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The map label for this gene is fnr [H]

Identifier: 238894548

GI number: 238894548

Start: 2444077

End: 2444829

Strand: Reverse

Name: fnr [H]

Synonym: KP1_2544

Alternate gene names: 238894548

Gene position: 2444829-2444077 (Counterclockwise)

Preceding gene: 238894549

Following gene: 238894547

Centisome position: 46.58

GC content: 53.78

Gene sequence:

>753_bases
ATGATCCCTGAGAAGCGAATTATTCGACGCATTCAGTCTGGCGGTTGTGCAATCCATTGTCAGGATTGCAGCATTAGCCA
GCTCTGCATCCCCTTTACTCTGAACGAGCATGAGCTTGATCAGCTGGATAATATTATCGAGCGGAAAAAGCCTATCCAGA
AAGGTCAAACCTTGTTCAAAGCCGGTGATGAGCTGAAGTCGTTGTACGCTATTCGCTCCGGGACCATCAAAAGCTATACC
ATCACCGAGCAAGGTGATGAGCAGATCACTGGCTTCCATCTGGCGGGCGACCTGGTGGGCTTTGACGCCATCGGCACCGG
TCTGCACCCGAGCTTTGCGCAGGCGCTGGAAACCTCGATGGTCTGCGAGATCCCCTTCGAAACCCTTGACGATCTTTCCG
GAAAAATGCCCAATCTGCGTCAGCAGATGATGCGCCTGATGAGCGGCGAGATTAAAGGCGACCAGGATATGATCCTGTTG
CTTTCCAAAAAGAATGCCGAAGAGCGCCTGGCCGCGTTTATCTATAACCTTTCTCGTCGTTTCGCCCAGCGCGGCTTCTC
ACCACGTGAGTTCCGGCTGACCATGACCCGCGGCGATATTGGCAACTATCTCGGCCTCACCGTCGAAACCATCAGCCGTC
TGCTGGGCCGTTTTCAGAAAAGCGGCATGCTGGCGGTGAAAGGCAAATATATCACTATTGAAAACAGCGATCTGCTGGCC
CAGTTGGCCGGGCAGGCGCGCAACGTCGCTTAA

Upstream 100 bases:

>100_bases
TTTACCCTGCTGATATTACGTGTTTCCGGGCCTGAAGACTTACCTGCTGATCAAAAAGATGTTAAAATTGACCAATATCA
ATTAAGGCCTGAGCAGACAT

Downstream 100 bases:

>100_bases
TCTCTGCGCAATACCTGGTCACGATCGGCAATTTTTTCAGATTTGTTGATCTGACCAGGCTCCTCCCCTGTTTCAATTCA
TCCATATAGGTTATCTTTTT

Product: fumarate/nitrate reduction transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGTGLHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENSDLLA
QLAGQARNVA

Sequences:

>Translated_250_residues
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGTGLHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENSDLLA
QLAGQARNVA
>Mature_250_residues
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGTGLHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENSDLLA
QLAGQARNVA

Specific function: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=250, Percent_Identity=97.6, Blast_Score=502, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27934; Mature: 27934

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFK
CCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVGFDAIGTGLHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHH
VCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSRR
EEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENSDLLA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECEEEEEECCHHHH
QLAGQARNVA
HHHHHHCCCC
>Mature Secondary Structure
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFK
CCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVGFDAIGTGLHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHH
VCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSRR
EEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENSDLLA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECEEEEEECCHHHH
QLAGQARNVA
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]