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The map label for this gene is mdmC [H]

Identifier: 238894497

GI number: 238894497

Start: 2393384

End: 2394058

Strand: Reverse

Name: mdmC [H]

Synonym: KP1_2488

Alternate gene names: 238894497

Gene position: 2394058-2393384 (Counterclockwise)

Preceding gene: 238894498

Following gene: 238894495

Centisome position: 45.61

GC content: 59.7

Gene sequence:

>675_bases
ATGGGGAAGCGTCATATGCAACAACAGTGGTCGGCAGTAGACAATTATTTGATTAAGGCCTTAATTCCCGGCGATCCTGT
GCTCGATCGGGTACTGGAAAACAACCATCGTGCCGGGCTCCCGGCACACGATGTCGCCGCCAATCAGGGTCAGTTTCTCG
CCCTGCTGGTACGGCTAACCCAGGCTAAGCGGATACTGGAGATCGGCACCCTCGGCGGCTATAGCACCATCTGGATGGCG
CGCGAGCTTCCTGCAGACGGCCAACTCCTCACCCTGGAGGCCGACGCGCATCATGCCCAGGTGGCGCGGGAGAATCTGCA
GCTGGCGGGCGTTGACCAGCGGGTCACGCTACGGGAGGGACCCGCGCTACAGTCCCTGGAGTCGCTTGGCGAATGTCCCG
CTTTCGATCTGATCTTCATCGATGCCGATAAGCCGAATAACCCCCATTATCTGCGCTGGGCGCTACGTTATTCCCGCCCA
GGAACCTTAATTATTGGCGATAACGTGGTACGCGACGGCGAAGTGGTCAACCCACAGAGCGCCGACGAGCGCGTTCAGGG
CGTGCGTCAGTTCATTGAGATGATGGGCGCCGAGCCACGGTTGACGGCAACGGCGCTGCAAACCGTGGGCACTAAAGGCT
GGGACGGCTTTACTCTGGCGTGGGTAAACGCTTAA

Upstream 100 bases:

>100_bases
CCAGCTTAGCGTGGTGCAGGTGAAGAACAACCTGCTGCTGGCGCAGATCGCTCTGTACCGGGCGCTGGGAGGCGGCTGGT
CTGACTCATCAGGGAGCTAA

Downstream 100 bases:

>100_bases
GCAAGTAGCCCCGGTAAGCGCAGCGCCACCGGGGACAACCAGCCAGGCTATGGGGTAATTTGCTCCATCGCCTGCAACAC
TCGCTTGTCCGAGATAGGAT

Product: putative O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MGKRHMQQQWSAVDNYLIKALIPGDPVLDRVLENNHRAGLPAHDVAANQGQFLALLVRLTQAKRILEIGTLGGYSTIWMA
RELPADGQLLTLEADAHHAQVARENLQLAGVDQRVTLREGPALQSLESLGECPAFDLIFIDADKPNNPHYLRWALRYSRP
GTLIIGDNVVRDGEVVNPQSADERVQGVRQFIEMMGAEPRLTATALQTVGTKGWDGFTLAWVNA

Sequences:

>Translated_224_residues
MGKRHMQQQWSAVDNYLIKALIPGDPVLDRVLENNHRAGLPAHDVAANQGQFLALLVRLTQAKRILEIGTLGGYSTIWMA
RELPADGQLLTLEADAHHAQVARENLQLAGVDQRVTLREGPALQSLESLGECPAFDLIFIDADKPNNPHYLRWALRYSRP
GTLIIGDNVVRDGEVVNPQSADERVQGVRQFIEMMGAEPRLTATALQTVGTKGWDGFTLAWVNA
>Mature_223_residues
GKRHMQQQWSAVDNYLIKALIPGDPVLDRVLENNHRAGLPAHDVAANQGQFLALLVRLTQAKRILEIGTLGGYSTIWMAR
ELPADGQLLTLEADAHHAQVARENLQLAGVDQRVTLREGPALQSLESLGECPAFDLIFIDADKPNNPHYLRWALRYSRPG
TLIIGDNVVRDGEVVNPQSADERVQGVRQFIEMMGAEPRLTATALQTVGTKGWDGFTLAWVNA

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=180, Percent_Identity=36.1111111111111, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17565612, Length=174, Percent_Identity=29.8850574712644, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25148771, Length=174, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24734; Mature: 24602

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKRHMQQQWSAVDNYLIKALIPGDPVLDRVLENNHRAGLPAHDVAANQGQFLALLVRLT
CCHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHH
QAKRILEIGTLGGYSTIWMARELPADGQLLTLEADAHHAQVARENLQLAGVDQRVTLREG
HHHHHHHHHCCCCCHHEEEEECCCCCCCEEEEECCCHHHHHHHHCCEEECCCCEEEECCC
PALQSLESLGECPAFDLIFIDADKPNNPHYLRWALRYSRPGTLIIGDNVVRDGEVVNPQS
CCHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCEEEECCCEECCCCCCCCCC
ADERVQGVRQFIEMMGAEPRLTATALQTVGTKGWDGFTLAWVNA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECC
>Mature Secondary Structure 
GKRHMQQQWSAVDNYLIKALIPGDPVLDRVLENNHRAGLPAHDVAANQGQFLALLVRLT
CHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHH
QAKRILEIGTLGGYSTIWMARELPADGQLLTLEADAHHAQVARENLQLAGVDQRVTLREG
HHHHHHHHHCCCCCHHEEEEECCCCCCCEEEEECCCHHHHHHHHCCEEECCCCEEEECCC
PALQSLESLGECPAFDLIFIDADKPNNPHYLRWALRYSRPGTLIIGDNVVRDGEVVNPQS
CCHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCEEEECCCEECCCCCCCCCC
ADERVQGVRQFIEMMGAEPRLTATALQTVGTKGWDGFTLAWVNA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]