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The map label for this gene is dcp [H]

Identifier: 238894613

GI number: 238894613

Start: 2507525

End: 2509570

Strand: Direct

Name: dcp [H]

Synonym: KP1_2614

Alternate gene names: 238894613

Gene position: 2507525-2509570 (Clockwise)

Preceding gene: 238894610

Following gene: 238894615

Centisome position: 47.78

GC content: 61.05

Gene sequence:

>2046_bases
ATGTCCGAACGAAACCCCTTTTTTAGCGTCAGTACGTTGCCTTACCAGGCGCCGCCGTTCGATGTGATTGACGACAGCCA
CTATCGCCCGGCGTTTGATGAGGGCGTCCGGCAGCAGCGGGCCGAAATTCGCGCTATTATCGACAATCCGCAGCCGGCCA
GTTTCGCCAACACGCTCGAGGCGCTGGAGCAGAGTGGTCAGCTGCTGGCGCGGGTGACGCGGGTCTTTTTCGCCATGGCT
GGCGCCCATACCAATCCTTATATTCAATCACTGGATGAACAATTTTCCGCCGAACTCGCCGAGCTGGGGAATGACATCTG
GCTTAATGCGGCCTTGTTTCAGCGCGTGAACAGCGTCTACGAGCAGCGCGACGCGCTGGCGCTGGACAGCGAGTCCTATC
GTCTCCTGACCCTGACGTGGCAACGTTTTGTTCACGCCGGGGCGACGCTGGCTCCCGAGCAGCAGGCGGCGCTGCGCACA
CTTAACACCGAAGCGGCTACGCTGCAAAGTCAGTTCCAGCAGCGACTGCTGGGAGCGGCAAAAAGCGGCGGCCTGGTGGT
TGATTACCGGCATCAACTGGCTGGCCTGAGCGATGAGGAGATAGCGGCGGCAGCTGACGCAGCGCGTGAAAGAGGGCTTA
GCGACCGCTGGTTGCTGACGCTGACCAATACCACCCAGCAGCCGCAGCTGCTTGCGCTGCGCGACCGGCAAACGCGGGAG
AATCTCTTCGCCGCCGGCTGGACCCGCAATCAGCAGGGCGATGAGCATGATACGCGTGCCCTGGTACTGCGGCTGGCGGC
GATCCGCGCGCAGCAGGCTGAGCTGTTGGGAGCCGCTGATTACGCCAGCTGGGCGCTGACCGATCAAATGGCGGCTTCCC
CGGCGGAGGCATTGGGCTTTATGCGCCGGATAGCGCCGGCGGCGCGGGCGAGGGCGGAACGAGAGCTGGCGGACATCCAG
CAGGTGATCGACAACGAAGGCGGGGGTTTTCGCGCGACGGCATGGGACTGGCTTTACTACAGCGAGCAGGTGCGGCGGGC
TGCCTATGCCATTGATGACGCGCAGCTCAAACCCTATTTTGCCCTCGAGCGGGTGCTGCAAGACGGTGTATTCTGGACGG
CCTCGCAGCTCTTTGGTCTGCGCTTTGTTGAGCGCTTCGATATACCGGTCTATCACCCGGATGTGCGGGTCTGGGAGATC
TTCGATCACAACGGCGAAGGGATGGCGCTGTTTTACGGTGACTACTACGCTCGTGACTCAAAGAGCGGCGGCGCATGGAT
GGATGTGTTTGTCGAACAGTCGACTCTGCGCGCGCAGCGCCCGGTTATCTACAATGTCTGCAACTACGTCCGCCCGCAGG
CAGGGCAGAGCGCGCTGCTGTCGTGGGATGAGGTGATCACCCTGTTTCATGAGTTCGGCCATACCCTGCATGGGCTGTTC
GCCAGCCAGCGCTACGCCAGTCTCTCGGGGACCAATACGCCGCGCGATTTTGTCGAATTTCCTTCGCAGATCTTCGAACA
CTGGGCCAGCCAGCCGCAGGTGTTTGCCCACTACGCGAAGCACTACCAGTCCGGGGAGCCGATGCCGCAAGCGCTACGCG
ACAATATGTTGCGTGCGGCAACCTTCAATAAAGGGTACGACATGAGCGAGCTGTTGGCTGCTGCGTTACTCGATATGCGG
TGGCATAGCCTGTCGACCTCGGCATTACCGGAGGAGGTGGACGCGTTTGAGCAGCTGGTGCTTCGGGAAGAGAACCTGGA
TCTGGCGGCGGTCCCCCCGCGCTATCGCAGCAGCTATTTCTCCCATATCTTCGGCGGCGGCTATGCGGCAGGCTATTACG
CCTATCTGTGGACCCAGATGCTGGCCGACGACGGCTATCAATGGTTCGTGGAGCAGGGCGGTTTGACCCGTGAGAACGGT
CAGCGTTTCCGTGAGGCGATTTTATCACGCGGGAACAGCACTGATTTAGCTGAACTGTATCGCCAGTGGCGCGGACACGA
TCCGCAGATTGAGCCGATGCTGAAAAATCGCGGGTTGAGTGCGTAG

Upstream 100 bases:

>100_bases
CATACCATAGCACGCACAGGCGGCGACCGGTAACGGAAATCATTGCGACCCCTTAAGGAGAGGCCTAATCTTACAGCATT
AGCCTGTACAGGAGAGAAAG

Downstream 100 bases:

>100_bases
GGCAATTTTAGTCTGACAAGATAACCGGGCGTGCTGCCCGGTTTTTTGTCTGATCTAGTCGTAACCTTATATTTCTTTTA
CCTCACGCTGCCTAAATCTC

Product: dipeptidyl carboxypeptidase II

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 681; Mature: 680

Protein sequence:

>681_residues
MSERNPFFSVSTLPYQAPPFDVIDDSHYRPAFDEGVRQQRAEIRAIIDNPQPASFANTLEALEQSGQLLARVTRVFFAMA
GAHTNPYIQSLDEQFSAELAELGNDIWLNAALFQRVNSVYEQRDALALDSESYRLLTLTWQRFVHAGATLAPEQQAALRT
LNTEAATLQSQFQQRLLGAAKSGGLVVDYRHQLAGLSDEEIAAAADAARERGLSDRWLLTLTNTTQQPQLLALRDRQTRE
NLFAAGWTRNQQGDEHDTRALVLRLAAIRAQQAELLGAADYASWALTDQMAASPAEALGFMRRIAPAARARAERELADIQ
QVIDNEGGGFRATAWDWLYYSEQVRRAAYAIDDAQLKPYFALERVLQDGVFWTASQLFGLRFVERFDIPVYHPDVRVWEI
FDHNGEGMALFYGDYYARDSKSGGAWMDVFVEQSTLRAQRPVIYNVCNYVRPQAGQSALLSWDEVITLFHEFGHTLHGLF
ASQRYASLSGTNTPRDFVEFPSQIFEHWASQPQVFAHYAKHYQSGEPMPQALRDNMLRAATFNKGYDMSELLAAALLDMR
WHSLSTSALPEEVDAFEQLVLREENLDLAAVPPRYRSSYFSHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENG
QRFREAILSRGNSTDLAELYRQWRGHDPQIEPMLKNRGLSA

Sequences:

>Translated_681_residues
MSERNPFFSVSTLPYQAPPFDVIDDSHYRPAFDEGVRQQRAEIRAIIDNPQPASFANTLEALEQSGQLLARVTRVFFAMA
GAHTNPYIQSLDEQFSAELAELGNDIWLNAALFQRVNSVYEQRDALALDSESYRLLTLTWQRFVHAGATLAPEQQAALRT
LNTEAATLQSQFQQRLLGAAKSGGLVVDYRHQLAGLSDEEIAAAADAARERGLSDRWLLTLTNTTQQPQLLALRDRQTRE
NLFAAGWTRNQQGDEHDTRALVLRLAAIRAQQAELLGAADYASWALTDQMAASPAEALGFMRRIAPAARARAERELADIQ
QVIDNEGGGFRATAWDWLYYSEQVRRAAYAIDDAQLKPYFALERVLQDGVFWTASQLFGLRFVERFDIPVYHPDVRVWEI
FDHNGEGMALFYGDYYARDSKSGGAWMDVFVEQSTLRAQRPVIYNVCNYVRPQAGQSALLSWDEVITLFHEFGHTLHGLF
ASQRYASLSGTNTPRDFVEFPSQIFEHWASQPQVFAHYAKHYQSGEPMPQALRDNMLRAATFNKGYDMSELLAAALLDMR
WHSLSTSALPEEVDAFEQLVLREENLDLAAVPPRYRSSYFSHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENG
QRFREAILSRGNSTDLAELYRQWRGHDPQIEPMLKNRGLSA
>Mature_680_residues
SERNPFFSVSTLPYQAPPFDVIDDSHYRPAFDEGVRQQRAEIRAIIDNPQPASFANTLEALEQSGQLLARVTRVFFAMAG
AHTNPYIQSLDEQFSAELAELGNDIWLNAALFQRVNSVYEQRDALALDSESYRLLTLTWQRFVHAGATLAPEQQAALRTL
NTEAATLQSQFQQRLLGAAKSGGLVVDYRHQLAGLSDEEIAAAADAARERGLSDRWLLTLTNTTQQPQLLALRDRQTREN
LFAAGWTRNQQGDEHDTRALVLRLAAIRAQQAELLGAADYASWALTDQMAASPAEALGFMRRIAPAARARAERELADIQQ
VIDNEGGGFRATAWDWLYYSEQVRRAAYAIDDAQLKPYFALERVLQDGVFWTASQLFGLRFVERFDIPVYHPDVRVWEIF
DHNGEGMALFYGDYYARDSKSGGAWMDVFVEQSTLRAQRPVIYNVCNYVRPQAGQSALLSWDEVITLFHEFGHTLHGLFA
SQRYASLSGTNTPRDFVEFPSQIFEHWASQPQVFAHYAKHYQSGEPMPQALRDNMLRAATFNKGYDMSELLAAALLDMRW
HSLSTSALPEEVDAFEQLVLREENLDLAAVPPRYRSSYFSHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQ
RFREAILSRGNSTDLAELYRQWRGHDPQIEPMLKNRGLSA

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=623, Percent_Identity=28.0898876404494, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI14149738, Length=597, Percent_Identity=26.8006700167504, Blast_Score=186, Evalue=7e-47,
Organism=Homo sapiens, GI156105687, Length=633, Percent_Identity=23.5387045813586, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1787819, Length=680, Percent_Identity=69.2647058823529, Blast_Score=944, Evalue=0.0,
Organism=Escherichia coli, GI1789913, Length=692, Percent_Identity=32.514450867052, Blast_Score=353, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI71999758, Length=478, Percent_Identity=22.3849372384937, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319793, Length=609, Percent_Identity=25.2873563218391, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6322715, Length=381, Percent_Identity=24.9343832020997, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21356111, Length=551, Percent_Identity=25.4083484573503, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI20129717, Length=438, Percent_Identity=25.7990867579909, Blast_Score=132, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 77085; Mature: 76954

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERNPFFSVSTLPYQAPPFDVIDDSHYRPAFDEGVRQQRAEIRAIIDNPQPASFANTLE
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ALEQSGQLLARVTRVFFAMAGAHTNPYIQSLDEQFSAELAELGNDIWLNAALFQRVNSVY
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHH
EQRDALALDSESYRLLTLTWQRFVHAGATLAPEQQAALRTLNTEAATLQSQFQQRLLGAA
HHHHHHEECCCCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCC
KSGGLVVDYRHQLAGLSDEEIAAAADAARERGLSDRWLLTLTNTTQQPQLLALRDRQTRE
CCCCEEEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEHHHHHHHH
NLFAAGWTRNQQGDEHDTRALVLRLAAIRAQQAELLGAADYASWALTDQMAASPAEALGF
HHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MRRIAPAARARAERELADIQQVIDNEGGGFRATAWDWLYYSEQVRRAAYAIDDAQLKPYF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHH
ALERVLQDGVFWTASQLFGLRFVERFDIPVYHPDVRVWEIFDHNGEGMALFYGDYYARDS
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCCEEEEEECCCCCCCC
KSGGAWMDVFVEQSTLRAQRPVIYNVCNYVRPQAGQSALLSWDEVITLFHEFGHTLHGLF
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ASQRYASLSGTNTPRDFVEFPSQIFEHWASQPQVFAHYAKHYQSGEPMPQALRDNMLRAA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHCHHHHH
TFNKGYDMSELLAAALLDMRWHSLSTSALPEEVDAFEQLVLREENLDLAAVPPRYRSSYF
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHH
SHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQRFREAILSRGNSTDLAELY
HHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
RQWRGHDPQIEPMLKNRGLSA
HHHCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
SERNPFFSVSTLPYQAPPFDVIDDSHYRPAFDEGVRQQRAEIRAIIDNPQPASFANTLE
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ALEQSGQLLARVTRVFFAMAGAHTNPYIQSLDEQFSAELAELGNDIWLNAALFQRVNSVY
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHH
EQRDALALDSESYRLLTLTWQRFVHAGATLAPEQQAALRTLNTEAATLQSQFQQRLLGAA
HHHHHHEECCCCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCC
KSGGLVVDYRHQLAGLSDEEIAAAADAARERGLSDRWLLTLTNTTQQPQLLALRDRQTRE
CCCCEEEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEHHHHHHHH
NLFAAGWTRNQQGDEHDTRALVLRLAAIRAQQAELLGAADYASWALTDQMAASPAEALGF
HHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MRRIAPAARARAERELADIQQVIDNEGGGFRATAWDWLYYSEQVRRAAYAIDDAQLKPYF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHH
ALERVLQDGVFWTASQLFGLRFVERFDIPVYHPDVRVWEIFDHNGEGMALFYGDYYARDS
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCCEEEEEECCCCCCCC
KSGGAWMDVFVEQSTLRAQRPVIYNVCNYVRPQAGQSALLSWDEVITLFHEFGHTLHGLF
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ASQRYASLSGTNTPRDFVEFPSQIFEHWASQPQVFAHYAKHYQSGEPMPQALRDNMLRAA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHCHHHHH
TFNKGYDMSELLAAALLDMRWHSLSTSALPEEVDAFEQLVLREENLDLAAVPPRYRSSYF
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHH
SHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQRFREAILSRGNSTDLAELY
HHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
RQWRGHDPQIEPMLKNRGLSA
HHHCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537804; 11677609 [H]