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The map label for this gene is yrhP [H]

Identifier: 238894777

GI number: 238894777

Start: 2659398

End: 2660018

Strand: Reverse

Name: yrhP [H]

Synonym: KP1_2786

Alternate gene names: 238894777

Gene position: 2660018-2659398 (Counterclockwise)

Preceding gene: 238894778

Following gene: 238894775

Centisome position: 50.68

GC content: 55.07

Gene sequence:

>621_bases
ATGCTCGTCACTGATTCACTTCTTGCTTACACCCTCGCTGCTACACTGCTTACCCTGACGCCAGGTCTTGATACTGCTCT
TATTCTCCGCACGGCGACTGCTGAAGGGGGACGCAAAGCCTTGCATGCCGCGTTAGGCATCGATCTCGGGTGCTTTATTT
GGGGCGCGCTGGTGGCCTTTGGTTTAGGTGCGCTACTGGCGGTTTCTGAGTTGGCTTATACCTTATTGAAATGGTGCGGA
GCAGGATACCTTTGCTGGCTGGGCATCCAGTTGCTCCTGCGACCACGCCAGCAATTTAACACCCACCCGGCCGAATCAGA
TTCCACGAGTAACTGGTTCCTGCGTGGGATGCTGGGGAATGTGTTTAACCCCAAAATGGGCGTCTTCTACGTTTCGTTTT
TGCCCCAGTTTATCCCTGCCGGGCATTCACCGATCAGCTGGACCTTTCTCCTGGTCACCATCCATGTATTGATAGGGACG
CTGTGGTCGTTAACGCTGATTACCGCCACTCGCTATGCCGCCGGCATCCTGAAAAAACCGGCCGTAGTGAAATGGATGGA
CCGAACGACCGGCTGCCTGTTTCTGTTGTTTGCCGCGAAGCTGGCCATGAGTCGGCGGTAG

Upstream 100 bases:

>100_bases
TTGCGTCAGGTAGACGGCTGGGTAAAAGTGGAGCAGGGTGAACATTGTTGTTGCAAAAATGTGAACGCTTCAGTAGCCTT
GTCTCTTTCGGAGACAGGAA

Downstream 100 bases:

>100_bases
TCACGCAGGGGCGTATGCCCCTGTTTTTGCCTTAAAAAATGAGCAACCCGTGGAGTACTACTCAGTGGTGAAACGATCGG
GCTCGAACGTACGTTTAGCC

Product: amino acid homoserine exporter

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MLVTDSLLAYTLAATLLTLTPGLDTALILRTATAEGGRKALHAALGIDLGCFIWGALVAFGLGALLAVSELAYTLLKWCG
AGYLCWLGIQLLLRPRQQFNTHPAESDSTSNWFLRGMLGNVFNPKMGVFYVSFLPQFIPAGHSPISWTFLLVTIHVLIGT
LWSLTLITATRYAAGILKKPAVVKWMDRTTGCLFLLFAAKLAMSRR

Sequences:

>Translated_206_residues
MLVTDSLLAYTLAATLLTLTPGLDTALILRTATAEGGRKALHAALGIDLGCFIWGALVAFGLGALLAVSELAYTLLKWCG
AGYLCWLGIQLLLRPRQQFNTHPAESDSTSNWFLRGMLGNVFNPKMGVFYVSFLPQFIPAGHSPISWTFLLVTIHVLIGT
LWSLTLITATRYAAGILKKPAVVKWMDRTTGCLFLLFAAKLAMSRR
>Mature_206_residues
MLVTDSLLAYTLAATLLTLTPGLDTALILRTATAEGGRKALHAALGIDLGCFIWGALVAFGLGALLAVSELAYTLLKWCG
AGYLCWLGIQLLLRPRQQFNTHPAESDSTSNWFLRGMLGNVFNPKMGVFYVSFLPQFIPAGHSPISWTFLLVTIHVLIGT
LWSLTLITATRYAAGILKKPAVVKWMDRTTGCLFLLFAAKLAMSRR

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=198, Percent_Identity=31.3131313131313, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788099, Length=197, Percent_Identity=28.9340101522843, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI48994978, Length=195, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 22446; Mature: 22446

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVTDSLLAYTLAATLLTLTPGLDTALILRTATAEGGRKALHAALGIDLGCFIWGALVAF
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHH
GLGALLAVSELAYTLLKWCGAGYLCWLGIQLLLRPRQQFNTHPAESDSTSNWFLRGMLGN
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHH
VFNPKMGVFYVSFLPQFIPAGHSPISWTFLLVTIHVLIGTLWSLTLITATRYAAGILKKP
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AVVKWMDRTTGCLFLLFAAKLAMSRR
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVTDSLLAYTLAATLLTLTPGLDTALILRTATAEGGRKALHAALGIDLGCFIWGALVAF
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHH
GLGALLAVSELAYTLLKWCGAGYLCWLGIQLLLRPRQQFNTHPAESDSTSNWFLRGMLGN
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHH
VFNPKMGVFYVSFLPQFIPAGHSPISWTFLLVTIHVLIGTLWSLTLITATRYAAGILKKP
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AVVKWMDRTTGCLFLLFAAKLAMSRR
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9308178 [H]