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The map label for this gene is emrA [H]

Identifier: 238894811

GI number: 238894811

Start: 2692042

End: 2693094

Strand: Direct

Name: emrA [H]

Synonym: KP1_2824

Alternate gene names: 238894811

Gene position: 2692042-2693094 (Clockwise)

Preceding gene: 238894810

Following gene: 238894812

Centisome position: 51.29

GC content: 63.44

Gene sequence:

>1053_bases
ATGCCAGCAATGAATCCGGCCAGTAAGAAAAGCGTCCTCGTTCTGGCGGCCCTGGGGGCTGCCGCCCTGGCGGCAGCGAG
CTACGGCGCTTACTGGTGGCATACCGGGCGCTTTATGCAGACCACCGATGATGCCTATGTCGGCGGCGACATTAGCGCCA
TCTCCAGCAAAGTCTCCGGCTATATCCAGCAGCTGGCGGTGCAGGACAATATGGCGGTGAAAAAAGGTGACCTGTTGATC
CGCATTGACGACCGCGATTATCGCGCCGCCCTCGCGAAAGCCGCCGGAGAAGTGGCGGCGCAGCAGGCCGCGCTGGCCGA
TATCCAGGCTACCCGCCAGCTTCAGCAGGCGACCATTGCCGGCTCTGCGGCCTCGTTACTGGCCGCCACGGCGGCAACCG
AAAAACTGGCTAACGACAACCGACGCTATAACGCCCTGGCCGCGTCGAGCGCGATTTCCGCACAGATCCGCGATAACGCC
TCCGCCGATTATCGCCGGGCGCACGCCGAGCAGGAGAAGGCCAAAGCGGATAAAACCGTGGCCGAACGTCAGCTGGCGGT
GCTGGATGCTCGCCAGCAGCAAATCCTGGCTGCCCTGGCGCAGGCCCAGGCTAACCTCGAGATGGCCAGGCTGAACCTCA
GCTATACCGACATTCGCGCACCGTTCGATGGGGTGATTGGCAACCGCCGCGCGTGGTCCGGCTCCTTCGTCAGCAGCGGT
ACGCAGCTGCTCTCCCTGGTACCCGCGCACGGCCTGTGGATTGACGCTAACTTCAAGGAAAACCAGCTGGCGCATATGCG
TGCCGGCCAGCCGGTGACCATCGTCGCCGATGTGCTGCCGAACCATACCTTTAAGGGGCATGTCGCCAGCCTGGCGCCGG
CGACCGGCTCACGCTTCAGCATTCTGCCGGCGGAGAACGCGACCGGGAATTTCACTAAAATCGTGCAGCGGGTGCCGGTC
CGCATTGCGCTGGAAGGTGACGGGGCAAAGCTTGACGTCCTGCGCCCGGGACTGTCGGTGATCGTCACCGTGAACGAAAA
GAGCCCTCGATGA

Upstream 100 bases:

>100_bases
GGCCCCGCCGCCTCGCCGCTGATGAAATATCGTCATGAATATCTGCTGCGCAAACGCGAAGGCGATAGCGGACAAAAATT
CCAACCGGAACCTTACAGAG

Downstream 100 bases:

>100_bases
GCACCGTTCAGGCGCTGTCCGCCCCGCAGGGTCTGTCGATGCCGACGGCGAAGAAGATCTTCGCCTTCGCCAGCATGTGC
GTGGGGATATTTATTGCCCT

Product: multidrug resistance secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MPAMNPASKKSVLVLAALGAAALAAASYGAYWWHTGRFMQTTDDAYVGGDISAISSKVSGYIQQLAVQDNMAVKKGDLLI
RIDDRDYRAALAKAAGEVAAQQAALADIQATRQLQQATIAGSAASLLAATAATEKLANDNRRYNALAASSAISAQIRDNA
SADYRRAHAEQEKAKADKTVAERQLAVLDARQQQILAALAQAQANLEMARLNLSYTDIRAPFDGVIGNRRAWSGSFVSSG
TQLLSLVPAHGLWIDANFKENQLAHMRAGQPVTIVADVLPNHTFKGHVASLAPATGSRFSILPAENATGNFTKIVQRVPV
RIALEGDGAKLDVLRPGLSVIVTVNEKSPR

Sequences:

>Translated_350_residues
MPAMNPASKKSVLVLAALGAAALAAASYGAYWWHTGRFMQTTDDAYVGGDISAISSKVSGYIQQLAVQDNMAVKKGDLLI
RIDDRDYRAALAKAAGEVAAQQAALADIQATRQLQQATIAGSAASLLAATAATEKLANDNRRYNALAASSAISAQIRDNA
SADYRRAHAEQEKAKADKTVAERQLAVLDARQQQILAALAQAQANLEMARLNLSYTDIRAPFDGVIGNRRAWSGSFVSSG
TQLLSLVPAHGLWIDANFKENQLAHMRAGQPVTIVADVLPNHTFKGHVASLAPATGSRFSILPAENATGNFTKIVQRVPV
RIALEGDGAKLDVLRPGLSVIVTVNEKSPR
>Mature_349_residues
PAMNPASKKSVLVLAALGAAALAAASYGAYWWHTGRFMQTTDDAYVGGDISAISSKVSGYIQQLAVQDNMAVKKGDLLIR
IDDRDYRAALAKAAGEVAAQQAALADIQATRQLQQATIAGSAASLLAATAATEKLANDNRRYNALAASSAISAQIRDNAS
ADYRRAHAEQEKAKADKTVAERQLAVLDARQQQILAALAQAQANLEMARLNLSYTDIRAPFDGVIGNRRAWSGSFVSSGT
QLLSLVPAHGLWIDANFKENQLAHMRAGQPVTIVADVLPNHTFKGHVASLAPATGSRFSILPAENATGNFTKIVQRVPVR
IALEGDGAKLDVLRPGLSVIVTVNEKSPR

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=337, Percent_Identity=35.6083086053413, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1788711, Length=324, Percent_Identity=35.4938271604938, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1790519, Length=306, Percent_Identity=31.6993464052288, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87081951, Length=324, Percent_Identity=27.1604938271605, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1789637, Length=347, Percent_Identity=28.2420749279539, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790012, Length=249, Percent_Identity=25.7028112449799, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790024, Length=246, Percent_Identity=23.5772357723577, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787013, Length=331, Percent_Identity=27.190332326284, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37120; Mature: 36989

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAMNPASKKSVLVLAALGAAALAAASYGAYWWHTGRFMQTTDDAYVGGDISAISSKVSG
CCCCCCCCCCCEEEEEHHHHHHHHHHHCCCEEEECCCEEEECCCCEECCCHHHHHHHHHH
YIQQLAVQDNMAVKKGDLLIRIDDRDYRAALAKAAGEVAAQQAALADIQATRQLQQATIA
HHHHHHHHCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSAASLLAATAATEKLANDNRRYNALAASSAISAQIRDNASADYRRAHAEQEKAKADKTV
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AERQLAVLDARQQQILAALAQAQANLEMARLNLSYTDIRAPFDGVIGNRRAWSGSFVSSG
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHCCCCHHHHCCCCCCCCCCHHHCC
TQLLSLVPAHGLWIDANFKENQLAHMRAGQPVTIVADVLPNHTFKGHVASLAPATGSRFS
HHHHHHCCCCCEEEECCCCCCCHHHHCCCCCEEEEEEHHCCCCCCCCHHEECCCCCCEEE
ILPAENATGNFTKIVQRVPVRIALEGDGAKLDVLRPGLSVIVTVNEKSPR
EEECCCCCCHHHHHHHHCCEEEEECCCCCEEEEECCCEEEEEEECCCCCC
>Mature Secondary Structure 
PAMNPASKKSVLVLAALGAAALAAASYGAYWWHTGRFMQTTDDAYVGGDISAISSKVSG
CCCCCCCCCCEEEEEHHHHHHHHHHHCCCEEEECCCEEEECCCCEECCCHHHHHHHHHH
YIQQLAVQDNMAVKKGDLLIRIDDRDYRAALAKAAGEVAAQQAALADIQATRQLQQATIA
HHHHHHHHCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSAASLLAATAATEKLANDNRRYNALAASSAISAQIRDNASADYRRAHAEQEKAKADKTV
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AERQLAVLDARQQQILAALAQAQANLEMARLNLSYTDIRAPFDGVIGNRRAWSGSFVSSG
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHCCCCHHHHCCCCCCCCCCHHHCC
TQLLSLVPAHGLWIDANFKENQLAHMRAGQPVTIVADVLPNHTFKGHVASLAPATGSRFS
HHHHHHCCCCCEEEECCCCCCCHHHHCCCCCEEEEEEHHCCCCCCCCHHEECCCCCCEEE
ILPAENATGNFTKIVQRVPVRIALEGDGAKLDVLRPGLSVIVTVNEKSPR
EEECCCCCCHHHHHHHHCCEEEEECCCCCEEEEECCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]