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The map label for this gene is emrK [H]

Identifier: 238894499

GI number: 238894499

Start: 2395435

End: 2396520

Strand: Reverse

Name: emrK [H]

Synonym: KP1_2490

Alternate gene names: 238894499

Gene position: 2396520-2395435 (Counterclockwise)

Preceding gene: 238894500

Following gene: 238894498

Centisome position: 45.66

GC content: 61.05

Gene sequence:

>1086_bases
ATGAGTCAGCAGGATGCGGCCAAACAACAGGCCAACACCCGGAATAATATTCGCGTGGTTTCCATTTTTACCGCCGCGGC
GATAGGCCTCGTCGGCGTGCTGGTGATCCTCTACGCCTGGCAACTGCCGCCGTTCACTCGTCATAGCCAGTTTACCGACA
ACGCCTATGTGCGCGGGCAGACCACCTTTATTAGCCCGCAGGTCAACGGCTATATCACTGCCGTCAACGTCAAAGATTTC
GCGATTGTCCAGCCGGGCGAGGTGCTGTTCCAGATAGACGATCGCATCTATAAACAGCGGGTGCATCAGGCCCAGGCTAC
CCTGGCGATGAAAGAGGCCGCGCTGCGCAATAACCTGCAACAGCGCAAAAGCGCCGAGGCGACGATCGCCAAGAATGAAG
CCGCGCTGCAAAACGCCCGCGCGCAGAATCTGAAAATCCAGGCCGATTTAAAACGCATCCAGCAGTTAACCGCCGACGGT
TCGCTGTCGATCCGCGAACGTGATTCGGCGCGGGCCAGCGCGGCGCAAGGGGCGGCGGATATTGAGCAGGCGAAAGCGGC
GCTGGAGATGTCGCGCCAGGACCGTGAATCGACCATCGTCAATCGCGATTCGCTGGAGGCCGACGTGGCCAGCGCCAAAG
CGGCGCTTGAGCTGGCGCAGATCGACCTGCAGAATACCCAGATTATCGCCCCCACCGGCGGCCAGCTGGGGCAGATCTCG
GTGCGTCTTGGCGCCTATGTCAGCGCCGGGACCCATCTGACCTCGCTGGTTCCGCCGCAGCACTGGGTGATTGCCAACCT
CAAAGAGACCCAGCTGGCCGAAGTACGCGTTGGCCAGCCGGTCACCTTCACCGTAGACGCGCTCAACGGCGAGACCTTCC
ACGGCAAGGTGCAGAGTATCTCCCCGGCGACCGGGGTGGAGTTCAGCGCCATCTCTCCGGACAACGCCACCGGCAATTTC
GTCAAGATCGCCCAGCGCATCCCGGTGCGTATTACGGTCAACGACGGGCAAAACAACAGCGAACGCCTGCGGCCGGGGAT
GTCGGTGCAGGTGACTATTGATACCCGTGCGGAGAAACAACCATGA

Upstream 100 bases:

>100_bases
GTTTTCTGGCGCTTAATTCGCTTACGACTGACTGCCCGTATCGCGTTGCAACGCGCTACCGGCAGCAAATAATTATCATC
ATTTCATCTCTGGAGTCGTT

Downstream 100 bases:

>100_bases
TCCGCCCGGTCGCCCTTGCTATCGTTCTGGCGCTGGTCGGCTGTCAATCCGCCGATGTGCAGCGCGCACAGCCGACCCTG
ACCATTCCTGCCGCCTGGCG

Product: putative multidrug resistance efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MSQQDAAKQQANTRNNIRVVSIFTAAAIGLVGVLVILYAWQLPPFTRHSQFTDNAYVRGQTTFISPQVNGYITAVNVKDF
AIVQPGEVLFQIDDRIYKQRVHQAQATLAMKEAALRNNLQQRKSAEATIAKNEAALQNARAQNLKIQADLKRIQQLTADG
SLSIRERDSARASAAQGAADIEQAKAALEMSRQDRESTIVNRDSLEADVASAKAALELAQIDLQNTQIIAPTGGQLGQIS
VRLGAYVSAGTHLTSLVPPQHWVIANLKETQLAEVRVGQPVTFTVDALNGETFHGKVQSISPATGVEFSAISPDNATGNF
VKIAQRIPVRITVNDGQNNSERLRPGMSVQVTIDTRAEKQP

Sequences:

>Translated_361_residues
MSQQDAAKQQANTRNNIRVVSIFTAAAIGLVGVLVILYAWQLPPFTRHSQFTDNAYVRGQTTFISPQVNGYITAVNVKDF
AIVQPGEVLFQIDDRIYKQRVHQAQATLAMKEAALRNNLQQRKSAEATIAKNEAALQNARAQNLKIQADLKRIQQLTADG
SLSIRERDSARASAAQGAADIEQAKAALEMSRQDRESTIVNRDSLEADVASAKAALELAQIDLQNTQIIAPTGGQLGQIS
VRLGAYVSAGTHLTSLVPPQHWVIANLKETQLAEVRVGQPVTFTVDALNGETFHGKVQSISPATGVEFSAISPDNATGNF
VKIAQRIPVRITVNDGQNNSERLRPGMSVQVTIDTRAEKQP
>Mature_360_residues
SQQDAAKQQANTRNNIRVVSIFTAAAIGLVGVLVILYAWQLPPFTRHSQFTDNAYVRGQTTFISPQVNGYITAVNVKDFA
IVQPGEVLFQIDDRIYKQRVHQAQATLAMKEAALRNNLQQRKSAEATIAKNEAALQNARAQNLKIQADLKRIQQLTADGS
LSIRERDSARASAAQGAADIEQAKAALEMSRQDRESTIVNRDSLEADVASAKAALELAQIDLQNTQIIAPTGGQLGQISV
RLGAYVSAGTHLTSLVPPQHWVIANLKETQLAEVRVGQPVTFTVDALNGETFHGKVQSISPATGVEFSAISPDNATGNFV
KIAQRIPVRITVNDGQNNSERLRPGMSVQVTIDTRAEKQP

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=364, Percent_Identity=33.2417582417582, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789041, Length=343, Percent_Identity=33.5276967930029, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1790519, Length=305, Percent_Identity=29.8360655737705, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI87081951, Length=325, Percent_Identity=27.3846153846154, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1789637, Length=332, Percent_Identity=27.4096385542169, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790024, Length=252, Percent_Identity=29.3650793650794, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790012, Length=249, Percent_Identity=26.5060240963855, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39195; Mature: 39064

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQDAAKQQANTRNNIRVVSIFTAAAIGLVGVLVILYAWQLPPFTRHSQFTDNAYVRGQ
CCCHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECE
TTFISPQVNGYITAVNVKDFAIVQPGEVLFQIDDRIYKQRVHQAQATLAMKEAALRNNLQ
EEEECCCCCCEEEEEEECEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRKSAEATIAKNEAALQNARAQNLKIQADLKRIQQLTADGSLSIRERDSARASAAQGAAD
HHHCCCHHHHCCHHHHHCCHHHCEEEHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCHHH
IEQAKAALEMSRQDRESTIVNRDSLEADVASAKAALELAQIDLQNTQIIAPTGGQLGQIS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEECCCCCCEEEE
VRLGAYVSAGTHLTSLVPPQHWVIANLKETQLAEVRVGQPVTFTVDALNGETFHGKVQSI
EEECEEEECCCCHHHCCCCCCEEEECCCHHHEEHEECCCCEEEEEECCCCCEEECEEEEC
SPATGVEFSAISPDNATGNFVKIAQRIPVRITVNDGQNNSERLRPGMSVQVTIDTRAEKQ
CCCCCCEEEEECCCCCCCHHHHHCCCCCEEEEEECCCCCHHHCCCCCEEEEEEECCCCCC
P
C
>Mature Secondary Structure 
SQQDAAKQQANTRNNIRVVSIFTAAAIGLVGVLVILYAWQLPPFTRHSQFTDNAYVRGQ
CCHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECE
TTFISPQVNGYITAVNVKDFAIVQPGEVLFQIDDRIYKQRVHQAQATLAMKEAALRNNLQ
EEEECCCCCCEEEEEEECEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRKSAEATIAKNEAALQNARAQNLKIQADLKRIQQLTADGSLSIRERDSARASAAQGAAD
HHHCCCHHHHCCHHHHHCCHHHCEEEHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCHHH
IEQAKAALEMSRQDRESTIVNRDSLEADVASAKAALELAQIDLQNTQIIAPTGGQLGQIS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEECCCCCCEEEE
VRLGAYVSAGTHLTSLVPPQHWVIANLKETQLAEVRVGQPVTFTVDALNGETFHGKVQSI
EEECEEEECCCCHHHCCCCCCEEEECCCHHHEEHEECCCCEEEEEECCCCCEEECEEEEC
SPATGVEFSAISPDNATGNFVKIAQRIPVRITVNDGQNNSERLRPGMSVQVTIDTRAEKQ
CCCCCCEEEEECCCCCCCHHHHHCCCCCEEEEEECCCCCHHHCCCCCEEEEEEECCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]