Click here to switch to the map view.

The map label for this gene is livG [H]

Identifier: 238895342

GI number: 238895342

Start: 3226319

End: 3227194

Strand: Reverse

Name: livG [H]

Synonym: KP1_3403

Alternate gene names: 238895342

Gene position: 3227194-3226319 (Counterclockwise)

Preceding gene: 238895343

Following gene: 238895341

Centisome position: 61.49

GC content: 61.42

Gene sequence:

>876_bases
ATGACCGACAGCATCTTACGCGTTGAGCATCTGATGATGCATTTCGGCGGCATCAAAGCGCTGAATGATGTCAATCTGGA
GGTGGAGCGGGGGTCGATCACCGCCCTGATAGGCCCCAACGGCGCGGGCAAGACCACGGTGTTTAATTGCCTGACCGGTT
TTTATCGGGCGACGGGGGGCAGTATCGTGCTGCGGGCGCGGGAAAAGGTCACCGATGTTATTCAGGTGCTGGGGCAGAAG
CTTCACCCGGACGATTTTCTCCACCCGGCGCAGCTGGGGAGGCGGATCTATTACAAGATGTTCGGTGGCACCCATCTGGT
GAACCGCGCTGGCCTGGCGCGCACCTTCCAGAATATACGTTTATTCCGCGAGATGTCGGTGATCGAGAACCTGCTGGTGG
CCCAGCATACCCAGGTCAACCGCCATCTGCTGGCCGGGATCCTCAATGCCCGTGGGTATCGGCAGGCGGAGAGTCAGGCG
CTGGATCGCGCTTTTTACTGGCTGGAGGTGGTGGAGATGGTGGACTGCGCCAACCGTCTGGCGGGGACCCTCTCCTACGG
ACAGCAGCGGCGGCTGGAGATCGCCCGCGCCATGTGCACCCGTCCGGAGATGATCTGTCTGGACGAGCCGGCCGCCGGCC
TCAACCCGGTGGAAACCCAGGCGCTGAGCCGGATTATTCGCTTTCTGCGCCAGCAGCACGGCATTACGGTGCTACTGATC
GAGCATGATATGGGGATGGTGATGGAGATTTCGGATCATATCATCGTCCTCGATCACGGGGACGTCATCGCCCGCGGCGC
GCCGCAGGCGATCCAGGCCAACGCCAGTGTGATTGCCGCCTATCTTGGCGCTGAGGAAGAGGAGACGCGCCGATGA

Upstream 100 bases:

>100_bases
TGCTGTTCGGCGTGCTGATGGTGATGATGATGATCTGGCGGCCGCGCGGCCTGGTGCGCACCAGCCGCAGCGGGGTTGCG
TTGCGAAAAGGAGTCGCGCC

Downstream 100 bases:

>100_bases
GCCAGCCTTTGCTTGCCTTTAATGAGGTGGATGTCTTCTACGGGCCGATCCAGGCCCTGAAGCAGGTCTCTCTCACCGTC
AACGAGGGGGAGACGGTGGC

Product: ABC-type high-affinity branched-chain amino acid transport system ATP-binding component

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTDSILRVEHLMMHFGGIKALNDVNLEVERGSITALIGPNGAGKTTVFNCLTGFYRATGGSIVLRAREKVTDVIQVLGQK
LHPDDFLHPAQLGRRIYYKMFGGTHLVNRAGLARTFQNIRLFREMSVIENLLVAQHTQVNRHLLAGILNARGYRQAESQA
LDRAFYWLEVVEMVDCANRLAGTLSYGQQRRLEIARAMCTRPEMICLDEPAAGLNPVETQALSRIIRFLRQQHGITVLLI
EHDMGMVMEISDHIIVLDHGDVIARGAPQAIQANASVIAAYLGAEEEETRR

Sequences:

>Translated_291_residues
MTDSILRVEHLMMHFGGIKALNDVNLEVERGSITALIGPNGAGKTTVFNCLTGFYRATGGSIVLRAREKVTDVIQVLGQK
LHPDDFLHPAQLGRRIYYKMFGGTHLVNRAGLARTFQNIRLFREMSVIENLLVAQHTQVNRHLLAGILNARGYRQAESQA
LDRAFYWLEVVEMVDCANRLAGTLSYGQQRRLEIARAMCTRPEMICLDEPAAGLNPVETQALSRIIRFLRQQHGITVLLI
EHDMGMVMEISDHIIVLDHGDVIARGAPQAIQANASVIAAYLGAEEEETRR
>Mature_290_residues
TDSILRVEHLMMHFGGIKALNDVNLEVERGSITALIGPNGAGKTTVFNCLTGFYRATGGSIVLRAREKVTDVIQVLGQKL
HPDDFLHPAQLGRRIYYKMFGGTHLVNRAGLARTFQNIRLFREMSVIENLLVAQHTQVNRHLLAGILNARGYRQAESQAL
DRAFYWLEVVEMVDCANRLAGTLSYGQQRRLEIARAMCTRPEMICLDEPAAGLNPVETQALSRIIRFLRQQHGITVLLIE
HDMGMVMEISDHIIVLDHGDVIARGAPQAIQANASVIAAYLGAEEEETRR

Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG0411

COG function: function code E; ABC-type branched-chain amino acid transport systems, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI215820660, Length=239, Percent_Identity=23.0125523012552, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI20143975, Length=239, Percent_Identity=23.0125523012552, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789864, Length=285, Percent_Identity=51.2280701754386, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI87082268, Length=285, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789593, Length=282, Percent_Identity=29.0780141843972, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1789672, Length=275, Percent_Identity=25.0909090909091, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787029, Length=272, Percent_Identity=24.6323529411765, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI48995001, Length=259, Percent_Identity=29.7297297297297, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788761, Length=268, Percent_Identity=26.865671641791, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788225, Length=273, Percent_Identity=27.8388278388278, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790544, Length=268, Percent_Identity=29.8507462686567, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790190, Length=262, Percent_Identity=27.8625954198473, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1788210, Length=250, Percent_Identity=30.4, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081709, Length=282, Percent_Identity=23.758865248227, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI48994943, Length=280, Percent_Identity=27.8571428571429, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788450, Length=265, Percent_Identity=25.2830188679245, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1789991, Length=258, Percent_Identity=28.6821705426357, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789586, Length=257, Percent_Identity=29.5719844357977, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786398, Length=248, Percent_Identity=26.2096774193548, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790162, Length=265, Percent_Identity=27.5471698113208, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786872, Length=270, Percent_Identity=24.4444444444444, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787712, Length=275, Percent_Identity=24.7272727272727, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790525, Length=273, Percent_Identity=28.9377289377289, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787370, Length=274, Percent_Identity=26.2773722627737, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788644, Length=278, Percent_Identity=27.6978417266187, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789032, Length=272, Percent_Identity=24.6323529411765, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1787089, Length=252, Percent_Identity=25, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790467, Length=263, Percent_Identity=23.574144486692, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI48994997, Length=270, Percent_Identity=26.2962962962963, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788897, Length=249, Percent_Identity=27.710843373494, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789891, Length=245, Percent_Identity=26.1224489795918, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1786703, Length=246, Percent_Identity=27.2357723577236, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786345, Length=270, Percent_Identity=22.962962962963, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787758, Length=283, Percent_Identity=23.321554770318, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787164, Length=250, Percent_Identity=24.4, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787547, Length=270, Percent_Identity=24.4444444444444, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786981, Length=266, Percent_Identity=27.8195488721804, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693107, Length=280, Percent_Identity=23.2142857142857, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788506, Length=93, Percent_Identity=31.1827956989247, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788165, Length=105, Percent_Identity=32.3809523809524, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 32466; Mature: 32335

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSILRVEHLMMHFGGIKALNDVNLEVERGSITALIGPNGAGKTTVFNCLTGFYRATGG
CCCHHHHHHHHHHHHCCCCEECCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
SIVLRAREKVTDVIQVLGQKLHPDDFLHPAQLGRRIYYKMFGGTHLVNRAGLARTFQNIR
EEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LFREMSVIENLLVAQHTQVNRHLLAGILNARGYRQAESQALDRAFYWLEVVEMVDCANRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTLSYGQQRRLEIARAMCTRPEMICLDEPAAGLNPVETQALSRIIRFLRQQHGITVLLI
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE
EHDMGMVMEISDHIIVLDHGDVIARGAPQAIQANASVIAAYLGAEEEETRR
ECCCCEEEEECCCEEEEECCCEEECCCCHHHHCCHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TDSILRVEHLMMHFGGIKALNDVNLEVERGSITALIGPNGAGKTTVFNCLTGFYRATGG
CCHHHHHHHHHHHHCCCCEECCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
SIVLRAREKVTDVIQVLGQKLHPDDFLHPAQLGRRIYYKMFGGTHLVNRAGLARTFQNIR
EEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LFREMSVIENLLVAQHTQVNRHLLAGILNARGYRQAESQALDRAFYWLEVVEMVDCANRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTLSYGQQRRLEIARAMCTRPEMICLDEPAAGLNPVETQALSRIIRFLRQQHGITVLLI
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE
EHDMGMVMEISDHIIVLDHGDVIARGAPQAIQANASVIAAYLGAEEEETRR
ECCCCEEEEECCCEEEEECCCEEECCCCHHHHCCHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2120183; 10984043 [H]