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The map label for this gene is envZ [H]

Identifier: 238894840

GI number: 238894840

Start: 2724732

End: 2726075

Strand: Reverse

Name: envZ [H]

Synonym: KP1_2857

Alternate gene names: 238894840

Gene position: 2726075-2724732 (Counterclockwise)

Preceding gene: 238894841

Following gene: 238894839

Centisome position: 51.94

GC content: 65.4

Gene sequence:

>1344_bases
ATGAGGTTCTGGCCCGCCTCGCTGCAGTCGAGGCTGATGGCGCTGCTGTTTCTGGCGCTGCTGCTGGCGAATACCTTAAC
CCTGTCGCTGCTGTTTTATGAGCGTATGAGCAGCGCTCGCAGCGTGATGCTGGGGAATCTGGCTTCCGATGTCGCCACCA
GCGTGGCGATCCTTGACCGCCTGCCGGCCGCTGAGCGGCCACAATGGCTGCCGAAGCTGGCGCGCGGCAATTATCGCTAT
CTGCTGGACGCCGGGGAGCGCGGCGATTACCCGGACAGCTGGCGCGCCCGGGACGCAGCGCGCTCCCTGCAGGAGGCGCT
GAGCGCGCAGTATCCGGTAAGTATTGTGGCGATCCCCGGCCCGCGGCAGCATATTCAGGCCCATATTACCCTTCATGACG
GCGCGCCGTTGACCCTCGACCTGTGGCCGAAACTACCGGCCATCGCCCGCTGGCTGCCGGTGGTGCTGATCGCTCAGTTT
GTCCTCCTGCTGGCCTGCGCCTGGTACGCGGTTCGCCAGGTATTGCTGCCCATCTCCCGCTTTACCCACGCGGTAAATGC
CCTGGAGCCGGCCAGCGACACGGCGGGAACTATGGCCGAGCAGGGGCCGGAGGAGGTGCGTCGCGCCGCCCGCGCGTTTA
ACGCGATGCAGGCGCGCATCCACGATCATCTGCAGGAGCGAGCGCGGATCCTTGCCGCCATCTCCCACGATCTGCAAACC
CCGATAACCCGAATGAAGCTGCGGGTGGAGATGGCCGACCAGCCGGAACTGCGCGGCAAACTGCTGCAGGATCTCGACAA
TATGACCCGTCTGGTGCGGGAGGGCATCGCCTTCGCCCGCACCTCGCAGCCGCTGGAGGAGGCGCGACAGCGGCTGAATC
TCGATGCGTTTCTCGACACTATCGTCTGCGATTATGCCGATGTCGGCCGGCCGGTCCAGTTTTGTCCCGAAGAGACCGCC
GGGGTGGTGTGGATCCCGCCGCAGGCTCTGCGCCGGGTGATGACCAATCTTATCGATAACGCCTTGAAATTCGGTACGAC
GGCCACGGTAACCCTGACCCGTGACGCCGTGGGAGATATCACCCTTCATGTGCTGGATGAGGGGCCGGGGATCCCAGAGG
CCTCGCTGCAGGCGGTGCTGCAGCCTTTTTATCGCCTGGAGGACTCGCGCAATCGCGATACCGGCGGCACCGGCCTGGGG
CTGGCGATCGCCGCGCAGCTGCTCAGCCAGATGGACGGCGCGCTGCGCCTGGCCAACCGCCCGCAGGGCGGCCTGGACGC
CAGCGTTCGCCTTGCCGCGGCGGGATTGTATCCTGCTGTATCTCCGGGAAAGACGGATAACTAA

Upstream 100 bases:

>100_bases
AGCGGCTACGGGAGGATGCCCGCGAGCCGGCCTACATTAAAACGGTGCGCAGCGAAGGCTATGTGCTGTCGGTGCCGGTC
TCCATTCGCGAGAGGCATGA

Downstream 100 bases:

>100_bases
GCCGACAATTCTCCCCCTTTCCCGACACATTCGCCTTACATGGCCTTGCTGTAATGTCGTGGCTGCCACTCTCGGCAGCG
ACGGCATAATGAGGAGAAGG

Product: putative signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MRFWPASLQSRLMALLFLALLLANTLTLSLLFYERMSSARSVMLGNLASDVATSVAILDRLPAAERPQWLPKLARGNYRY
LLDAGERGDYPDSWRARDAARSLQEALSAQYPVSIVAIPGPRQHIQAHITLHDGAPLTLDLWPKLPAIARWLPVVLIAQF
VLLLACAWYAVRQVLLPISRFTHAVNALEPASDTAGTMAEQGPEEVRRAARAFNAMQARIHDHLQERARILAAISHDLQT
PITRMKLRVEMADQPELRGKLLQDLDNMTRLVREGIAFARTSQPLEEARQRLNLDAFLDTIVCDYADVGRPVQFCPEETA
GVVWIPPQALRRVMTNLIDNALKFGTTATVTLTRDAVGDITLHVLDEGPGIPEASLQAVLQPFYRLEDSRNRDTGGTGLG
LAIAAQLLSQMDGALRLANRPQGGLDASVRLAAAGLYPAVSPGKTDN

Sequences:

>Translated_447_residues
MRFWPASLQSRLMALLFLALLLANTLTLSLLFYERMSSARSVMLGNLASDVATSVAILDRLPAAERPQWLPKLARGNYRY
LLDAGERGDYPDSWRARDAARSLQEALSAQYPVSIVAIPGPRQHIQAHITLHDGAPLTLDLWPKLPAIARWLPVVLIAQF
VLLLACAWYAVRQVLLPISRFTHAVNALEPASDTAGTMAEQGPEEVRRAARAFNAMQARIHDHLQERARILAAISHDLQT
PITRMKLRVEMADQPELRGKLLQDLDNMTRLVREGIAFARTSQPLEEARQRLNLDAFLDTIVCDYADVGRPVQFCPEETA
GVVWIPPQALRRVMTNLIDNALKFGTTATVTLTRDAVGDITLHVLDEGPGIPEASLQAVLQPFYRLEDSRNRDTGGTGLG
LAIAAQLLSQMDGALRLANRPQGGLDASVRLAAAGLYPAVSPGKTDN
>Mature_447_residues
MRFWPASLQSRLMALLFLALLLANTLTLSLLFYERMSSARSVMLGNLASDVATSVAILDRLPAAERPQWLPKLARGNYRY
LLDAGERGDYPDSWRARDAARSLQEALSAQYPVSIVAIPGPRQHIQAHITLHDGAPLTLDLWPKLPAIARWLPVVLIAQF
VLLLACAWYAVRQVLLPISRFTHAVNALEPASDTAGTMAEQGPEEVRRAARAFNAMQARIHDHLQERARILAAISHDLQT
PITRMKLRVEMADQPELRGKLLQDLDNMTRLVREGIAFARTSQPLEEARQRLNLDAFLDTIVCDYADVGRPVQFCPEETA
GVVWIPPQALRRVMTNLIDNALKFGTTATVTLTRDAVGDITLHVLDEGPGIPEASLQAVLQPFYRLEDSRNRDTGGTGLG
LAIAAQLLSQMDGALRLANRPQGGLDASVRLAAAGLYPAVSPGKTDN

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=275, Percent_Identity=28.7272727272727, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=28.6919831223629, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=29.7297297297297, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786783, Length=300, Percent_Identity=27, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=26.1818181818182, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=29.0598290598291, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082128, Length=296, Percent_Identity=22.972972972973, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790861, Length=296, Percent_Identity=23.3108108108108, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=28.8288288288288, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789403, Length=295, Percent_Identity=27.7966101694915, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=26.0416666666667, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=28.1385281385281, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87081816, Length=228, Percent_Identity=27.6315789473684, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786600, Length=205, Percent_Identity=27.8048780487805, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49156; Mature: 49156

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFWPASLQSRLMALLFLALLLANTLTLSLLFYERMSSARSVMLGNLASDVATSVAILDR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPAAERPQWLPKLARGNYRYLLDAGERGDYPDSWRARDAARSLQEALSAQYPVSIVAIPG
CCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCC
PRQHIQAHITLHDGAPLTLDLWPKLPAIARWLPVVLIAQFVLLLACAWYAVRQVLLPISR
CHHHEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTHAVNALEPASDTAGTMAEQGPEEVRRAARAFNAMQARIHDHLQERARILAAISHDLQT
HHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PITRMKLRVEMADQPELRGKLLQDLDNMTRLVREGIAFARTSQPLEEARQRLNLDAFLDT
HHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
IVCDYADVGRPVQFCPEETAGVVWIPPQALRRVMTNLIDNALKFGTTATVTLTRDAVGDI
HHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCE
TLHVLDEGPGIPEASLQAVLQPFYRLEDSRNRDTGGTGLGLAIAAQLLSQMDGALRLANR
EEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PQGGLDASVRLAAAGLYPAVSPGKTDN
CCCCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRFWPASLQSRLMALLFLALLLANTLTLSLLFYERMSSARSVMLGNLASDVATSVAILDR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPAAERPQWLPKLARGNYRYLLDAGERGDYPDSWRARDAARSLQEALSAQYPVSIVAIPG
CCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCC
PRQHIQAHITLHDGAPLTLDLWPKLPAIARWLPVVLIAQFVLLLACAWYAVRQVLLPISR
CHHHEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTHAVNALEPASDTAGTMAEQGPEEVRRAARAFNAMQARIHDHLQERARILAAISHDLQT
HHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PITRMKLRVEMADQPELRGKLLQDLDNMTRLVREGIAFARTSQPLEEARQRLNLDAFLDT
HHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
IVCDYADVGRPVQFCPEETAGVVWIPPQALRRVMTNLIDNALKFGTTATVTLTRDAVGDI
HHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCE
TLHVLDEGPGIPEASLQAVLQPFYRLEDSRNRDTGGTGLGLAIAAQLLSQMDGALRLANR
EEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PQGGLDASVRLAAAGLYPAVSPGKTDN
CCCCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]