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The map label for this gene is actII-2 [H]

Identifier: 238895072

GI number: 238895072

Start: 2952778

End: 2954355

Strand: Reverse

Name: actII-2 [H]

Synonym: KP1_3104

Alternate gene names: 238895072

Gene position: 2954355-2952778 (Counterclockwise)

Preceding gene: 238895074

Following gene: 238895071

Centisome position: 56.29

GC content: 62.23

Gene sequence:

>1578_bases
ATGGCGACAGTTTATTCTTTCTTGCCGACTGATGAGGGCCGCCCGATGTTACTCCCCGCCAGAACACCTTCCCGATACGC
CAGCGCCCTGGCCGCGCTTTCTGTCTTTATGGCGGCCTTGCTGCTGCCGTTAAGTTTTACCGGCGGCGTCATGACCACCC
CCGCGATACAGCAGTCGCTGGGCGGCTCTCCCGCTGCGCTGTCGTGGCTGACCAATGGCTTTATGCTGACTTTCGGCAGC
TTTTTGCTGGCCGCAGGGGTGGCGGCGGATGCCATCGACAGAAAACGTATTTTTATCGCCGGCGCCGCGCTGTTGTGCCT
GAGCAGCCTGCTGTTTTGTCTGACGCACAATCTCTTCCTGTCAGGCGTGTTGAGGGCGCTGCAGGGCCTGGCCGCGGCGA
TGATTTTAGCCAGCGGCAGTGCGGCGCTGGCCCAGCTGTATGATGGCGCTCAGCGGACCAGGGCATTCAGCATCCTCGGC
ACGGTGTTCGGCGTTGGCCTGGCGTTCGGTCCGCTGCTGATCGGCTTCATGACCGACGCGGTGGGTTGGCGCGGCGTATA
CGCCCTGTTTGCGCTGCTCTCGGCGATAGTTCTGCTTATCGGTCTGGCGTATCTGCCCGCGGCAGAAAAAAGCGAGCCGC
AGACACCCGACAACCTGGGCTTAACCCTGTTTACGCTGGCCCTGATGCTGTTTACTGCATCGCTTATGGTCATTCCGGCC
CGCGGTTTTTTATCCCTGACCACGCTGGCCTTGCTCATCGCGTCGGGGGGGCTGTTCGTGGCGTTTGTCGTACGCTGCCG
GAGGGTGAACAACCCGGTGCTGGAACTCTCCCTGCTGCGTCATCCGCGTTTTGTCGGCGTACTGTTGTTGCCTGTCGCCA
CCTGCTGTTGCTACGTGGTCCTGCTGATTATTGTTCCACTGCATTTTATGGGCGGAGAGGGGATGAGTGAGTCGCAGAGC
GCACTGTATCTGATGGCGCTGACCACGCCGATGCTGGTTTTCCCATCCGTTGCGGCCCTGCTCACCCGCTGGTTTTCACC
GGGGCAGGTGTCCACGGCGGGACTGATGATGGCCTCCGTCGGGTTGTTGTTGCTGGGCGATGCTTTTCACAGTAACCACC
TCCCGCAACTGGTGCTGGCGCTGCTCCTCTGTGGGGCGGGGGCAGCGCTTCCCTGGGGACTGATGGATGGCCTGGCGATA
TCCGCTGTGCCGGTCGCCAAAGCCGGTATGGCGGCAGGCCTGTTCAACACCGTACGCGTTGCCGGCGAGGGGATCGCCCT
GGCGATAGTCTCCGCGGTATTAACGGCAAGCAATACCCTGACCCTGCAGAGCCGCGTACACGGGTATGCGCCTGAGGTGA
TTGACCGCGCCGCAGGCTGGCTGGGGGCCGGCAATATGCCGCAGGCGGCTGCGCTTTTGCCTGACTTTTCCCTCCGGGCG
CTGCGCGAGAGCTATGACTCTGCTTATACGCTACTGTTTAGCGGGCTGGCGGTCGTCACCCTGCTGTGCGCCCTGATGGT
CTGGCGGACGCTATGCCGGAAGGGGGGCGCTATCCAAACCCGCGACAGTGGATCCTGA

Upstream 100 bases:

>100_bases
AAAGGACGTCAACGAGGTGAGGCTGTCCATCGATTATAAACCTTATGTCTCTTAAGAAGATATTTTCAGTCTATTTATCG
GCAATAACATCCGCAATAGG

Downstream 100 bases:

>100_bases
ACCCCCTTGATAGCGCGGTGGCGTCACGCTTCCCGGTCTGCTCAGCGAACCGGAACTGTTATTGTTTCGCTGACGGAATT
ATGCTGATTAGGGCGGCCAT

Product: putative transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MATVYSFLPTDEGRPMLLPARTPSRYASALAALSVFMAALLLPLSFTGGVMTTPAIQQSLGGSPAALSWLTNGFMLTFGS
FLLAAGVAADAIDRKRIFIAGAALLCLSSLLFCLTHNLFLSGVLRALQGLAAAMILASGSAALAQLYDGAQRTRAFSILG
TVFGVGLAFGPLLIGFMTDAVGWRGVYALFALLSAIVLLIGLAYLPAAEKSEPQTPDNLGLTLFTLALMLFTASLMVIPA
RGFLSLTTLALLIASGGLFVAFVVRCRRVNNPVLELSLLRHPRFVGVLLLPVATCCCYVVLLIIVPLHFMGGEGMSESQS
ALYLMALTTPMLVFPSVAALLTRWFSPGQVSTAGLMMASVGLLLLGDAFHSNHLPQLVLALLLCGAGAALPWGLMDGLAI
SAVPVAKAGMAAGLFNTVRVAGEGIALAIVSAVLTASNTLTLQSRVHGYAPEVIDRAAGWLGAGNMPQAAALLPDFSLRA
LRESYDSAYTLLFSGLAVVTLLCALMVWRTLCRKGGAIQTRDSGS

Sequences:

>Translated_525_residues
MATVYSFLPTDEGRPMLLPARTPSRYASALAALSVFMAALLLPLSFTGGVMTTPAIQQSLGGSPAALSWLTNGFMLTFGS
FLLAAGVAADAIDRKRIFIAGAALLCLSSLLFCLTHNLFLSGVLRALQGLAAAMILASGSAALAQLYDGAQRTRAFSILG
TVFGVGLAFGPLLIGFMTDAVGWRGVYALFALLSAIVLLIGLAYLPAAEKSEPQTPDNLGLTLFTLALMLFTASLMVIPA
RGFLSLTTLALLIASGGLFVAFVVRCRRVNNPVLELSLLRHPRFVGVLLLPVATCCCYVVLLIIVPLHFMGGEGMSESQS
ALYLMALTTPMLVFPSVAALLTRWFSPGQVSTAGLMMASVGLLLLGDAFHSNHLPQLVLALLLCGAGAALPWGLMDGLAI
SAVPVAKAGMAAGLFNTVRVAGEGIALAIVSAVLTASNTLTLQSRVHGYAPEVIDRAAGWLGAGNMPQAAALLPDFSLRA
LRESYDSAYTLLFSGLAVVTLLCALMVWRTLCRKGGAIQTRDSGS
>Mature_524_residues
ATVYSFLPTDEGRPMLLPARTPSRYASALAALSVFMAALLLPLSFTGGVMTTPAIQQSLGGSPAALSWLTNGFMLTFGSF
LLAAGVAADAIDRKRIFIAGAALLCLSSLLFCLTHNLFLSGVLRALQGLAAAMILASGSAALAQLYDGAQRTRAFSILGT
VFGVGLAFGPLLIGFMTDAVGWRGVYALFALLSAIVLLIGLAYLPAAEKSEPQTPDNLGLTLFTLALMLFTASLMVIPAR
GFLSLTTLALLIASGGLFVAFVVRCRRVNNPVLELSLLRHPRFVGVLLLPVATCCCYVVLLIIVPLHFMGGEGMSESQSA
LYLMALTTPMLVFPSVAALLTRWFSPGQVSTAGLMMASVGLLLLGDAFHSNHLPQLVLALLLCGAGAALPWGLMDGLAIS
AVPVAKAGMAAGLFNTVRVAGEGIALAIVSAVLTASNTLTLQSRVHGYAPEVIDRAAGWLGAGNMPQAAALLPDFSLRAL
RESYDSAYTLLFSGLAVVTLLCALMVWRTLCRKGGAIQTRDSGS

Specific function: Promotes the efflux of actinorhodin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=388, Percent_Identity=23.9690721649485, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790195, Length=263, Percent_Identity=27.7566539923954, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324954, Length=434, Percent_Identity=25.3456221198157, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 54772; Mature: 54641

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVYSFLPTDEGRPMLLPARTPSRYASALAALSVFMAALLLPLSFTGGVMTTPAIQQSL
CCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHC
GGSPAALSWLTNGFMLTFGSFLLAAGVAADAIDRKRIFIAGAALLCLSSLLFCLTHNLFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SGVLRALQGLAAAMILASGSAALAQLYDGAQRTRAFSILGTVFGVGLAFGPLLIGFMTDA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGWRGVYALFALLSAIVLLIGLAYLPAAEKSEPQTPDNLGLTLFTLALMLFTASLMVIPA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
RGFLSLTTLALLIASGGLFVAFVVRCRRVNNPVLELSLLRHPRFVGVLLLPVATCCCYVV
CHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LLIIVPLHFMGGEGMSESQSALYLMALTTPMLVFPSVAALLTRWFSPGQVSTAGLMMASV
HHHHHHHHHCCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
GLLLLGDAFHSNHLPQLVLALLLCGAGAALPWGLMDGLAISAVPVAKAGMAAGLFNTVRV
HHHHHCCHHHCCCHHHHHHHHHHHCCCCCCCHHHHCCCHHHHCHHHHHHHHHHHHHHHHH
AGEGIALAIVSAVLTASNTLTLQSRVHGYAPEVIDRAAGWLGAGNMPQAAALLPDFSLRA
HCCCHHHHHHHHHHHCCCCEEEHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHCCCHHHHH
LRESYDSAYTLLFSGLAVVTLLCALMVWRTLCRKGGAIQTRDSGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ATVYSFLPTDEGRPMLLPARTPSRYASALAALSVFMAALLLPLSFTGGVMTTPAIQQSL
CCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHC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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1878971; 12000953 [H]