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The map label for this gene is fruA [H]

Identifier: 238894778

GI number: 238894778

Start: 2660204

End: 2661310

Strand: Reverse

Name: fruA [H]

Synonym: KP1_2787

Alternate gene names: 238894778

Gene position: 2661310-2660204 (Counterclockwise)

Preceding gene: 238894779

Following gene: 238894777

Centisome position: 50.71

GC content: 51.67

Gene sequence:

>1107_bases
ATGTCTCTAAAACAAATATGGCAAGCAGCAAACCCTAAAGGACATCTGCTGACCGCTATCTCGTTTCTGATCCCCATTGT
CTGTGGTTCTGGGTTTATTATCGCCATCGGCATGGGGCTTGGCGGAACGGTGCAGGACACGTTAACGCCGGGACAATTTG
ATGTATGGCAGGCAATGGCCACCCTGGGCGCCAAGGCGCTTGGGCTGTTGCCGGTGGTGATTGCCGTGGGAATATCTGGC
TCGATCGCCGGCAAACCAGGCATCGCGCCAGGATTTGTCGTCGGGCTGGCGGCGAATACCATAAGCGCAGGCTTTATCGG
TGGGATGATTGGTGGCTATATTGCGGGGTATATTGCGCTGGCGATCATTAAAAACGTCAAGGTGCCTGACTGGGCCCGCG
GGTTGATGCCGACGCTGATCGTTCCCTTTTTTGCCTCCATTATCAGCTGCCTGATTATGGTCTATATCATCGGTACGCCT
ATCGGTATCTTTACGGAAGCGCTTACGTCTTTCCTGAGAAGCATGGGCACGTCGTCGAATTTGGTGTTAGGCGCAGTCAT
AGGCGCATTGTGTATTGTTGACTTTGGCGGCCCGCTAAATAAGACATGCTTTGCTTTCGTGCTGACCCTGCAGGCGCAGG
GGATAAATGAACCCATTACCGCACTTCAGTTAGTTAACACCGCTACGCCTATCGGATTTGGCCTGGCTTTCTTTATTGCC
AAACTGCTGCGTAAAAATATCTATAACCGTGAAGAAGTGGAAACCTTAAAATCAGCGGTTCCGATGGGGATTGTGAATAT
CGTTGAGGGTTCTATTCCGATCGTCATGAATGATATTGTGCGCGGTATCGCGGCGGCGGCTATCGGCGGCGCGTGCGGCG
GGGCGGTCACCATGGTCTATGGTGCGGATGCGACGGTTCCTTTTGGCGGAGTATTGATGATCCCCACGATGTCACATCCG
ATGGCAGGCATCATGGCCCTGCTGGTGAATATCGTTGTTACCGCCACGGTTTATGCTGTCATCAAAAAAGATATTCCGCG
TGATGTGCTGGTTACTCATGATCACGAAGAAGAGGATATCGACCTTAATGATATTAAAGTGAGCTAA

Upstream 100 bases:

>100_bases
GGCAGTCAAATCCCCCAATAAGTTGATTGAAAAACTCAGTGAAATAGTCAATTCATAATTTTATTTCGGCCTGGCGACTC
TACATTAAAGGGCGTGACTT

Downstream 100 bases:

>100_bases
CTTACCCCTGTATTATTTTATCAATGGCGTTGAGCTAGTCCTGCAACTCAGCCCATAACCGAGGGGTCCTTAGTTATGGG
CTGAGTTGCGTCAGGTAGAC

Product: fructose-mannitol-specific PTS family enzyme IIC component

Products: NA

Alternate protein names: EIIBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSLKQIWQAANPKGHLLTAISFLIPIVCGSGFIIAIGMGLGGTVQDTLTPGQFDVWQAMATLGAKALGLLPVVIAVGISG
SIAGKPGIAPGFVVGLAANTISAGFIGGMIGGYIAGYIALAIIKNVKVPDWARGLMPTLIVPFFASIISCLIMVYIIGTP
IGIFTEALTSFLRSMGTSSNLVLGAVIGALCIVDFGGPLNKTCFAFVLTLQAQGINEPITALQLVNTATPIGFGLAFFIA
KLLRKNIYNREEVETLKSAVPMGIVNIVEGSIPIVMNDIVRGIAAAAIGGACGGAVTMVYGADATVPFGGVLMIPTMSHP
MAGIMALLVNIVVTATVYAVIKKDIPRDVLVTHDHEEEDIDLNDIKVS

Sequences:

>Translated_368_residues
MSLKQIWQAANPKGHLLTAISFLIPIVCGSGFIIAIGMGLGGTVQDTLTPGQFDVWQAMATLGAKALGLLPVVIAVGISG
SIAGKPGIAPGFVVGLAANTISAGFIGGMIGGYIAGYIALAIIKNVKVPDWARGLMPTLIVPFFASIISCLIMVYIIGTP
IGIFTEALTSFLRSMGTSSNLVLGAVIGALCIVDFGGPLNKTCFAFVLTLQAQGINEPITALQLVNTATPIGFGLAFFIA
KLLRKNIYNREEVETLKSAVPMGIVNIVEGSIPIVMNDIVRGIAAAAIGGACGGAVTMVYGADATVPFGGVLMIPTMSHP
MAGIMALLVNIVVTATVYAVIKKDIPRDVLVTHDHEEEDIDLNDIKVS
>Mature_367_residues
SLKQIWQAANPKGHLLTAISFLIPIVCGSGFIIAIGMGLGGTVQDTLTPGQFDVWQAMATLGAKALGLLPVVIAVGISGS
IAGKPGIAPGFVVGLAANTISAGFIGGMIGGYIAGYIALAIIKNVKVPDWARGLMPTLIVPFFASIISCLIMVYIIGTPI
GIFTEALTSFLRSMGTSSNLVLGAVIGALCIVDFGGPLNKTCFAFVLTLQAQGINEPITALQLVNTATPIGFGLAFFIAK
LLRKNIYNREEVETLKSAVPMGIVNIVEGSIPIVMNDIVRGIAAAAIGGACGGAVTMVYGADATVPFGGVLMIPTMSHPM
AGIMALLVNIVVTATVYAVIKKDIPRDVLVTHDHEEEDIDLNDIKVS

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=339, Percent_Identity=35.1032448377581, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1790386, Length=310, Percent_Identity=32.258064516129, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1786951, Length=288, Percent_Identity=30.5555555555556, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI87082348, Length=373, Percent_Identity=26.5415549597855, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788729, Length=352, Percent_Identity=23.8636363636364, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 38091; Mature: 37960

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKQIWQAANPKGHLLTAISFLIPIVCGSGFIIAIGMGLGGTVQDTLTPGQFDVWQAMA
CCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHCCCCCHHHHHHHHH
TLGAKALGLLPVVIAVGISGSIAGKPGIAPGFVVGLAANTISAGFIGGMIGGYIAGYIAL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIIKNVKVPDWARGLMPTLIVPFFASIISCLIMVYIIGTPIGIFTEALTSFLRSMGTSSN
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
LVLGAVIGALCIVDFGGPLNKTCFAFVLTLQAQGINEPITALQLVNTATPIGFGLAFFIA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHH
KLLRKNIYNREEVETLKSAVPMGIVNIVEGSIPIVMNDIVRGIAAAAIGGACGGAVTMVY
HHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEE
GADATVPFGGVLMIPTMSHPMAGIMALLVNIVVTATVYAVIKKDIPRDVLVTHDHEEEDI
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
DLNDIKVS
CCCCCEEC
>Mature Secondary Structure 
SLKQIWQAANPKGHLLTAISFLIPIVCGSGFIIAIGMGLGGTVQDTLTPGQFDVWQAMA
CHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHCCCCCHHHHHHHHH
TLGAKALGLLPVVIAVGISGSIAGKPGIAPGFVVGLAANTISAGFIGGMIGGYIAGYIAL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIIKNVKVPDWARGLMPTLIVPFFASIISCLIMVYIIGTPIGIFTEALTSFLRSMGTSSN
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
LVLGAVIGALCIVDFGGPLNKTCFAFVLTLQAQGINEPITALQLVNTATPIGFGLAFFIA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHH
KLLRKNIYNREEVETLKSAVPMGIVNIVEGSIPIVMNDIVRGIAAAAIGGACGGAVTMVY
HHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEE
GADATVPFGGVLMIPTMSHPMAGIMALLVNIVVTATVYAVIKKDIPRDVLVTHDHEEEDI
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
DLNDIKVS
CCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3076173; 9278503; 9097040; 1981619 [H]