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The map label for this gene is mlc [H]

Identifier: 238894596

GI number: 238894596

Start: 2491311

End: 2492531

Strand: Direct

Name: mlc [H]

Synonym: KP1_2597

Alternate gene names: 238894596

Gene position: 2491311-2492531 (Clockwise)

Preceding gene: 238894595

Following gene: 238894597

Centisome position: 47.47

GC content: 57.17

Gene sequence:

>1221_bases
GTGGTAGCGGATAGTCAACCAGGCCATATCGATCAAATAAAGCAGACCAATGCGGGCGCCGTGTATCGCCTGATTGATCA
GCTCGGCCCGGTATCGCGTATCGACCTTTCCCGATTTGCGCAACTGGCGCCGGCCAGCATCACCAAAATCGTCCGCGAAA
TGCTGGAAGCGCATCTGGTTCAGGAGACCGAGATCCAGGAGCCCGGCAGCCGCGGCCGCCCGGCGGTGGGGCTGATGGTG
GAGACCGAGGCATGGCACTATCTGGCGGTGCGCATCAGCCGCGGTGAGATCCATCTTTCGCTGCGTGATTTAAGCAGTCA
GCTGGTGGTGGAGGATCAGCTGGAGCTGGCGCTCACCGACAGCACGCCGTTTCTGACGCGCGTTATCGACCATATTGATC
GCTTCTTTATTCGCCATCAAAAGAAGCTGGAACGCCTTACCTCCATCGCCATGACGATGCCCGGTATTATCGATACCGAA
AATGGCATTATTCATCGCATGCCGTTTTATGAGGATGTTAAAGATGTCCCGCTCGGCGAAGCGCTGGCCAATCATACCGG
GGTGCCAGTCTATATTCAGCATGACATCAGCGCCTGGACCATGGCGGAATCTTTGTTTGGCGCCTCGCGCGGCGCCCGGG
ACGTCATTCAGGTGGTCATCGATCATAACGTCGGCGCCGGGGTGATCACCGATGGGCGCCTGCTGCACGCCGGCAGCAGC
AGCCTGGTGGAGATTGGCCATACCCAGGTCGATCCCTACGGCAAACGCTGTTACTGCGGCAACCATGGTTGCCTGGAGAC
AATTGCCAGCGTAGAAAGCGTGCTGGAGCTGGCGCAGATGCGCATGGCGCAGTCGATGAGCTCGCTGCTGCACCAGCGTC
CGCTGAGCGTGGAGTGGCTTTGTCAGGCGGCGCTGCAGGGCGATTTGTTAGCCCGGGACATCATCAGCGGCGTGGGTAAT
CACGTTGGGCGGATTCTGGCGATCATGGTCAATCTGTTTAATCCGCAGAAAATTCTGATTGGCTCGCCGTTCAATCTGGC
GGCAGAAATTCTTTTTCCGGCAATTTCCAGCTGTATTCGGCAACAATCTCTCCCAGCCTATAGCCGGCATATTACCGTTG
AAAGTACTCAGTTCTCCAACCGCGGAACGATGGCTGGCGCGGCGCTGGTTAAAGATGCGCTCTATAACGGATCCTTACTC
ATACGACTGTTACAGGGTTAA

Upstream 100 bases:

>100_bases
CGGTAAATCACAAGGCTAAGTAAAAATTTGACGTTCACCGTCGAAGTGCTTCACCATAGCCGAAAGTTTATTTCGAAGCG
CGAAAATAAGGGAGTCAATG

Downstream 100 bases:

>100_bases
CATTTTTTCATAGTCACACCAAAAATTGCGCTATCTCAAGCTGACCTCAGACGGCTTCACGTAGACTTTGCCCACCGTTG
ATTATTTCTCTCCCGTATAT

Product: putative NAGC-like transcriptional regulator

Products: NA

Alternate protein names: Making large colonies protein [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MVADSQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRFAQLAPASITKIVREMLEAHLVQETEIQEPGSRGRPAVGLMV
ETEAWHYLAVRISRGEIHLSLRDLSSQLVVEDQLELALTDSTPFLTRVIDHIDRFFIRHQKKLERLTSIAMTMPGIIDTE
NGIIHRMPFYEDVKDVPLGEALANHTGVPVYIQHDISAWTMAESLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSS
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVESVLELAQMRMAQSMSSLLHQRPLSVEWLCQAALQGDLLARDIISGVGN
HVGRILAIMVNLFNPQKILIGSPFNLAAEILFPAISSCIRQQSLPAYSRHITVESTQFSNRGTMAGAALVKDALYNGSLL
IRLLQG

Sequences:

>Translated_406_residues
MVADSQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRFAQLAPASITKIVREMLEAHLVQETEIQEPGSRGRPAVGLMV
ETEAWHYLAVRISRGEIHLSLRDLSSQLVVEDQLELALTDSTPFLTRVIDHIDRFFIRHQKKLERLTSIAMTMPGIIDTE
NGIIHRMPFYEDVKDVPLGEALANHTGVPVYIQHDISAWTMAESLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSS
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVESVLELAQMRMAQSMSSLLHQRPLSVEWLCQAALQGDLLARDIISGVGN
HVGRILAIMVNLFNPQKILIGSPFNLAAEILFPAISSCIRQQSLPAYSRHITVESTQFSNRGTMAGAALVKDALYNGSLL
IRLLQG
>Mature_406_residues
MVADSQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRFAQLAPASITKIVREMLEAHLVQETEIQEPGSRGRPAVGLMV
ETEAWHYLAVRISRGEIHLSLRDLSSQLVVEDQLELALTDSTPFLTRVIDHIDRFFIRHQKKLERLTSIAMTMPGIIDTE
NGIIHRMPFYEDVKDVPLGEALANHTGVPVYIQHDISAWTMAESLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSS
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVESVLELAQMRMAQSMSSLLHQRPLSVEWLCQAALQGDLLARDIISGVGN
HVGRILAIMVNLFNPQKILIGSPFNLAAEILFPAISSCIRQQSLPAYSRHITVESTQFSNRGTMAGAALVKDALYNGSLL
IRLLQG

Specific function: Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI190014632, Length=231, Percent_Identity=25.974025974026, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI4885285, Length=231, Percent_Identity=25.974025974026, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI298566325, Length=231, Percent_Identity=25.974025974026, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI298566315, Length=231, Percent_Identity=25.974025974026, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787878, Length=406, Percent_Identity=85.2216748768473, Blast_Score=721, Evalue=0.0,
Organism=Escherichia coli, GI1786891, Length=401, Percent_Identity=39.1521197007481, Blast_Score=304, Evalue=8e-84,
Organism=Escherichia coli, GI87082127, Length=371, Percent_Identity=22.1024258760108, Blast_Score=89, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: NA

Molecular weight: Translated: 44569; Mature: 44569

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVADSQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRFAQLAPASITKIVREMLEAHLV
CCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
QETEIQEPGSRGRPAVGLMVETEAWHYLAVRISRGEIHLSLRDLSSQLVVEDQLELALTD
HHHHCCCCCCCCCCEEEEEEECCCEEEEEEEEECCEEEEEHHHHCCHHEEECCEEEEEEC
STPFLTRVIDHIDRFFIRHQKKLERLTSIAMTMPGIIDTENGIIHRMPFYEDVKDVPLGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEECCCHHHHHCCCCHH
ALANHTGVPVYIQHDISAWTMAESLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSS
HHHCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCEEEECCCC
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVESVLELAQMRMAQSMSSLLHQRPLSVEWL
CCEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
CQAALQGDLLARDIISGVGNHVGRILAIMVNLFNPQKILIGSPFNLAAEILFPAISSCIR
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
QQSLPAYSRHITVESTQFSNRGTMAGAALVKDALYNGSLLIRLLQG
HHCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHCCHHHHEEECC
>Mature Secondary Structure
MVADSQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRFAQLAPASITKIVREMLEAHLV
CCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
QETEIQEPGSRGRPAVGLMVETEAWHYLAVRISRGEIHLSLRDLSSQLVVEDQLELALTD
HHHHCCCCCCCCCCEEEEEEECCCEEEEEEEEECCEEEEEHHHHCCHHEEECCEEEEEEC
STPFLTRVIDHIDRFFIRHQKKLERLTSIAMTMPGIIDTENGIIHRMPFYEDVKDVPLGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEECCCHHHHHCCCCHH
ALANHTGVPVYIQHDISAWTMAESLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSS
HHHCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCEEEECCCC
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVESVLELAQMRMAQSMSSLLHQRPLSVEWL
CCEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
CQAALQGDLLARDIISGVGNHVGRILAIMVNLFNPQKILIGSPFNLAAEILFPAISSCIR
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
QQSLPAYSRHITVESTQFSNRGTMAGAALVKDALYNGSLLIRLLQG
HHCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7766024; 9097039; 9278503 [H]