTGGTTGTGGAAGAGCGTCAGCGTGGCCTGACCAGTCTGCGGCAAATTAACCGCAAGAC
CCGGGAGGTGGTGGGGATCGCTTTTGACGATCCGGCCTATGTCACCTGGCTTGCCTATAATCCGGAGCCCGAAACGTCGC
GACTGCGCTACGGCTATTCCTCCATGACTACGCCGGATACGCTGTTTGAACTGGATATGGATACCGGCGAACGAAGAGTG
ATCAAACAGCAGGAGGTAAAGGGGCTGGATACGAGCTGCTACCAGAGCGAACACCTGTGGGTGACCGCCCGCGATGGCGT
CGAAGTCCCGGTCTCTCTGGTCTACCATCGCGAACATTTTCGCAAAGGGAGCAACCCGCTGCTGGTCTATGGCTATGGCT
CATATGGCGAGAGTATCGATGCCGATTTCAGCGCCAGCCGGCTGAGCCTGCTCAACCGCGGCTTTGTCTACGCCATCGCC
CACGTCCGCGGCGGCGGCGAGCTGGGTCAGCAATGGTATGAAGACGGTAAATTCCTGTGTAAGAAAAATACCTTCAACGA
CTATCTGGACGTCTGTGACGCGCTGCTTGCCCAGGGGTACGGCGATCCGCGGCTCTGCTACGGCATGGGGGGCAGCGCCG
GCGGAATGCTGATGGGCGTGGCCGTGAATGAACGGCCAGAGCTGTTCCATGGCGTGATAGCCCAGGTGCCGTTCGTCGAT
GTGGTGACCACCATGCTGGATGAAACTATTCCGCTGACCACCGGTGAATTTGAAGAGTGGGGAAATCCGCAGGATGAAAC
CTATTATCACTATATGAAAAGCTACAGTCCCTATGACGGCGTGAGGGCGCAGGCGTATCCCCACATGCTGGTGACTACCG
GTCTGCATGATTCCCAGGTGCAATACTGGGAGCCGGCTAAATGGGTGGCGAAACTGCGGGAACTGAAAACCGACGATAAC
CTGCTGCTGCTCTGCACCGATATGGATTCCGGACATGGCGGAAAATCCGGGCGCTTTAAAAGCTATGAAGGGGTGGCGCT
GGAGTACGCCTTTTTCATCGCCCTGGCGCAGGGGACACTGCCGGGAAAAGCGGCAGTGTAG

Upstream 100 bases:

>100_bases
TCGCTCGCGTCTTTTGCCACCCTTATAGACACGTCATCATTCAGGCGCCACCCTGCGGCCTGAATGCTCTTGTGTCACGA
TAAAGCAGCAGAAGAATAAC

Downstream 100 bases:

>100_bases
GCGCTATTCCCCGAGGTAATGCCTGAGCGTCAGGCGCAGTTCGGGGCTCATGCGGTCGAGATTGTTGAATAACCAGCGCA
GATAGCCTGGATCGTTTTCA

Product: protease 2

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 686; Mature: 685

Protein sequence:

>686_residues
MPPKAKRIPHAMTLHGDTRIDNYYWLRDDERARPDVLEYLHAENAYGKQVMDSQLSLQERLLKEIIDRIPQREVSAPYSK
NGFRYRQVYEPGCEYAIYQRQSVLKEEWDEWEILLDANQRAAKSEFYTLGGLGIAPNNQLMAVAEDYLSRRQYGLRFCDL
SNGEWYPEILENVTSGFAWSNDSRFVWYVRKHPTTLLPYQVWRHTVGTPAQSDALVYEEKDETFYVSVHKTTSQQFVVIY
LSSATTSEVLLLNAELPDAEPVCFLPRRKDHEYSLDHYQHAFYLRSNREGKNFGLYRTVLRDEEQWTTLIPPRHDVMLEG
FTLFTDWLVVEERQRGLTSLRQINRKTREVVGIAFDDPAYVTWLAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRV
IKQQEVKGLDTSCYQSEHLWVTARDGVEVPVSLVYHREHFRKGSNPLLVYGYGSYGESIDADFSASRLSLLNRGFVYAIA
HVRGGGELGQQWYEDGKFLCKKNTFNDYLDVCDALLAQGYGDPRLCYGMGGSAGGMLMGVAVNERPELFHGVIAQVPFVD
VVTTMLDETIPLTTGEFEEWGNPQDETYYHYMKSYSPYDGVRAQAYPHMLVTTGLHDSQVQYWEPAKWVAKLRELKTDDN
LLLLCTDMDSGHGGKSGRFKSYEGVALEYAFFIALAQGTLPGKAAV

Sequences:

>Translated_686_residues
MPPKAKRIPHAMTLHGDTRIDNYYWLRDDERARPDVLEYLHAENAYGKQVMDSQLSLQERLLKEIIDRIPQREVSAPYSK
NGFRYRQVYEPGCEYAIYQRQSVLKEEWDEWEILLDANQRAAKSEFYTLGGLGIAPNNQLMAVAEDYLSRRQYGLRFCDL
SNGEWYPEILENVTSGFAWSNDSRFVWYVRKHPTTLLPYQVWRHTVGTPAQSDALVYEEKDETFYVSVHKTTSQQFVVIY
LSSATTSEVLLLNAELPDAEPVCFLPRRKDHEYSLDHYQHAFYLRSNREGKNFGLYRTVLRDEEQWTTLIPPRHDVMLEG
FTLFTDWLVVEERQRGLTSLRQINRKTREVVGIAFDDPAYVTWLAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRV
IKQQEVKGLDTSCYQSEHLWVTARDGVEVPVSLVYHREHFRKGSNPLLVYGYGSYGESIDADFSASRLSLLNRGFVYAIA
HVRGGGELGQQWYEDGKFLCKKNTFNDYLDVCDALLAQGYGDPRLCYGMGGSAGGMLMGVAVNERPELFHGVIAQVPFVD
VVTTMLDETIPLTTGEFEEWGNPQDETYYHYMKSYSPYDGVRAQAYPHMLVTTGLHDSQVQYWEPAKWVAKLRELKTDDN
LLLLCTDMDSGHGGKSGRFKSYEGVALEYAFFIALAQGTLPGKAAV
>Mature_685_residues
PPKAKRIPHAMTLHGDTRIDNYYWLRDDERARPDVLEYLHAENAYGKQVMDSQLSLQERLLKEIIDRIPQREVSAPYSKN
GFRYRQVYEPGCEYAIYQRQSVLKEEWDEWEILLDANQRAAKSEFYTLGGLGIAPNNQLMAVAEDYLSRRQYGLRFCDLS
NGEWYPEILENVTSGFAWSNDSRFVWYVRKHPTTLLPYQVWRHTVGTPAQSDALVYEEKDETFYVSVHKTTSQQFVVIYL
SSATTSEVLLLNAELPDAEPVCFLPRRKDHEYSLDHYQHAFYLRSNREGKNFGLYRTVLRDEEQWTTLIPPRHDVMLEGF
TLFTDWLVVEERQRGLTSLRQINRKTREVVGIAFDDPAYVTWLAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRVI
KQQEVKGLDTSCYQSEHLWVTARDGVEVPVSLVYHREHFRKGSNPLLVYGYGSYGESIDADFSASRLSLLNRGFVYAIAH
VRGGGELGQQWYEDGKFLCKKNTFNDYLDVCDALLAQGYGDPRLCYGMGGSAGGMLMGVAVNERPELFHGVIAQVPFVDV
VTTMLDETIPLTTGEFEEWGNPQDETYYHYMKSYSPYDGVRAQAYPHMLVTTGLHDSQVQYWEPAKWVAKLRELKTDDNL
LLLCTDMDSGHGGKSGRFKSYEGVALEYAFFIALAQGTLPGKAAV

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=695, Percent_Identity=24.3165467625899, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI284172438, Length=575, Percent_Identity=26.7826086956522, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI284172431, Length=575, Percent_Identity=26.7826086956522, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI284172420, Length=575, Percent_Identity=26.7826086956522, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI284172413, Length=575, Percent_Identity=26.7826086956522, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI70778815, Length=575, Percent_Identity=26.7826086956522, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI108860686, Length=217, Percent_Identity=38.7096774193548, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI108860692, Length=214, Percent_Identity=38.785046728972, Blast_Score=146, Evalue=6e-35,
Organism=Escherichia coli, GI1788150, Length=685, Percent_Identity=81.3138686131387, Blast_Score=1194, Evalue=0.0,
Organism=Drosophila melanogaster, GI24583414, Length=685, Percent_Identity=23.3576642335766, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI221510989, Length=712, Percent_Identity=24.2977528089888, Blast_Score=150, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 78880; Mature: 78749

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPKAKRIPHAMTLHGDTRIDNYYWLRDDERARPDVLEYLHAENAYGKQVMDSQLSLQER
CCCCCCCCCCEEEECCCCEECCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
LLKEIIDRIPQREVSAPYSKNGFRYRQVYEPGCEYAIYQRQSVLKEEWDEWEILLDANQR
HHHHHHHHCCCHHCCCCCCCCCCEEEEECCCCCCEEHHHHHHHHHHCCCCEEEEEECCCC
AAKSEFYTLGGLGIAPNNQLMAVAEDYLSRRQYGLRFCDLSNGEWYPEILENVTSGFAWS
HHHCCEEEECCEEECCCCCEEHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHCCCEEC
NDSRFVWYVRKHPTTLLPYQVWRHTVGTPAQSDALVYEEKDETFYVSVHKTTSQQFVVIY
CCCEEEEEEECCCCEECCHHHHHHCCCCCCCCCEEEEEECCCEEEEEEEECCCCEEEEEE
LSSATTSEVLLLNAELPDAEPVCFLPRRKDHEYSLDHYQHAFYLRSNREGKNFGLYRTVL
EECCCCCEEEEEECCCCCCCCEEECCCCCCCCCCHHHHEEEEEEECCCCCCCCCHHHHHH
RDEEQWTTLIPPRHDVMLEGFTLFTDWLVVEERQRGLTSLRQINRKTREVVGIAFDDPAY
CCCCCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCE
VTWLAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRVIKQQEVKGLDTSCYQSEHLW
EEEEEECCCCCCHHEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHCCCCEEE
VTARDGVEVPVSLVYHREHFRKGSNPLLVYGYGSYGESIDADFSASRLSLLNRGFVYAIA
EEECCCCCCCHHHEEEHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCEEEEEE
HVRGGGELGQQWYEDGKFLCKKNTFNDYLDVCDALLAQGYGDPRLCYGMGGSAGGMLMGV
EECCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEE
AVNERPELFHGVIAQVPFVDVVTTMLDETIPLTTGEFEEWGNPQDETYYHYMKSYSPYDG
EECCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCCCC
VRAQAYPHMLVTTGLHDSQVQYWEPAKWVAKLRELKTDDNLLLLCTDMDSGHGGKSGRFK
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
SYEGVALEYAFFIALAQGTLPGKAAV
CCCCHHHHHEEEEHHHCCCCCCCCCC
>Mature Secondary Structure 
PPKAKRIPHAMTLHGDTRIDNYYWLRDDERARPDVLEYLHAENAYGKQVMDSQLSLQER
CCCCCCCCCEEEECCCCEECCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
LLKEIIDRIPQREVSAPYSKNGFRYRQVYEPGCEYAIYQRQSVLKEEWDEWEILLDANQR
HHHHHHHHCCCHHCCCCCCCCCCEEEEECCCCCCEEHHHHHHHHHHCCCCEEEEEECCCC
AAKSEFYTLGGLGIAPNNQLMAVAEDYLSRRQYGLRFCDLSNGEWYPEILENVTSGFAWS
HHHCCEEEECCEEECCCCCEEHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHCCCEEC
NDSRFVWYVRKHPTTLLPYQVWRHTVGTPAQSDALVYEEKDETFYVSVHKTTSQQFVVIY
CCCEEEEEEECCCCEECCHHHHHHCCCCCCCCCEEEEEECCCEEEEEEEECCCCEEEEEE
LSSATTSEVLLLNAELPDAEPVCFLPRRKDHEYSLDHYQHAFYLRSNREGKNFGLYRTVL
EECCCCCEEEEEECCCCCCCCEEECCCCCCCCCCHHHHEEEEEEECCCCCCCCCHHHHHH
RDEEQWTTLIPPRHDVMLEGFTLFTDWLVVEERQRGLTSLRQINRKTREVVGIAFDDPAY
CCCCCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCE
VTWLAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRVIKQQEVKGLDTSCYQSEHLW
EEEEEECCCCCCHHEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHCCCCEEE
VTARDGVEVPVSLVYHREHFRKGSNPLLVYGYGSYGESIDADFSASRLSLLNRGFVYAIA
EEECCCCCCCHHHEEEHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCEEEEEE
HVRGGGELGQQWYEDGKFLCKKNTFNDYLDVCDALLAQGYGDPRLCYGMGGSAGGMLMGV
EECCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEE
AVNERPELFHGVIAQVPFVDVVTTMLDETIPLTTGEFEEWGNPQDETYYHYMKSYSPYDG
EECCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCCCC
VRAQAYPHMLVTTGLHDSQVQYWEPAKWVAKLRELKTDDNLLLLCTDMDSGHGGKSGRFK
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
SYEGVALEYAFFIALAQGTLPGKAAV
CCCCHHHHHEEEEHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1769955; 9097040; 9278503 [H]