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The map label for this gene is alsE [H]

Identifier: 238894745

GI number: 238894745

Start: 2628597

End: 2629286

Strand: Reverse

Name: alsE [H]

Synonym: KP1_2752

Alternate gene names: 238894745

Gene position: 2629286-2628597 (Counterclockwise)

Preceding gene: 238894746

Following gene: 238894744

Centisome position: 50.1

GC content: 57.1

Gene sequence:

>690_bases
ATGCGTTATTACCTTTCTCCCTCGCTGATGTGTATGGACATGATGAAGCTGACGGAACAGCTGCGATTTCTAAACAGCAA
AGCCGACAGGCTGCATGTCGACATCATGGACGGCCACTATGTCAAAAATCTGGCGTTGTCGGCCAGCTTTGTGGCGCAGA
TCCGTCCCTACACCTCGCTTCCTATCGATGTCCATCTGATGGTCGAAGCGCCCGCTTCGTTTATACCGGCGCTGTTAGAC
GCCGGCGCAGACGCCTTCTCACTGCATCCGGAGACCATCTGCCGCGAAGCGTTCCGGGTTATCAATATGCTTCGTCAGGC
GGGGAAAGAGGTGGGAATGGTGCTCAATCCCGCCACACCGGTTGAGAGCATCCAGCACTATCTGCATCTGCTCGATAAGG
TGACGGTGATGACCGTCGACCCAGGCTATGCCGGTCAGCCGTTTATTCCTGAAATGCTCGCCAAAATTACGCAGCTTCAT
CAGCTCAAAGAGACCGGCAGCCTCCGCTTCTTGCTGGAAGTCGATGGCTCCTGTAACCGCAACACCTACCGCGCGCTGCT
GGGCGCCGGCGCACAGATATTAGTGATGGGCAGCAGCGGTTTATTCCGCGCTGATATGCCGCTCGAGCTGGCCTGGGAAA
CCATGTCCCGCGAACTGTCCGCCGCGCTGCACTCCCCCGAGCTGGTATAG

Upstream 100 bases:

>100_bases
CATGACGTGACGGTTAATACGCGCAATGTCGAAACGCTGCTTACCGCGGCAGGGCCAGACTTTGCCTGAATTCAGCCACC
ACCGGAATAAATGAGGCCTT

Downstream 100 bases:

>100_bases
AGGAGCGAATGATGTCAGGAAAAGTCTGTGTTTTTGGTTCATTCAATTTCGACATGGTCGCCAGGGTGGATCGCTTTCCG
GTACCAGGTGAGTCGTTAGT

Product: allulose-6-phosphate 3-epimerase

Products: fructose-6-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MRYYLSPSLMCMDMMKLTEQLRFLNSKADRLHVDIMDGHYVKNLALSASFVAQIRPYTSLPIDVHLMVEAPASFIPALLD
AGADAFSLHPETICREAFRVINMLRQAGKEVGMVLNPATPVESIQHYLHLLDKVTVMTVDPGYAGQPFIPEMLAKITQLH
QLKETGSLRFLLEVDGSCNRNTYRALLGAGAQILVMGSSGLFRADMPLELAWETMSRELSAALHSPELV

Sequences:

>Translated_229_residues
MRYYLSPSLMCMDMMKLTEQLRFLNSKADRLHVDIMDGHYVKNLALSASFVAQIRPYTSLPIDVHLMVEAPASFIPALLD
AGADAFSLHPETICREAFRVINMLRQAGKEVGMVLNPATPVESIQHYLHLLDKVTVMTVDPGYAGQPFIPEMLAKITQLH
QLKETGSLRFLLEVDGSCNRNTYRALLGAGAQILVMGSSGLFRADMPLELAWETMSRELSAALHSPELV
>Mature_229_residues
MRYYLSPSLMCMDMMKLTEQLRFLNSKADRLHVDIMDGHYVKNLALSASFVAQIRPYTSLPIDVHLMVEAPASFIPALLD
AGADAFSLHPETICREAFRVINMLRQAGKEVGMVLNPATPVESIQHYLHLLDKVTVMTVDPGYAGQPFIPEMLAKITQLH
QLKETGSLRFLLEVDGSCNRNTYRALLGAGAQILVMGSSGLFRADMPLELAWETMSRELSAALHSPELV

Specific function: D-ALLOSE METABOLISM. ESSENTIAL FOR THIS PATHWAY. [C]

COG id: COG0036

COG function: function code G; Pentose-5-phosphate-3-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribulose-phosphate 3-epimerase family [H]

Homologues:

Organism=Homo sapiens, GI40385883, Length=206, Percent_Identity=33.495145631068, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI219879828, Length=206, Percent_Identity=31.0679611650485, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI24307923, Length=161, Percent_Identity=27.9503105590062, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790523, Length=218, Percent_Identity=51.3761467889908, Blast_Score=251, Evalue=3e-68,
Organism=Escherichia coli, GI1789788, Length=225, Percent_Identity=32.8888888888889, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790754, Length=156, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17552948, Length=228, Percent_Identity=30.7017543859649, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322341, Length=243, Percent_Identity=29.2181069958848, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24586301, Length=223, Percent_Identity=30.4932735426009, Blast_Score=118, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000056
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00834 Ribul_P_3_epim [H]

EC number: 5.1.3.- [C]

Molecular weight: Translated: 25461; Mature: 25461

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS01085 RIBUL_P_3_EPIMER_1 ; PS01086 RIBUL_P_3_EPIMER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYYLSPSLMCMDMMKLTEQLRFLNSKADRLHVDIMDGHYVKNLALSASFVAQIRPYTSL
CEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCC
PIDVHLMVEAPASFIPALLDAGADAFSLHPETICREAFRVINMLRQAGKEVGMVLNPATP
CEEEEEEEECCHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHCCHHCCEEECCCCC
VESIQHYLHLLDKVTVMTVDPGYAGQPFIPEMLAKITQLHQLKETGSLRFLLEVDGSCNR
HHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
NTYRALLGAGAQILVMGSSGLFRADMPLELAWETMSRELSAALHSPELV
HHHHHHHCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRYYLSPSLMCMDMMKLTEQLRFLNSKADRLHVDIMDGHYVKNLALSASFVAQIRPYTSL
CEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCC
PIDVHLMVEAPASFIPALLDAGADAFSLHPETICREAFRVINMLRQAGKEVGMVLNPATP
CEEEEEEEECCHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHCCHHCCEEECCCCC
VESIQHYLHLLDKVTVMTVDPGYAGQPFIPEMLAKITQLHQLKETGSLRFLLEVDGSCNR
HHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
NTYRALLGAGAQILVMGSSGLFRADMPLELAWETMSRELSAALHSPELV
HHHHHHHCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-allulose-6-phosphate [C]

Specific reaction: D-allulose-6-phosphate = fructose-6-phosphate [C]

General reaction: Isomerases; Racemases and Epimerases; Acting on Carbohydrates and Derivatives [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 9401019 [H]