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The map label for this gene is asd [H]

Identifier: 238894809

GI number: 238894809

Start: 2690071

End: 2691189

Strand: Reverse

Name: asd [H]

Synonym: KP1_2822

Alternate gene names: 238894809

Gene position: 2691189-2690071 (Counterclockwise)

Preceding gene: 238894816

Following gene: 238894803

Centisome position: 51.28

GC content: 51.3

Gene sequence:

>1119_bases
ATGAAGCAGGTGGGTATTGTTGGTTGGCGAGGGATGGTGGGCTCAGTATTGTTGCAACGCATGATCGAAGAAAATGATTT
CGACGATATTACAGCGCATTTTTTTAGTACCTCCAGTGCGGGTGCCCCGGGCCCGGTTATTAATGGTAAAAGCGACAGGC
TGAAAGATGCGAATTCCCTTAGCGCACTCGCCGAAATGGATATCATCATCACCTGTCAGGGCGGGGATTATACCAAAGCC
ATCTATCCGGCGTTAATTAACCATGGCTGGCAAGGTTACTGGATTGATGCGGCTTCGGCGCTGCGGATGGATGAAAAAGC
CTGCATTATTCTCGACCCGGTCAACCGCGAAAATATCGATAGTGCGGTAAAAGCGGGAATTAAACTGTTTGTCGGCGGCA
ACTGCTCCATTACGCTGAGCCTGATGGGGTTGGCCGGGCTGATAAAAGCGGATCTTATCGAATGGATGAGCGTGATGACC
TATCAGTCTGCCTCCGGGGCGGGCGCCAAACAGGTGCGGGAATTAATAGCGCAAAGCGCTTATATCAGTCAGCATTTATC
CGCTGATGAACTGACATCATCAGGTTCCGTGCTGCCATTGGTAAATAAAGTGAGTGAGTTGATTAACAGCGCGGGCATGC
CGGTGGAGAATTTTGGCGTCCCCCTCATGGGCAGCATCATTCCGTGGATCGACAGCGATCTGGGCGATGGAAACAGCCGC
GAAGAATGGAAGGGCGAGGCGGAAACTAATAAAATTCTTGGCCTTGCGCCGGGTACCATCCCGGTCAATGGTTTATGCAT
TCGGGTCGGGGTGATCCGCTGTCACAGCGCGGCGATTACGCTGAAACTTAAACGTGAGGTCAGCGAAGCAGAATTTGCTG
AGTTAGTCACCCATTCCCATCCGTGGGTAAACTATGTCCGCAATAATAAGCAAGAGAGTGTCAGTAAATTGACCCCGGCT
GCTATTAGTGGTTCGCTGCAGGTAGGTATTGGCCGCTACAAGAAAATGTCGCTAAATAATGACCCAGTCTACTCGGTGTT
AACGGTTGGCGATCAGCTATTGTGGGGGGCGGCGGAACCCCTGCGCCGCATGTTAAATATCCTGCTGGGCAAAATATAG

Upstream 100 bases:

>100_bases
TAAAAATCGATGTGCTGGGTAATGACCTTTATTGGGGGATACGATATAAGGTATGGCGACACTCAAATTAACATTCTCAT
AACTTATAAAGGTTAAATAA

Downstream 100 bases:

>100_bases
TTACGGTCATCCGGGGAAAGCCCTCGCGCGCAGGCGGTTAAGACAAATGTTTAACGAAGCGTTTGCGAACCTCCTTGTAG
CCGTTATTTTCATAAAATTG

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKQVGIVGWRGMVGSVLLQRMIEENDFDDITAHFFSTSSAGAPGPVINGKSDRLKDANSLSALAEMDIIITCQGGDYTKA
IYPALINHGWQGYWIDAASALRMDEKACIILDPVNRENIDSAVKAGIKLFVGGNCSITLSLMGLAGLIKADLIEWMSVMT
YQSASGAGAKQVRELIAQSAYISQHLSADELTSSGSVLPLVNKVSELINSAGMPVENFGVPLMGSIIPWIDSDLGDGNSR
EEWKGEAETNKILGLAPGTIPVNGLCIRVGVIRCHSAAITLKLKREVSEAEFAELVTHSHPWVNYVRNNKQESVSKLTPA
AISGSLQVGIGRYKKMSLNNDPVYSVLTVGDQLLWGAAEPLRRMLNILLGKI

Sequences:

>Translated_372_residues
MKQVGIVGWRGMVGSVLLQRMIEENDFDDITAHFFSTSSAGAPGPVINGKSDRLKDANSLSALAEMDIIITCQGGDYTKA
IYPALINHGWQGYWIDAASALRMDEKACIILDPVNRENIDSAVKAGIKLFVGGNCSITLSLMGLAGLIKADLIEWMSVMT
YQSASGAGAKQVRELIAQSAYISQHLSADELTSSGSVLPLVNKVSELINSAGMPVENFGVPLMGSIIPWIDSDLGDGNSR
EEWKGEAETNKILGLAPGTIPVNGLCIRVGVIRCHSAAITLKLKREVSEAEFAELVTHSHPWVNYVRNNKQESVSKLTPA
AISGSLQVGIGRYKKMSLNNDPVYSVLTVGDQLLWGAAEPLRRMLNILLGKI
>Mature_372_residues
MKQVGIVGWRGMVGSVLLQRMIEENDFDDITAHFFSTSSAGAPGPVINGKSDRLKDANSLSALAEMDIIITCQGGDYTKA
IYPALINHGWQGYWIDAASALRMDEKACIILDPVNRENIDSAVKAGIKLFVGGNCSITLSLMGLAGLIKADLIEWMSVMT
YQSASGAGAKQVRELIAQSAYISQHLSADELTSSGSVLPLVNKVSELINSAGMPVENFGVPLMGSIIPWIDSDLGDGNSR
EEWKGEAETNKILGLAPGTIPVNGLCIRVGVIRCHSAAITLKLKREVSEAEFAELVTHSHPWVNYVRNNKQESVSKLTPA
AISGSLQVGIGRYKKMSLNNDPVYSVLTVGDQLLWGAAEPLRRMLNILLGKI

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=368, Percent_Identity=54.6195652173913, Blast_Score=422, Evalue=1e-119,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 40038; Mature: 40038

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVGIVGWRGMVGSVLLQRMIEENDFDDITAHFFSTSSAGAPGPVINGKSDRLKDANSL
CCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHCCCHHHH
SALAEMDIIITCQGGDYTKAIYPALINHGWQGYWIDAASALRMDEKACIILDPVNRENID
HHHHHCCEEEEECCCCCHHHHHHHHHHCCCCEEEECCHHHHCCCCCCEEEECCCCCCHHH
SAVKAGIKLFVGGNCSITLSLMGLAGLIKADLIEWMSVMTYQSASGAGAKQVRELIAQSA
HHHHCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
YISQHLSADELTSSGSVLPLVNKVSELINSAGMPVENFGVPLMGSIIPWIDSDLGDGNSR
HHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHCCCCCCCCCC
EEWKGEAETNKILGLAPGTIPVNGLCIRVGVIRCHSAAITLKLKREVSEAEFAELVTHSH
HHCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEECCEEEEEEEHHHHHHHHHHHHHHCCC
PWVNYVRNNKQESVSKLTPAAISGSLQVGIGRYKKMSLNNDPVYSVLTVGDQLLWGAAEP
CHHHHHHCCHHHHHHHCCHHHHCCCEEECCCCEEEECCCCCCCEEEEHHCHHHHHCCHHH
LRRMLNILLGKI
HHHHHHHHHCCC
>Mature Secondary Structure
MKQVGIVGWRGMVGSVLLQRMIEENDFDDITAHFFSTSSAGAPGPVINGKSDRLKDANSL
CCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHCCCHHHH
SALAEMDIIITCQGGDYTKAIYPALINHGWQGYWIDAASALRMDEKACIILDPVNRENID
HHHHHCCEEEEECCCCCHHHHHHHHHHCCCCEEEECCHHHHCCCCCCEEEECCCCCCHHH
SAVKAGIKLFVGGNCSITLSLMGLAGLIKADLIEWMSVMTYQSASGAGAKQVRELIAQSA
HHHHCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
YISQHLSADELTSSGSVLPLVNKVSELINSAGMPVENFGVPLMGSIIPWIDSDLGDGNSR
HHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHCCCCCCCCCC
EEWKGEAETNKILGLAPGTIPVNGLCIRVGVIRCHSAAITLKLKREVSEAEFAELVTHSH
HHCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEECCEEEEEEEHHHHHHHHHHHHHHCCC
PWVNYVRNNKQESVSKLTPAAISGSLQVGIGRYKKMSLNNDPVYSVLTVGDQLLWGAAEP
CHHHHHHCCHHHHHHHCCHHHHCCCEEECCCCEEEECCCCCCCEEEEHHCHHHHHCCHHH
LRRMLNILLGKI
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9084174; 10984043 [H]