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The map label for this gene is btuC [H]

Identifier: 238895224

GI number: 238895224

Start: 3105574

End: 3106560

Strand: Reverse

Name: btuC [H]

Synonym: KP1_3273

Alternate gene names: 238895224

Gene position: 3106560-3105574 (Counterclockwise)

Preceding gene: 238895225

Following gene: 238895222

Centisome position: 59.19

GC content: 64.84

Gene sequence:

>987_bases
ATGCTGACTCTCGCCCATCTTCAACAGCGCCGTAGCCGGCGTTGGCTCTTCGGATTAACGCTGTTGCTGCTGGTCACCCT
GCTGATCAGCCTGTGCGCGGGGGAGCAATGGATCCCGCCCGGCGAGTGGCTCAGCGCCAAAGGTCAGCTGTTTATCTGGC
AGATCCGCCTGCCGCGAACCCTGGCGGTGCTGCTGGTGGGGGCGGCGCTGGCGCTCTCCGGGGCGATTATGCAGGCGTTG
TTTGAAAATCCTCTGGCGGAGCCGGGGCTGCTGGGGGTCTCCAACGGCGCGGGCGTCGGGCTGATTGCCGCCGTCCTGCT
GGGCAAAGGAGTCTTGCCCGGCTGGGCGCTCGGCCTGTGTGCCATCTTTGGCGCGCTGCTGATCACTTTTATTCTGCTGC
GTTTCGCCCGCCGCCATCTGTCTACCAGCCGTCTGCTGCTGGCGGGGGTGGCGCTGGGGATCATCTGCAGCGCCCTGATG
ACCTGGGCAGTCTACTTCTCCACCTCTTTTGACCTGCGTCAGCTAATGTACTGGATGATGGGCGGGTTTGGCGGCGTCGA
CTGGCAACAGCTGTGGCTGATGATAGCCCTCCTGCCGGTGCTCTGCTGGGTCTGTCTGCAGTCGCAACCCCTGAATTTAC
TGGCGCTGGGCGAAGTCTCCGCTCGTCAGCTTGGGCTGCCGCTGTGGCTGTGGCGCAAATTACTGGTGGTGGCGACCGGC
TGGATGGTCGGCGTTAGCGTGGCGCTGGCGGGGGCGATTGGCTTTATCGGTCTGGTGATCCCGCATATTCTGCGGCTATG
CGGCTTGAGCGATCACCGGGTGTTGCTCCCGGCCTGTATGCTGGCCGGGGCAAGCGCCTTGCTGGGGGCGGATATCATTG
CCCGGCTGGCGCTTTCCGCCGCAGAGCTGCCGATTGGCGTGGTGACGGCGACCCTGGGCGCGCCGGTCTTTATCTGGTTG
CTGCTGCGTTCGCGGGGGCGGGGATAG

Upstream 100 bases:

>100_bases
GAGCCTCCTCCGCGTCGACGTTTGGTCGTGAGGTTTTCCTTTTCTCACCGCGACAGCCACCGTAAAATCAGCCTCTTGTT
CCCCCTGCGTAATGGAATCT

Downstream 100 bases:

>100_bases
CGCGGCGCCGTCGGCAGGGACGGCGCCGGTTCAGGCTTACCAGCCTTTGATCGCGTCGCCTTTGTAGACTTCCTTCGCTT
TTTCCGCGACTTCGCTGGTC

Product: vtamin B12-transporter permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MLTLAHLQQRRSRRWLFGLTLLLLVTLLISLCAGEQWIPPGEWLSAKGQLFIWQIRLPRTLAVLLVGAALALSGAIMQAL
FENPLAEPGLLGVSNGAGVGLIAAVLLGKGVLPGWALGLCAIFGALLITFILLRFARRHLSTSRLLLAGVALGIICSALM
TWAVYFSTSFDLRQLMYWMMGGFGGVDWQQLWLMIALLPVLCWVCLQSQPLNLLALGEVSARQLGLPLWLWRKLLVVATG
WMVGVSVALAGAIGFIGLVIPHILRLCGLSDHRVLLPACMLAGASALLGADIIARLALSAAELPIGVVTATLGAPVFIWL
LLRSRGRG

Sequences:

>Translated_328_residues
MLTLAHLQQRRSRRWLFGLTLLLLVTLLISLCAGEQWIPPGEWLSAKGQLFIWQIRLPRTLAVLLVGAALALSGAIMQAL
FENPLAEPGLLGVSNGAGVGLIAAVLLGKGVLPGWALGLCAIFGALLITFILLRFARRHLSTSRLLLAGVALGIICSALM
TWAVYFSTSFDLRQLMYWMMGGFGGVDWQQLWLMIALLPVLCWVCLQSQPLNLLALGEVSARQLGLPLWLWRKLLVVATG
WMVGVSVALAGAIGFIGLVIPHILRLCGLSDHRVLLPACMLAGASALLGADIIARLALSAAELPIGVVTATLGAPVFIWL
LLRSRGRG
>Mature_328_residues
MLTLAHLQQRRSRRWLFGLTLLLLVTLLISLCAGEQWIPPGEWLSAKGQLFIWQIRLPRTLAVLLVGAALALSGAIMQAL
FENPLAEPGLLGVSNGAGVGLIAAVLLGKGVLPGWALGLCAIFGALLITFILLRFARRHLSTSRLLLAGVALGIICSALM
TWAVYFSTSFDLRQLMYWMMGGFGGVDWQQLWLMIALLPVLCWVCLQSQPLNLLALGEVSARQLGLPLWLWRKLLVVATG
WMVGVSVALAGAIGFIGLVIPHILRLCGLSDHRVLLPACMLAGASALLGADIIARLALSAAELPIGVVTATLGAPVFIWL
LLRSRGRG

Specific function: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane [H]

COG id: COG4139

COG function: function code H; ABC-type cobalamin transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=324, Percent_Identity=83.3333333333333, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI1790740, Length=292, Percent_Identity=39.041095890411, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790741, Length=283, Percent_Identity=34.6289752650177, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786805, Length=290, Percent_Identity=38.6206896551724, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786347, Length=275, Percent_Identity=31.6363636363636, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1786804, Length=275, Percent_Identity=30.9090909090909, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35200; Mature: 35200

Theoretical pI: Translated: 10.95; Mature: 10.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLAHLQQRRSRRWLFGLTLLLLVTLLISLCAGEQWIPPGEWLSAKGQLFIWQIRLPRT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEECHHH
LAVLLVGAALALSGAIMQALFENPLAEPGLLGVSNGAGVGLIAAVLLGKGVLPGWALGLC
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHCCCCCCHHHHHHH
AIFGALLITFILLRFARRHLSTSRLLLAGVALGIICSALMTWAVYFSTSFDLRQLMYWMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GGFGGVDWQQLWLMIALLPVLCWVCLQSQPLNLLALGEVSARQLGLPLWLWRKLLVVATG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHH
WMVGVSVALAGAIGFIGLVIPHILRLCGLSDHRVLLPACMLAGASALLGADIIARLALSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELPIGVVTATLGAPVFIWLLLRSRGRG
HHCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTLAHLQQRRSRRWLFGLTLLLLVTLLISLCAGEQWIPPGEWLSAKGQLFIWQIRLPRT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEECHHH
LAVLLVGAALALSGAIMQALFENPLAEPGLLGVSNGAGVGLIAAVLLGKGVLPGWALGLC
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHCCCCCCHHHHHHH
AIFGALLITFILLRFARRHLSTSRLLLAGVALGIICSALMTWAVYFSTSFDLRQLMYWMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GGFGGVDWQQLWLMIALLPVLCWVCLQSQPLNLLALGEVSARQLGLPLWLWRKLLVVATG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHH
WMVGVSVALAGAIGFIGLVIPHILRLCGLSDHRVLLPACMLAGASALLGADIIARLALSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELPIGVVTATLGAPVFIWLLLRSRGRG
HHCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA