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The map label for this gene is pphA [H]

Identifier: 238895414

GI number: 238895414

Start: 3301998

End: 3302651

Strand: Reverse

Name: pphA [H]

Synonym: KP1_3481

Alternate gene names: 238895414

Gene position: 3302651-3301998 (Counterclockwise)

Preceding gene: 238895417

Following gene: 238895408

Centisome position: 62.93

GC content: 61.47

Gene sequence:

>654_bases
ATGTATCAACGTATTAACGGCAGCGACTGGCGTAATATCTGGCTGATGGGCGATCTGCATGGCTGCTTTGCGCTGCTGAT
GAATCGCCTGCGTCAGCTGCGTTTTGATCCCTGGGCCGATCTGCTGATCTCGGTGGGCGATCTGATCGATCGCGGGCCGC
AGAGCGCCGATTGTCTTGGCCTGTTGCGCTGTCGCTGGTTCAGGGCCGTTCGGGGGAATCATGAGCAGATGGCGCTGGAG
GCGCTGGAGAGCGGAGATATGCGGCTCTGGCAGATGAACGGTGGCGACTGGTACGTCAAGGGCGATGCGCGGCAGCGGGC
CGACGTCGATCGGCTGCTGGCGCACTGTCGGCGGCTACCGTTGATTATTGAAGTGGAATGCGGGAAAGCGCGGCATGTGA
TCGCCCACGCCGATTACCCGGCGCCGGTCTATCGCTGGCAGCAGCCGGTGGATCCCCAACGGGTACTATGGAGCCGCCAT
CGTCTGAGTGAACACCTGGCGGGGCGCCATGGCGCTATTGCCGGCGCGGACCATTTCTGGTTTGGCCATACGCCGCTTCA
GGCGCGTTATGACCACGATAATCAACACTATATTGATACGGGCGCTGTGTTTGGTGGGACGCTGACGCTGGTGGCGCTGC
AGTCGGCAGGCTAA

Upstream 100 bases:

>100_bases
CGGACTATATTTGCCGTCTGTTTAAAATTGATTGAGGTGTAAATTAAATTCCGTGGACCTTTGCTGGAATTACCTATAAT
TACCGCTGAGAGGTAATTAT

Downstream 100 bases:

>100_bases
AAGTCGCTGTATTCGCTGGCGGGTTGCCAGAAGCCATCAATAAAATCTTCTATCGGGTAGCAGCCACCGTGGCGGATCCG
CTGATCCTCCATCGCCACTA

Product: serine/threonine protein phosphatase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MYQRINGSDWRNIWLMGDLHGCFALLMNRLRQLRFDPWADLLISVGDLIDRGPQSADCLGLLRCRWFRAVRGNHEQMALE
ALESGDMRLWQMNGGDWYVKGDARQRADVDRLLAHCRRLPLIIEVECGKARHVIAHADYPAPVYRWQQPVDPQRVLWSRH
RLSEHLAGRHGAIAGADHFWFGHTPLQARYDHDNQHYIDTGAVFGGTLTLVALQSAG

Sequences:

>Translated_217_residues
MYQRINGSDWRNIWLMGDLHGCFALLMNRLRQLRFDPWADLLISVGDLIDRGPQSADCLGLLRCRWFRAVRGNHEQMALE
ALESGDMRLWQMNGGDWYVKGDARQRADVDRLLAHCRRLPLIIEVECGKARHVIAHADYPAPVYRWQQPVDPQRVLWSRH
RLSEHLAGRHGAIAGADHFWFGHTPLQARYDHDNQHYIDTGAVFGGTLTLVALQSAG
>Mature_217_residues
MYQRINGSDWRNIWLMGDLHGCFALLMNRLRQLRFDPWADLLISVGDLIDRGPQSADCLGLLRCRWFRAVRGNHEQMALE
ALESGDMRLWQMNGGDWYVKGDARQRADVDRLLAHCRRLPLIIEVECGKARHVIAHADYPAPVYRWQQPVDPQRVLWSRH
RLSEHLAGRHGAIAGADHFWFGHTPLQARYDHDNQHYIDTGAVFGGTLTLVALQSAG

Specific function: Can hydrolyze phosphorylated Ser-, Thr- or Tyr- substrates in vitro. The natural substrate is unknown [H]

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081988, Length=214, Percent_Identity=60.2803738317757, Blast_Score=253, Evalue=6e-69,
Organism=Escherichia coli, GI1789090, Length=214, Percent_Identity=45.3271028037383, Blast_Score=187, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR006186 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 24898; Mature: 24898

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQRINGSDWRNIWLMGDLHGCFALLMNRLRQLRFDPWADLLISVGDLIDRGPQSADCLG
CCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHH
LLRCRWFRAVRGNHEQMALEALESGDMRLWQMNGGDWYVKGDARQRADVDRLLAHCRRLP
HHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCEEEEECCCHHHCCHHHHHHHHHHCC
LIIEVECGKARHVIAHADYPAPVYRWQQPVDPQRVLWSRHRLSEHLAGRHGAIAGADHFW
EEEEEECCCCEEEEEECCCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCEE
FGHTPLQARYDHDNQHYIDTGAVFGGTLTLVALQSAG
ECCCCCEEECCCCCCEEEECCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MYQRINGSDWRNIWLMGDLHGCFALLMNRLRQLRFDPWADLLISVGDLIDRGPQSADCLG
CCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHH
LLRCRWFRAVRGNHEQMALEALESGDMRLWQMNGGDWYVKGDARQRADVDRLLAHCRRLP
HHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCEEEEECCCHHHCCHHHHHHHHHHCC
LIIEVECGKARHVIAHADYPAPVYRWQQPVDPQRVLWSRHRLSEHLAGRHGAIAGADHFW
EEEEEECCCCEEEEEECCCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCEE
FGHTPLQARYDHDNQHYIDTGAVFGGTLTLVALQSAG
ECCCCCEEECCCCCCEEEECCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11717262; 11677609 [H]